Concept-Level Semantic Representations Remain Decodable in Chronic Post-Stroke Aphasia biorxiv.org 2026-07-25 Aphasia is characterized by impaired word retrieval, yet most cognitive models of word production assume that underlying conceptual-semantic represent
A Circulating TLR2pos CD14neg CD16neg '' Unclassified Subset '' is Decreased in Multiple Myeloma Patients and May Comprise CD163pos Dendritic Cells. biorxiv.org 2026-07-25 Background: Strategies to define human monocytes by flow cytometry vary considerably across studies.
Intracellular pathogen targeting by IL32 elicits cell-autonomous immunity biorxiv.org 2026-07-25 Interferon gamma safeguards humans against intracellular pathogens, yet how most interferon-stimulated genes protect host cells, and how human-adapted
Cryo-electron microscopy structure of Jabs, a bacteriophage infecting the multidrug-resistant pathogen Mycobacterium abscessus biorxiv.org 2026-07-25 Exploring bacteriophage structural diversity is essential for understanding phage biology and for advancing phage-based therapies.
Prevalent phenotypic mutation impairs binding of broadly neutralizing antibodies to influenza hemagglutinin biorxiv.org 2026-07-25 Mistakes during protein synthesis, such as transcription errors, occur often and lead to non-inheritable amino acid replacements generally known as ph
Structural and Stereochemical Elucidation of Cyanochelin C, a Siderophore Associated with Novel Class of Cyanobacterial Acyl Hydrolases biorxiv.org 2026-07-25 Iron is a key micronutrient that constrains microbial growth and productivity in many aquatic and terrestrial environments due to its limited bioavail
Intrafilament nucleotide exchange in a prokaryotic actin homolog biorxiv.org 2026-07-25 Polymerisation and disassembly govern the cellular functions of cytoskeletal proteins.
Outbreak of Dermatophilus congolensis skin infection among contact sport practitioners, Norway, summer 2025 biorxiv.org 2026-07-25 Dermatophilus congolensis is a zoonotic gram-positive bacterium causing dermatophilosis, a skin infection primarily affecting animals and uncommonly r
Characterization of NPR-14 in the Regulation of Sleep-Like Behaviour in Caenorhabditis elegans biorxiv.org 2026-07-25 Sleep-like quiescence is an evolutionarily conserved state essential for physiological homeostasis; however, its dysregulation can lead to sleep disor
Optimized cryo-FIB milling strategy to generate thin, minimally damaged biological lamellae biorxiv.org 2026-07-25 Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron mi
Bidirectional Electron Transfer in Far-Red-Light Adapted Photosystem I. Implications for the Photosystem's Functionality biorxiv.org 2026-07-25 Far-Red (FR) Light Photoacclimation (FaRLiP) enables cyanobacteria to extend photosynthetic activity into the far-red region by extensively remodellin
Genetic architecture of soluble arabinoxylan fibre in elite genotypes of bread wheat revealed by genome-wide association analysis biorxiv.org 2026-07-24 Dietary fibre intake remains below recommended levels, and increasing fibre content of widely consumed white wheat flour (derived from the starchy end
Olfactory Search Behavior Across Flow Regimes Supports a Unifying Framework biorxiv.org 2026-07-24 How animals perform odor-guided search across the broad range of dynamic flow conditions they encounter in nature is not well understood.
The Barcode Inference Pipeline (BIP): From Sequencer Output to DNA Barcodes biorxiv.org 2026-07-24 DNA barcoding involves the recovery of a DNA sequence for a target gene region from its source specimen.
GatorPrism: Prototype-Conditioned Routing across Coalition Graph Experts for Spatial Multi-Omics Integration biorxiv.org 2026-07-24 Spatial multi-omics integration requires balancing cross-omics consensus with modality-specific signals whose importance varies across tissue location
EXCAVATE-HT: A Bioinformatic Pipeline to Identify Targetable Genomic Variants for Allele-Specific Editing biorxiv.org 2026-07-24 Allele-specific CRISPR/Cas editing is a powerful tool with great potential for treating genetic diseases and for uncovering the effects of allelic div
A new automated pipeline for whole genome shotgun sequencing analysis and hazard characterization of microbial pesticides biorxiv.org 2026-07-24 Microbial pesticides are increasingly important for sustainable crop protection, yet hazard analysis and risk assessment remain challenging and requir
Ovarian cancer-on-chip for patient-specific profiling of treatment responses to sequential chemotherapy and PD-L1 blockade biorxiv.org 2026-07-24 Ovarian cancer (OvCa) ranks as the most lethal gynecological malignancy in women worldwide.
