Parallel construction of object motion from retina to cortex biorxiv.org 2026-07-29 Detecting a moving object against a moving background is fundamental to survival.
Deep conservation of head direction circuits in bees, ants and flies biorxiv.org 2026-07-29 To navigate, animal brains must continuously estimate the body's heading in space and compare it with internal goals to guide movement.
The endosomal trafficking protein Myopic differentially regulates Drosophila C virus infection in cultured cells and adult flies biorxiv.org 2026-07-29 Positive-sense RNA viruses extensively exploit host membrane trafficking pathways to establish intracellular replication organelles required for effic
Hierarchical divergence across genomic, phenotypic, and microbiome dimensions in two annual killifish species from Malawi biorxiv.org 2026-07-29 Divergence among populations and species commonly occurs across multiple biological levels, yet the extent to which genomic, phenotypic, and ecologica
Differential benefits for temporal intervals and line segments with feedback and relevance to new learning with transfer effects biorxiv.org 2026-07-29 Learning to accurately estimate temporal intervals and spatial magnitudes is important to everyday behavior, yet few studies have directly compared ho
Asymmetry and Allostery: Insights into the Mechanism of DirectionalPeptide Translocation in AAA+ Unfoldases biorxiv.org 2026-07-29 Molecular motors convert stochastic ATP chemistry into directional motion.
Integrative Ensemble Modeling reveals RNA conformations targetable by small molecules biorxiv.org 2026-07-29 RNA molecules explore heterogeneous conformational ensembles that are essential for their biological function and molecular recognition, yet this intr
Automated Virtual Pathology Panels for Mass Spectrometry Imaging biorxiv.org 2026-07-29 Mass spectrometry imaging (MSI) records rich molecular spectra at each pixel, but pathology-oriented interpretation requires visualizations analogous
Evaluating Temporal Orders for Local Non-Stationary Biological Signals Analysis: A Python Framework and Simulation Study biorxiv.org 2026-07-29 Background and Objective: Accurately parameterizing dynamic, time-varying interactions in physiological systems is a methodological challenge, as glob
Differential modulation of temporal precision and perceived timing by tactile spatial and temporal context biorxiv.org 2026-07-29 Perception of sensory events depends not only on the stimulus itself but also on the surrounding spatial and temporal context.
Novel native serum peptidomics workflow enables the discovery of circulating subtype-specific peptide biomarkers in acute ischemic and haemorrhagic stroke biorxiv.org 2026-07-29 Novel serum peptidomics offers a direct insight into proteolytic activity, tissue injury, and systemic signaling.
Altered Attention Network Dynamics in Resting-State fMRI of Individuals with High Smartphone Addiction Scores biorxiv.org 2026-07-29 Altered attention network activity has been consistently reported in recent neuroimaging literature of smartphone addiction and problematic smartphone
Targeting soluble immunoglobulins ameliorates idiopathic multicentric Castleman disease in a mouse model biorxiv.org 2026-07-29 Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder that affects lymph nodes at multiple sites and can progress to
BMP2 signaling cooperates with retinoic acid to activate a meiotic-entry transcriptional program in chicken primordial germ cells biorxiv.org 2026-07-29 The initiation of meiosis in germ cells is largely regulated by extrinsic cues from the gonadal environment, but the logic of these signals remains po
UDIST: unsupervised disentanglement of shape and texture for multi-scale phenotypic profiling in 2D microscopy biorxiv.org 2026-07-29 Microscopy-based phenotypic profiling relies increasingly on autonomous, unsupervised feature extraction, yet no existing method explicitly separates
Discovery of GluA3 preferring AMPA receptor positive allosteric modulator BRD3290 biorxiv.org 2026-07-29 Schizophrenia is a debilitating neuropsychiatric disease that lacks effective treatments for many symptom domains including negative, cognitive and sl
Covariant Biochemical Systems Theory: cBST1~cBST3 Descriptors and Quantitative Validation biorxiv.org 2026-07-29 Biochemical Systems Theory (BST) represents nonlinear biochemical rate laws by local power-law approximations in logarithmic concentration coordinates
Behavioral Economic Profiles in Theft Recidivists with and without Kleptomania biorxiv.org 2026-07-29 Recurrent theft, such as shoplifting, is a devastating social problem that poses a significant economic burden on society.
