Sustained loss of Pptc7 triggers variable skeletal muscle dysfunction and diminished body mass through dysregulation of BNIP3 biorxiv.org 2026-07-18 The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and per
Ablation of GM3 Gangliosides in cardiomyocytes modestly impacts heart size but does not protect the murine heart against ischemia reperfusion injury biorxiv.org 2026-07-18 Advances in mass spectrometry have seen the identification of hundreds of new lipid species, some of which have been found to be associated with adver
CBR4 is essential for mice but not for skeletal muscle function biorxiv.org 2026-07-18 The mitochondrial fatty acid synthesis (mtFAS) pathway is a highly conserved process in mitochondria implicated in metabolic state sensing.
Astrocytic FMRP regulates the function of spinal parvalbumin-expressing neurons in Fragile X Syndrome biorxiv.org 2026-07-19 Tactile hypersensitivity is a common symptom of Fragile X Syndrome (FXS) characterized by over-responsiveness to innocuous touch or textures.
Excitatory delay-coupling explains in-phase and antiphase functional connectivity biorxiv.org 2026-07-19 Coordinated oscillatory activity between brain regions underpins cognition, yet the phase relationships governing this coordination remain poorly unde
Early Adversity Selectively Reshapes the Somato-Cognitive Action Network in the Developing Brain biorxiv.org 2026-07-19 Early adversity is among the most potent environmental influences on the developing brain; yet whether it remodels the areal layout of cortical networ
Learning to read a second language establishes a parallel L2 representation alongside the native one in the VWFA biorxiv.org 2026-07-19 Learning to read a second language requires the brain to incorporate a new writing system into an already established native-language reading network,
Large-scale population neuroimaging reveals latent subgroup structure in functional brain organisation biorxiv.org 2026-07-19 Large-scale functional MRI datasets provide resources to understand inter-individual variation in human brain function and relate this variation to be
Functional connectivity gradients depend on cortical sampling position and brain state biorxiv.org 2026-07-19 Functional-connectivity analyses often treat signals sampled from nearby cortical positions as interchangeable, despite anatomical and hemodynamic tra
Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MS biorxiv.org 2026-07-19 One of the defining features of neurons is their compartmentalisation into soma, dendrites and axon.
Emergent topological structure in spontaneous brain-organoid activity biorxiv.org 2026-07-19 Neural activity is widely held to organize on low-dimensional structure embedded in a high-dimensional state space.
Manipulating speech perception with amplitude-modulated kilohertz magnetic perturbation (AM-kTMP) biorxiv.org 2026-07-19 Speech perception has been hypothesized to exploit neural activity that entrains to the rhythmic properties of the utterance.
Neurodevelopment of Corticostriatal Circuits and Risk for Alcohol Use During the Transition from Adolescence to Adulthood biorxiv.org 2026-07-19 Adolescence and early adulthood are marked by rapid neurobehavioral development in reward and decision-making processes, coinciding with the initiatio
Similar Synaptic and Current Input Properties of Aromatase and Nonaromatase Neurons in the Zebra Finch Auditory Telencephalon biorxiv.org 2026-07-19 Estrogens, commonly known for their role in sexual development and maturation, support a wide variety of brain functions, including cognition, neuropr
Developmental enrichment enhances a topographically structured proprioceptive cortical code biorxiv.org 2026-07-19 The organization of proprioceptive cortex emerges from experience-dependent patterns of limb use during development, rather than merely reflecting per
Phosphoproteomic Insights into TRPV4 - AMPK Signaling Axis in the Choroid Plexus Epithelium: Implications for Therapeutic Targeting in Hydrocephalus biorxiv.org 2026-07-18 Background Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid (CSF) due to disrupted secretion, circulation, or reabsorpti
Modulation of retroviral capsid assembly halts ARC-mediated TDP-43 intercellular spreading biorxiv.org 2026-07-18 Intercellular propagation of pathological TDP-43 drives the progression of ALS and FTD, yet the mechanisms enabling transmission remain elusive.
