STRIDE: Signal Transfer and Aligned Ion-Peak Discrimination for Peptidoform Evidence for Consistent Quantification of Site-Localized Post-Translational Modifications in Large-Scale DIA-MS biorxiv.org 2026-07-28 Data-independent acquisition (DIA) mass spectrometry has emerged as a powerful method for comprehensive post-translational modification profiling in p
Sex-Specific Modulation of Gene Expression by 17beta-Estradiol in Human Meniscal Cells: Pathways to Targeted Osteoarthritis Therapies biorxiv.org 2026-07-28 Osteoarthritis (OA) disproportionately affects women, and estrogen has been implicated in cartilage and joint homeostasis, yet its effects on meniscal
Adaptive immune responses are not causal to SGN death after kanamycin-induced hair cell loss biorxiv.org 2026-07-28 Aminoglycoside antibiotics such as kanamycin induce sensorineural hearing loss by killing hair cells, resulting in secondary degeneration of spiral ga
Colon-to-hind paw cross-organ sensitization is partially mediated by TrkB.T1-facilitated spinal neuroinflammation to activate lumbar DRG neurons biorxiv.org 2026-07-28 Patients with bowel disease can develop referred somatic pain at a later time with unknown molecular mechanisms.
Sex-specific associations of childhood adversity with frontostriatal network organization and anhedonia in young adulthood biorxiv.org 2026-07-28 Introduction: Anhedonia is a transdiagnostic psychiatric symptom linked to increased functional connectivity between the prefrontal cortex and striatu
A geometric-to-neural cascade for cerebral microbleed detection in susceptibility-weighted MRI biorxiv.org 2026-07-28 Cerebral microbleeds (CMBs) are established imaging biomarkers of cerebral small vessel disease and are a defining feature of cerebral amyloid angiopa
Prioritizing Non-coding Variants in Rice GWAS Loci with a Chromatin-Informed DNA Language Model biorxiv.org 2026-07-28 Numerous genome-wide association studies in rice have identified loci associated with diverse agronomic traits.
Flow alters fibrin molecular and network structure and decreases binding of fibrinolytic enzymes biorxiv.org 2026-07-28 Thrombolysis with tissue Plasminogen Activator (tPA), approved for treating acute ischemic stroke (AIS) within 3-4.5 h of symptom onset, converts Plas
H3K27me3 maintains baseline network excitability after status epilepticus biorxiv.org 2026-07-28 The processes by which epileptic insults precipitate the molecular, cellular, and network alterations in the brain that lead to epilepsy are poorly un
PRIME: A Neurophysiology-Informed Bayesian Optimization Framework for Adaptive TMS Motor Hotspot Mapping, Algorithm Design and Monte Carlo Evaluation biorxiv.org 2026-07-28 Background: Accurate primary motor cortex (M1) hotspot identification is a prerequisite for reliable transcranial magnetic stimulation (TMS) protocols
Evaluation of harmonization methods to mitigate assay and cohort effects in plasma p-tau217 biorxiv.org 2026-07-28 INTRODUCTION: The growing number of assay platforms measuring blood-based biomarkers (BBMs) for Alzheimer's disease (AD) has introduced challenges in
Fishery Cooperatives as Institutional Intermediaries in Fragile Contexts: Assessing Social-Ecological Resilience in South-Central Somalia biorxiv.org 2026-07-28 Small-scale fisheries provide essential coastal livelihoods in developing regions, yet they often confront severe institutional voids within fragile-s
A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALS biorxiv.org 2026-07-28 Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease characterized by the loss of upper motor neurons in the motor cortex (
How do Cockroach Groups Integrate Multiple Attributes in a Best-of-N Task? biorxiv.org 2026-07-28 Collective decision-making experiments have largely focused on simple scenarios in which groups choose between two options that differ along a single
Leveraging Segmentation Variability to Improve Brain Age Prediction biorxiv.org 2026-07-28 Analytical variability in neuroimaging pipelines contributes to concerns about reproducibility in the field.
Mucus cell and ionocyte precursors migrate between epithelial cells to disperse through the zebrafish epidermis biorxiv.org 2026-07-28 Mucus-secreting cells and ionocytes play critical roles in many organs.
