FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits the let-7 microRNA to maintain multipotency during dauer biorxiv.org 2026-07-20 Animals rapidly reprogram gene expression to adapt development to environmental stress.
SMART: A Somatic Mutation Annotation and Reporting Tool for cancer genomics biorxiv.org 2026-07-19 Motivation: Translational interpretation of somatic variants from targeted oncology panels is hampered by inconsistent transcript prioritisation and b
Rho ({rho}) Analysis to Dissect RNA Folding and Assembly Pathways biorxiv.org 2026-07-19 The modular structure and energetics of RNA simplifies its folding.
Quantifying Cross-Modal Shared Information Between Histomorphology and Spatial Transcriptomics via Spatiotemporal Trajectory Correlation biorxiv.org 2026-07-19 Histopathological imaging and spatial transcriptomics (ST) provide synergistic morphological and molecular insights into tissue architecture.
Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays biorxiv.org 2026-07-19 Volume-regulated anion channels (VRACs), formed by leucine-rich repeat-containing 8 (LRRC8) proteins, are ubiquitously expressed chloride channels ess
Investigating the mechanism of resistance to indaziflam in Poa annua biorxiv.org 2026-07-19 Indaziflam is an effective herbicide for controlling Poa annua, a weed, in turfgrass, orchards, and rangelands.
In silico framework for benchmarking optogenetic hearing restoration biorxiv.org 2026-07-19 Background.
Non-invasive Vagal Nerve Stimulation as a Potential Treatment for Repetitive Blast Trauma biorxiv.org 2026-07-19 Background: Polytrauma caused by exposure to high explosives (blast) is increasingly common among military personnel and civilians yet treatment for r
A novel rat model of body first subtype of Parkinsons disease biorxiv.org 2026-07-19 The recent growing evidence support the existence of two subtypes of Parkinsons disease (PD), a body first and brain first subtype owing to variabilit
Jamaican fruit bats are susceptible to henipaviruses but rapidly control infection biorxiv.org 2026-07-19 Henipaviruses (HNV), Hendra (HeV) and Nipah (NiV) virus, cause severe pulmonary and neurologic disease in humans and other mammals.
Extended floral longevity does not increase seed production under experimental pollinator decline biorxiv.org 2026-07-19 Premise of research: In plant species that depend on pollinators to produce seeds, declines in pollinator populations should strengthen natural select
Insulin-degrading enzyme activity is modulated by interaction with pyrroline-5-carboxylate reductase 1 biorxiv.org 2026-07-19 Insulin-degrading enzyme (IDE, insulysin, insulinase) is a peptidase that hydrolyzes a number of bioactive peptides including insulin and the amyloid
EndoAge Atlas: Non-linear dynamics of endothelial aging reveal organ-specific vascular trajectories in mice biorxiv.org 2026-07-19 Aging is a complex and multifactorial condition that leads to a gradual decline in organ functions and subsequent vulnerability to various diseases.
Best for the Eye, Not for the Algorithm: Anisotropy in Fitting Atomic Models in Cryo-EM biorxiv.org 2026-07-19 Most atomic model refinement methods in cryo-EM fit models to the reconstructed density map and effectively treat Fourier voxels as equally reliable.
An aptamer targeting TfR1 enhances ASO delivery to muscle tissue biorxiv.org 2026-07-19 Oligonucleotide based therapeutics continue to rise as a significant class of medicines for the treatment of human disease.
Human-Relevant Lead Exposure During Differentiation Alters the Transcriptomic Profile of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes biorxiv.org 2026-07-19 Cardiovascular disease (CVD) etiology is strongly influenced by lead (Pb) exposure, but the underlying molecular and functional mechanisms are unclear
Motor Occupancy Defines Emergent Mechanical States in Cardiac Myosin Ensembles biorxiv.org 2026-07-19 Myosin II generates force through the collective action of mechanically coupled motor ensembles, yet the mechanisms by which these ensembles sense cha
Emergent, cost-free surplus of core biosynthesis governs bacterial fitness biorxiv.org 2026-07-19 Cells often express essential components in excess of the levels required to sustain steady-state growth.
Microbiota-sensitive glial and metabolic programs define a critical window in early postnatal brainstem development biorxiv.org 2026-07-19 Paediatric brain tumours are increasingly recognised as diseases of disrupted development, arising when lineage progression programs, that normally go
Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb biorxiv.org 2026-07-19 Neuronal circuits in the olfactory bulb (OB) perform computations fundamental to pattern classification including a decorrelation and normalization of
An Inverse Transwell Assay for Airway Mucus Barrier Function Reveals both Virus- and Mucin-Specific Impacts on Infection biorxiv.org 2026-07-19 Respiratory viruses are a significant cause of morbidity and mortality world-wide and an important trigger of acute exacerbation in chronic lung disea
Genomic Insights into Bacterial Communities of Coenocytic Algae Using Metagenome Assembled Genomes biorxiv.org 2026-07-19 Coenocytic algae are organisms that undergo karyokinesis without cytokinesis, resulting in multinucleated cells.
Demographic compensation buffers population decline under variable grazing intensities in alpine grasslands biorxiv.org 2026-07-19 Identifying optimal grazing intensities for sustainable population growth is crucial for informing management strategies.
Host insect microRNAs are translocated to an obligate endosymbiont biorxiv.org 2026-07-19 Many insects rely on intimate interactions with bacterial symbionts housed in specialized cells called bacteriocytes.
Temporal ordering of migration increments carries directional memory under MYO10 depletion and collagen exposure biorxiv.org 2026-07-20 Cell migration is commonly summarized by speed, mean-squared displacement, or a single persistence time, although these descriptors discard the order
R-Ras coordinates reciprocal activation of ERK5 and ERK1/2 under single pathway inhibition in melanoma biorxiv.org 2026-07-20 Malignant melanoma is an aggressive cancer driven by aberrant Mitogen Activated Protein Kinase (MAPK) signaling.