Survivorship Bias Explains Age-Dependent Extinction in Fossil Genera biorxiv.org 2026-07-24 Fossil genera exhibit pronounced age-dependent extinction: older genera are more likely to survive extinction events than younger ones.
Imaging-Based Age- and Sex-specific Cardiovascular and Skeletal Phenotypes in Fbn1C1041G/+ Mice biorxiv.org 2026-07-24 Marfan syndrome is a multisystem connective tissue disorder with age-dependent and sex-dependent phenotypic variability.
Hyaluronan and CD44 targeting reverses early matrix changes, proinflammatory signals and fibrosis in primary sclerosing cholangitis biorxiv.org 2026-07-24 Primary sclerosing cholangitis (PSC) is a rare, progressive liver disease characterized by biliary inflammation and bile duct strictures and no approv
Simulating neural network criticality and resource dynamics with Rydberg gases biorxiv.org 2026-07-24 Efficient operation of neural networks has been linked to criticality in their underlying non-equilibrium excitation dynamics.
The Critical Role of Pdyn-Lineage Enteric Neurons in Colonic Motility and Visceral Interoception biorxiv.org 2026-07-24 Sensory neurons play well defined roles in the regulation of intestinal motility, digestion, and interoception, but transcriptional dissection of intr
Gastric-brain coupling dynamics in response to a cognitive challenge reveal distinct autonomic and psychological correlates in healthy individuals and patients with irritable bowel syndrome biorxiv.org 2026-07-24 The gastric's intrinsic slow-wave rhythm couples to ongoing cortical activity in humans, but the functional significance of this gastric-brain couplin
A chicken interferon stimulated gene screen reveals limited genes restricting influenza replication biorxiv.org 2026-07-24 Avian influenza A virus (IAV) is a major global health threat.
Host-like Temperature Unlocks Glucose Uptake and Metabolism in Pathogenic Leptospira biorxiv.org 2026-07-24 Pathogenic Leptospira transitions between environmental reservoirs and mammalian hosts, expose the bacterium to distinct temperature conditions.
Efficient CRISPR/Cas9-mediated homology independent sequence replacement in vivo and non-dividing primary cells biorxiv.org 2026-07-24 Precise sequence replacement in non-dividing cells remains a major challenge for genome editing.
An open-source application for applying rapid transient perturbations using a split-belt treadmill biorxiv.org 2026-07-24 Background: The use of specialized perturbation systems has become an increasingly popular approach for investigating walking stability.
AINN-Express: A Leakage-Aware, Sequence-Only Predictor of VHH Antibody Expression Built on the AINN-P1 Protein Foundation Model biorxiv.org 2026-07-24 Expression -- whether an antibody can be produced at usable yield -- is one of the earliest and most expensive filters in therapeutic discovery.
MeioBIOME: A snakemake workflow for the parallel analysis of meiofaunal genomes and host-associated bacteria/archaea biorxiv.org 2026-07-24 Microbes closely interact with every living organism, including meiofauna (i.e., microbial eukaryotes 38 m - 1 mm in length), and influence the develo
Ultrastructural remodelling of tau fibrils during ghost tangle formation in Alzheimer's disease brain biorxiv.org 2026-07-24 Tau aggregation into intracellular neurofibrillary tangles (NFTs) is one of the major hallmarks of Alzheimer's disease (AD).
Diversity at the HYP1 locus in potato cyst nematodes does not result from developmentally-programmed somatic mutations biorxiv.org 2026-07-24 Most genetic diversity stems from spontaneous mutations, that is, errors in DNA repair or replication.