Analog intrinsic recoding measures RNA dynamics without chemical conversion biorxiv.org 2026-07-28 Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression.
Bayesian Network Analysis Identifies PREX1 as a Master Regulator of Cytoskeletal Disruption in Inflammatory Bowel Disease biorxiv.org 2026-07-28 Background: Inflammatory bowel diseases are complex multifactorial and polygenic conditions with incompletely understood etiology.
A Curvature Guided Composite Kernel Framework for Differential Gene Selection in Cancer Transcriptomics biorxiv.org 2026-07-28 Identification of differentially expressed genes is a crucial step for downstream tasks on gene data such as biomarker discovery, drug target identifi
Image-based Disease-wide Association Study via Self-supervised Learning links Abdominal MRI Features to 158 Diseases biorxiv.org 2026-07-28 Medical images contain rich phenotypic information that is often not fully captured by manual clinical assessment.
Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases biorxiv.org 2026-07-28 Leptomeningeal metastases are the primary source of morbidity and mortality for pediatric medulloblastoma patients.
Goal-directed action selection relies on conjunctive representations that bind goals, actions and expected sensory outcomes biorxiv.org 2026-07-28 Goal directed actions are performed to obtain specific sensory outcomes.
Combinatorial Control of Corticospinal Axon Growth by Retinoic Acid Receptors biorxiv.org 2026-07-28 Regeneration of central nervous system (CNS) axons depends on Transcription Factors (TFs) that reactivate developmental growth programs, yet most such
Carbonyl stress primes the metastable aging brain for Alzheimer's disease biorxiv.org 2026-07-28 Alzheimer's disease (AD) is defined by amyloid-{beta} (A{beta}) plaques and tau tangles, yet the inflammation that comes with it is only partly locali
Blade-dependent molecular identity and neurogenic potential in the adult dentate gyrus biorxiv.org 2026-07-28 The dentate gyrus (DG) is a key hippocampal gateway for cognition and emotion and a major site of adult neurogenesis, yet its organization along the t
Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer's disease biorxiv.org 2026-07-28 INTRODUCTION: Alzheimer's disease (AD) progresses over decades, yet plasma biomarkers that resolve disease stage rather than simply detect disease rem
Invasiveness Screening Kit (ISK) v3: an integrated multilingual decision-support platform for non-native species risk identification biorxiv.org 2026-07-28 Risk identification of non-native species is widely used to support prioritization, early warning, horizon scanning and management decisions.
The epigenomic landscape of deep lineage divergence: The case of the European sea bass biorxiv.org 2026-07-28 Understanding the role of non-coding genomic variation in speciation remains a major challenge in evolutionary biology.
A Preparation-Free Mixture-of-Experts Framework for Protein-Ligand Affinity Prediction biorxiv.org 2026-07-28 Protein-ligand affinity (PLA) prediction is central to AI-driven drug discovery, but precise interaction-based methods require costly conformation pre
PG-LLM: Benchmarking General-Purpose Language Models for Protein Variant Ranking biorxiv.org 2026-07-28 General-purpose language models are being increasingly utilized in protein-design workflows, yet their ability to evaluate variant effects remains unc
Droplet microfluidics reports digital and tuneable single-platelet ADP secretion describing primed, active and hyper-active states biorxiv.org 2026-07-28 New platelet function assays that provide an accurate assessment of platelet reactivity as a surrogate for thrombosis risk could change the paradigm f
Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales biorxiv.org 2026-07-28 White matter hyperintensities (WMH) are a highly prevalent finding on FLAIR MRI scans and a prominent feature of white matter pathology across cerebro
Laser-integrated nanophotonic neural probes with on-chip sensors for addressable photostimulation biorxiv.org 2026-07-28 Studying the role of individual neurons in behavior and disease requires tools for controlling neural activity with high spatiotemporal resolution.
