Temporal Development of the Tracheal Microbiome Across Production Phases in Broiler Chickens biorxiv.org 2026-07-11 The respiratory microbiome plays important roles in poultry health, immune regulation, and pathogen resistance, yet its development throughout the bro
Cultivation of halophilic archaea in shallow subsurface martian conditions has implications for extant life on Mars biorxiv.org 2026-07-11 The present-day martian surface is generally considered inhospitable to life because of low atmospheric pressure, intense surface radiation, global de
Lytic bacteriophages against Salmonella Typhi as a potential alternative to antibiotics biorxiv.org 2026-07-11 Introduction: Enteric fever, being endemic with seasonal peaks in low- and middle-income countries, is a major health concern.
Ruminococcus hollandia sp. nov. and Ruminococcus vasco sp. nov., two novel starch-degrading Ruminococcus isolated from the rumen of Holstein dairy cattle biorxiv.org 2026-07-11 This study investigated the genomic and biochemical characteristics of two amylolytic microbial strains, NATIVEDY160T (=NRRL B-68523) and NATIVEDY161T
SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell Conditions biorxiv.org 2026-07-11 Single-cell transcriptomics has enabled systematic profiling of cellular states across ordered biological contexts, including developmental stages, tr
Limitations of EBV transformed human Raji B cells as a model for measuring canonical NF-κB activation biorxiv.org 2026-07-11 Autoimmune diseases, such as systemic lupus erythematosus (SLE), are underscored by dysregulated B cell function including the production of autoantib
A genetically buffered helicase network promotes tolerance of G-quadruplex stabilization in Saccharomyces cerevisiae biorxiv.org 2026-07-11 G-quadruplexes (G4s) are non-canonical DNA secondary structures that can impede DNA replication and transcription and provoke genome instability, and
Placental invasion mismatch underlines pregnancy disorders and cancers biorxiv.org 2026-07-11 Mammalian placentas vary dramatically in invasiveness, parallel aggressive cancers, and are dysregulated in pregnancy disorders, yet whether they shar
Gene model for the ortholog of raptor in Drosophila grimshawi biorxiv.org 2026-07-11 Gene model for the ortholog of raptor in the D.
Metagenomic contextualization of proteins with state space models biorxiv.org 2026-07-11 Since the early adoption of metagenomics (the culture-free sequencing of microbial community genomes) in 2011, sequence data has increased over 500-fo
Assessment of sensorimotor cortical beta oscillations from peripheral electromyography and force recordings biorxiv.org 2026-07-11 The beta oscillations of the human primary sensorimotor cortex (SM1) play a crucial role in regulating motor and cognitive behavior in health and dise
Optimizing MR-based gaze-decoding for eyes-closed eye-tracking in fMRI biorxiv.org 2026-07-11 Eye movements provide valuable insights into human cognition and are a critical variable in numerous functional magnetic resonance imaging (fMRI) stud
Simple Geometric Recentering Rivals Deep Sequence Models for Cross-Session EEG Motor-Imagery Decoding biorxiv.org 2026-07-11 A large and growing body of work applies increasingly complex deep architectures to EEG motor-imagery (MI) decoding, yet rarely tests whether that com
E-cadherin maintains oral Langerhans cell barrier surveillance to preserve microbiota-dependent immune homeostasis biorxiv.org 2026-07-11 Langerhans cells (LC) are specialized antigen-presenting cells that form a dense immune surveillance network within the oral epithelium.
A transcriptional continuum links viral burden and host-cell biology in human lymphoid tissue biorxiv.org 2026-07-11 Human immunodeficiency virus (HIV-1) persistence in lymphoid tissue remains a major barrier to cure, yet infected cells are commonly represented using
Tricuspid valve regurgitation accelerates heart failure via a cardio-intestinal innate immune circuit biorxiv.org 2026-07-11 Activation of the immune system impacts the progression of heart failure (HF), but the underlying mechanisms remain incompletely understood.