The Tsallis index of the human cortical transcriptome is invariant between bipolar II disorder and control: a pre-registered, cross-platform null with the disease question relocated to correlation structure biorxiv.org 2026-07-24 Gene-expression fluctuations are heavy-tailed and resist description by additive (Boltzmann-Gibbs) statistics, motivating a non-extensive (Tsallis) ac
Stress limits the beneficial effects of glutamine in male ob/ob mice biorxiv.org 2026-07-24 Introduction: Obesity is a major health issue associated with metabolic and psychological comorbidities, as well as an increased prevalence of disorde
Global structure of new relational knowledge networks is represented in retrosplenial complex, and node-distance in hippocampus biorxiv.org 2026-07-25 Much of our knowledge is structured in networks, but how the brain represents such networks remains unclear.
Deep Phenotyping with Global Brain Activity and Plasticity Mapping Identify the Dorsal Raphe-Basolateral Amygdala Circuit as a Mediator of Adaptive Stress Responses biorxiv.org 2026-07-25 Exposure to chronic environmental challenges triggers divergent behavioral trajectories across individuals.
A significant enrichment that is not: spatial nulls, co-expression, and the imaging transcriptomics of EEG alpha-power genetics biorxiv.org 2026-07-25 Background.
Distinct forms of dopamine transmission control locomotion and learning biorxiv.org 2026-07-25 The neuromodulator dopamine is essential for voluntary movement and learning from experience.
Live-imaging of endogenous neurofascins reveals glial adhesion shapes developing nodes of Ranvier biorxiv.org 2026-07-25 The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuro
Developmental tuning of functional manifold dimensionality across the human brain biorxiv.org 2026-07-25 Neural representations vary in their complexity across brain regions and tasks.
AI segmentation requires accounting for brain size to maintain performance on developmental MRI cohorts biorxiv.org 2026-07-25 The human brain undergoes rapid developmental changes through early life, underpinning the emergence of function but also marking a period of vulnerab
Wrong but useful: Bombyx silkworm W chromosome assemblies are flawed but still capture strongly reduced diversity of repetitive DNA biorxiv.org 2026-07-24 Degenerate sex chromosomes (e.g., the Y or W) remain among the most difficult regions of eukaryotic genomes to assemble because they are highly repeti
Comparison of multiple video tracking-based behavioral summary approaches for compound discrimination biorxiv.org 2026-07-24 The rapidly increasing number of video tracking-based behavioral summary tools and methods raises the question as to the most suitable approaches for
Integrated Bioinformatics Analysis Reveals Candidate Hub Genes and Regulatory Networks Associated with Preeclampsia biorxiv.org 2026-07-24 Preeclampsia (PE) is a severe pregnancy-associated hypertensive disorder and a major contributor to maternal and perinatal morbidity and mortality.
CNVeil resolves haplotype-specific copy number and uncovers subclonal architecture hidden from total copy number profiling in single-cell cancergenomes biorxiv.org 2026-07-24 Single-cell DNA sequencing (scDNA-seq) resolves copy number variation (CNV) at single-cell resolution, revealing tumor heterogeneity and subclonal str
Deconvolution-derived cell-type expression targets for personal genome sequence-to-expression prediction biorxiv.org 2026-07-24 Sequence-to-function models learn regulatory features from genomic sequence, but they remain limited in their ability to predict gene-expression diffe
VizR: An Interactive Web Platform for End-to-End RNA-Seq Analysis and Visualization in Plant Biology biorxiv.org 2026-07-24 RNA sequencing (RNA-seq) is widely used to investigate transcriptional programs in plant biology, yet the need to combine multiple specialized tools a
Revisiting Logistic Regression for High-Dimensional Gene Expression Data biorxiv.org 2026-07-24 Logistic regression remains a widely used classification method due to its interpretability and computational efficiency, but its direct application t
Recurring daytime and nighttime modes of VOC emissions in a cool-temperate oak forest biorxiv.org 2026-07-24 Plants emit substantial amounts of biogenic volatile organic compounds (VOCs) that link plant physiological activity to ecological interactions and at
Age-Related Changes in the Neural Dynamics of Speech Production Following Noninvasive Brain Stimulation biorxiv.org 2026-07-24 Non-nvasive brain stimulation is a promising technique to restore neural function in older adults by enhancing cortical excitability.