Quantum Encoding Strategies for Drug Response Prediction: An Exhaustive Benchmark on a 20-Qubit Superconducting QPU biorxiv.org 2026-07-13 We present the first systematic, hardware-executed benchmark of twelve distinct quantum data-encoding strategies for drug-response prediction on a rea
A Bayesian Network-Based Framework for Causal Cancer Drug Target Discovery Integrating Patient and Cell Line Data biorxiv.org 2026-07-13 Current approaches to cancer drug target discovery face two key limitations: poor translation of cell line-derived targets to patient tumors, and the
Learning proteomic disease trajectories with flow matching biorxiv.org 2026-07-13 High-throughput proteomics has enabled detailed characterization of molecular states across health and disease.
Lipid droplet shape and tendency towards budding: insight from theory and molecular simulations biorxiv.org 2026-07-13 Lipid droplets (LDs) are cellular organelles responsible for lipid storage and metabolism.
Measuring magnetic field effects in fluorescent flavoproteins via spin-dependent fluorescence intensity requires photoexcitation to be faster than spin-independent ground state recovery biorxiv.org 2026-07-13 Weak magnetic fields affect many biological processes across the tree of life, though the precise molecular sensors and pathways involved in such magn
A Spatial Agent-Based Model of AGE-RAGE Feedback in Hepatic Fibrosis Reveals Stage-Dependent Irreversibility Thresholds biorxiv.org 2026-07-13 Hepatic fibrosis progression involves a well-characterized but computationally unmodeled feedback loop: Advanced Glycation End-products (AGEs) accumul
Amyloid-beta is present in the spinal cord of APP/PS1 mice and may contribute to neuropathology manifesting as lower urinary tract dysfunction biorxiv.org 2026-07-13 Urinary incontinence (UI) is a common and debilitating comorbidity in Alzheimer's disease (AD), yet its underlying pathophysiology remains poorly defi
Electrocorticographic Network Feature Space Constriction as a Preictal Biomarker biorxiv.org 2026-07-13 In patients with epilepsy, seizures are associated with pathological neural synchronization.
Activation of mu-opioid receptors slows pacemaking in hypothalamic A11 dopamine neurons biorxiv.org 2026-07-13 Hypothalamic A11 dopamine neurons provide the only known source of spinal dopamine and critically modulate pain and motor systems.
Generation of hypoimmunogenic gastric insulin-secreting organoids biorxiv.org 2026-07-13 Gastric insulin-secreting organoids (GINS) represent a promising source of {beta}-like cells for type 1 diabetes (T1D) therapy.
Faf2 is required for neural differentiation in embryonic neural progenitor cells biorxiv.org 2026-07-13 Neural progenitor cell differentiation is a complex process requiring the proper integration of instructive and permissive factors.
Macroalgal fucoidan can activate the biological carbon pump biorxiv.org 2026-07-13 Macroalgae secrete complex carbohydrate polymers, their extracellular matrix, as protection against microbial degradation.
Using BONCAT-FACS to probe the active soil microbial community during nitrous oxide production biorxiv.org 2026-07-13 Nitrous oxide (N2O) is a potent greenhouse gas and is largely produced by incomplete denitrification.
An ice-bucket challenge: investigating ice algae physiology in laboratory microcosms. biorxiv.org 2026-07-13 John Raven pioneered the field of algae ecophysiology, advancing our understanding of cellular resource economics, carbon acquisition, and energy allo
From biofilms to birth: Quantitative murburn rationale for hydrated polymer-centred biological transduction, coherence, and evolution of complex life biorxiv.org 2026-07-13 Hydrated extracellular polymeric phases (such as mucus, biofilms, and extracellular matrices) have traditionally been viewed as passive barriers.
