Grant writing coaching groups: A randomized trial to discern the influences of coaching duration and engagement of scientific mentors on participants proposal submission and success rates biorxiv.org 2026-07-30 Introduction The acquisition of National Institutes of Health (NIH) grants is an increasingly competitive undertaking.
Beyond Generic Signal Peptides: ApexSP Enables Cargo-Specific Secretion Design biorxiv.org 2026-07-30 Recombinant proteins are widely used in biopharmaceuticals, industrial manufacturing, and molecular diagnostics; however, efficient secretion remains
Anticodon nucleotide modifications affect translational tuning by the ribosomal CAR surface biorxiv.org 2026-07-30 Nucleotide modifications of the tRNA anticodon can affect protein translation fidelity and speed.
Higher Impulsivity in the Heterogeneous Structure of Theft Recidivists with and without Kleptomania biorxiv.org 2026-07-30 Impulsivity is associated with various maladaptive behaviors, although its specific role in criminology has remained largely unexplored.
Structure-free, site-resolved contrastive learningextends small-molecule discovery beyond the reachof structure-based modeling biorxiv.org 2026-07-30 Virtual screening asks which molecules, among an enormous space of drug-like chemistry, are worth synthesizing and testing against a protein target.
The tripartite neural plate border is a common trait of vertebrates and tunicates biorxiv.org 2026-07-30 The neural crest and neurogenic placodes, which arise from the neural plate border, give rise to morphological characteristics that distinguish verteb
Single-cell lineage tracing of human neuromesoderm organoids reveals TBX6-mediated posterior mesoderm fate diversification biorxiv.org 2026-07-30 Neuromesodermal progenitors (NMPs) drive vertebrate posterior axis elongation, but the lineage hierarchy of human NMP derivatives remains poorly defin
HiBASIL: Hierarchical Bayesian Source Inference and Localization for Spatial Epidemiology biorxiv.org 2026-07-30 1. Identifying spatial origins of biological invasions, disease outbreaks, or environmental contaminants is critical for timely intervention.
Bridging physiological responses to population outcomes under variable thermal stress biorxiv.org 2026-07-30 Embedding thermal tolerance metrics into population dynamics offers a promising toolkit for understanding the impacts of stressful heat events, but th
Global patterns of helminths associated with gelatinous zooplankton: a missing link in marine parasite transmission biorxiv.org 2026-07-30 Gelatinous zooplankton are abundant predators and prey in marine food webs, yet their role in helminth (parasitic worms) transmission remains poorly r
Early and current environments exert distinct effects on immune function in the Orang Asli biorxiv.org 2026-07-30 Humans evolved in environments characterized by subsistence foraging and hunting, high levels of physical activity, and regular and diverse pathogen e
The Candida Genome Database: New Interface and New Tools biorxiv.org 2026-07-30 The Candida Genome Database (CGD; www.candidagenome.org) is both a model organism database and a fungal pathogen database.
Plug-and-Play 3D localization microscopy biorxiv.org 2026-07-30 Point-spread-function engineering by depth-encoding phase masks enables volumetric super-resolution imaging by 3D single-molecule localization microsc
Characterization of PduU Reveals a Modular Tool for Tuning Microcompartment Permeability biorxiv.org 2026-07-30 Bacterial microcompartments (MCPs) are versatile proteinaceous organelles that compartmentalize metabolic pathways, offering promising scaffolds for s
A pan-cancer single-cell atlas of pericytes biorxiv.org 2026-07-30 Pericytes display marked tissue-specific transcriptional identities, raising the question of whether tumour-associated pericytes converge towards shar
NFYA regulates spermatogenesis through multifaceted chromatin interactions biorxiv.org 2026-07-30 During spermatogenesis, germ cells undergo extensive chromatin remodeling to promote highly diverse and stage-specific transcriptional programs that d
One-step generation of mice by Transposon-Enhanced Multi-Plex Orchestration Editing(TEMPO-Editing) biorxiv.org 2026-07-30 Genome-edited mice are widely used to elucidate molecular mechanisms in vivo and are an indispensable tool, particularly for studies aimed at clarifyi
Seasonal Rebalancing of Assembly Processes and Cross-Domain Network Restructuring in Microbial Communities of a Large Eutrophic Lake biorxiv.org 2026-07-30 Harmful algal bloom (HAB) succession in eutrophic lakes arises from seasonal rebalancing of selection, dispersal, and drift across interacting microbi
Lipoprotein(a) promotes thrombosis through platelet activation and promotion of a lysis-resistant thrombus architecture biorxiv.org 2026-07-30 Elevated levels of lipoprotein(a) (Lp(a)) are an independent risk factor for the development of atherothrombotic diseases.
