Self-thresholding hierarchical outlier-detection for animal movement tracks biorxiv.org 2026-07-17 1). Erroneous locations are ubiquitous in animal tracking data and prove notoriously difficult to remove, particularly so in an unsupervised manner.
Cessation of diel vertical migration by an inshore dinoflagellate bloom under prey deprivation biorxiv.org 2026-07-17 Many dinoflagellates are mixotrophic and regulate their vertical position to navigate dynamic gradients in light, nutrients, and prey.
From wings to tails: the aspect ratio of propulsive surfaces as a general proxy for vertebrate dispersal potential biorxiv.org 2026-07-17 Dispersal influences many fundamental processes, however, direct measures of dispersal are scarce for most taxa, limiting our ability to evaluate ecol
ClimLimits: a global database of multivariate realized climate limits for animal species biorxiv.org 2026-07-17 Introduction and Aim: Assessing the realized climate limits for a species based on the climate conditions (i.e., different aspects of temperature and
Widespread decoupling between abundance and genetic diversity, and strong local genetic structuring in marine unicellular eukaryotes biorxiv.org 2026-07-17 How abundance, connectivity, and genetic diversity covary across space remains a central question in evolutionary biology.
Shifting resource limitation explains multiphasic patterns of density dependence biorxiv.org 2026-07-17 Several recent studies have presented sublinear density dependence as a universal phenomenon across species, driven by factors unrelated to resource l
A conundrum of pleiotropy: GWAS-derived pleiotropy is weakly negatively associated with co-expression network centrality in Arabidopsis thaliana biorxiv.org 2026-07-17 Pleiotropy, the influence of a single gene on multiple phenotypic traits, is a fundamental feature of genetic systems but remains difficult to quantif
Hybrid breakdown is temporary and not expressed in a novel environment during 50 generations of experimental evolution in Tetranychus urticae hybrids biorxiv.org 2026-07-17 Hybridization, the interbreeding between species or genetically distinct populations, can lead to deleterious fitness consequences, but simultaneously
A high aneuploidy supply rate underlies parallel evolution of fluconazole resistance in Saccharomyces cerevisiae biorxiv.org 2026-07-17 Copy number variants (CNVs) of ERG11 play a major role in acquisition of resistance to the commonly used azole family of antifungal drugs in many path
Chromosome-scale genome assembly of Cycas revoluta provides insights into cycad diversification and species diversity biorxiv.org 2026-07-17 Cycads are an ancient group of seed plants. Despite their ancient origin, many extant cycad genera exhibit high species diversity.
Structural elements required for the efficient loading and activation of HELB on RPA-coated single-stranded DNA biorxiv.org 2026-07-17 HELB is a human helicase involved in DNA repair and replication that interacts physically with the single-stranded DNA binding protein RPA.
A Robust and Generalizable Low-Input Spatial Proteomics Workflow Enabling Deep Proteome Coverage biorxiv.org 2026-07-17 Spatial proteomics has rapidly emerged as a powerful approach for deciphering the molecular architecture of complex tissues, offering critical insight
Multivalent Tau-Fyn interactions cooperatively arrest postsynaptic density condensate dynamics biorxiv.org 2026-07-17 Tau-Fyn signaling at postsynaptic sites is implicated in synaptic dysfunction and neuronal hyperexcitability in Alzheimer's disease and related tauopa
Integrated Interactomics Reveals Novel Protein Associations: The FOXA1-PBX1 Complex as a Case Study biorxiv.org 2026-07-17 Protein-protein interactions (PPIs) are fundamental to cellular signaling networks, yet many remain undetected due to technical limitations of individ
Genetic encoding of 3-cyano-tyrosine and its use in controlling the chromophore isomeric state of the fluorescent protein mKate biorxiv.org 2026-07-17 Switchable beta barrel-type fluorescent proteins are essential genetically encoded probes for super-resolution imaging.
