An Integrated Preclinical Platform for Lethal Neuroendocrine Prostate Cancer from Rapid Autopsy Bone and Liver Metastases. biorxiv.org 2026-07-23 Treatment-emergent neuroendocrine prostate cancer (NEPC) is an aggressive, therapy-resistant disease arising in up to 20% of castration resistant pros
An immune-stimulating antibody conjugate spatiotemporally targeting CD47 and TLR9 elicits macrophage-dependent tumor clearance and durable anti-cancer adaptive immunity biorxiv.org 2026-07-23 Cluster of differentiation 47 (CD47) blockade promotes tumor cell phagocytosis; however, transitioning this initial innate immune event into durable a
Vitamin K2 Limits Ferroptosis-Associated Lipid Peroxidation and Attenuates Aortic Valve Stenosis biorxiv.org 2026-07-23 Background: Calcific aortic valve stenosis (AS) is the most common valvular heart disease in the aging population and lacks effective pharmacological
Elevated CO2 enhances tomato tolerance to Botrytis cinerea through transcriptional and metabolic defence reprogramming biorxiv.org 2026-07-23 Atmospheric CO2; concentration is projected to rise substantially over the coming decades, yet its impact on the molecular mechanisms governing plant
Schwann Cell-Specific TDP-43 Rescue Improves Peripheral Nerve Myelin Pathology Without Altering Motor Behaviour in a Mouse Model of ALS biorxiv.org 2026-07-23 Amyotrophic lateral sclerosis (ALS) is a terminal disease caused by motor neuron loss.
IFNγ at the crossroads of systemic protection and brain vulnerability to coronavirus infection biorxiv.org 2026-07-23 The COVID-19 pandemic, together with previous outbreaks caused by highly pathogenic coronaviruses, highlighted the importance of understanding the hos
TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism biorxiv.org 2026-07-23 TMEM135 has been implicated in lipid metabolism, but its role in regulating hepatic lipid homeostasis remains unclear.
Toxoplasma GRA8 engages the host ESCRT accessory protein ALG-2 and is necessary for parasite metabolic integrity biorxiv.org 2026-07-23 The endosomal sorting complex required for transport (ESCRT) is a hetero-multimeric membrane-remodeling machinery essential for endosomal sorting, int
p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells biorxiv.org 2026-07-23 Age is a principal risk factor for chronic respiratory diseases.
Structural modeling supports an interaction between the Drosophila Estrogen-Related Receptor and Sima/HIF-1α biorxiv.org 2026-07-23 The Drosophila Estrogen Related Receptor (dERR) is an orphan nuclear receptor that regulates developmental metabolism, yet the protein cofactors that
Maps of historical forests in France and their temporal continuity since the first half of the 19th century biorxiv.org 2026-07-23 Integrating environmental history is essential for understanding present-day ecosystem dynamics and guiding modern conservation strategies, particular
eIF5A is an indispensable protein for eukaryotic cells biorxiv.org 2026-07-23 eIF5A is an evolutionarily conserved protein found in all eukaryotes, and in Archaea and bacteria.
Circadian transcriptome in cultured cells depends on synchronisation method and differs from in vivo condition biorxiv.org 2026-07-23 In vitro synchronisation is widely used to study circadian clocks in cells, but whether cultured cells recapitulate tissue-level rhythmic outputs rema
Harmonized nucleoside mass spectrometry enables reproducible cross-platform RNA modification quantification biorxiv.org 2026-07-23 RNA modification analysis by LC-MS/MS is central to epitranscriptomics, yet quantitative comparison across laboratories and instrument platforms remai
Self-powered electronics-free Wearable Disposable Electrotherapy (WDE) platform for accelerated wound healing biorxiv.org 2026-07-23 Electrical stimulation accelerates wound repair by modulating endogenous bioelectric signals that regulate inflammation, angiogenesis, extracellular m
Macrophage-instructed GSDME couples glioblastoma cell-state plasticity with inflammatory cell death biorxiv.org 2026-07-23 Glioblastoma (GBM) cell states reflect spatial microenvironmental interactions.
Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in mice. biorxiv.org 2026-07-23 Background: Protease-activated receptor 4 (PAR4) is the only functional thrombin receptor on mouse platelets.
Morphomechanically-Informed Spatial Curvature Sequencing in Prostate Cancer biorxiv.org 2026-07-23 Morphological changes in prostate glands, assessed by Gleason grading, remain the gold standard for diagnosing prostate cancer, yet molecular biomarke
Diesel exhaust particles disrupt mouse and human iPSC-derived microglial function and Amyloid-beta clearance in Alzheimer's disease models biorxiv.org 2026-07-23 Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, yet the environmental drivers that accelerate its progression remain p
Complement protein concentrations and activity in human cervical mucus biorxiv.org 2026-07-22 Abstract Problem: Complement, a system of over 30 interacting proteins, functions as a critical immune mediator at mucosal surfaces including the inte
Non-retroviral Endogenous Viral Element Acts as a Stable Antiviral Regulator Across Mosquito Life Stages and Generations biorxiv.org 2026-07-22 Endogenous viral elements (EVEs) from non-retroviral RNA viruses are widespread in host genomes, yet their functional significance in vivo remains poo
Promoter architecture decodes response regulator phosphorylation into distinct transcriptional logics in Pseudomonas aeruginosa biorxiv.org 2026-07-22 Two-component systems convert environmental signals into transcriptional responses, but how one response-regulator phosphorylation state produces diff
Detection of bifidobacterial lipoproteins with anti-viral potential in donor human milk biorxiv.org 2026-07-22 Background: Group B coxsackieviruses (CVBs) are involved in triggering type 1 diabetes.
Proteomic mapping of the dengue virus NS1 microenvironment in infected cells identifies novel host dependency factors including TM9SF3 biorxiv.org 2026-07-22 Dengue virus (DENV) is endemic in over 100 countries and causes approximately 100 million symptomatic infections annually, with symptoms ranging from
A boundary-referenced framework for quantifying shoreline-associated movement in white sharks biorxiv.org 2026-07-22 Persistent habitat edges can structure animal movement, yet many analyses treat boundary geometry only implicitly.
Parallel and Divergent Evolution in Pseudomonas aeruginosa Under Constant and Fluctuating Predator-Mediated Selection biorxiv.org 2026-07-22 Environmental predation is a major driver of bacterial evolution and may indirectly influence virulence through coincidental selection.
Contamination of widely used databases compromises rRNA based taxonomic assignment of metagenomes and metatranscriptomes biorxiv.org 2026-07-22 axonomic annotation of metagenomic and metatranscriptomic datasets frequently relies on aligning small subunit (SSU) rRNA reads to annotated reference
A Disease-Agnostic Nasal Microbiome Wellness Index for Standardized Assessment of Upper-Airway Respiratory Health biorxiv.org 2026-07-22 Background: Upper-airway and respiratory conditions impose a large and growing global burden, yet there is no standardized way to assess whether a nas
Interaction of involuntary and executive attention during development biorxiv.org 2026-07-22 Attentional control requires the fine-tuned interaction of attentional networks supporting alertness, orienting and higher-level executive control.
A roadmap for enriching rare cell populations from human post-mortem brain, demonstrated by 100% microglial purity. biorxiv.org 2026-07-22 Understanding brain disease requires studying the specific cell types that drive each condition: microglia in Alzheimer's, dopaminergic neurons in Par
Endogenous attention is invariant to sequential effects in performance around the visual field biorxiv.org 2026-07-22 Covert spatial attention selects and prioritizes relevant sensory information. Endogenous attention is voluntary, goal-driven, and flexible.
Branch-resolved IFN/STING-linked lesion-state architecture in psoriasis: multi-cohort derivation, held-out bulk replication and single-cell context analysis biorxiv.org 2026-07-22 Objective and design: We tested whether a frozen branch-resolved IFN/STING-linked lesion-state architecture derived from paired psoriasis transcriptom
A Synthetic Microbial Therapy Rewires Antitumor Immunity Across Multiple Cancer Types biorxiv.org 2026-07-22 Microbial immunotherapies show promise against cancer, yet broad efficacy and mechanistic insight remain elusive.
