The copine protein NRA-1 regulates activity-dependent cholinergic signalling and sensory integration in C. elegans biorxiv.org 2026-07-13 Membrane-associated proteins regulate the localisation and function of ligand-gated ion channels, yet how they shape synaptic efficacy and behaviour r
Myosin 5A mediates membrane-associated periodic skeleton reassembly during axon regeneration in response to ROCK-2 inhibition biorxiv.org 2026-07-13 The membrane-associated periodic skeleton (MPS) is a submembrane lattice composed of actin rings and spectrin tetramers that repeats every 190 nm alon
Restoring Parkin Function: An AAV Gene Therapy Approach for Early-Onset Parkinson's Disease biorxiv.org 2026-07-13 Background: Biallelic loss-of-function mutations in PRKN gene (encoding Parkin protein) cause early-onset Parkinsons disease (EOPD).
A preliminary study of HMGB1 defense in Crohn's disease biorxiv.org 2026-07-13 Introduction: Intestinal barrier failure is a key characteristic of both kinds of inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn'
Long dsRNA on the move: Extracellular vesicles deliver dsRNA for antiviral protection in human cells biorxiv.org 2026-07-13 Viruses make long (>40 bp) double stranded RNA (LdsRNA) during replication, which stimulates the innate antiviral immune response.
Potential of exogenous biological nitrification inhibitor addition to improve soil nitrogen availability for crop growth. biorxiv.org 2026-07-13 Modern agriculture is characterized by substantial fertilizer nitrogen (N) losses from soils, resulting in low crop N-use efficiency.
Higher-order assembly of a type IX retron enables exploitation for designer antimicrobials biorxiv.org 2026-07-13 Bacterial defense systems provide a rich reservoir for biotechnological innovation.
Resistance to the conjugation inhibitor AZT reveals mating partner incompatibility during plasmid transfer biorxiv.org 2026-07-13 Plasmid-mediated dissemination of antibiotic resistance genes (ARGs) is a major driver of antimicrobial resistance (AMR).
Seasonal dynamics of microbial communities mediate aroma and flavour formation during palm sap fermentation biorxiv.org 2026-07-13 In many tropical countries, fermentation of palm sap into palm wine is an important fermented beverage contributing to local economies, tradition, and
Crop-associated differences in soil chemical properties and root-associated bacterial communities between Welsh onion and sweet potato biorxiv.org 2026-07-13 Crop species may shape soil chemical properties and root-associated microbiota, but direct comparisons between contrasting crops remain limited.
BR-bodies link RNA homeostasis to stress tolerance and intracellular fitness in Brucella biorxiv.org 2026-07-13 Bacterial gene expression depends on the coordinated regulation of RNA synthesis, processing, and decay.
Beyond efficacy: Persistence and off-target effects of three biological nitrification inhibitors in two contrasting agricultural soils biorxiv.org 2026-07-13 The use of nitrogen (N) fertilizers to meet global food demands is expected to continue rising.
PEONY: a global reference database of DNA viral (vOTU) sequences from viral size-fractionated metagenomes (viromes) biorxiv.org 2026-07-13 We present an update to the PIGEON (Phages and Integrated Genomes Encapsidated or Not) reference database of DNA viral sequences (vOTUs, mostly dsDNA
Co-dissemination of anti-phage defence systems and multidrug resistance is associated with the seventh-pandemic Vibrio cholerae defensome biorxiv.org 2026-07-13 Anti-phage defence systems in Vibrio cholerae are increasingly recognised as cargo on mobile genetic elements (MGE) that also carry antimicrobial resi
Determinants of dicentric chromosome breakage in Drosophila biorxiv.org 2026-07-13 Eukaryotic genomes often have fragile sites where chromosomes are particularly prone to break.
Asymmetric Structural Transfer Between Natural Language and Biological Foundation Models biorxiv.org 2026-07-13 Cross-domain transfer is a defining property of foundation models, yet whether such transfer is symmetric across domains remains unknown.