Identifying factors that contribute to the behavioral effects of psilocybin in preclinical mouse models biorxiv.org 2026-07-28 Psychedelic drugs offer a potentially promising avenue for novel therapeutics for the treatment of psychiatric conditions, including for mood and anxi
Characterization of nucleus accumbens dopamine dynamics during positive and negative operant reinforcement in rats biorxiv.org 2026-07-28 We previously reported, using in-vivo fiber photometry, that operant responding reinforced by access to a peer (social self-administration) is associa
Autonomic Decoupling in Listening Effort: Why Single-Channel Biomarkers Fail biorxiv.org 2026-07-28 Objective: Current theoretical frameworks operationalize listening effort as a monolithic, unified sympathetic response, driving the search for a sing
Rapid direct neuronal reprogramming of human dental pulp stem cells biorxiv.org 2026-07-28 Direct neuronal reprogramming offers an alternative to induced pluripotent stem cell-based differentiation by converting somatic cells directly into n
Circadian phase reconfigures information transmission in the mouse visual thalamus biorxiv.org 2026-07-28 Circadian clocks are a ubiquitous feature of the mammalian brain, yet whether they regulate how neural circuits encode and transmit information remain
Concurrent TMS and Spinal Cord fMRI Reveal Intensity-Dependent Modulation of Spinal Circuits biorxiv.org 2026-07-28 The spinal cord serves as a crucial relay for motor commands, yet the role of its local circuitry in sensorimotor integration remains poorly understoo
Multiple morphological pathways underlie climatic adaptation in North American mustelids biorxiv.org 2026-07-28 Ecogeographic rules predict that endotherms inhabiting colder environments exhibit larger body sizes and shorter appendages to reduce heat loss.
Cross-session generalization in automated behavioral tracking of Galleria mellonella larvae: comparison of classical computer vision, deep learning and generative domain adaptation biorxiv.org 2026-07-28 Background: Automated behavioral tracking is increasingly used in biological and biomedical research; however, robustness across heterogeneous imaging
Baseline regulatory programs in larval and adult neural progenitors converge towards an injury-induced state after spinal cord injury biorxiv.org 2026-07-28 Regeneration after spinal cord injury requires progenitor cells to convert injury-associated signals into coordinated remodeling of gene regulatory pr
Nocturnin drives mitochondrial NADP(H)/NAD(H) rhythms to regulate steroid rhythm amplitude and time metabolism biorxiv.org 2026-07-28 Circadian rhythms are conserved biological timekeeping mechanisms crucial for the temporal compartmentalization of metabolic processes.
Nyx: a flexible framework for sleep scoring across species, lifespan and modalities biorxiv.org 2026-07-28 Sleep is a key factor in almost every physiological process, yet scoring tools lag behind innovations in basic to clinical research.
Serotonin Receptor Signaling Promotes Amoeboid Migration of Melanoma Cells Through cAMP/PKA Activation biorxiv.org 2026-07-28 Melanoma cells frequently utilize bleb-driven amoeboid migration to navigate confined microenvironments during metastasis.
STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in TP53-mutated AML biorxiv.org 2026-07-28 TP53-mutated acute myeloid leukemia (AML) has dismal outcomes with current treatments and represents a critical unmet need.
Targeting CBP/p300 Overcomes Acquired Vincristine Resistance in Medulloblastoma biorxiv.org 2026-07-28 Background: Medulloblastoma is the most common malignant pediatric brain tumor.
Solanum americanum Bs2 and ZAR1 homologs recognize Xanthomonas euvesicatoria effectors essential for infection. biorxiv.org 2026-07-28 Multiple recognition events of pathogen-secreted effectors by immune receptors confer robust disease resistance in plants.
Engineering antigen-driven co-stimulation and T helper cell activity into TCR-T cells with CD8-41BB fusion receptors enhances anti-tumor activity biorxiv.org 2026-07-28 Adoptive cell therapy using tumor antigen-targeting T cell receptors (TCRs) offers a compelling approach to treat both hematological cancers and solid
A targeted plasma-proteomic axis separates autoimmune thyroid disease from growth-hormone deficiency biorxiv.org 2026-07-28 Targeted mass spectrometry (multiple-reaction monitoring, MRM) enables reproducible, multiplexed quantification of plasma proteins, but whether a fixe