A PDMS-based microfluidic platform enabling dual biochemical and electric-field stimulation for modeling sensory neuron-intervertebral disc crosstalk biorxiv.org 2026-07-30 Inflammation-driven increases in nociception are prominent in pain pathologies associated with intervertebral disc (IVD) degeneration yet are difficul
Impedance-Derived Heart Rate and Heart Rate Variability from tDCS Output Voltage: Sensorless Physiological Monitoring During Electrical Neuromodulation biorxiv.org 2026-07-30 Background: Transcranial direct current stimulation (tDCS) devices adjust output voltage to maintain the target current despite varying impedance.
Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer biorxiv.org 2026-07-30 Small cell lung cancer (SCLC) remains a highly lethal disease with limited targetable surface antigens beyond delta-like ligand 3 (DLL3).
Custom Probe-Based Spatial Transcriptomics Enables Microbiome Detection in FFPE Colorectal Cancer Tissue biorxiv.org 2026-07-30 Intratumoral bacteria have emerged as functionally relevant components of the tumor microenvironment, yet the spatial relationship between these bacte
Global integrators of light signalling and nutrient homeostasis safeguard symbiosis under light stress biorxiv.org 2026-07-30 Their large, protein-rich seeds render many legume plants like beans, peas or soy attractive food or fodder crops.
Evolutionary Origins and Synthetic Reconstruction of Gingerols biorxiv.org 2026-07-30 How new enzymatic activities become integrated with existing metabolic networks to generate lineage-restricted plant chemistry remains a central quest
A genetic switch involving EGR1 and EZH2 links aging and development across human tissues biorxiv.org 2026-07-30 Aging is often regarded as the last chapter of development. There is growing evidence that aging and development are mechanistically linked.
Modulation of noisy gene expression by general sequestration mechanisms biorxiv.org 2026-07-30 Sequestration of gene products through diverse mechanisms forms a fundamental layer of regulation in intracellular biochemical processes, including po
Dynamics of a Hes1-Dll1 regulatory network in coupled muscle stem cells: stability, bifurcations, and coexistence of oscillatory states biorxiv.org 2026-07-30 Muscle regeneration relies on the coordinated activation of muscle stem cells, whose fate decisions are regulated by intracellular gene expression dyn
Combination of indomethacin and temperature produces reliable strobilation in Cassiopea xamachana but batch effects create high variability in ephyra outcomes biorxiv.org 2026-07-30 Indomethacin and temperature shocks are both widely used to induce ephyra production in Cassiopea polyps, yet the combined effect of these stimuli on
Aerobic GenX Defluorination by a Wastewater Cladosporium halotolerans Strain with a Genomically Expanded Haloacid Dehalogenase Repertoire biorxiv.org 2026-07-29 Per- and polyfluoroalkyl substances (PFAS) such as GenX (HFPO-DA) are aerobically recalcitrant contaminants for which biological treatment options rem
Taxonomic vs. Functional Diversity for the Impact Assessment of Offshore Oil & Gas Activities: An Exploratory Study on Benthic Prokaryotes biorxiv.org 2026-07-29 Improving environmental management in the offshore Oil & Gas sector requires approaches that capture the ecosystem services (ES) provided by marin
Microbial Biogeography Across the Bovine Body: A Meta-analysis of 27 Anatomical Niches biorxiv.org 2026-07-29 Cattle harbor diverse bacterial communities across the gastrointestinal, respiratory, reproductive, mammary and other anatomical systems, but body-wid
A Single Lipid Nanoparticle Formulation Enables Delivery of Diverse RNA Therapeutics to Human Muscle Models of Duchenne Muscular Dystrophy biorxiv.org 2026-07-29 Duchenne muscular dystrophy is a lethal neuromuscular disorder caused by the absence of dystrophin, for which no curative treatment is available.
