Longitudinal Reorganization of Cortical and Cerebellar Functional Networks in Spinocerebellar Ataxia Type 7 biorxiv.org 2026-08-02 Spinocerebellar ataxia type 7 (SCA7) is a rare neurodegenerative disorder characterized by progressive cerebellar ataxia and visual impairment.
MreB is dispensable for viability but critical for rod shape, motility and biofilm fitness in Pseudomonas aeruginosa biorxiv.org 2026-08-02 Despite growing interest in the MreBCD morphogenetic complex as a potential antimicrobial target, its function in Pseudomonas aeruginosa remains poorl
Methodological Impacts on Microbiome Structure and Indicator Status in the Human Lower Respiratory Tract biorxiv.org 2026-08-02 Rationale: Lung cancer is the leading cause of cancer-related death globally, and rising incidence among traditionally low-risk individuals intensifie
MassGAT: a graph-based collective learning approach for untargeted detection and annotation of LC-MS data biorxiv.org 2026-08-02 Motivation: The untargeted processing of Liquid Chromatography coupled to High-Resolution Mass Spectrometry (LC-HRMS) data is a major challenge for th
Energetics of stalk intermediates elucidated from hydrostatic pressure effects on membrane fusion biorxiv.org 2026-08-02 Membrane fusion is an essential process in cells that requires a balance of lipid composition to establish biophysical properties conducive to topolog
Naturally cysteine-less LOV domains from halophilic archaea exhibit magnetic field effects on their fluorescence biorxiv.org 2026-08-02 Magnetic fields can modulate the function of certain flavoproteins through the radical pair mechanism, in which they influence the spin evolution of a
Benchmarking Deep Learning Predictions of Mutation-Induced Fold Switching biorxiv.org 2026-08-02 Many proteins are known to adopt multiple distinct folded states which are often associated with key functional behavior.
Minocycline engages microglia in the midbrain periaqueductal grey to attenuate hypoxia-triggered panic-like behaviour in rats biorxiv.org 2026-08-02 Panic disorder (PD) is a chronic and highly disabling psychiatric disorder characterised by recurrent and unexpected panic attacks, with underlying ne
Multifaceted and evolutionarily dynamic interactions between Caenorhabditis elegans SPO-11 and its cofactors ensure proper formation of meiotic DNA double-strand breaks biorxiv.org 2026-08-02 DNA double-strand breaks (DSBs) generated during meiotic prophase by the topoisomerase-like protein SPO11 are essential to create crossovers between h
The gut microbiome of infants with hypoplastic left heart syndrome is enriched in pathobionts and exhibits altered responses to nutritional intervention biorxiv.org 2026-08-02 Congenital heart disease (CHD) can expose infants to chronic cyanosis, altered intestinal perfusion, and prolonged hospitalization.
Systematic comparison of pathogenic variants of the RNA exosome gene EXOSC3/RRP40 in Saccharomyces cerevisiae reveals variant-specific functional consequences biorxiv.org 2026-08-02 The RNA exosome is an essential, evolutionarily conserved ribonuclease complex that processes and degrades many classes of RNA.
Genome-wide analysis reveals the importance of histone acetyltransferase Esa1 in transcriptional regulation during nitrogen starvation biorxiv.org 2026-08-02 Macroautophagy/autophagy is a process that degrades intracellular components and is strongly triggered by nitrogen starvation (-N).
Population-Scale Landscape of Mobile Element Insertions Across 82 Diverse Indian Populations biorxiv.org 2026-08-02 Mobile element insertions (MEIs) are a major source of structural variation in human DNA that can affect gene regulation and disrupt coding sequences.
Prevalence of chloroquine and antifolate drug resistance markers in Plasmodium falciparum parasites in Rwanda, 2018 biorxiv.org 2026-08-02 Background Antimalarial drug efficacy is threatened by the development of drug resistance.
PG-MLD: Physics-Guided Molecular Representation Learning via Dynamic 3D Trajectory Distillation biorxiv.org 2026-08-02 Molecular representation learning underpins molecular property prediction and drug design by capturing molecular structure-property relationships.
