Coupling Mechanical and Metabolic Behavior in Huxley-type Muscle Models biorxiv.org 2026-07-23 Accurate prediction of both mechanical and metabolic behavior of muscle remains an important challenge in biomechanics.
Microtubule architecture and detyrosination bidirectionally modulate sarcomere shortening in skeletal muscle fibers biorxiv.org 2026-07-23 Although microtubules (MT) are established regulators of striated muscle mechanics, how MT lattice organization and post-translational modifications (
Leveraging Supramolecular Polymers to Induce the Targeted Protein Degradation of α-Synuclein biorxiv.org 2026-07-23 Halting the progression of neurodegenerative diseases remains one of the foremost challenges in medicinal chemistry due to the complex biology that dr
Programmed chromosome elimination correlates with the overexpression of cohesin and additional B chromosome-encoded genes in Aegilops speltoides biorxiv.org 2026-07-23 Programmed chromosome elimination is a highly controlled developmental process in which specific chromosomes are selectively lost from defined cell ty
A highly penetrant LMNA R541C variant associated with dilated cardiomyopathy leads to dysregulation in metabolism and proliferation pathways in stem cell-derived cardiomyocytes biorxiv.org 2026-07-23 Background LMNA codes a widely expressed nuclear cytoskeletal protein (lamin A/C) with multiple important functions.
PhytoFam: A Nextflow Pipeline for Genome-Wide Analysis of Plant Gene Families biorxiv.org 2026-07-23 Genome-wide identification of plant gene families is essential for functional and evolutionary studies but often requires the use of multiple independ
Nanopore Electrometry Resolves Peptide Charge Patterns beyond Ionic-Current Blockade biorxiv.org 2026-07-23 Localized measurements of electric fields offer a promising route to expand the information content of nanopore-based single-molecule sensing beyond c
Symmetry-breaking flow bifurcation as an under-recognised haemodynamic factor in valve-associated thrombosis biorxiv.org 2026-07-23 Venous thrombosis commonly develops in the vicinity of venous valve pockets, where disturbed haemodynamics, xreduced washout, and endothelial dysfunct
Endometrial transcriptomic and ciliation analysis after scratch shows no signature linked to live birth following IVF biorxiv.org 2026-07-23 Objective: To determine whether endometrial scratch induces differences in transcriptomic profiles or epithelial cell ciliation in the endometrium at
Movement Directions Aligned in Joint Space Are Not Aligned in Muscle Space biorxiv.org 2026-07-23 Learned movements are thought to be represented in both extrinsic and intrinsic coordinate systems.
Non-invasive tracking of ripple-like activity during human sleep using MEG biorxiv.org 2026-07-23 Hippocampal ripples are considered a key mechanism of sleep-dependent memory consolidation.
Sex-biased transcriptional rewiring of neuronal circuits associated with eprinomectin resistance in Haemonchus contortus biorxiv.org 2026-07-23 Anthelmintic resistance poses a critical threat to livestock health, with clinical failures of eprinomectin and other macrocyclic lactones documented
Mediterranean dispersal imposed bottlenecks in Neolithic sheep and goats biorxiv.org 2026-07-23 The Neolithic period in western Eurasia involved major dispersal events, including the translocation of livestock into Europe.
Antibody evasion and receptor binding of SARS-CoV-2 variants PQ.16.1.1 and RK.1 biorxiv.org 2026-07-23 The recent global expansion of the SARS-CoV-2 variant NB.1.8.1 has driven the emergence of sublineages PQ.16.1.1 and RK.1, which independently acquire
PINK1 stabilizes RMDN3-VAPB interaction without altering the landscape of mito-ER contact sites biorxiv.org 2026-07-23 Mitochondria-ER contact sites (MERCS) have emerged as central hubs of organellar biology, participating in the exchange of lipids, Ca2+ and even prote
PROPEL: a high-throughput shear-stress platform reveals organotypic thresholds in endothelial mechano-adaptation biorxiv.org 2026-07-23 Endothelial cells exhibit organotypic specialization, yet the tools to decode whether hemodynamic shear shapes this diversity across vascular beds hav
Proprotein convertase activity regulates cumulus-oocyte-complex matrix integrity and cumulus cell migration during ovulation via a GDF9-dependent mechanism biorxiv.org 2026-07-23 Cumulus cells have well-established roles early in ovulation but the key molecules that drive their behavior in later stages, leading to follicle rupt
A gene-agnostic FACS technique to isolate stem cells in Hydractinia symbiolongicarpus validated with cytology biorxiv.org 2026-07-23 Hydractinia symbiolongicarpus is a powerful model for stem cell research and maintains a population of pluripotent adult stem cells throughout its lif
Cyclin B3-CDK1 couples translational de-repression to embryonic mitoses via OMA protein degradation in C. elegans. biorxiv.org 2026-07-23 During early embryogenesis, gene expression relies on maternally loaded mRNAs whose translation is controlled by RNA binding proteins.