Early Partitioning of Structural Paralog Diversity Shapes Immune Evolution Across Habitat Transitions in Gobiiform Fishes biorxiv.org 2026-07-29 Habitat transitions expose species lineages to novel pathogen regimes and are often hypothesized to drive adaptive diversification of immune gene fami
A single-nucleus atlas of the adult laying hen liver reveals metabolic specialization and improved cellular resolution through enhanced genome annotation biorxiv.org 2026-07-29 The liver of laying hens plays a central role in metabolism and reproduction, supporting the synthesis of egg yolk precursors under strong hormonal re
Parallel and scalable balanced minimum evolution algorithm for large-scale phylogenetic inference biorxiv.org 2026-07-29 The rapid growth of biological data demands scalable yet robust phylogenetic methods.
How a highly acidic SH3 domain binds to its intrinsically disordered partner through the formation of an encounter complex intermediate biorxiv.org 2026-07-29 Electrostatic interactions often play a role in determining the thermodynamic and kinetic properties of protein-protein interactions.
A minimal kinase-phosphatase system and its lipid substrates self-organize into dynamic patterns biorxiv.org 2026-07-29 Competing lipid kinases and phosphatases are critical for organizing cellular membranes, but whether a minimal system can autonomously organize protei
Cellular origin and therapeutic potential of SERPINA3N in ischemic stroke biorxiv.org 2026-07-29 Murine serine protease inhibitor clade A member 3N (SERPINA3N) and its human homolog SERPINA3 are injury-associated molecules induced in virtually all
Microbial diversity and insights into feeding behavior of the two-spot cotton leaf hopper (Amrasca biguttula) biorxiv.org 2026-07-29 The recent invasion of the two-spot cotton leaf hopper (TSCL) (Amrasca biguttula) into the U.S.
Capsular polysaccharide can sensitize bacteria to non-antibiotic drugs biorxiv.org 2026-07-29 Medications administered over long durations, such as phenothiazine antipsychotics, accumulate in the gut at concentrations that affect microbial grow
Saprotrophic soil fungus dissolves lithium lepidolite through inositol rescue metabolism biorxiv.org 2026-07-29 Microbial weathering of minerals represents a key biogeochemical process through which microorganisms access essential nutrients locked within rock an
The orphan histidine kinase TodK controls Myxococcus xanthus biofilm development by inactivating the CRP/Fnr homolog, MrpC biorxiv.org 2026-07-29 Environmental bacteria have abundant signaling systems wired into complex gene regulatory networks to adapt to fluctuating conditions.
Molecular basis for chikungunya virus recognition of a mosquito-specific receptor biorxiv.org 2026-07-29 Alphaviruses are arthropod-borne viruses that recognize cellular receptors in both vertebrate hosts and mosquito vectors to complete their transmissio
Deep Mutational Scanning of the GPCR Rhodopsin Reveals Pleiotropic Mutational Effects and Their Roles in Modulating Light Sensitivity biorxiv.org 2026-07-29 Biophysical pleiotropy, the phenomenon in which a mutation affects multiple protein properties, underlies many genetic diseases and shapes protein evo
Genomic Population Structure of Atlantic surfclams: Cryptic Taxonomic Units and Population Connectivity biorxiv.org 2026-07-29 The Atlantic surfclam, Spisula solidissima solidissima supports multimillion dollar harvests in the western North Atlantic, including Georges Bank and
Histone methyltransferase MET-2 differentially regulates autosome and X-chromosome structure and transcription during meiosis in C. elegans biorxiv.org 2026-07-29 During meiosis, accurate chromosome segregation requires significant condensation and compaction.
PlasChain: an algorithm for improving long plasmid reconstruction from metagenome assemblies biorxiv.org 2026-07-29 Background: Plasmids play a critical role in horizontal gene transfer and the spread of antibiotic resistance.
SketchDNA: A GUI-Enabled Toolkit for Multiscale Modeling of Topological DNA Structures biorxiv.org 2026-07-29 Computational modeling tools have enabled detailed exploration of the structural dynamics of nucleic acids at the nanoscale.
Stator pool size shapes the mechanosensitivity of the bacterial flagellar motor biorxiv.org 2026-07-29 The bacterial flagellar motor adapts to mechanical load by adding or removing stator units, which can either be inactive in the inner membrane (the st