Synaptic Development of Fine Spatial Scale Organization of Neuronal Orientation Tuning in Mouse Primary Visual Cortex biorxiv.org 2026-07-21 Primary sensory cortices often organize neurons with similar stimulus preference into spatially functional maps.
Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality biorxiv.org 2026-07-21 Chemical modifications expand the functional repertoire of nucleic acids, but the extent to which complex glycans can be integrated into genetic polym
Protective effects of a novel RIPK3 antagonist against neutrophil necroptosis and formation of neutrophil extracellular traps biorxiv.org 2026-07-21 Functionally competent, highly purified neutrophils were isolated from healthy human donors.
Rapid removal of nuclear aggregates via proteasome- and VCP-dependent disaggregation biorxiv.org 2026-07-21 Cells use multiple protein quality control (PQC) mechanisms to counteract the toxic effects of protein aggregation caused by cellular stress, ageing o
Dynamic diffusion analysis of the yeast plasma membrane using Airyscan based microscopic techniques biorxiv.org 2026-07-21 The yeast plasma membrane (PM) is highly compartmentalised into distinct nanoscale domains.
Single-Cell Proteomics Reveals Heterogeneous and Bimodal Proteome Responses to DNA Damage biorxiv.org 2026-07-21 DNA damage response (DDR) involves coordinated activation of repair, checkpoint, and stress adaptive signalling pathways following genomic toxicity.
Transcriptional regulation by Tbx2 paralogs creates diversity within photoreceptor subtypes biorxiv.org 2026-07-21 Photoreceptors are retinal neurons whose subtype-specific opsin expression and mosaic organization enable parallel encoding of spectral and spatial vi
Spatial Patterning of Otic Vesicles in Human Inner Ear Organoids biorxiv.org 2026-07-21 During development axial patterning of the otic vesicle sets up the blueprint for the adult inner ear.
Dynamic knowledge representation of blood brain barrier activation, injury and restitution with a novel agent-based model biorxiv.org 2026-07-21 The blood brain barrier (BBB) tightly regulates the interface between the central nervous system and the systemic circulation.
Thermal variability interacts with infection load and the evolution of host-parasite defense biorxiv.org 2026-07-21 Rising temperatures and unpredictable weather patterns are directly linked to emerging infectious diseases that threaten global biodiversity.
Fat body CLOCK restrains innate immunity and maintains survival under dietary stress in Drosophila biorxiv.org 2026-07-21 Both aging and a high-fat diet (HFD) dampen circadian gene transcription rhythms and promote chronic inflammation.
Riverine input and eddy edge effects on microeukaryotic biodiversity in the Northern Gulf biorxiv.org 2026-07-21 Marine microorganisms drive the biogeochemical processes that sustain ocean ecosystems, such as primary production, nutrient cycling, and the transfer
Termination dynamics set RNAPII elongation rate and gate the response to CDK12 inactivation biorxiv.org 2026-07-21 The transcriptional fidelity of RNA polymerase II (RNAPII) is governed by a tight equilibrium between elongation and termination activities, a balance
DNA Polymerase beta Accelerates Cellular DNA Base Excision Repair by Suppressing Excessive PARP1 Engagement biorxiv.org 2026-07-21 DNA polymerase beta (POLB) is required for rapid rates of cellular DNA base excision repair (BER).
Comprehensive landscape of potential CTCF-binding sites across the complete telomere-to-telomere human genome biorxiv.org 2026-07-21 CCCTC-binding factor (CTCF) is a master regulator of the human genome, directly modulating both transcription and 3D genome organization.
Combining Stability-Centered Atomistic Design with Machine Learning for Targeted Enzyme Optimization biorxiv.org 2026-07-21 FuncLib and high-throughput FuncLib (htFuncLib) generate diverse, functional protein libraries using a stability-centered design; however, this substr
Physiological Cross-Sectional Surfaces: A Method for Estimating Muscle Functional Capacity from 3D Digital Models of Fiber Architecture biorxiv.org 2026-07-21 Physiological cross-sectional area (PCSA) is defined as the summed cross-sectional area of all muscle fibers contracting in parallel and at optimal le
Distinct Effects of the Extracellular Matrix on Tumor Organization and Response to Cancer Virotherapy biorxiv.org 2026-07-21 Extracellular matrix (ECM) regulates tumor architecture and immune accessibility, but its impact on virus-based anticancer therapies is not well under
Rapid reconstitution and kinase-controlled regulation of algal pyrenoid condensates in engineered Nicotiana benthamiana biorxiv.org 2026-07-21 The pyrenoid is an organelle found in nearly all algae that concentrates CO2 around Rubisco to enhance photosynthetic carbon fixation.