golgi: an open-source graphical platform for image-to-recruitment modeling of peripheral nerve stimulation biorxiv.org 2026-07-13 Computational models of peripheral nerve stimulation-coupling finite-element bioelectric fields to biophysical axon models-have become essential for d
Peptide additives reprogram the lipid nanoparticle corona and enhance gene delivery in a serum-free environment for lung epithelium biorxiv.org 2026-07-13 Lipid nanoparticles (LNPs) have become a clinical standard for systemically-administered nucleic acid drugs and vaccines, but the LNP pipeline for loc
Anisotropic Thermal Conductivity in Topologically Networked Protein-MXene Composites biorxiv.org 2026-07-13 Governing thermal transport in engineered materials creates opportunities to redirect and recover the excess heat generated in electronic and energy-c
Tissue nanotransfection-mediated induction of neurogenic programs promotes myoprotective responses in denervated skeletal muscle biorxiv.org 2026-07-13 Peripheral nerve injuries often result in prolonged skeletal muscle denervation, leading to progressive atrophy, fibrosis, neuromuscular instability,
golgi: open-source software for automated nerve model generation and recruitment simulation biorxiv.org 2026-07-13 golgi is an open-source platform that takes a peripheral nerve from image to stimulated fiber population through a single graphical interface, with an
Electrostatics and Local Aromatic Residues Govern Lipid Binding and Membrane Penetration of Synaptotagmin C2 Domains biorxiv.org 2026-07-13 Synaptotagmins (Syts) are Ca2+-sensing exocytosis regulators whose tandem C2 domains interact with phosphoinositides and membranes to trigger neurotra
Genetically distinct microenvironment determines cancer survival and response to therapy in mice biorxiv.org 2026-07-13 Genetic uniqueness of the tumor microenvironment significantly influences cancer growth, survival, and response to therapy, independent of the cancer
Specific F1 ATP synthase inhibition delivers transient mitochondrial stress for selective targeting of acute myeloid leukemia biorxiv.org 2026-07-13 Targeting oxidative phosphorylation (OXPHOS) represents an attractive therapeutic strategy in acute myeloid leukemia, which exhibits exceptional depen
Microbial Invasion and Immunosuppression Drives Adenoma Progression in Early Colorectal Cancer Development biorxiv.org 2026-07-13 Several inherited predispositions to colorectal cancer exist, most notably familial adenomatous polyposis (FAP), which typically involves a germline l
First O-demethylation activity in Arabidopsis specialized metabolism resolves the missing step in esculetin biosynthesis biorxiv.org 2026-07-13 Coumarins are phenylpropanoid-derived specialized metabolites that contribute to plant defence, shape plant-microbe interactions in the rhizosphere, a
Adenylyl cyclases combinatorially integrate opposing dopamine receptor signals biorxiv.org 2026-07-13 Dopamine receptors are divided into two families which exert opposing effects on the second messenger cyclic AMP (cAMP).
Oral Administration of Hyperimmune Eggs Induces Mucosal IgA Responses, Anti-Idiotypic Antibodies, and HIV-1 Neutralizing Activity: A Proof-of-Concept Preclinical Study biorxiv.org 2026-07-13 The development of effective mucosal vaccination strategies against human immunodeficiency virus type 1 (HIV-1) remains a major challenge.
De novo design of selective kinase modulators biorxiv.org 2026-07-13 Protein kinases are critical regulators of cellular signaling, but precise modulation of their activity remains challenging due to their high structur
A model for PIP2/3 and Rnd1 effects on Plexin-B1 GAP activity on Rap1b GTPase derived from molecular dynamics simulations biorxiv.org 2026-07-13 Plexin-B1 is a transmembrane receptor that integrates signals from Rho-family and Ras-family (Rap1b) GTPases to regulate cellular processes.
Development and Characterization of a FRET-based Formin Tension Sensor in Living Cells biorxiv.org 2026-07-13 Mechanotransduction via the actin cytoskeleton is linked to fundamental cellular processes such as morphogenesis, cell division, and motility, requiri
APOBEC3 activity and polymerase-ε deficiency are associated with distinct IDH1 R132 hotspot mutations biorxiv.org 2026-07-13 IDH1 R132 mutations are among the most frequent hotspot mutations in cancer, but their mutational origins have remained unclear.
A Bioengineered Live Biotherapeutic Exploits Inflammation to Restore Gut Liver Brain Axis Function under Diet-Induced Stress biorxiv.org 2026-07-13 Live biotherapeutic products (LBPs) show promise for treating metabolic and inflammatory diseases, but their efficacy is limited by poor persistence i
Structural modeling uncovers diverse predicted transcriptional and post-transcriptional modulators among type III effectors of symbiotic Rhizobia biorxiv.org 2026-07-13 Rhizobia are soil bacteria that establish nitrogen-fixing symbioses with legumes.