A structured-illumination miniscope for optically sectioned imaging and real-time neural decoding biorxiv.org 2026-07-18 Single-photon miniscopes enable large-scale calcium imaging in freely behaving animals but are limited by out-of-focus background fluorescence that de
Molecular architecture of excitatory and inhibitory neurons in the first gustatory relay biorxiv.org 2026-07-18 Taste perception is a major determinant of food intake and is dynamically modulated by hunger and satiety signals across species.
PathoBench: an open community-driven benchmark registry for pathogen bioinformatics tools biorxiv.org 2026-07-17 The proliferation of pathogen bioinformatics pipelines has outpaced the community ability to compare them on common ground.
MEGAHIT k-mer range tuning trades computational efficiency for improved recovery of functional genes across cave sediment and wastewater metagenomes biorxiv.org 2026-07-17 Shotgun metagenomics is a powerful approach for profiling complex microbial ecosystems and discovering functional genes, including antimicrobial resis
Fluorescence cross-correlation spectroscopy quantifies affinity, cooperativity, and kinetic stability in ternary protein complexes biorxiv.org 2026-07-17 Many biological processes and emerging therapeutic modalities rely on higher-order protein complexes whose properties cannot be predicted from their c
Inflammatory arthritis disrupts ocular immune privilege by compromising blood-retinal barrier integrity and promoting uveitogenic T cell recruitment biorxiv.org 2026-07-17 Inflammatory arthritis and uveitis frequently co-exist, yet the mechanisms linking joint and ocular inflammation remain ill-defined.
SemVac: A Semantic Vaccinology Paradigm Powered by LLMs for Antigen Discovery biorxiv.org 2026-07-17 Reverse vaccinology has enabled sequence-based antigen discovery, but it overlooks the rich semantic knowledge embedded in the biomedical literature.
Experimental evolution and functional genetics identify KIC1 as a determinant of reduced artemisinin susceptibility in Bangladeshi Plasmodium falciparum biorxiv.org 2026-07-17 Bangladesh has greatly reduced malaria transmission, but persistent Plasmodium falciparum transmission in the Chittagong Hill Tracts (CHT), bordering
Bravo! A Mosquito Antiviral Protein that Restricts Arboviruses through an RRM3-Dependent Nuclear Mechanism biorxiv.org 2026-07-17 Culex quinquefasciatus mosquitoes are vectors for several medically important viruses, yet their antiviral immune responses remain understudied compar
Standing Genomic Variation inferred by popGWAS Predicts Seedling Drought Survival Experiment in Fagus sylvatica biorxiv.org 2026-07-17 Intensifying drought regimes across Central Europe, driven by global climate change, pose an increasing threat to forest regeneration, with the seedli
Truncating ASXL1 variants rewire cellular metabolism via mitochondrial pyruvate carrier repression biorxiv.org 2026-07-17 Bohring-Opitz syndrome (BOS, OMIM#605309) is a rare neurodevelopmental disorder caused by heterozygous and truncating variants in ASXL1 (Additional Se
The genome of the avian malaria parasite Haemoproteus majoris (lineage WW2) and its relationship to other Plasmodium species biorxiv.org 2026-07-17 Avian malaria parasites form a highly prevalent and genetically diverse group within the haemosporidians, yet they have long been overlooked relative
Aquaporin-4 mislocalization from astrocyte endfeet prolongs survival in a prion-cerebral amyloid angiopathy model biorxiv.org 2026-07-17 Aquaporin 4 (AQP4) water channels are polarized to astrocytic endfeet at blood vessel interfaces, and lose polarity in vascular diseases, including st
Ocular community state types reveal distinct microbial compositions among microbiomes with implications for trachoma control biorxiv.org 2026-07-17 Trachoma, a chronic ocular disease caused by Chlamydia trachomatis (Ct), is the leading infectious cause of blindness worldwide.
Mutation-agnostic gene insertion therapy for RHO-associated autosomal dominant retinitis pigmentosa using zinc finger nucleases biorxiv.org 2026-07-17 Purpose: Autosomal dominant retinitis pigmentosa caused by mutations in the rhodopsin gene (RHO-adRP) is among the most prevalent inherited retinal dy
The ecology of remembering and forgetting: quantity-quality trade-offs in the spatiotemporal memory of a forager biorxiv.org 2026-07-17 One way that animals can cope with the challenge of locating ephemeral food in time and space is by tracking elapsed time and planning revisits to the
A capsule polysaccharide synthesis locus database for the Klebsiella oxytoca Species Complex biorxiv.org 2026-07-17 The Klebsiella oxytoca Species Complex (SC) represents an emerging healthcare-associated group of opportunistic pathogens.