miR-10a-5p as a critical molecular regulator of dopaminergic impulsivity in the nucleus accumbens biorxiv.org 2026-07-21 Impulsive-compulsive disorders (ICDs), including pathological gambling, hypersexuality, and compulsive buying, are frequently precipitated by dopamine
Evolutionary trade-offs between growth and reproduction under obesogenic conditions: sex-biased skeletal and gonadal maturation in mice biorxiv.org 2026-07-21 Adolescence is a brief period during which finite energy resources are reallocated from linear growth toward reproductive maturation.
Using large language models for enhancing accessibility for Monte Carlo photon transport simulations and beyond biorxiv.org 2026-07-21 Significance: Computational modeling and the use of simulation software tools are essential for biomedical optics research.
ChatGEM: An Agentic Architecture Enabling Interactive Simulation of Genome-Scale Metabolic Models biorxiv.org 2026-07-21 Genome-scale metabolic models (GEMs) are powerful tools for predicting cellular phenotypes and guiding microbial strain engineering, yet broad adoptio
Epidermal and ECM Damage Following Pinch Injury Restricts Dendrite Regeneration in Drosophila biorxiv.org 2026-07-21 Neuronal dendrites can be injured by a number of insults, but the cellular mechanism by which dendrites respond to tissue injury and undergo repair is
A lipid acyl code-based Dip2-Pkc1 signalling axis maintains mitochondrial integrity in eukaryotes biorxiv.org 2026-07-21 Organelle membranes employ diverse lipids to relay key signals for efficient coordination of cellular processes.
VASP Promotes Aortic Valve Calcification by Interacting with FBLIM1 to Activate the Focal Adhesion Pathway biorxiv.org 2026-07-21 Objective: Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease, yet there is no effective pharmacological therapy to hal
Solid-state NMR Reveals Mobility-Based Organisation of the Schizosaccharomyces pombe Cell Wall biorxiv.org 2026-07-21 Fungal cell walls are hierarchically organised polysaccharide networks whose mechanical and functional properties depend on both chemical composition
Anionic lipids regulate PLCβ membrane recruitment biorxiv.org 2026-07-21 Phospholipase C-{beta} (PLC{beta}) enzymes are essential effectors of G protein-coupled receptor signaling that hydrolyze phosphatidylinositol 4,5-bis
An Atomistic Description of Heterotypic Lipid Exchange by Sec14-like Phosphatidylinositol Transfer Proteins biorxiv.org 2026-07-21 Lipid transfer proteins (LTPs) are core regulators of the membrane dynamics, lipid signaling and intracellular communication networks that connect eve
A Composite Endomembrane Suspension Governs Cytoplasm Rheology biorxiv.org 2026-07-21 The cytoplasm of eukaryotic cells is populated by dense disordered suspensions of filamentous and granular endomembranes, yet how they contribute to t
Environment and plant genetics shape barley rhizosphere microbiome structure across contrasting locations biorxiv.org 2026-07-21 Soil microorganisms are crucial for plant survival and productivity, but factors governing rhizosphere recruitment across diverse regions remain uncle
Peripheral nerve injury reallocates primary afferent input through spinal parvalbumin microcircuits biorxiv.org 2026-07-20 Complex neural functions rely on finely tuned circuits in which the recruitment of local interneurons gates the flow of information, determining wheth
What we miss shapes what we protect: sea turtles as a case study of grey literature and language bias in an evidence synthesis biorxiv.org 2026-07-20 Evidence-based approaches are increasingly advocated and applied in conservation to provide reliable recommendations for management and policymaking.
The brain-meningeal interface functions as a reservoir and entry site for brain parenchymal macrophages biorxiv.org 2026-07-20 Microglia are regarded as self-maintaining brain parenchymal macrophages without contribution from adult hematopoiesis.