Adeno-Associated Virus (AAV) Synthetic Inverted Terminal Repeats Enhance Tissue-Specific Transduction and Alter the Vector Induced Stress Response biorxiv.org 2026-07-13 While adeno-associated virus (AAV) vectors have shown therapeutic benefit in clinical applications, noted challenges include low transduction efficien
From background to foreground: secondary antibodies coupled to lipophilic ATTO dyes enable high-density membrane labeling in super-resolution and expansion microscopy biorxiv.org 2026-07-13 Classical immunolabeling approaches can achieve homogeneous and continuous labeling of cellular membranes and organelles at wide-field and confocal re
A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription biorxiv.org 2026-07-13 The Ca2+ release-activated Ca2+ (CRAC) channel mediates store-operated calcium entry (SOCE), a ubiquitous pathway essential for many cell types, inclu
A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies biorxiv.org 2026-07-13 Severe proteinopathies, such as retinitis pigmentosa, a form of inherited blindness, are driven by genetic mutations that overwhelm the quality contro
Short term effects of salinization on the plankton community of an oligotrophic mountain lake biorxiv.org 2026-07-13 Freshwater salinization is of increasing concern for integrity and functioning of freshwater habitats worldwide.
An overlooked distal regulatory signal on a shared haplotype drives the neuroinflammatory cascade underlying GBA1-associated Parkinson's disease biorxiv.org 2026-07-13 BACKGROUND The persistent puzzle of how GBA1 coding variants underlying monogenic Gaucher disease confer such strong risk for polygenic Parkinson's di
Capillary Network Generation Framework for Estimating Volumetric Capillary Density from Histological Vascular Measurements biorxiv.org 2026-07-13 Angiogenesis drives the formation and remodeling of capillary networks throughout tissue repair, regulating the vascular environment that supports hea
Myeloid-Specific Pck1 Deficiency Does Not Alter Aortic Root Atherosclerosis in Mice biorxiv.org 2026-07-12 Background: We previously performed a strain intercross between atherosclerosis resistant AKR Apoe-/- mice and atherosclerosis sensitive DBA/2 Apoe-/-
ProtBLIP2-SST: Protein Function Prediction via BLIP2 with Sequence, Structure, and Text biorxiv.org 2026-07-12 Protein function prediction traditionally relies on structured gene ontology (GO) labels or multi-label classifiers.
OCellus: A Language-Model Framework for Single-Cell, Spatial, and Perturbation Biology with Natural-Language Reasoning biorxiv.org 2026-07-12 Computational modeling of cellular behavior - the virtual cell - has emerged as a stated grand challenge at the intersection of artificial intelligenc
Genomic Annotation Infrastructure (GAIn): Pipelines and Resource Repositories for Annotating Variants, Positions, and Regions biorxiv.org 2026-07-12 Interpretation of genomic variants, positions, and regions depends on reliable annotation - adding evidence such as predicted effect, conservation, po
A geometric atlas of how ESM3 organizes modalities across depth biorxiv.org 2026-07-12 Protein language models learn general-purpose representations from large collections of protein sequences and structures, and have advanced the predic
TEscape: Defining the human transposable element transcriptome using multiplatform long-read sequencing biorxiv.org 2026-07-12 Transposable elements (TEs) not only account for half of the human genome sequence but also generate transcripts that contribute to transcriptomic div
EcoMorph: Universal morphological trait quantification from natural language prompts for ecological research biorxiv.org 2026-07-12 1.
Gene Regulatory Networks Mediate Pattern Scaling in Growing Tissues biorxiv.org 2026-07-12 Developmental patterns can scale with size during growth, a phenomenon commonly attributed to morphogen scaling.
A practical framework for measuring protein oligomerization equilibria by fluorescence correlation spectroscopy biorxiv.org 2026-07-12 Protein oligomerization equilibria are central to many biological processes and are often highly sensitive to environmental conditions such as ionic s
Spatial Glyco-Codes Define Human Liver Pathology and Progression biorxiv.org 2026-07-12 Glycosylation is a fundamental process regulating cellular function, tissue organization, and disease progression.