Molecular Mechanism of Lipid Recognition and Membrane-Guided Gating in Plant Minimal START Proteins biorxiv.org 2026-07-23 The hydrophobic nature of lipids requires specialized transport mechanisms, and one such non-vesicular transport mechanism involves START (StAR-relate
Programming protein shape as an explicit design layer via CAD blueprint-guided diffusion biorxiv.org 2026-07-23 In engineering, industrial design principles link geometric form with function.
Towards interoperable modeling of toehold-mediated strand exchange circuits across DNA nanotechnology and engineering biology biorxiv.org 2026-07-23 Originally developed for DNA nanotechnology, toehold-mediated strand exchange (TMSE) circuits are gaining traction in synthetic biology due to their h
GLP-1 and GIP receptor agonism does not directly drive skeletal muscle atrophy or impair myogenesis in primary human myotubes biorxiv.org 2026-07-23 GLP1 and GIP/GLP1 receptor agonists produce substantial weight loss in clinical trials but significant loss of lean body mass is reported.
Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress biorxiv.org 2026-07-23 Perceived or volitional control over a stressor is a critical determinant of resilient versus susceptible behavioral phenotypes.
DROSOPHILA PRICKLE MUTANTS DISPLAY COMORBID NEUROLOGICAL PHENOTYPES AND PROVIDE A GENETIC LINK BETWEEN EPILEPSY AND AUTISM SPECTRUM DISORDER biorxiv.org 2026-07-23 Epilepsy affects approximately 30% of individuals with autism spectrum disorder (ASD).
Phylogenomics resolves a 200-year-old puzzle: a revised tribal classification of Afro-Eurasian dung beetles (Coleoptera: Scarabaeinae) biorxiv.org 2026-07-23 Background.
Non-Canonical Activation of HSF1 Stimulates mTORC1-Mediated Translation in HCMV-Infected Monocytes biorxiv.org 2026-07-23 Human cytomegalovirus (HCMV) is a major cause of organ disease among immunonaive and immunocompromised individuals.
Single-cell analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes Ahr-dependent seboatrophy with elevated expression of infundibular Blimp1 biorxiv.org 2026-07-23 In humans, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces chloracne, a skin condition that presents with acanthosis, hyperkeratosis, comedones, an
Circulating APOH promotes aortic dissection by activating the vascular smooth muscle cell NR5A1-PPARγ pathway. biorxiv.org 2026-07-23 Introductions: Aortic dissection (AD) is a life-threatening vascular disease with limited therapeutic targets.
