Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure biorxiv.org 2026-07-31 Alcohol-induced toxicity is driven largely by the accumulation of acetaldehyde and disruption of hepatic redox homeostasis during ethanol metabolism.
mock-fastq-generator: A synthetic FASTQ generator biorxiv.org 2026-07-31 Validating bioinformatics pipelines and benchmarking sequence processing algorithms requires reliable test datasets.
CyFj11: FlowJo v11 Workspace Import and Legacy Format Export for R-Based Flow Cytometry Analysis biorxiv.org 2026-07-31 High-dimensional flow cytometry measures immune cells at single-cell resolution, enabling systematic characterization of cell populations at scale.
Gastrin releasing peptide and cholecystokinin employ different intracellular pathways to elicit similar safe Ca2+ signals biorxiv.org 2026-07-31 Repetitive cytosolic Ca2+ spikes in pancreatic acinar cells, elicited by low (physiological) concentrations of acetylcholine (ACh), cholecystokinin (C
Comparative connectomics of parasite esophagus suggests evolutionary simplification of a nervous system biorxiv.org 2026-07-31 Several prominent examples suggest that the evolution of parasitism is accompanied by nervous system simplification.
Adgrd1 deficiency reveals increased hippocampal vulnerability and selective behavioral alterations in mice biorxiv.org 2026-07-31 ADGRD1 (GPR133) is an orphan adhesion G protein-coupled receptor (aGPCR) that primarily signals through Gs to regulate intracellular cAMP levels and i
The Lifespan Architecture of Human EEG biorxiv.org 2026-07-31 Human brain maturation and aging are highly nonlinear, yet their organization at the level of large-scale electrophysiological activity remains poorly
Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and Inflammation biorxiv.org 2026-07-31 Cell death, DNA damage, and inflammation are closely interconnected processes implicated in ageing, cancer, and inflammatory disorders, yet the endoge
Does diet influence physiological and behavioural responses to predation risk? biorxiv.org 2026-07-31 As one of the strongest selective forces, predation risk induces antipredator responses in prey that not only maximise survival probability but are en
Real-time electrochemical protein monitoring using molecular pendulum sensors biorxiv.org 2026-07-31 Continuous monitoring of proteins in complex biological fluids is essential for advancing personalized medicine, yet existing biosensors are often lim
A curated human lactylome and protein language model framework enable accurate prediction and reveal local determinants of lysine lactylation biorxiv.org 2026-07-31 Lysine lactylation is a dynamic post-translational modification that can alter protein function and has been implicated in diverse physiological and p
vOMIX-MEGA: An ultra-fast end-to-end pipeline for terabyte-scale viral metagenomics analysis. biorxiv.org 2026-07-31 Viral identification for terabyte-scale metagenomic data is limited by scalability and computational resources.
Membrane mimetics control internal hydration and catalytic activity of the copper ATPase LpCopA from Legionella pneumophila biorxiv.org 2026-07-31 Membrane protein function depends critically on the surrounding lipid bilayer, which supports specific lipid-protein interactions and imposes constrai
Biophysical characterization of novel biomarkers and bioaffinity reagents (NanoMIPs): on the road for a low-cost diagnostic test for intestinal schistosomiasis biorxiv.org 2026-07-31 Schistosoma mansoni is a vector-borne intestinal parasite, endemic in ~70 tropical countries.
Evolutionary Dynamics of AI, Politicization, Contestation, and Trust in Science Funding biorxiv.org 2026-07-31 Economic stability and progress in modern technological societies depend on vigorous and independent public funding of science and engineering researc
Mapping Enteric Neural Circuits by Anterograde Transsynaptic Tracing biorxiv.org 2026-07-31 The diverse functions of the enteric nervous system (ENS) arise from communication between molecularly distinct neuronal populations organized into co
Ire1 membrane stress responses support cell growth upon disruptions in inter-organelle contacts biorxiv.org 2026-07-31 Disruptions in inter-organelle contacts result in membrane lipid homeostasis defects that ultimately impair cellular function and viability.
Embryonic TGF-β signaling imposes persistent changes to HSPC clonality and inflammatory landscape biorxiv.org 2026-07-31 Embryonic hematopoiesis is essential for establishing lifelong blood and immune system function.
Neglecting movement-disease feedback biases wildlife epidemic forecasts biorxiv.org 2026-07-31 In wildlife populations, movement drives host contact networks and disease spread.
Evaluation of ivermectin effectiveness under contrasting anthelmintic resistance scenarios in beef cattle: a comparative study in Italy and Argentina biorxiv.org 2026-07-31 Beef cattle farming plays a crucial role in the livestock-related economies of both Italy and Argentina.
An organ-resolved rat FFPE phosphoproteome map enables directional kinase activity inference biorxiv.org 2026-07-31 Formalin fixed paraffin embedded (FFPE) tissue is the dominant clinical pathology resource yet whether it faithfully preserves organ signalling biolog
Mapping human-macaque encounter potential by integrating visitor-use and macaque-use intensity in Kamikochi, Japan biorxiv.org 2026-07-31 Managing visitor-wildlife interactions in high-use protected areas requires identifying not only where visitors concentrate but also where visitor use
Toxoplasma gondii Fatty Acid Elongases are Important for Virulence and Persistence biorxiv.org 2026-07-31 Toxoplasma gondii is an apicomplexan parasite which can infect a diverse range of warm-blooded host species.
Molecular factors shaping small RNA content in mouse sperm biorxiv.org 2026-07-31 In mammalian reproduction, sperm and oocytes fuse to generate embryos.