Multi-Omics Characterization of Plasma and Urine Extracellular Vesicles Identifies Non-Invasive Biomarkers for IgA Nephropathy biorxiv.org 2026-07-17 Abstract Background IgA nephropathy (IgAN) is increasingly recognized as a systemic immune-mediated disease characterized by aberrant IgA1 glycosylati
Identification of type III polyketide synthases from Ginger for dehydrogingerdione and curcumin biosynthesis by engineered Escherichia coli biorxiv.org 2026-07-17 Many valuable plant metabolites are synthesized by type III polyketide synthases (PKS) that have become targets for the engineering of microbial produ
Fungal microbial enrichment method enables fungal metagenomics directly from human clinical samples biorxiv.org 2026-07-17 Fungi play important roles in health and disease, but current methods such as culture, PCR, and amplicon sequencing cannot provide genome-level charac
A deployable microfluidic platform for parallel and longitudinal hyperpolarised magnetic resonance metabolic phenotyping biorxiv.org 2026-07-17 Hyperpolarised magnetic resonance (MR) enables real-time measurement of metabolic flux in living systems but remains difficult to deploy for cell-base
Distributed resonant coupling enables high efficiency power transfer to mm-scale bioelectronics biorxiv.org 2026-07-17 Miniaturized implantable bioelectronics offer breakthrough potential in disease treatment, biomarker monitoring, and physiological sensing.
PFM: perturbed flow matching for structure-based drug design biorxiv.org 2026-07-17 Generating 3D molecules that bind to specific protein targets via generative models has shown great promise in structure-based drug design.
Gravitropism Shapes the Pareto Front of Root System Architecture biorxiv.org 2026-07-17 The root systems of wild tomatoes (S.
Gene-metabolite networks reveal physiological trade-offs but not transcriptional co-regulation between carotenoids and dry matter in cassava (Manihot esculenta) roots biorxiv.org 2026-07-17 Provitamin A biofortification of cassava (Manihot esculenta) is constrained by a negative genetic correlation between total carotenoid (TC) and dry ma
Deep tissue removal in wounds facilitates algal colonization and inhibits healing and regeneration in tropical corals biorxiv.org 2026-07-17 Although corals are highly regenerative, some colonies in reef ecosystems completely recover from sublethal damage while other colonies exhibit partia
Photo-thermal Bidirectional Coupling Model for Transcranial Photobiomodulation biorxiv.org 2026-07-17 Background: Accurate optical-field simulation is critical for precise dosage delivery in transcranial photobiomodulation (tPBM).
A spatially-specific pattern of cortical thickness in frontal lobe predisposes to faster future amyloid accumulation in individuals with subjective cognitive decline biorxiv.org 2026-07-17 The risk of developing AD is conferred through numerous genetic and environmental factors.
MTERF1 loss buffers against pathogenic mtDNA deletions through transcriptional regulation biorxiv.org 2026-07-17 Large-scale mitochondrial DNA (mtDNA) deletions cripple oxidative phosphorylation once they exceed a critical heteroplasmy threshold, causing incurabl
Structural tuning of native type V fimbriae shapes mechanical specialization in Porphyromonas gingivalis biorxiv.org 2026-07-17 Bacterial fimbriae are central to adhesion, colonization, and biofilm formation, yet how related fimbriae systems are structurally and mechanically sp
Subunit vaccination enhances protection conferred by prior Mycobacterium tuberculosis exposure biorxiv.org 2026-07-16 Mycobacterium tuberculosis (Mtb) remains the leading cause of death from a single infectious agent.
The NBSGW RIP-DTR Mouse: An Integrated Platform for Diabetes Induction, Human Immune Reconstitution and Transplantation Studies biorxiv.org 2026-07-16 Using toxin receptor-mediated cell ablation, a diabetes mouse model was generated that supports engraftment of human hematopoietic stem/progenitor cel
Hepatitis C virus genotype homogeneity and lack of major Sofosbuvir resistance-associated substitutions among blood donors in Ethiopia biorxiv.org 2026-07-16 Hepatitis C virus (HCV) is a hepatotropic virus that causes a spectrum of liver diseases.
Human coronavirus nucleocapsid proteins have disparate innate immune evasion abilities biorxiv.org 2026-07-16 During infection, coronaviruses produce abundant double-stranded RNA (dsRNA) which can induce antiviral innate immune responses such as the interferon
Using Natural Vector Method for Population Genomic Analysis on Human Mitochondrial Genome Data biorxiv.org 2026-07-16 The natural vector method is an important method for the analysis of biological sequences.