Adipose GPD2 Couples Glycolytic Signals to Epigenetic Control of Metabolic Homeostasis biorxiv.org 2026-07-20 The glycerol-3-phosphate shuttle (G3PS) is a classic reducing equivalent transferring system, yet its role in adipose metabolism remains poorly unders
Multi-Modal photoFRESH: Light-Pipe Embedded Printing of Heterogeneous Hydrogel and Tissue Architectures biorxiv.org 2026-07-20 Recreating the complex spatial gradients and multi-material transitions of native tissues remains a fundamental challenge in 3D bioprinting.
Chemokine-Dependent Natural Killer Cells Prevent Pulmonary Metastasis in a Newly Established Mouse Osteosarcoma Model biorxiv.org 2026-07-20 Rampant genomic instability of osteosarcoma (OS) and associated inter- and intratumoral heterogeneity convey a high risk of metastasis despite contemp
KIR Expression Defines a Transcriptionally Distinct CD8+ T-cell Population that Confounds Antigen-Specific T-cell Detection biorxiv.org 2026-07-20 HLA-C--restricted CD8+ T-cell responses remain poorly defined compared with HLA-A and HLA-B responses, despite the central role of HLA-C as both a pep
A hybrid machine learning and enzyme-constrained metabolic model for ab initio prediction of proteome reallocation biorxiv.org 2026-07-21 High expression of heterologous proteins in microbial cell factories frequently triggers a severe burden due to reallocation of finite cellular proteo
Widespread occurrence of bovine-like and new viruses in wild deer across the United States biorxiv.org 2026-07-20 Over the past several decades, deer populations in North America have grown considerably, resulting in frequent contact with humans and livestock, and
Cross-talk among miRNAs, lncRNAs, and DNA methylation in three coral species reveal conserved epigenetic regulatory architecture biorxiv.org 2026-07-20 Epigenetic mechanisms support phenotypic plasticity across metazoans, enabling dynamic response to environmental change.
Characterization of Chromatin-Associated Circular RNAs (cacRNAs) biorxiv.org 2026-07-20 Circular RNAs (circRNAs) have emerged as novel regulators of gene expression by interacting with various proteins and RNAs in a spatiotemporal manner.
JAK and TYK2 inhibitors differentially modulate interferon/TNF-driven inflammation, stemness and proliferation in the colonic epithelium of ulcerative colitis biorxiv.org 2026-07-20 Background: Janus kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway is a key regulator of inflammatory signaling in ulcerat
Highly Pathogenic Avian Influenza H5N5 in a Polar Bear and Atlantic Walrus, Svalbard, 2026, with Widespread Seroconversion in Polar Bears biorxiv.org 2026-07-20 Highly pathogenic avian influenza virus (HPAIV) subtype H5N5 was detected in a one-year-old polar bear (Ursus maritimus) and an adjacent adult Atlanti
Optogenetic Regulation of Mitochondrial Function to Modulate Cell Death biorxiv.org 2026-07-21 Cell death is a critical process involved in physiological and pathological conditions, including neurodegenerative diseases and cancer.
Spatial genotypic patterns within monospecific stands of a dominant coral revealed through photogrammetry-guided sampling. biorxiv.org 2026-07-21 Local and global stressors are driving declines in competitive reef-building corals and favouring stress-tolerant, weedy species.
Tracing the 'Panda of the Sea': Species-Specific qPCR Assays for eDNA Monitoring of Critically Endangered Bahaba taipingensis in the Pearl River Estuary biorxiv.org 2026-07-21 Chinese Bahaba (Bahaba taipingensis, Sciaenidae) is a Critically Endangered, Grade I state protected marine fish in China.
A large-scale crowd-sourced annotated acoustic dataset of Indian fauna biorxiv.org 2026-07-21 Global rates of biodiversity loss warrant conservation action and monitoring at large geographic scales.
Urban larval mosquito surveillance in Antananarivo, Madagascar: spatiotemporal heterogeneity and associated vector dynamics biorxiv.org 2026-07-20 Mosquito-borne diseases, such as malaria, remain an important public health problem globally, including on the island of Madagascar.
Long-term vegetation change in protected calcareous fens is driven by land-use change and management abandonment biorxiv.org 2026-07-20 Aims Historical land use has shaped plant diversity in Central Europe for centuries, and many plant communities of high conservation value have been m