Cardiomyocyte pyruvate dehydrogenase kinase 1 knockout activates Rho-mediated remodeling and decreases fatty acyl availability in female mice biorxiv.org 2026-07-31 Pyruvate dehydrogenase kinase 1 (PDK1) inhibits pyruvate dehydrogenase (PDH) and therefore may regulate the balance between glucose and fatty acid oxi
The 3D micro- and nanostructure of the apical extracellular matrix in Drosophila biorxiv.org 2026-07-31 The apical extracellular matrix (aECM) serves as a dynamic scaffold, orchestrating tissue growth, cellular communication, and wound repair, and thus f
Evolution of a genome-architecture-encoded gene regulation system in trypanosomatids biorxiv.org 2026-07-31 Transcriptional regulation of protein-coding genes is a hallmark of eukaryotic gene expression.
β-endorphin primes NK cells and NK-derived Extracellular Vesicle to enhance anti-tumor cytotoxicity biorxiv.org 2026-07-31 Psychoneuroimmunology suggests that positive physiological states, including laughter, could affect anti-tumor immunity, but the underlying mechanisms
Salicylic acid mediates graft incompatibility by repressing auxin-dependent vascular reconnection in tomato biorxiv.org 2026-07-31 Graft incompatibility limits the combination of scion and rootstock, yet the signals that block vascular reconnection remain poorly understood.
Climate change drives declines in seed germination potential, particularly in woody species and warmer, drier landscapes of a temperate bioregion biorxiv.org 2026-07-31 Climate change is accelerating species losses in ecosystems across the world.
Capturing the missing gene content of elite wheat by analysis of wheat landraces biorxiv.org 2026-07-31 There is a need to breed superior wheat cultivars to meet increasing global food demand.
ATP-Free Fatty Aldehyde Biosynthesis Enables an Autonomous Lux-Based Bioluminescence System biorxiv.org 2026-07-31 Autonomous bioluminescence systems enable continuous light emission in engineered organisms by genetically encoding both luciferase enzymes and their
Mitochondrial RNA processing promotes translation by resolving structured precursor RNAs biorxiv.org 2026-07-31 Mammalian mitochondrial mRNAs (mt-mRNAs) are excised from polycistronic precursors primarily through cleavage of flanking tRNAs.
ADSS1 is a suppressed metabolic control node in dystrophic skeletal muscle biorxiv.org 2026-07-31 Duchenne muscular dystrophy (DMD) is initiated by dystrophin loss but is accompanied by profound metabolic remodelling.
Hydrogen sulfide dynamically upregulates copper uptake and localization biorxiv.org 2026-07-31 The reactivity of copper, an essential micronutrient that undergoes facile cycling between Cu1+ and Cu2+ redox states, is carefully controlled within
Reconstructing whole-organism cell phylogenies with resolved ancestral transcriptional states biorxiv.org 2026-07-31 Combining cell lineage tracing with single-cell RNA sequencing can reconstruct a phylogenetic tree to integrate single-cell transcriptomic atlas.
A nuclear targeting approach enables efficient transgenesis in the milkweed bug Oncopeltus fasciatus biorxiv.org 2026-07-31 Insects show extreme diversity and have long intrigued biologists.
Time-lagged causal inference corroborates presumed drivers of North Atlantic seabird ecology biorxiv.org 2026-07-31 Disentangling causation from correlation is the foundation of the scientific method.
Characterizing benthic community structure across Western Pacific seamounts to ~5,000 m depth: Implications for conservation biorxiv.org 2026-07-31 Aim Seamounts are key components of deep-sea ecosystems.
Community diversity and interaction of bacterial, cyanobacteria and protist among aquatic and soil micro-food chains biorxiv.org 2026-07-31 Microorganisms, found in every environment, play an important role in recycling matter and providing energy to the ecosystem.
PlumageParts: A fine-grained avian plumage segmentation dataset and benchmark for ecological image analysis biorxiv.org 2026-07-31 Fine-grained localisation of plumage regions is a prerequisite for computational analyses of avian colouration, patterning and visual traits in ecolog
Female-biased continental farmer ancestry contribution to the modern Japanese genome biorxiv.org 2026-07-31 Modern mainland Japanese formed through admixture between the Jomon hunter-gatherers and continental farmers who arrived probably in northern Kyushu a
Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions biorxiv.org 2026-07-31 Thioamides are natural post-translational modifications of the peptide backbone and can be introduced synthetically to probe protein folding or functi
Nitrogen metabolic map of Escherichia coli mediated by multi-functional aminotransferases biorxiv.org 2026-07-31 Nitrogen is a key element of organic molecules essential to all life.
Errors in peptide synthesis are a source of discrepancies in Aβ42 studies biorxiv.org 2026-07-31 Amyloid-{beta}42 (A{beta}42) aggregation is highly sensitive to experimental conditions, making reproducibility a persistent challenge in Alzheimer's
The HSP-90 co-chaperone CDC-37 regulates oomycete immunity in C. elegans through a membrane-associated pseudokinase biorxiv.org 2026-07-31 Innate immune responses depend on rapid and tightly regulated signalling to ensure effective defence against invading pathogens.
Discovery of a regulatory node that coordinates cell envelope assembly in mycobacteria biorxiv.org 2026-07-31 Mycobacteria possess a complex double-membrane cell envelope critical for survival and pathogenesis.
Prompting Beyond Pairs: Decoupled Semantic Supervision for Knowledge-Guided Multiplex Virtual Staining biorxiv.org 2026-07-31 Virtual staining provides a non-invasive alternative to fluorescence microscopy, yet existing deep learning approaches fundamentally rely on pixel-ali
Mesh convergence depends on the element formulation of finite element brain models biorxiv.org 2026-07-31 Finite element (FE) head models are virtual tools to study brain biomechanics and their predictions must be numerically convergent.