Predictive abstract task representations support few-shot learning in the rat brain biorxiv.org 2026-07-29 Few-shot learning reveals core mechanisms of flexible cognition and adaptive decision-making in animal behavior by showing how animals rapidly infer r
Catch-bond engineering surpasses high-affinity maturation for T cell receptor therapies against solid tumors biorxiv.org 2026-07-29 The sensitivity of T cell receptors (TCRs) has traditionally been attributed to their affinity, a principle that has long underpinned both T cell biol
Closed-loop sensory feedback enables fast and reliable instrumental acquisition in head-fixed mice biorxiv.org 2026-07-29 Instrumental learning typically requires hundreds to thousands of trials in which subjects learn to link motor responses to sensory cues.
Asymmetric Neurogenomic States Emerge in Winners and Losers After Social Competition biorxiv.org 2026-07-29 Winner and loser effects can influence future aggressive behavior following social competition, but their neurogenomic basis remains poorly understood
Manifold Agentic Reasoning: Extending Agentic POMDPs and Post-Training Reasoning to Riemannian State and Reasoning Spaces biorxiv.org 2026-07-29 Agentic reasoning systems increasingly interact with environments whose states are only partially observed, dynamically evolving, and constrained by p
Sleep reactivation of positive self-evaluation reveals neural-evaluative alignment that varies with depressive symptoms biorxiv.org 2026-07-29 Positive self-evaluation underpins resilience and mental health, yet how to enhance positive self-evaluation and the underlying neurocognitive mechani
Neural control of respiration in Drosophila biorxiv.org 2026-07-29 Adaptive control of breathing is essential for life, yet the neural circuits that couple respiration to locomotion and internal physiological state re
From periodic/aperiodic to static/dynamic: rethinking the decomposition of neural power spectra biorxiv.org 2026-07-29 The power spectrum of electrophysiological signals exhibits both narrowband peaks and a broadband 1/f-like slope.
Multiomic analysis of non-glaucomatous human trabecular meshwork cells. biorxiv.org 2026-07-29 Glaucoma is an irreversible blinding disease that affects millions of individuals worldwide.
Mechanical History and Substrate Stiffness Shape Integrin-Mediated Endothelial Cell Behavior on Bioactive Hydrogels biorxiv.org 2026-07-29 Synthetic blood contacting devices frequently fail due to the lack of requisite biochemical and biomechanical cues needed to support transanastamotic
An Open-Source Magnetofluorescence Imaging Platform forPlate-Scale Screening of Magnetic Field Effects in LiveBacteria biorxiv.org 2026-07-29 Magnetic field effects (MFEs) in biological systems are typically small and experimentally challenging to measure reproducibly across large sample pop
seqproc: An efficient, flexible, and concise tool for sequence geometry description and transformation biorxiv.org 2026-07-29 Motivation: Novel sequencing technologies (for example, different single-cell chemistries and protocols) produce complex data.
CellColoc: A modular, open-source workflow for cell colocalization, segmentation, and feature extraction in microscopy images biorxiv.org 2026-07-29 Quantitative cell colocalization in fluorescence microscopy often depends on ad hoc combinations of image loading, segmentation, region selection, man
Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington's disease models biorxiv.org 2026-07-29 Huntington's disease (HD) is a life-altering genetic neurodegenerative disorder, with cognitive, motor, and psycho-social effects that have consequent
Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene biorxiv.org 2026-07-29 Somatic instability (SI) of expanded DNA repeats is a hallmark of repeat expansion disorder (REDs) and drives onset and progression in Huntington's di
A tribal-scale phylogenomic perspective on ancestry and major lineages of the allotetraploid Hawaiian silversword alliance (Madieae, Compositae) biorxiv.org 2026-07-29 Premise of the study: Disentangling ancestry of insular plant lineages is important for resolving their evolutionary histories but often complicated b
Vocal biomarkers of aging and Parkinson's disease in a songbird biorxiv.org 2026-07-29 Purpose: Similar vocal impairments occur in normative aging and Parkinson's disease (PD), making differential diagnosis challenging in early stages.