Dynamics of the α2-chimaerin-Rac1 interface in Duane retraction syndrome and computational design of candidate probes biorxiv.org 2026-08-02 Duane retraction syndrome (DRS) is an eye movement disorder caused by gain-of-function mutations in CHN1, which encodes 2-chimaerin.
CD133+ progenitor cells promote pulmonary hypertension through CXCR4 signaling biorxiv.org 2026-08-02 Background: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling and smooth muscle cell accumulation, but the progenitor-like
Clutter does not affect the spatial tuning of * category representations in human object-selective cortex * biorxiv.org 2026-08-02 Natural vision is frequently impaired when the visual field is crowded with multiple competing objects.
SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes biorxiv.org 2026-08-02 SLAM-associated protein (SAP) is required for T follicular helper (Tfh)-B cell interactions that underlie germinal center formation, but it is unclear
The solid tumor microenvironment changes the hierarchy of CD155 and CD112 receptors, shaping checkpoint blockade outcome biorxiv.org 2026-08-02 Reproducing a physiologically relevant tumor microenvironment in vitro is essential for developing effective immunotherapeutic treatments.
Genetic background diversifies mutational paths but converges on membrane depolarization for bleomycin resistance in yeast biorxiv.org 2026-08-01 Drug resistance evolution is shaped by both selective agent and genetic background in which resistant mutations arise, but most experimental evolution
Evolution of a large and diverse phospholipase gene cluster that defines the plant pathogenic genus Ceratocystis biorxiv.org 2026-08-01 Many Ceratocystis species cause cankers and unique vascular wilt diseases, often on a broad and unpredictable range of plant hosts.
Enhancing Recombinant Vector Assembly Efficiency: A Novel Methodological Approach biorxiv.org 2026-08-01 With the rapid development of modern biotechnology, DNA vectors have become fundamental tools for inserting, transferring, and expressing specific gen
Combinatorial sequence elements fine-tune mitochondrial protein import to facilitate dual localization biorxiv.org 2026-08-01 The dual targeting of mitochondrial proteins regulates a host of cellular processes, including metabolism, cofactor biosynthesis, mitophagy, and stres
An alphabet of allostery: a transferable transfer entropy contact patterns predicts allosteric-site character and conformational rewiring biorxiv.org 2026-08-01 Allostery is increasingly understood as the propagation of dynamic information through a protein, yet the computational descriptors of that flow are c
Reconstructing lineage-constrained gene-program dynamics with PhyloFM biorxiv.org 2026-08-01 Cell-fate dynamics are defined not only by where cells end, but by when fate programs emerge, diverge, and reshape population structure.
Equi-depth pooling for standardized and cost-effective Adaptive Immune Receptor Repertoire sequencing (AIRRseq) biorxiv.org 2026-08-01 Bulk B- and T-cell adaptive immune receptor (BCR/TCR) repertoire sequencing (AIRRseq) enables comprehensive analysis of adaptive immune diversity, but
DEAR-OWL: a fully browser-based hybrid resource for instant or precise differential gene expression analysis biorxiv.org 2026-08-01 Motivation: Differential gene expression analysis (DEA) via RNA sequencing (RNA-seq) is essential but remains challenging for wet-lab biologists due t
A hyperspherical deep Bayesian model for interpretable clustering and relationship prediction in microbiome multi-omics integration biorxiv.org 2026-08-01 The microbiome plays a significant role in the development and progression of many diseases, yet extracting interpretable insights from multi-omics da
Optimized Multiple Circular Sequence Alignment for Cyclic Peptide Motif Discovery biorxiv.org 2026-08-01 Head-to-tail (H2T) cyclized peptides are an increasingly important modality in drug discovery, combining high target affinity and selectivity with met
Joint modeling of multi-timepoint spatial observations for time-resolved spatial-unit-specific gene regulatory network inference biorxiv.org 2026-08-01 Background: How gene regulatory programs reorganize across space and time is central to development and disease, but current methods infer regulatory
Systematic assessment of sequencing depth requirements for Hi-C-derived metrics biorxiv.org 2026-08-01 Hi-C experiments produce genome-wide chromatin contact maps from which structural features can be quantified across multiple genomic scales, ranging f
MetaAMI: A Novel Meta-Learning Approach for Predicting In-Hospital Mortality in Acute Myocardial Infarction biorxiv.org 2026-08-01 Acute myocardial infarction (AMI) is one of the leading cardiovascular diseases worldwide and remains a major cause of mortality.
