Architectural chromatin interactions provide a framework for context-dependent gene regulation biorxiv.org 2026-07-20 Gene regulation depends on coordinated interactions between promoters and distal cis-regulatory elements, yet understanding how these regulatory eleme
Legumain (asparaginyl endopeptidase) modulates extracellular matrix dynamics in pulmonary fibrosis biorxiv.org 2026-07-21 Pulmonary fibrosis is characterized by extracellular matrix (ECM) deposition driven by fibroblast to myofibroblast transition (FMT) and by an altered
ProteinSketch translates spatial intuition into protein design with bimanual interaction in VR biorxiv.org 2026-07-20 Generative AI-based protein design can create diverse structures for desired functions but offers human designers limited control over three-dimension
ProtSyntax: a protein large language model for decoding post-translational modification syntax and function biorxiv.org 2026-07-21 Post-translational modifications (PTMs) regulate protein function through dependencies among residue chemistry, sequence context, three-dimensional mi
Chaotic internal dynamics coexist with a stable temporal scaffold in a mesoscale sarcomere model informed by high-resolution recordings biorxiv.org 2026-07-20 Cardiomyocytes maintain a coherent mechanical rhythm despite fluctuations in myosin motors and local contractile units.
A Pan-Cancer Multi-Omic Analysis of Copy Number Signature Clusters and Genomic Instability biorxiv.org 2026-07-21 Copy number alterations (CNAs) are major contributors to genomic instability in cancer, and copy number signatures (CNS) provide a compact representat
Mapping Functional Tumor Suppressor Networks in Esophageal Adenocarcinoma Using In Vivo CRISPR Screening and Perturb-sequencing biorxiv.org 2026-07-21 Esophageal adenocarcinoma (EAC) is a genetically heterogeneous malignancy with few recurrent drivers, limiting effective targeted therapies.
Vision Normalizing Flows for the probability-informed detection of banana diseases from in-field images biorxiv.org 2026-07-21 Banana diseases impose severe production losses in tropical smallholder farming systems, yet accurate in-field visual diagnosis remains difficult: sym
Limitations of pupil diameter as a proxy for modes of locus coeruleus activity biorxiv.org 2026-07-21 The locus coeruleus-norepinephrine (LC-NE) system plays multiple roles in higher brain function that are thought to depend on its mode of activation,
Antagonistic regulation of HBZ splicing by hnRNPA1 and hnRNPH1 drives HTLV-1 leukemogenesis. biorxiv.org 2026-07-21 Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive leukemia driven by Human T-cell Leukemia Virus type 1 (HTLV-1) and remains largely refract
Unmasking Early Renal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen biorxiv.org 2026-07-21 Fibrotic remodeling of extracellular matrix is a central driver of autosomal dominant polycystic kidney disease (ADPKD) progression since early stages
Binocular visual input is essential for prey capture but not attention to prey in the praying mantis Sphodromantis lineola biorxiv.org 2026-07-20 Binocular vision provides animals with several evolutionary advantages.
Deep learning framework for kinematic event detection and stimulation decoding in primate reaching behavior biorxiv.org 2026-07-20 Accurate analysis of motor behavior requires the reliable detection of ongoing kinematic events and a granular characterization of the changes in moto
From vehicles to wildlife: transferable deep learning for trajectory generation biorxiv.org 2026-07-20 Realistic simulation of animal movement is fundamental to conservation, habitat modeling, and ecological scenario evaluation.