Unconventional presentation of an immunodominant HLA-DR15-restricted nephritogenic proteinase 3 epitope implicated in vasculitis biorxiv.org 2026-07-22 Proteinase 3 (PR3) anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is associated with HLA-DR15, implicating HLA-DR15-restricted CD4
A sensitive bioassay for detecting Plasmodiophora brassicae in canola field soils biorxiv.org 2026-07-22 We describe a biodegradable-cup bioassay for detecting viable Plasmodiophora brassicae in soil samples.
Widespread introgression and a potential role for a neo-sex chromosome in booby diversification and speciation biorxiv.org 2026-07-22 Speciation in marine taxa is dynamic and complex, often occurring in the absence of absolute geographic barriers to gene flow.
Development of Audiovisual Integration in Beginning Readers: A Longitudinal fMRI Study biorxiv.org 2026-07-22 Acquiring reading proficiency, unlike spoken language, requires the brain to engage several specialized neural systems to map visual symbols (letters)
Sensory experience and mTORC1 interplay orchestrates the maturation of cortical interneuron connectivity and tactile sensitivity biorxiv.org 2026-07-23 Sensory abnormalities are core features of neurodevelopmental disorders, including autism.
Hierarchical neural integration of musical structure during expert performance biorxiv.org 2026-07-23 Music, which is organized hierarchically (notes, phrases, sections), provides an ideal model for studying fine-grained motor sequence production.
Constraints for spatially and temporally precise learning in a neural circuit model of reinforcement learning biorxiv.org 2026-07-22 Reinforcement learning is a key means by which animals learn appropriate actions in a given context.
Enhanced neural encoding of individual exemplars in the Super-Recogniser brain is specific to faces biorxiv.org 2026-07-22 Super-Recognisers are known for their exceptional ability to encode and remember faces.
Prior experience dynamically determines differential cue weighting in the medial entorhinal cortex biorxiv.org 2026-07-22 Spatial navigation depends on integrating multiple cue sets whose influence is determined primarily by their inferred reliability.
Genotype-by-environment-by-environment (GxExE) interactions have the potential to shape adaptation in response to multiple stressors biorxiv.org 2026-07-22 Rapid adaptation in complex environments depends not only on the amount of genetic variation, but also on patterns of covariation among traits targete
Evolution of regulatory chromatin contacts: insights from duplicated genes biorxiv.org 2026-07-22 In multicellular organisms, gene expression is controlled by numerous cis-regulatory elements that can be located far away from their target genes on
Cerebral Encoding of Word Classes is Distributed and Context-Dependent biorxiv.org 2026-07-23 Word classes such as nouns, verbs, and adjectives are fundamental units of language, but their neural encoding remains unclear.
Embodied reinforcement learning in the primate cortico-basal ganglia system biorxiv.org 2026-07-23 Learning the value of environmental stimuli from reward experience allows animals to make advantageous choices.
Unsupervised nonmotor learning in the human cerebellum biorxiv.org 2026-07-23 A core motor function of the cerebellum is error-based learning: it uses prediction errors--mismatches between predicted and actual sensory feedback--
Lexical and Semantic Coding in the Occipital Cortex of Sighted and Blind biorxiv.org 2026-07-23 How early visual cortex (EVC) supports language and semantic processing in sighted and congenitally blind individuals remains debated.
Area-level context and functional brain organization across the lifespan biorxiv.org 2026-07-23 The neighborhoods children grow up in are associated with cognitive and mental health outcomes across the lifespan.
Sulfur amino acid restriction prevents S-adenosylmethionine-driven liver steatosis, hepatocellular carcinoma, and metabolic remodeling in high-fat-fed GNMT-null mice biorxiv.org 2026-07-22 The expression of glycine N-methyltransferase (GNMT), a critical regulator of S-adenosylmethionine (SAM) levels, is down-regulated in humans with meta