Northward expansion of Rugulopteryx okamurae (Dictyotales, Ochrophyta) in the southeastern Iberian Peninsula: first record in Calpe (Comunitat Valenciana) biorxiv.org 2026-07-11 The non-indigenous brown macroalga Rugulopteryx okamurae has emerged as one of the most aggressive marine invaders in European waters, deeply altering
A Novel Operant Conditioning Task to Assess Motivation to Exercise in Rats biorxiv.org 2026-07-11 Voluntary physical activity is a highly motivated behavior with important implications for physical and mental health, yet the neural and endocrine me
Somatic mutation inference from single-cell transcriptomics: A survey in the esophagus biorxiv.org 2026-07-11 Human somatic tissues accumulate mutations during normal aging.
AGPI: An AI-Powered Genomic Pathogen Intelligence Platform for Integrated Classification, Visualization, and Therapeutic Targeting biorxiv.org 2026-07-11 Rapid and accurate pathogen detection remains a major challenge in modern bioinformatics, as existing tools are often fragmented and require multiple
Dynamics of ML-based Morphological Features Indicate a Shear Stress-Dependent Bifurcation of hiPSC-Derived Endothelial Cell States biorxiv.org 2026-07-11 Cell states are increasingly conceptualized as attractors of high-dimensional dynamical systems, yet quantitative approaches for integrating phenotypi
ERK overstimulation leads to cell hyperproliferation in hereditary hemorrhagic telangiectasia landscape biorxiv.org 2026-07-11 Hereditary hemorrhagic telangiectasia (HHT) is a rare vascular disorder caused by pathogenic variants in members of the BMP9/ALK1 signaling hub.
Cytotoxicity of Pelargonic Acid and Its Commercial Formulation Roundup NL (Glyphosate-Free Roundup) biorxiv.org 2026-07-11 Evidence of negative health and environmental effects of glyphosate-based herbicides (GBHs) has led to marketing of glyphosate-free formulations.
Comparing Harmonization Approaches for Protocol-Related Variability in Multisite Diffusion MRI Data biorxiv.org 2026-07-11 Diffusion MRI (dMRI) enables assessment of white matter microstructural abnormalities in Alzheimer's disease (AD), and multisite datasets enable more
Primate visual cortex spontaneously computes the beauty of objects biorxiv.org 2026-07-11 During everyday vision, beauty is a spontaneous experience.
Encoding and Retrieval in Parallel: ERP Correlates of Continuous Recognition Memory for Natural Scenes biorxiv.org 2026-07-11 Human long-term memory for visual scenes is remarkably robust, yet the neural mechanisms supporting memory encoding and retrieval remain poorly unders
Structure-guided computational design and mechanistic understanding of the p95HER2-targeting NAZ-mAb antibody and its variants biorxiv.org 2026-07-11 Human epidermal growth factor receptor 2 (HER2) is an oncogenic receptor tyrosine kinase in breast cancer and other malignancies.
Scalable 3D cell-interaction analysis via supercell graphs for prostate cancer risk stratification biorxiv.org 2026-07-11 Cellular interactions underlie fundamental biological processes but are not fully represented in conventional 2D histology images.
First report on Chicken Pediculosis in Modern Battery-Cage Layer Farms in Bangladesh: Behavioral, Pathological and Production Performance Impacts biorxiv.org 2026-07-11 The recent shift in Bangladesh from tradition backyard rearing system to modern commercial layer farming has made the birds immune to infectious disea
Griphus Software for Multi Panel Figure Composition and Experimentation with Emphasis on Taxonomy biorxiv.org 2026-07-11 The preparation of multi panel figures remains a labor intensive step in scientific publication.
APOE4 genotype and old age interact to impact cerebrovascular function, brain volume, and neuroinflammation in mice biorxiv.org 2026-07-11 Old age and the apolipoprotein E4 (APOE4) genotype are two of the greatest risk factors for late-onset Alzheimer's disease (LOAD).
Cortical Activity During Sustained Isometric Ankle Contractions Following Chronic Sleep Restriction: A High-Density EEG Study biorxiv.org 2026-07-11 Background: Chronic sleep restriction (CSR) impairs cognitive function, but its effects on the cortical dynamics underlying active motor performance r
Spatial confinement shapes organelle architecture and remodeling in axons biorxiv.org 2026-07-11 Axons are extended cellular compartments that mediate neuronal connectivity over extraordinary distances, placing unique demands on local organelle or
Age-Associated Behavioral Alterations in Laboratory-Housed Octodon degus biorxiv.org 2026-07-11 Octodon degus are long-lived, diurnal, and highly social rodents increasingly used in studies of aging and neurodegeneration.
