Structure-based recasting of a mammalian DNA transpososomeas an obligate heterodimer biorxiv.org 2026-07-16 Eukaryotic DNA transpososomes assemble as nucleoprotein complexes containing multiple identical transposase protomers.
Prototype-based AI triage for 3D pathology biorxiv.org 2026-07-15 Non-destructive 3D pathology enables high-resolution slide-free imaging of intact clinical specimens, providing comprehensive visualization of tissue
Effect of Immunosuppressive Drugs on Glucose-Stimulated Insulin Secretion: Concentration-Response Studies in Dynamic Perifusion Assays biorxiv.org 2026-07-15 Immunosuppressive drugs, which are required to maintain graft function in transplant recipients, are associated with many unavoidable side effects inc
Before the eye moves: microsaccade preparation expands spatial integration at the center of gaze biorxiv.org 2026-07-15 Fixation is often treated as a period of stable visual processing.
A Deep Learning Framework for Biomarker Segmentation and Classification in Traumatic Brain Injury biorxiv.org 2026-07-15 Traumatic brain injury (TBI) triggers widespread biomarker activation, including astrocytic markers such as glial fibrillary acidic protein (GFAP) and
From Hummingbird to Elephant: Amyloid Formation in Natural Transthyretin Variants biorxiv.org 2026-07-15 Transthyretin (TTR) is a secreted protein associated with cardiac and other amyloid diseases via misfolding.
Partial epithelial-to-mesenchymal transition mediates profound gap closure through growth and fluidization biorxiv.org 2026-07-15 Epithelial gap closure is essential for maintaining tissue integrity during development and wound healing.
COB: a comprehensive database of chloroplast outer envelope beta-barrel proteins biorxiv.org 2026-07-15 Despite their central role in metabolite exchange, lipid trafficking, and protein import, chloroplast outer envelope beta-barrel proteins lack a dedic
A robust, sensitive phylogenetic method enables gene-level metagenomic analyses biorxiv.org 2026-07-15 A key goal in the microbiome field is to move from taxonomic associations towards mechanistic hypotheses about microbial gene function.
No effects of APOE ε4 on spatial navigation and broader cognition in young adults genetically at risk for Alzheimer's disease biorxiv.org 2026-07-15 Alzheimer's disease (AD) causes progressive memory loss and disorientation.
Pediatric traumatic brain injury elicits acute neuroinflammation and long-term changes in social, cognitive, and decision-making behaviors in male and female rats biorxiv.org 2026-07-15 Traumatic brain injury (TBI) is one of the leading causes of emergency room visits in children under 10.
LARP4 is a B cell-specific metabolic checkpoint for plasma cell differentiation and a therapeutic target in systemic lupus erythematosus biorxiv.org 2026-07-15 RNA-binding protein LARP4 plays an important role in T cell activation and differentiation, but its role in B cell biology and the pathogenesis of sys
A geometric and dynamical theory of latent computations in biological neural networks biorxiv.org 2026-07-15 Many neural recordings have revealed low-dimensional sets of behaviorally relevant variables encoded within large-scale neural activity patterns.
Brain Structural and Resting-state Functional Network Changes Following Expiratory Musculature Targeted Resistance Training in Healthy Young Adults: A Pilot Study biorxiv.org 2026-07-15 Multimodal imaging approaches that combine structural and functional neuroimaging provide a robust framework for examining neuroplastic adaptations th
Flexible predictive control in human interception under visual occlusion and altered gravity biorxiv.org 2026-07-15 Interception of moving objects requires the nervous system to compensate for sensory delays and uncertainty, yet how behavior is controlled remains de
Effects of acute intranasal allergen exposure on resident immune cells and sensory neurons in the mouse olfactory epithelium biorxiv.org 2026-07-15 The main olfactory epithelium (MOE) is the primary site of olfaction and consists of multiple cell types including olfactory sensory neurons (OSNs), s
Boredom and the representation of information content in the neocortex biorxiv.org 2026-07-15 Boredom - a pervasive mental state - promotes the pursuit of novel information by assigning negative value to monotonous conditions.
Coordination Failures Generate Selection Gradients in Animal Collectives biorxiv.org 2026-07-15 Collective animal behavior occurs in high-stakes contexts where failing to coordinate effectively with group-mates can spell disaster for individuals.