Uncovering key genes related to potato tuber starch concentration from the tuber bulking, maturation stage to storage biorxiv.org 2026-07-29 Potato is the world's fourth major staple crop, and tuber starch is a critical dietary energy source and a food processing raw material.
Hepatic huntingtin loss drives an acute phase response and liver injury in multiple mouse models biorxiv.org 2026-07-29 Multiple therapeutic strategies are being developed to slow Huntington's disease (HD) progression through targeted reduction of huntingtin (HTT) prote
A Bioactive Phospholipid Promotes Rapid Progenitor Lung Progenitor Activation via AP-1 biorxiv.org 2026-07-29 Upon injury to the distal lung, alveolar type 2 cells (AT2s) must make a discrete switch from surfactant factories to stem cells capable of regenerati
The linker histone H1.4 condenses chromatin in maturing postmitotic neurons biorxiv.org 2026-07-29 H1 histones are abundant nuclear proteins that bind to linker DNA at the entry and exit points of nucleosomes.
Midbody inheritance predicts re-entry into quiescence, but not lineage potential, in mouse hematopoietic stem cells biorxiv.org 2026-07-29 Hematopoietic stem cells (HSCs) give rise to all blood cell lineages and possess self-renewal potential.
Targeted DUX4 base editing improves muscle function in an iPSC-derived model of childhood-onset FSHD biorxiv.org 2026-07-29 Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common dominant muscular dystrophies and remains without an approved disease modifyin
Molecular organization of the eukaryotic secretory pathway biorxiv.org 2026-07-29 The eukaryotic secretory pathway is an essential subcellular network comprised of the endoplasmic reticulum (ER) and Golgi organelles.
Evolving stem cell fate capacities and transcriptional priming in the developing olfactory epithelium biorxiv.org 2026-07-29 The olfactory epithelium of adult mammals contains two populations of stem cells that support its remarkable ability to regenerate neuronal and non-ne
Loss of PRDM16 Drives Nasal Septal Deviation through Dysregulated TGFβ2 Signaling biorxiv.org 2026-07-29 Nasal septal deviation affects approximately 20% of newborns globally and 80% individuals in the United States.
A new player in the biochemistry of Anammox bacteria: a multidomain HAO-like protein biorxiv.org 2026-07-29 Anaerobic ammonium-oxidizing (anammox) bacteria are essential players in the global nitrogen cycle, responsible for converting ammonium and nitrite di
ESCAPE: assigning site-specific activity to covalent ligands in cells by prime editing biorxiv.org 2026-07-29 Chemical proteomics has identified covalent ligands targeting cysteine residues across many hundreds of human proteins.
Distinct spatiotemporal immunometabolic remodeling following acute traumatic brain injury biorxiv.org 2026-07-29 Traumatic brain injury induces profound metabolic reprogramming across neurons, astrocytes, and microglia, yet the spatiotemporal organization of thes
Prebiotic cationic amino acids support formation of an ancient protein fold biorxiv.org 2026-07-29 The evolutionary basis for the selection of the standard proteinogenic amino acids remains elusive, particularly for the long cationic amino acids, ly
Cross-species Study of Canine and Human Peripheral Nerve Sheath Tumors: Clinical and Molecular Perspectives biorxiv.org 2026-07-29 Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas. An obstacle to treating MPNSTs is a lack of effective systemic therapies.
Integrated ex vivo screening and transcriptomic profiling to prioritize drug combinations for rare cancers biorxiv.org 2026-07-29 Discovering effective drug combinations requires testing many dose combinations across a diverse panel of tumor models.