An openly licensed benchmark and per-gene calibration map for missense pathogenicity predictors on activating cancer drivers biorxiv.org 2026-07-23 Missense pathogenicity predictors such as AlphaMissense are increasingly used in clinical variant interpretation, yet they are trained on germline lab
pHaseMD4AI: Phase-Space Dynamics Dataset with Chemical and pH Perturbations for Physically and Kinetically Consistent Biomolecular AI biorxiv.org 2026-07-23 Protein function emerges from dynamic conformational ensembles and transitions that are challenging to characterize experimentally and computationally
Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model biorxiv.org 2026-07-23 Repeated low dose psilocybin is being developed as a scalable outpatient treatment for mood and anxiety disorders, but chronic exposure raises concern
Dronedarone hydrochloride reverses obesity-related metabolic syndrome while preserving skeletal muscle mass biorxiv.org 2026-07-23 Obesity-driven metabolic syndrome poses a critical global threat, yet standard therapies like GLP-1 receptor agonists trigger substantial lean mass wa
Persistent microbial material contributes to Alzheimer disease and is targetable by vaccination biorxiv.org 2026-07-23 Chronic neuroinflammation is increasingly recognized as a contributor to Alzheimer disease, yet the upstream stimuli that sustain it remain poorly def
A predictive theory of experimental design for inferring neural population geometry in large-scale recordings biorxiv.org 2026-07-23 Ongoing technological advances will lead to recordings with progressively increasing numbers of neurons, while trial counts may only increase modestly
Individual limb measures of split-belt adaptation are correlated with shifts in lower limb position sense biorxiv.org 2026-07-23 Stable gait in humans relies on both precise estimates of lower limb position and the ability to robustly adapt walking movements across different env
Decoding Individual Musical Pitches in Perception and Imagery using Evoked Theta and Beta Power in EEG biorxiv.org 2026-07-23 Imagery evokes perceptual-like experiences and recruits similar neural activity to perception.
Uni-TINT: Unifying T and Innate Lymphoid Cell Taxonomy with a high resolution, pan-disease and pan-tissue single-cell transcriptomic atlas biorxiv.org 2026-07-23 T cells and innate lymphoid cells (ILCs) exhibit extensive phenotypic diversity across tissues and diseases, yet inconsistent annotation limits cross-
Evolutionary dynamics of the Timopheevii wheat lineage biorxiv.org 2026-07-23 Wheat, the most widely cultivated crop globally, includes multiple species with varying ploidy levels.
Can urban fence lizards identify cats? biorxiv.org 2026-07-23 Urban habitats can serve as wildlife refuges, or as ecological traps.
Flower engineering by yeasts: reversal of nectar sugar concentration gradient within Darwin's syndrome inflorescences biorxiv.org 2026-07-23 Yeasts thriving in floral nectar have a proven ecological engineering capacity, as they modify the internal environment and the rewards of individual
Host traits, phylogeny, and symbiont identity explain variation in colony-level symbiont switching across reef-building corals biorxiv.org 2026-07-23 Flexibility in the coral-algal symbiosis has been proposed as a mechanism by which coral colonies may acclimatize to shifting environmental conditions
Species traits shape the intercontinental introduction patterns of bark and ambrosia beetles biorxiv.org 2026-07-23 1.
Local trait responses and aquatic microclimates increase projected habitat suitability for field-collected Anopheles stephensi in southern Ethiopia biorxiv.org 2026-07-23 Background Trait-based models of mosquito environmental suitability commonly use global thermal performance curves compiled from laboratory studies.
Warming amplifies short-term responses to disturbance in lake food webs biorxiv.org 2026-07-23 Ecological communities can exhibit transient amplification after disturbance even if asymptotically stable, yet how environmental change reshapes thes
High resolution structure of plant Light-Harvesting Complex II (LHCII) provides insight into lutein conformations and energy quenching biorxiv.org 2026-07-23 Plant Light Harvesting Complex II (LHCII) is found in the thylakoid membranes of chloroplasts and balances two roles: energy collection for photosynth
A de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells biorxiv.org 2026-07-23 Photocatalytic proximity labeling proteomics (photo-PLP) has emerged as a powerful technology for rapid capture of protein interactomes in situ.
Extracellular vesicles derived from cells overexpressing HGSNAT rescue defects in Mucopolysaccharidosis IIIC neurons biorxiv.org 2026-07-23 Mucopolysaccharidosis III type C (MPS IIIC) is a rare neurological lysosomal storage disorder caused by genetic deficiency of the lysosomal membrane e
iG6PSnFR: A genetically encoded fluorescent sensor for observing glucose-6-phosphate dynamics in living preparations biorxiv.org 2026-07-23 Glucose-6-phosphate (G6P) is a key intermediate in multiple energetic and anabolic pathways, and quantifying its dynamics is essential for understandi
Nuclear size and physical properties of the nucleoplasm are determined by colloid osmotic pressure at the nuclear envelope biorxiv.org 2026-07-23 The size of the nucleus scales with cell size, suggesting a universal scaling rule.