Evolutionary history and microbial cross-feeding shape lifestyle-stratified dominance of Bifidobacterium longum subspecies in infants biorxiv.org 2026-07-13 Bifidobacterium longum (Bl.) is a key early-life gut symbiont, yet its evolutionary origin and mechanisms underlying the global biogeographic distribu
Airway Diameter-Matched Injury Improves Severity and Reproducibility of Experimental Rabbit Tracheal Stenosis biorxiv.org 2026-07-13 Objective Reliable animal models of tracheal stenosis are necessary for the development and translational testing of anti-fibrotic and regenerative th
Cue-guided performance is disrupted during pedunculotegmental-induced motor arrest biorxiv.org 2026-07-13 Optogenetic stimulation of the rostral pedunculotegmental nucleus (PTg) induces global motor arrest, but it remains unclear whether this is merely a s
Augmenting Speech Comprehension using Rapid Frequency Tagging biorxiv.org 2026-07-13 Speech comprehension under adverse listening conditions benefits from visual speech, but whether visual input can be modulated to improve listening re
Testicular but not ovarian hormones shape patch-leaving adaptation and impulsive choice in rats biorxiv.org 2026-07-13 Hormonal regulation of patch-leaving decision-making remains poorly understood.
TOPAS: phosphoproteome data analysis and decision support platform for molecular tumor boards biorxiv.org 2026-07-13 The molecular tumor board (MTB) is central to precision oncology, providing personalized treatment recommendations based on molecular profiles of pati
EcoXAI: Autonomous Agentic Ecosystem for Explainable Artificial Intelligence and Biomedical Discovery biorxiv.org 2026-07-13 Motivation: As biomedical datasets and knowledge graphs continue to grow in size, complexity, and heterogeneity, navigating and extracting actionable
Charge Imbalance Drives Salt-Optimized Nucleosome Phase Separation under Physiological Conditions biorxiv.org 2026-07-13 Liquid-liquid phase separation (LLPS) of chromatin contributes to genome organization and regulates genome accessibility to control gene expression.
Supplementation via DAF-16 and pnk-1 driven pantothenate-coenzyme A flux improves disease related stress resistance in C. elegans biorxiv.org 2026-07-13 Metabolic pathways are increasingly recognized as tractable targets in aging and disease.
Assessing Microcirculation Impairment in Ischemic Stroke Mice Using Arteriovenous Co-fluctuation Analysis biorxiv.org 2026-07-13 Accurate assessment of cerebral hemodynamics impairment traditionally relies on arterial metrics, yet often overlooks venous drainage and arteriovenou
Single-nuclear RNA sequencing reveals an ATF3-independent sensory-neuron program after surgical incision biorxiv.org 2026-07-13 Background.
Longitudinal Subject Pairing in Cross-Sectional Neonatal Data Reveals Asynchronous Structural and Functional Brain Maturation biorxiv.org 2026-07-13 The asynchronous development of structural and functional brain networks in early childhood remains largely unexamined, primarily due to the scarcity
Gas-vacuolate Microcystis evolves cyanophage resistance under low nitrogen conditions biorxiv.org 2026-07-13 Cyanophages can influence the dynamics of toxic cyanobacterial blooms.
A Two-Arm Metabolic-Efflux Adaptation Framework in Klebsiella pneumoniae under Mixed Pharmaceutical Exposure: rutA-Linked Oxidative Entry and rutR-Associated Regulation biorxiv.org 2026-07-13 Chemically complex pharmaceutical mixtures in wastewater and sludge can affect microbial adaptation; however, the responses to different co-occurring
Multi-omics integration identifies a reproducible inflammatory host-response axis in pediatric sepsis biorxiv.org 2026-07-13 Sepsis is a major cause of morbidity and mortality in children, yet biological heterogeneity in host responses has limited progress toward targeted th
Adaptive landscape of the metallo-β-lactamase NDM to emerging β-lactam-based therapies biorxiv.org 2026-07-13 The New Delhi metallo-{beta}-lactamase (NDM) is a major determinant of carbapenem resistance.