Secure LSL: A Unified Encryption Architecture for the Lab Streaming Layer biorxiv.org 2026-07-11 Objective: The Lab Streaming Layer (LSL) protocol, widely adopted for synchronized multimodal biosignal recording in neuroscience research, transmits
Structural presentation of amyloid β by HLA biorxiv.org 2026-07-11 HLA-DR-restricted T-cell reactivity to amyloid {beta} (A{beta}) has been associated with Alzheimer's disease (AD), but structural evidence for HLA pre
Robustness tuning: mechanisms of acclimation-driven plasticity in a central pattern generator biorxiv.org 2026-07-11 Temperature influences neuronal and circuit output and extreme temperatures can disrupt neuronal performance.
Cycles of contamination and recovery: Combined sewer overflows drive acute but transient antimicrobial resistance exposure in an urban stream biorxiv.org 2026-07-10 Combined sewer overflows (CSOs) are a major pathway for untreated wastewater into urban streams, yet their role in shaping antimicrobial resistance (A
Diet-Induced Obesity Exacerbates Helicobacter pylori-Associated Precancerous Phenotypes biorxiv.org 2026-07-10 Stomach infection with the bacterium Helicobacter pylori (Hp) can cause chronic gastric inflammation, metaplasia (transdifferentiation of mature cell
Biphasic bacterial community assembly predicted from generalized first principles of monoculture growth and inferred species interactions biorxiv.org 2026-07-10 Microbial communities occur in all habitats, yet how individual growth on available nutrients scales to community assembly remains poorly understood.
Climate isolation and percolation as drivers of terrestrial vertebrate richness biorxiv.org 2026-07-10 Climate is a strong predictor of global species richness, but the effects of climatic conditions are difficult to separate from the geography of the c
Sequential predictive e-diagnostics for hidden Markov models of animal movement biorxiv.org 2026-07-10 Hidden Markov models are standard for inferring behavioural states from animal movement data, but checking whether a fitted latent-state model predict
InsectDCT: A generalized pipeline for detection, taxonomic classification, and tracking of insects in camera-trap recordings biorxiv.org 2026-07-10 Automated monitoring of insect pollinators in natural environments with insect camera traps and trained deep learning algorithms provides novel data f
move2utils: a utility toolkit for the move2 ecosystem biorxiv.org 2026-07-10 1. Studying animal movement at the population scale requires a stable, modern software substrate.
New genes play a prominent role in evolution of new sperm classes of Drosophila biorxiv.org 2026-07-10 The widespread and regulated production of infertile parasperm assisting fertilization of eusperm provides a compelling model for elucidating the mech
Chromosome-level genome assembly of Calotes wangi with dynamic colour variation biorxiv.org 2026-07-10 The Wang's garden lizard, Calotes wangi, is a widely distributed agamid species in Southern China and Northern Vietnam and exhibits pronounced colour
Evolutionary trade-offs between antimicrobial resistance and virulence in Pseudomonas aeruginosa biorxiv.org 2026-07-10 Antibiotics impose strong selection on bacteria, resulting in the emergence and spread of antimicrobial resistance.
Inbreeding depression is greater in benign than in stressful environments biorxiv.org 2026-07-10 The potential for environmental change to compound the detrimental effects of inbreeding depression in small and isolated populations is a significant
The gonad as a mediator of life history tradeoffs: Antagonistic hormonal pleiotropy facilitates evolutionary divergence in reproductive strategies biorxiv.org 2026-07-10 High investment in current reproduction can limit future reproductive opportunities, but how selection shapes these hormone-mediated traits remains po
Protein fitness landscapes are simpler under evolutionary distributions biorxiv.org 2026-07-10 Understanding how mutations combine to shape protein fitness remains a central challenge in biology, driven in part by the prevalence of high-order ep