Hidden assumptions in nascent RNA sequencing pipelines define reproducibility states biorxiv.org 2026-07-17 Reproducibility of sequencing analyses is often assumed when identical data are processed with established pipelines, yet outcomes can depend on libra
Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics biorxiv.org 2026-07-17 Fear conditioning is widely used to assess associative memory in mice, yet percent freezing conflates memory with baseline locomotor and anxiety-relat
An Integrated EEG, TMS-EEG and Behavioural Dataset for Investigating the Neural Correlates of Working Memory biorxiv.org 2026-07-17 Working memory is a fundamental process that underlies cognition.
Task-specific neural mechanisms underlie biases in human orientation perception biorxiv.org 2026-07-17 Prior experience shapes both visual perception and its underlying neural circuits.
Macrophage calcium signaling dynamics revealed using genetically-encoded sensors biorxiv.org 2026-07-17 Macrophages (M{varphi}s) inhabit all mammalian organs, adapting to and influencing the tissues in which they reside.
Butyrivibrio azoria sp. nov., a novel cellulolytic microorganism isolated from the rumen of a Holstein dairy cow biorxiv.org 2026-07-17 This study describes the characteristics of NATIVEDY162T (= JL13D10T = NRRL B-68525T) a novel bacterium isolated from the rumen of a healthy Holstein
Addressing viral genomic variability towards developing a Cas13b-based therapy biorxiv.org 2026-07-17 Viral genome diversity may limit the effectiveness of antiviral RNA-editing tools such as CRISPR-Cas13 that can be used to destroy specific mRNA targe
Two-locus CRISPR toxin-antidote gene drive for confined population modification biorxiv.org 2026-07-17 Gene drive systems enable rapid spread of desired transgenes throughout populations.
Evidence of two centromeres in the germline-restricted chromosome (GRC): insights from zebra finch lampbrush chromosomes biorxiv.org 2026-07-17 The germline-restricted chromosome (GRC) of the zebra finch Taeniopygia guttata represents a well-established model of programmed DNA elimination in v
Total Biosynthesis of Pseudomonas aeruginosa-Derived Azabicyclocarbamates Identifies Distinct Dehydrating Condensation Family Proteins biorxiv.org 2026-07-17 Bacterial azabicyclocarbamates and related pyrrolizidine alkaloids play important roles in microbial interactions, and are scaffolds of therapeutic po
Robean: A Standalone Freeware for Automated Rodent Neurobehavioural Analysis with Integrated Tracking, Visualization, and Reporting biorxiv.org 2026-07-17 Quantitative analysis of rodent behaviour is fundamental to neuroscience, preclinical drug discovery and neurotoxicology research.
Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes biorxiv.org 2026-07-17 Within the vasculature, pannexin 1 (PANX1) channels in smooth muscle cells (SMCs) regulate -adrenergic constriction and blood pressure.
A validated neuronal SH-SY5Y platform reveals critical experimental variables for reproducible Aβ 1-42 self-assembly neurotoxicity assessment biorxiv.org 2026-07-17 Reliable in vitro evaluation of amyloid-{beta} (A{beta}) toxicity is essential for the development of anti-amyloid therapeutics, yet experimental work
Autonomic challenge uncovers hidden link between diastolic blood pressure and mental imagery vividness biorxiv.org 2026-07-17 Mental imagery is viewed as a fundamental component of human cognition, supporting memory, emotional processing, future simulation, and conscious expe
Resolving early cochlear inflammation prevents lasting damage from noise exposure biorxiv.org 2026-07-17 Noise-induced hearing loss (NIHL) is a leading cause of permanent hearing impairment worldwide, yet no pharmacological therapies are currently availab
Abdominal-B neurons selectively drive vibrations in Drosophila biorxiv.org 2026-07-17 Male Drosophila courtship includes two communication signals: airborne song and substrate-borne vibrations.