Robust Myocardial Regeneration After Selective Cardiomyocyte Loss Is Driven by Cardiac Stem Cell Activation Through the miR-221-p57 Axis biorxiv.org 2026-07-13 A central unresolved and highly contested question in cardiac biology is whether the adult mammalian heart, believed to have a very limited endogenous
Structure-guided design of a CD81-binding mini-protein that blocks hepatitis C virus entry biorxiv.org 2026-07-13 Despite the success of direct-acting antivirals, preventing hepatitis C virus (HCV) reinfection remains a critical global challenge.
Language Model Embedding Classifiers Enable Identification of Multiple Sclerosis-Associated BCRs and Repertoires biorxiv.org 2026-07-13 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease.
Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease biorxiv.org 2026-07-13 Objective: Disease progression modeling (DPM) or "amyloid time" is increasingly used to stage Alzheimer disease (AD).
Spliceosome loss in the red tide ciliate Mesodinium rubrum presents a symbiotic cul-de-sac biorxiv.org 2026-07-13 Mesodinium rubrum, a marine microbial eukaryote associated with some of the largest red tides on Earth, has the remarkable ability to commandeer the p
Associative Visual Memory in Aphantasia: Evidence for Intact Object and Spatial Memory, Metacognitive Awareness, but Different Strategies biorxiv.org 2026-07-13 Many forms of memory are thought to rely on visual imagery, but individuals who report lacking visual imagery (aphantasia) can still perform various m
Diffusion Latent Representations for Neural Decoding biorxiv.org 2026-07-13 Neural decoding can be viewed as a representation learning problem in which neural activity is mapped into an intermediate representation before downs
White-Matter BOLD Encoding Beyond Marginal Connectivity biorxiv.org 2026-07-13 Functional MRI studies have traditionally focused on gray matter, whereas white-matter BOLD signals have often been treated as weak or artifactual.
Can we trust subthalamic local field potential? Geometrical and dynamical factors constraining the interpretability of extracellular recordings biorxiv.org 2026-07-13 Local field potentials (LFPs) are widely interpreted as readouts of population synaptic activity, an assumption derived almost entirely from cortical
Tau Isoform Expression Drives Disease Outcomes Following a Single Closed Head Injury biorxiv.org 2026-07-13 Tau protein has been implicated as an important mediator of traumatic brain injury (TBI).
IL-21-producing peripheral helper T cells associate with autoimmune bile duct injury in biliary atresia biorxiv.org 2026-07-13 Abstract Background: Biliary atresia (BA) is a severe neonatal liver disease characterized by progressive fibrosis and bile duct obliteration.
Endophytic colonization pathways of Pseudomonas chlororaphis M71 and Trichoderma atroviride SC1 in grapevine following stem injection biorxiv.org 2026-07-13 Endophytic biocontrol agents may contribute to grapevine health, but their ability to establish, persist, and move within woody tissues remains poorly
The MiDAS global genome catalog: 53,501 long-read MAGs representing all core prokaryotic genera in the global activated sludge microbiome biorxiv.org 2026-07-13 Wastewater treatment relies on complex microbial communities, yet existing genome-resolved references for this essential engineered ecosystem remain d
Isolation and characterization of novel filamentous phages from Swiss-type cheeses infecting the Gram-positive bacterium Propionibacterium freudenreichii biorxiv.org 2026-07-13 Filamentous phages infecting Gram-positive bacteria remain largely unexplored.
Glutamine Metabolism Supports α cell Mass and Glucagon Secretion biorxiv.org 2026-07-13 The liver- cell axis is a finely tuned biological rheostat that regulates whole body amino acid availability.
Contrasting effects of glucose and methylglyoxal supplementation on blood oxidative status, blood cells' telomere dynamics and apoptosis in birds biorxiv.org 2026-07-13 Birds exhibit longer lifespans than similarly sized mammals, despite having higher mass-adjusted blood glucose levels.
PolliCrop: A high-throughput computer vision pipeline for pollinator monitoring in agroecosystems biorxiv.org 2026-07-13 Flower-visiting insect populations are declining since the 1990s, especially because of the decrease of floral resources in agricultural settings.
Does ensembling improve feature attributions from sequence-to-activity models? biorxiv.org 2026-07-13 Sequence-to-activity models take as input DNA sequence and predict genomic activities such as transcription factor binding and gene expression.