Interpretable Prediction of Phase Separation and Disease Variant Effects in Intrinsically Disordered Regions biorxiv.org 2026-07-20 Coding mutations within intrinsically disordered regions (IDRs) of proteins are increasingly implicated in human diseases yet remain poorly interprete
DNAS-Bench: Deterministic Nucleic Acid Screener Benchmarking biorxiv.org 2026-07-20 The rapid growth of biotechnology manufacturing for synthetic DNA and proteins has raised concerns that adversaries could exploit commercial synthesis
multiScaleAC: Cell-Cell interaction with Moran's I as a function of kernel bandwidth biorxiv.org 2026-07-20 Over the last decade, spatial transcriptomic technology has transformed our understanding of tissue architecture including cell-cell interactions with
Interpretable Peripheral Blood Cell Classification via Vision-Language Concept Bottleneck and Soft Decision Tree biorxiv.org 2026-07-20 Motivation: Deep learning classifiers for medical image analysis typically function as black boxes, disclosing neither the image features underlying t
Glucose and methylglyoxal alter plasma protein dynamics, immune traits and glucose homeostasis in a sex- and season-dependent manner in zebra finches biorxiv.org 2026-07-20 Birds maintain unusually high circulating glucose levels compared with other vertebrates without developing the diabetic complications observed in mam
Palmitoylation calibrates mitochondrial transport of insulin across the endothelium in insulin resistance biorxiv.org 2026-07-20 Impaired insulin transport across the endothelium contributes to insulin resistance, a poorly understood condition implicated in diabetes and many oth
Temporal integration in the subcortical auditory system and behavioral evidence of its dysfunction after "temporary" noise-induced hearing loss biorxiv.org 2026-07-20 How sensory information is processed over time is often conceptualized as a process of temporal integration.
Serotonin induces DOWN states across the anesthetized mouse forebrain biorxiv.org 2026-07-20 Serotonergic neurons in the dorsal raphe nucleus (DRN) project extensively throughout the forebrain, yet their influence on global network states rema
Single-neuron and population contributions of hippocampal LFPs to spike prediction biorxiv.org 2026-07-20 Local field potentials (LFPs) contain signals generated by individual neurons and by coordinated population activity, but distinguishing these contrib
Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration biorxiv.org 2026-07-20 A central challenge in systems neuroscience is understanding how computational mechanisms -- including those implemented within a single brain region
Canonical Correlation Analysis and Multi-Channel Cardiography Improve Artefact Cleaning in Heartbeat-Locked Analyses biorxiv.org 2026-07-20 Cardiac artefacts are problematic for neurophysiological analyses, especially for heartbeat-locked brain responses where neural activity and artefacts
Toxoplasma TgATG2 works with TgATG9 and TgProp1 to drive autophagic flux for parasite extracellular survival and persistence. biorxiv.org 2026-07-20 Chronic infection by Toxoplasma gondii depends on long-term survival of bradyzoites within tissue cysts, a parasite stage highly resistant to current
Under pressure: Evolutionary trade-offs shape the single visual opsin of deep-sea octopods biorxiv.org 2026-07-20 Octopods possess remarkable camera-type eyes and specialised image-forming vision that support orientation, prey detection, predator avoidance and vis
Uhrf1 loss disrupts Ctcf-associated chromatin organization during early mouse embryogenesis biorxiv.org 2026-07-20 UHRF1 is a chromatin-binding protein essential for maintaining DNA methylation and histone modification states, yet its integrated role in vivo remain
Bacterial DNA invasion triggers transposable element proliferation and genome expansion biorxiv.org 2026-07-20 Genome size variation in eukaryotes is driven largely by transposable elements (TEs), yet the biological mechanisms that initiate their proliferation
Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis biorxiv.org 2026-07-20 Lupus nephritis requires long-term immunosuppressive therapy, which is often associated with severe systemic side effects.
A conserved lncRNA regulates trehalose-glucose homeostasis through direct RNA-RNA interactions biorxiv.org 2026-07-20 Trehalose is a primary circulating sugar in insects and essential for energy homeostasis, yet its non-coding RNA-based regulatory circuitry remains en
A Bayesian method for estimation of plant soil water content with application to low-cost horticultural robotics biorxiv.org 2026-07-20 Climate change represents a challenge to food security by interfering with the environmental conditions needed for productive plant growth.
Developmental stage-dependent decoupling of molecular and phenotypic responses to heat in wheat grain biorxiv.org 2026-07-20 Heatwaves during flowering and grain development threaten global wheat production, yet the extent to which developmental stage shapes molecular and ph
Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice biorxiv.org 2026-07-20 Physical activity produces widespread benefits to physical and mental health, including protection against stress-related behavioral outcomes.
Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking biorxiv.org 2026-07-20 Background: Alcohol use disorder is characterized by continued alcohol use despite negative consequences, also known as aversion-resistant drinking.
Neural Representations of Ensemble Mean and Variance Across Visual Features biorxiv.org 2026-07-20 Humans can rapidly extract summary statistics, such as the mean and variance of visual features, to efficiently represent complex visual environments
When does more data help? Spectral Geometry and Scaling Laws in MRI Transformers biorxiv.org 2026-07-20 Scaling laws describe how model performance improves as the amount of training data increases, and recent theories such as the zeta law suggest that s
The All Window-Size Search method for improved statistical power in multiple comparisons correction biorxiv.org 2026-07-20 Correcting for multiple comparisons is a fundamental challenge throughout the biological sciences, particularly for data sampled over ordered continua
cf-Cabernet: Nick Repair Prior to End Repair Preserves Endogenous DNA Methylation Information in Cell-Free DNA Methylation Sequencing biorxiv.org 2026-07-20 Cell-free DNA (cfDNA) methylation profiling holds great promise for non-invasive cancer detection, yet accurate methylome analysis is compromised by D
Anticipatory discovery of entry inhibitors against emerging viruses guided by viral phylogeny biorxiv.org 2026-07-20 Emerging viruses pose a major threat to global health, underscoring the need to improve antiviral preparedness.
Long-term SARS-CoV-2 Persistence in Syrian Hamsters biorxiv.org 2026-07-20 SARS-CoV-2 persistence has been proposed as a potential contributor to the pathogenesis of long COVID, with reservoir tissues potentially serving as s
CreaSol(R) SSAT (Stabilized Tyrosol) Enhances Creatine on Muscle Performance and Anti-fatigue Capacity in Trained Mice biorxiv.org 2026-07-20 Tyrosol, a natural polyphenolic compound, has been identified as a potent cellular antioxidant.
Muscle mass and denervation explain variability in maximal power and rapid force across the adult female lifespan biorxiv.org 2026-07-20 Background: Dynamic power declines earlier across the lifespan and shows a more pronounced and complex pattern than isometric strength, particularly i
Autonomic and cortical responses to heartbeat-synchronous auditory omissions during an auditory attention task biorxiv.org 2026-07-20 Cardiovascular regulation depends on bidirectional communication between autonomic cardiac control and cardiac afferent signals ascending to the centr
Region-Specific Delta and Alpha2 Relative Power Alterations in Male Adolescent Schizophrenia: Occipital Predominance in Resting-State EEG biorxiv.org 2026-07-20 Resting-state electroencephalography (EEG) studies consistently report increased slow-wave activity and reduced alpha power in schizophrenia.
Effect of Spatial Release from Masking on Listening Effort in Different Semantic Contexts biorxiv.org 2026-07-20 Humans often communicate and learn in noisy, complex listening environments.
Closed-loop control of in vitro neuronal activity using reinforcement learning after in silico pre-training biorxiv.org 2026-07-20 Controlling specific neuronal dynamics with electrical stimulation is critical for therapeutic neuromodulation, yet deriving optimal control policies
The Q1K Integrated EEG and Eye-Tracking Experimental Test Battery for Open Autism Science biorxiv.org 2026-07-20 The Quebec 1000 Families (Q1K) platform has been designed to recruit, phenotype, and collect biospecimens from a large cohort of families with at leas
Selection navigates a degenerate circuit space: behavioral individuation without structural differentiation in constrained neuroevolution biorxiv.org 2026-07-20 Neural degeneracy, the capacity of structurally distinct circuits to perform the same function, is typically studied as an emergent property of biolog
Interconnected reservoirs of multidrug-resistant bacteria and plasmids within the hospital built environment biorxiv.org 2026-07-20 Hospital sinks and wastewater streams are hotspots for contamination and colonization with multidrug-resistant Gram-negative bacteria (MDR-GNB).