Evidence for a Nod-like signalling system in cyanobacterial symbiosis with O. sativa biorxiv.org 2026-07-15 Symbiotic interactions between plants and nitrogen-fixing microorganisms are essential for sustainable agriculture, yet the molecular mechanisms under
Galangin and Caffeic acid inhibit Methylglyoxal-induced Advanced Glycation End Product formation in Bovine Serum Albumin biorxiv.org 2026-07-15 Glycation, a non-enzymatic reaction occurring between sugars and biological macromolecules, plays a critical role in ageing and disease pathogenesis.
Allosteric modulation of β1 integrin through the hybrid domain reverses articular cartilage injury and functional impairment in a murine model of inflammatory arthritis biorxiv.org 2026-07-15 Rheumatoid arthritis is a chronic inflammatory joint disease in which progressive destruction of cartilage and bone drives long-term disability.
Hyperbolic Brain Modelling and Neurocognitive Decline Analysis for Disease Detection biorxiv.org 2026-07-15 Mapping hierarchical brain networks within traditional Euclidean space causes significant structural distortion, undermining neuroimaging diagnostic f
Neurobehavioural correlates of changing one's mind in ADHD and OCD biorxiv.org 2026-07-15 Cognitive flexibility is an executive function that allows individuals to adjust behaviour in response to changing environmental demands.
Trait Resilience Modulates the Association Between Cortisol and Aperiodic Neural Dynamics biorxiv.org 2026-07-15 Cortisol, our stress hormone, exerts widespread influence on neural activity.
Audiovisual stimulation using wearable shutter glasses robustly evokes 40 Hz neuronal activity but does not modulate associative memory biorxiv.org 2026-07-15 Audiovisual stimulation is a promising approach for studying and modulating human neuronal gamma (>30 Hz) oscillations and associated memory proces
Low-latency neuromorphic closed-loop control of hippocampal ripples in vivo biorxiv.org 2026-07-15 Real-time closed-loop neuromodulation, in which stimulation is precisely timed to ongoing brain dynamics, holds transformative potential for treating
The CD19-4-1BBL antibody fusion protein unleashes the immune system against high-risk chronic lymphocytic leukemia biorxiv.org 2026-07-15 CD19-4-1BBL is a bispecific antibody fusion protein that targets CD19 and costimulates 4-1BB on T cells and other immune cells.
SIGLEC1 FACILITATES MACROPHAGE-CD8+ T CELL INTERACTIONS AND CORRELATES WITH CANCER IMMUNOTHERAPY RESPONSE biorxiv.org 2026-07-15 Antigen-presenting cell (APC) interactions with cytotoxic T cells are critical for anti-tumour immunity and response to immune checkpoint blockade (IC
Development of a High-throughput in vivo Assay for the Determination of Adenylation Domain Specificities biorxiv.org 2026-07-15 Natural product synthesis by non-ribosomal peptide synthetases (NRPS) is greatly defined by the substrate selectivity of the adenylation (A) domains.
A Minimally Invasiveness Hybrid Brain-Computer Interface: A Distributed, Scalable and Evolvable Architecture for Whole Brain Access biorxiv.org 2026-07-15 Brain-computer interfaces face a fundamental trade-off between the signal fidelity and stimulation precision of noninvasive systems and the surgical b
Detecting Sleep Deprivation from Running Biomechanics Using Machine Learning Classification: A Comparison Between Wearable and Laboratory Motion Capture biorxiv.org 2026-07-15 Sleep deprivation is associated with impaired endurance performance and an increased risk of running-related injury.
5β-Dihydrotestosterone reveals a mutant androgen receptor vulnerability in prostate cancer biorxiv.org 2026-07-15 Bipolar androgen therapy (BAT) exploits the paradoxical vulnerability of castration-resistant prostate cancer (CRPC) cells to rapid cycling between ca
Gut microbiome derived folate metabolite suppresses colorectal cancer progression biorxiv.org 2026-07-15 The gut microbiota influences colorectal cancer (CRC) progression, primarily through the secretion of small molecule metabolites.