Who Funds Open Data Sharing? Analysis of data availability statements in biomedical publications biorxiv.org 2026-07-20 Open data sharing is increasingly mandated by research funders, journals, and institutions, yet large-scale compliance measurement remains challenging
Prenatal cannabis exposure affects human fetal neurodevelopment: anintegrated multi-omics study biorxiv.org 2026-07-20 Prenatal cannabis use is on the rise, and observational studies suggest that such use results in neurodevelopmental deficits in the offspring.
Morphogenomic description of Cranifera cranifera (Chitwood, 1932) Kloss, 1960 from captive Blaptica dubia Serville, 1838 cockroach biorxiv.org 2026-07-20 Nematodes of the superfamily Thelastomatoidea are found in the digestive system of various arthropods, feeding on their host microbiome.
Stressor identity shapes plasma proteomic and metabolic responses in humans biorxiv.org 2026-07-20 Acute stress triggers rapid physiological adaptations, yet how distinct stress modalities shape the human circulating molecular landscape remains uncl
Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells biorxiv.org 2026-07-20 Fetal hemoglobin (HbF) expression is silenced postnatally in adult erythroid cells.
Cell-resolved transcriptional responses during heat-induced coral bleaching and recovery biorxiv.org 2026-07-19 Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causin
Planning in Nonhuman Primates Emerges from Structure Knowledge and is Distinct from Attention, Working Memory, Effort Control, and Learning biorxiv.org 2026-07-19 Forward planning involves mentally simulating future choices.
Bovine-derived H5N1 influenza virus efficiently infects lactating swine via the mammary gland biorxiv.org 2026-07-18 Since 2024, highly pathogenic influenza A(H5N1) viruses have spread extensively among U.S.
A Structurally Defined C12-Alkyl Quaternary Ammonium Compound reduces bacterial burden and biofilm in an infected wound model biorxiv.org 2026-07-18 Background: Methicillin-resistant Staphylococcus aureus (MRSA) remains a common cause of skin and soft tissue infections, and topical agents that comb
Nowhere to Hide: The Effect of Centromere Architecture on LTR Retrotransposon Dynamics biorxiv.org 2026-07-18 Centromere architecture can determine where transposable elements persist, yet its effects on retrotransposon turnover remain poorly understood.
Metabolic inhibition can enable compact physical integration of microbial partners biorxiv.org 2026-07-18 Microbes often generate by-products that inhibit own or consortial growth.
From diet to defense: serpin duplication and gene-expression evolution as putative contributors to poison-frog alkaloid sequestration biorxiv.org 2026-07-18 Diverse organisms use toxins as antipredator defenses.
Discovery and genomic characterization of a novel wild clownfish hybrid from the Philippines biorxiv.org 2026-07-18 Hybridization is widespread among marine fishes and can contribute to adaptation, diversification, and the generation of novel phenotypes.
Phasing of the 'Wonderful' Pomegranate Genome Using Haploid DNA Extracted from Pollen Grains biorxiv.org 2026-07-18 The scientific and commercial interest in pomegranate (Punica granatum L.) cultivation has increased noticeably during the last two decades.
Genomic insights into the karyotypic radiation of a narrow endemic holocentric plant Carex helodes biorxiv.org 2026-07-18 Holocentric chromosomes allow rapid genome changes through chromosomal rearrangements such as fissions, fusions, inversions or translocations.
scWeave: A deep learning model that bidirectionally translates between gene expression and chromatin structure at single cell resolution biorxiv.org 2026-07-18 Chromatin structure and gene expression are intimately linked, yet characterizing how the two covary has proven challenging, primarily because the two
Cellular-Resolution Spatial Transcriptomics Reveals Laminar VSMC Phenotypic Remodeling and a Hypoxic Medial Core in Human Thoracic Aortic Dissection biorxiv.org 2026-07-18 Sporadic ascending aortic dissection (AAD) carries high short-term mortality and long-term morbidity.
Whole-genome resequencing identified loci underwent divergent selection and improved local adaptability in groundnut (Arachis hypogaea) biorxiv.org 2026-07-18 There is an urgent need to expand groundnut genomics knowledge base to improve yield and adaptability in the target environments.
PrimeKG-Plus: a literature-derived expansion of a multimodal precision medicine knowledge graph biorxiv.org 2026-07-18 Biomedical knowledge evolves rapidly, yet most disease-centered knowledge graphs remain unchanged after publication.
User-friendly transcriptomic data analysis with ArrayAnalysis biorxiv.org 2026-07-18 Transcriptomic profiling has become a cornerstone of modern biomedical research.
Survey and Evaluation of Applied Containerization Practices in Bioinformatics biorxiv.org 2026-07-18 Containerization enables portable, reproducible, and scalable scientific computing.
Direct detection of alternative DNA conformations with long-read sequencing and machine learning approaches biorxiv.org 2026-07-18 Progress has been made in identifying G-quadruplexes (G4s) and other non-canonical (non-B) DNA structures in live cells.
Long-read transcriptomics highlights venom gland specialization and Inhibitor Cystine Knot (ICK) rich toxin diversity in Philippine tarantulas biorxiv.org 2026-07-18 Animal venoms are a rich source of bioactive molecules, yet their diversity remains incompletely characterized in many species.
Cooperativity and Conformational Rearrangements in Protein-Protein and Protein-Ligand Interactions biorxiv.org 2026-07-18 Streptavidin-biotin, avidin-biotin interactions are classical models for protein-ligand binding, yet the energetic changes accompanying biotin binding