Promoter architecture diversifies ParR-dependent transcription in Pseudomonas aeruginosa biorxiv.org 2026-07-16 Two-component systems convert environmental signals into transcriptional responses, but how one response-regulator phosphorylation state produces diff
Quinoa: Efficient and Robust CTF Estimation for CryoET Tilt Series biorxiv.org 2026-07-16 Accurate contrast transfer function (CTF) estimation is a critical first step in cryo-electron tomography (cryoET), enabling recovery of information f
Structure-activity of outer membrane proteins in native bacterial membrane vesicles by solid-state NMR biorxiv.org 2026-07-16 The outer membranes (OMs) of bacterial pathogens are potent virulence factors and serve as the first line of defense against host immunity.
Membrane controlled Mechanoregulation in PIEZO1 Interactions biorxiv.org 2026-07-16 PIEZO channels are mechanosensitive membrane proteins whose activation is governed by the surrounding lipid environment.
SERPINB13 is a prognostic biomarker for LUSC associated with an immune-inflamed tumor phenotype and modulated by immune cells biorxiv.org 2026-07-16 Non-small cell lung cancer (NSCLC) is the most common form of lung cancer accounting for most cancer-related deaths worldwide.
Phosphocitrate Is Superior to Pyrophosphate in Preventing Soft Connective Tissue Calcification in a Mouse Model of Pseudoxanthoma Elasticum biorxiv.org 2026-07-16 Pseudoxanthoma elasticum (PXE) is a rare inherited disorder characterized by progressive ectopic calcification of soft connective tissues, including s
Shifu: an integrated framework for deep learning of RNA secondary structure biorxiv.org 2026-07-16 Deep learning has advanced RNA secondary-structure prediction by bypassing explicit energy rules to capture long-range dependencies, yet progress is l
The distribution of integer partitions in human genome-wide genealogies reflects gene flow from a super-archaic lineage biorxiv.org 2026-07-16 Several recent studies have found evidence for ancient gene flow between the ancestors of modern humans and an unsampled super-archaic lineage.
L-2-hydroxyglutarate recycling is linked to coenzyme Q biosynthesis biorxiv.org 2026-07-16 The mitochondrial COQ metabolon catalyzes the late stages of the biosynthesis of coenzyme Q, an essential and ubiquitous cofactor.
The overlooked role of muscle regeneration failure in post-implantation complications: a thorough investigation into mechanisms of recurrent urethral stricture biorxiv.org 2026-07-16 Bioresorbable collagen membranes rarely achieve complete organ regeneration, often necessitating secondary operations.
Single-cell multi-omic analyses resolve the cellular diversity of ALK/ROS1/MET/NTRK-fused gliomas in infants and older children biorxiv.org 2026-07-16 Pediatric cancers are thought to arise from dysregulation of developmental programs, otherwise tightly regulated in time and space.
Primary Hyperparathyroidism Reveals Limited Adipose Remodeling in Human biorxiv.org 2026-07-16 Preclinical models implicate the parathyroid hormone/parathyroid-hormone-related protein (PTH/PTHrP)-PTH1 receptor (PTH1R) axis in adipocyte lipolysis
Plant actin networks are rapid mechano-adaptive scaffolds biorxiv.org 2026-07-17 The actin cytoskeleton is among the most highly conserved eukaryotic structures.
SNPstar: A Web Server Linking Allelic Variation to Protein Structure and Function in Arabidopsis thaliana biorxiv.org 2026-07-16 Understanding how natural genetic variants affect protein structure and function is central to plant biology.
Mapping the distribution of elms in Britain after a century of Dutch elm disease biorxiv.org 2026-07-16 The establishment of novel pests and pathogens that devastate populations of trees is increasing around the world, giving rise to policy and managemen
The Unlabeled Organ: Adipose tissue and normativity in anatomy and physiology texts biorxiv.org 2026-07-17 Adipose tissue is a dynamic and essential organ system with roles in metabolism, endocrine signaling, immune function, thermoregulation, and structura
Negligible participation in the scientific literature of AI unicorn startups biorxiv.org 2026-07-16 Artificial intelligence (AI) development is concentrated within private firms, yet their participation in scientific publishing remains poorly underst