Loss of either RASSF1A alone or in combination with Caveolin-1 inhibition is associated with different premalignant histopathological alterations in the mammary glands of transgenic mice biorxiv.org 2026-07-15 Analyses of human breast carcinomas (BCs) and premalignant breast lesions show that the loss of RASSF1A is an early event in the development of ER-pos
Cube-based screening identifies a quinoa-derived synthetic microbial community that promotes plant growth and modulates root epidermal responses under salt stress biorxiv.org 2026-07-15 Plant-associated bacteria can improve plant performance under abiotic stress, but beneficial functions in plant microbiomes may depend on defined comb
Storing >1 byte of information in 16S ribosomal RNA using orthogonal trans-splicing ribozymes biorxiv.org 2026-07-15 Catalytic-RNA (cat-RNA) expressed from mobile DNA can record cellular events, such as the uptake of plasmids via horizontal gene transfer, by splicing
Engineered Pseudomonas putida reconfigures metabolic fluxes to support energy demands during muconate bioproduction from lignin-related aromatics biorxiv.org 2026-07-15 Muconic acid is a versatile platform chemical that can be biologically produced from lignocellulosic substrates, including from lignin-related aromati
Overcoming protocatechuate and catechol accumulation in muconic acid production via adaptive laboratory evolution and metabolic engineering in Pseudomonas putida biorxiv.org 2026-07-15 Muconic acid is an industrially valuable molecule that can be biologically produced from diverse biogenic and waste-derived feedstocks, including suga
NMDA receptor-dependent Hebbian plasticity refines hippocampal spatial representations during two-dimensional navigation learning biorxiv.org 2026-07-15 Hippocampal place cell activity represents the location of an animal in space; yet, how hippocampal neuronal population dynamics change with spatial l
OTTR-CLASH: improved biochemical and bioinformatic identification of Argonaute 2-mediated microRNA-target RNA interactions biorxiv.org 2026-07-15 Various methods have detected miRNA-target interactions via immunoprecipitation of UV-crosslinked Argonaute ribonucleoprotein complexes, followed by i
SH3KBP1/CIN85, a new actor of ER-phagy in muscle biorxiv.org 2026-07-15 The endoplasmic reticulum (ER) and its muscle-specialized form, the sarcoplasmic reticulum (SR), are crucial organelles in muscle cells, involved nota
Safety Transparency in Animal Cell-Cultured Ingredients for Pet Food: A Case Study Establishing the Standard for Public Disclosure biorxiv.org 2026-07-15 Animal cell-cultured ingredients are entering the EU and UK pet food markets under frameworks that do not require pre-market, ingredient-level safety
Micro-CT: A reversible contrast-based protocol for non-destructive imaging of cardiac morphology in an avian model. biorxiv.org 2026-07-15 Microcomputed tomography (micro-CT) is a useful tool that can be utilised for 3D structural characterisation and volumetric quantification of small bi
The hidden multiverse of ecological roles in Fungi biorxiv.org 2026-07-15 Ecological roles are treated as discrete, bounded units of biological organization, even as evidence shows that many taxa are versatile, performing mo
Physiological limits of localized hypothermia in the human cochlea: The role of vascular heat transport biorxiv.org 2026-07-15 Purpose: Mild therapeutic hypothermia (MTH) preserves cochlear function in animal models and is now entering early-phase human trials for hearing pres
Palliative Irradiation Affects Temporal Degradation of Rodent Vertebral Bone Mechanics, Architecture, and Composition biorxiv.org 2026-07-15 Background: Palliative radiation therapy (RT) for metastatic spine disease significantly increases the risk of vertebral fractures.
Single-cell gene networks nominate IKZF1 as an Alzheimer's microglial regulator biorxiv.org 2026-07-15 Background: Microglia drive neuroinflammation in Alzheimer's disease (AD), yet no approved therapy targets this compartment.
Epithelial Stem Cell Fate Determines Chemoradiotherapy Response in Rectal Cancer biorxiv.org 2026-07-15 Rectal cancers are often treated with neoadjuvant chemoradiotherapy (CRT), yet 85% of patients do not achieve a pathological complete response.
Evidence of predictive information compression in latent space in humans during speech listening biorxiv.org 2026-07-15 Speech perception requires transforming acoustic input into neural representations that support linguistic understanding, yet its underlying computati
Electrophysiological features of signals recorded from white matter biorxiv.org 2026-07-15 Intracranial neurophysiology studies have typically ignored signals from electrodes located in white matter (WM), assuming that their information cont