CPPLocPred: Subcellular Localization of Cell-Penetrating Peptides biorxiv.org 2026-08-01 Cell-penetrating peptides (CPPs) are widely used to deliver therapeutic cargoes into cells.
Automating 3DED data processing at eBIC biorxiv.org 2026-08-01 Three-dimensional electron diffraction (3DED) is an emerging and useful technique for solving molecular structures of small and biological macromolecu
SPINDLE: Unlocking protein dynamics from single-field NMR relaxation data using a deep learning ensemble. biorxiv.org 2026-08-01 A protein's function is derived from its three-dimensional structure and the motions of the atoms about that structure.
Toward scalable ambulatory light dosimetry: sensor-placement bias under naturalistic conditions biorxiv.org 2026-08-01 Background: Personal light dosimeters enable exposure assessment under free-living conditions, but sensors are rarely positioned near the eyes-the rel
Xanthophyll acyl esters in pepper (Capsicum annuum): Delineating the role of two xanthophyll acyltransferases CaPYP1 and CaPYP1-like via gene silencing and genetic complementation. biorxiv.org 2026-08-01 Pepper fruit accumulated xanthophyll acyl esters during ripening.
Delineating the posterior bank of the feline auditory cortex based on neurofilament proteins expressing SMI-32 biorxiv.org 2026-08-01 The feline auditory cortex is understood to consist of 13 distinct subregions with unique anatomical and functional properties.
Macroscale dynamics of EEG microstates determine the periodic and aperiodic features of the neural power spectrum biorxiv.org 2026-08-01 The global signal characteristics of scalp-recorded electroencephalography (EEG) are composed of periodic oscillatory rhythms and aperiodic broadband
An end-to-end framework for single-cell-resolution, whole-transcriptomic spatial profiling in post-mortem human brain biorxiv.org 2026-08-01 Single-cell resolution spatial transcriptomics enables transcriptome-wide molecular profiling within intact tissue architecture, providing unprecedent
cGMP signaling regulates context-dependent sensory valence in C. elegans biorxiv.org 2026-08-01 An animal's response to chemosensory cues depends on the animal's prior experience, internal state, or life stage.
Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapy biorxiv.org 2026-08-01 We interrogate antigen-specific CD4 T cells during immunotherapy in pancreatic ductal adenocarcinoma.
Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy biorxiv.org 2026-08-01 Immune checkpoint inhibitors (ICI) that are antibodies against CTLA-4 have achieved therapeutic effects on multiple types of cancers, but the mechanis
Fermentation-Derived Metabolites Shape Host Biology to Attenuate Severity of Inflammatory and Metabolic Disease biorxiv.org 2026-08-01 Fermented foods are among the few dietary interventions shown to increase gut microbiome diversity and reduce systemic inflammation in healthy adults,
Convergent genomic variation and wild-type composite RNA-seq profiling identify candidate modules associated with 3-nitropropionic acid utilization in Leclercia barmai biorxiv.org 2026-08-01 3-Nitropropionic acid (3-NPA) is a toxic nitroaliphatic compound, but the genomic basis of bacterial adaptation to 3-NPA remains incompletely resolved
A zebrafish leprosy model identifies interferon and plasminogen signaling as survival determinants in mycobacterial infection biorxiv.org 2026-08-01 Although many genes are associated with leprosy, a skin and nerve infection by Mycobacterium leprae, the function of most of these genes in infection
Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension biorxiv.org 2026-08-01 Background: Right ventricular (RV) adaptation determines outcomes in pulmonary arterial hypertension (PAH), yet multicellular molecular programs assoc
Nitric oxide inhibits platelet adhesion to platelet-microparticles through reducing integrin αIIbβ3 activation biorxiv.org 2026-08-01 Increased platelet microparticle (PMP) levels in individuals with risk factors for cardiovascular disease correlate with clinical outcomes in these pa
An inversion-rich genome shapes admixture outcomes, generating a mosaic of lineage-specific ancestries in the European sardine biorxiv.org 2026-08-01 The role of chromosomal inversions in modulating the outcomes of admixture between divergent evolutionary lineages remains poorly understood.