TRAFIKK: systematic prediction and mechanistic interpretation of anticancer drug synergies biorxiv.org
Acute inflammation-mediated attenuation of behavioural sensitization in methamphetamine-sensitized mice via distinct COX-2 and TNF-α pathways biorxiv.org
Early plasma proteomic alterations precede amyloidosis diagnosis, reflecting cardiac and immune dysregulation biorxiv.org
Microbiome Composition Regulates Cathepsin Expression in Vaginal Fluid Across BV Diagnoses and Community State Types biorxiv.org
Sex-differentiated hormonal microenvironments recapitulate in vivo liver metabolism in human iPSC-derived organoids biorxiv.org
Pre-existing systemic and nasal antibodies against avian H5 influenza A viruses vary according to childhood imprinting biorxiv.org
A computational model reveals that spatial localization of cancer stem cells increases radioresistance in tumorspheres biorxiv.org
BAT: an integrated pipeline for gene tree construction, annotation, and functional inference biorxiv.org
Temporal-deviation-driven community detection uncovers early-warning signals for critical transitions in complex diseases biorxiv.org
SigBridgeR: An Integrative Framework and Toolkit for Comprehensive Screening and Benchmarking of Phenotype-Associated Cell Subpopulations in Single-Cell Transcriptomics biorxiv.org
Dual-view Guided Context-aware Network for Automated Bone Lesion Segmentation and Quantification in Whole-body SPECT biorxiv.org
Humanization of N-glycan-dependent protein quality control system in Kluyveromyces marxianus promotes glycoprotein secretion biorxiv.org
Dual Immune Checkpoint and Cytokine Receptor Modulation by an Engineered Human CTLA-4/IL-10 Bispecific Fusion Protein biorxiv.org
A Three-Layered Agent-Based Model of Adult Hippocampal Neurogenesis (HANG-AB3L) with Stochastic Cell Fate Determination biorxiv.org
Diet-dependent effects of kombucha on the gut microbiome and its neuroactive potential: Associations with reduced anxiety and depressive-like behaviors in mice biorxiv.org
Source-space EEG functional connectivity and prediction of cognition in Parkinsons disease: No added benefit of individualized head models over standard templates biorxiv.org
Experimental and natural peripheral HSV-1 infection: Neurotropism and impact on Alzheimer's disease-related molecular markers biorxiv.org
Efficacy evaluation of glasedgib Sonic Hedgehog pathway inhibition with or without inotuzumab in B-ALL cells using a new co-culturing system model and a validated chemosensitivity assay biorxiv.org
Figra: A WebAssembly-based Excel Add-in for publication-quality scientific visualization with ggplot2 biorxiv.org
Online characterization of surrogate metrics for metabolic phenotype in human induced pluripotent stem cell bioprocessing biorxiv.org
Predicting curvature evolution on biological surfaces from clinical imaging-derived area dilation: a closed-form interpretable framework biorxiv.org
An Innovative, Low-Cost Medium for the Bioproduction of Prodigiosin by Serratia marcescens. biorxiv.org
Testing the null model for polyandry: the need to breed explains multiple mating and constrains trading-up biorxiv.org
Seasonal microbiome community dynamics in the massive coral Porites lobata impacted by sedimentation biorxiv.org
Activation by statins unveils two putative agonist binding sites in the pore domain of TRPA1 biorxiv.org
Self-organizing physical and biochemical interactions explain diverse behaviours in Physarum polycephalum biorxiv.org
Engineering a pacemaker-driven human mini-heart guided by spatial multi-omics of sinoatrial node development biorxiv.org
Dogcatcher2: Improved statistical detection of transcriptional readthrough and repetitive element analysis across sequencing platforms biorxiv.org
Carbohydrate active enzymes in Pectobacteriaceae: coevolving enzyme sets and host adaptation biorxiv.org
Discovery and Characterization of Interleukin-4-Specific Affibodies for Affinity-Controlled Protein Release and Macrophage Polarization biorxiv.org
Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing biorxiv.org
Molecular Star Gazing: Development and Validation of an Environmental DNA Assay for the Imperiled Sunflower Sea Star (Pycnopodia helianthoides) biorxiv.org
Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response biorxiv.org