The D2-mdx mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sites biorxiv.org 2026-07-12 Introduction.
The Tricuspid Valve Maladapts in a Pulmonary Hypertension Rat Model biorxiv.org 2026-07-12 Tricuspid valve regurgitation is a frequent valve lesion and, if severe, an independent predictor of mortality.
Striatal cholinergic and dopaminergic driven astrocyte Ca2+ activity is disrupted in Parkinsonian mice biorxiv.org 2026-07-12 Brain neuromodulatory systems exert powerful effects on local neuronal circuit function and behavior.
Muscle spatial lipidomics identifies early ALS signatures in presymptomatic SOD1G93A mice biorxiv.org 2026-07-12 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease whose diagnosis often remains delayed.
Transcriptional Characterization of Nuclear-Integrated Organellar DNA in Populus biorxiv.org 2026-07-12 The continuous transfer of organellar DNA into the nuclear genome during eukaryotic evolution has resulted in the widespread occurrence of nuclear pla
Fertility Gene Introns Harbor Transposable Elements that Shape Y-Loop Architecture biorxiv.org 2026-07-12 Transposable elements (TEs) are powerful drivers of genome evolution, yet how they persist under selection and become incorporated into host regulator
The YTHDC1 glutamate-rich domain docks to the ADAR1 Zα Domain, linking the N6-methyladenosine modification of pre-mRNAs to dsRNA editing biorxiv.org 2026-07-12 The p150 isoform of the double-stranded RNA editing enzyme ADAR1 binds Z-DNA and Z-RNA through the conserved winged helix-turn-helix Z domain.
BioMetAll v2.0: Introducing Scores, Metal Discrimination, and Side-Chain Descriptors for Predicting Metal-Binding Sites in Proteins. biorxiv.org 2026-07-12 Predicting the location of metal-binding sites in proteins is crucial for fundamental biological questions and biotechnological applications.
Structures of the human sodium-citrate cotransporter NaCT with and without substrates biorxiv.org 2026-07-12 The human sodium-citrate cotransporter NaCT imports various tri- and dicarboxylates into the cell as TCA cycle intermediates.
Synovium-Restricted Armored PD-1-Targeted CAR-T Cells Reprogram Immunity and Resolve Experimental Arthritis biorxiv.org 2026-07-12 Despite major therapeutic advances, a substantial fraction of patients with autoimmune disease remains refractory to treatment.
Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signaling biorxiv.org 2026-07-11 Background Repeated stress is a risk factor for developing motivational deficits which are common across a variety of disease states including depress
Shared lipidome and proteome signatures of frontotemporal lobar degeneration and Alzheimer's disease biorxiv.org 2026-07-11 Frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD) differ in their clinical features and genetic etiologies but share progressive c
Entropy regularised reinforcement learning reconciles aversive and action prediction errors in the tail of the striatum biorxiv.org 2026-07-11 Dopamine activity in the tail of the striatum (TS) presents a novel challenge for reinforcement-learning theories of dopamine.
The most common epilepsy-causing mutation in EEF1A2 (E122K) perturbs the translation of specific transcripts but not the rate of global protein synthesis biorxiv.org 2026-07-11 Heterozygous de novo missense mutations in the EEF1A2 gene encoding translation elongation factor eEF1A2 result in neurodevelopmental disorders, typic
A cross-species protocol for ultrasound-guided intrauterine injections across gestation biorxiv.org 2026-07-11 This step-by-step protocol provides a cross-species, non-surgical approach that enables prenatal gene delivery to the developing nervous system in rat
FUNCTIONAL FRAGMENTATION AND STRUCTURAL DRIVERS OF THALAMO-CORTICAL CIRCUITS IN TEMPORAL LOBE EPILEPSY biorxiv.org 2026-07-11 Objective.
A Donor T-Cell Receptor Structural Signature Determines Alloreactive Potential and Predicts Acute Graft-Versus-Host Disease biorxiv.org 2026-07-11 Acute graft-versus-host disease (GVHD) remains a lethal barrier to successful allogeneic hematopoietic cell transplantation, yet pre-transplant donor
Intrinsic T-cell programming and immune spatial organization govern sex-biased tuberculosis immunity biorxiv.org 2026-07-11 Biological sex can profoundly influence the susceptibility to infectious diseases, yet the mechanisms behind the sex-dependent protective immunity aga
Lipid chlorination mobilizes Neutrophil Elastase to initiate NETosis biorxiv.org 2026-07-11 Neutrophils are the first cells recruited to sites of infection, where they contain and kill pathogens through phagocytosis, degranulation, and the re
Multidecadal Remote Sensing of Macrocystis Pyrifera in Argentina biorxiv.org 2026-07-11 The Southern Hemisphere is home to extensive forests of giant kelp (Macrocystis pyrifera), including in Argentina and the southern islands of Tierra d
Spatial specialization of antioxidant defenses dictates predation success in Myxococcus xanthus biorxiv.org 2026-07-11 Redox-based chemical warfare is a primary driver of microbial community assembly.
Competition among kin generates balancing selection in a wild population biorxiv.org 2026-07-11 If an individual's niche is determined by its genotype, then competition for limiting resources should be most intense among individuals of the same g
Latitudinal Patterns in Immunogenetic and Microbiome Diversity in two anuran species: Bufo bufo and Bufo spinosus biorxiv.org 2026-07-11 Evolutionary and demographic processes such as selection, drift and migration shape the genetic variation of populations.
Driver-independent lexAop-tdTomato.nls reporter signal in the adult Drosophila proventriculus biorxiv.org 2026-07-11 Reporters are widely used in Drosophila genetics to visualize gene expression and cell lineages.
Interactome Specialization Predicts Genome-Wide Binding-Site Degeneracy in Drosophila melanogaster Transcription Factors biorxiv.org 2026-07-11 Transcription factors (TFs) recognize short, degenerate DNA motifs that occur thousands of times throughout the genome, implying that binding specific
First-Trimester Non-Invasive Prediction of Preterm Birth Using Cell-Free DNA Fragmentomics biorxiv.org 2026-07-11 Objective.
AptViralDB: A Repository of Experimentally Validated Antiviral Aptamers biorxiv.org 2026-07-11 In an era of increasing drug resistance, exploring alternative molecules is crucial for the efficient management and treatment of viral diseases.
ProtAug: An Empirical Investigation of pLM-Guided Data Augmentation for Protein Sequence Prediction Tasks biorxiv.org 2026-07-11 Protein language models (pLMs) offer great potential for protein sequence analysis, yet the scarcity of labeled data often limits their effectiveness
GBZ-base and GAF-base: Indexed pangenome file formats biorxiv.org 2026-07-11 Motivation: Existing pangenome file formats are designed for batch processing.
ProtPen combines sequence- and structure-based approaches to facilitate protein function predictions on a proteome-wide scale biorxiv.org 2026-07-11 Proteins of unknown function represent a significant gap in our understanding of biological processes, encompassing large portions of the proteomes of
PKProbDesign: RNA inverse folding including pseudoknots by optimizing thermodynamic folding probability biorxiv.org 2026-07-11 Motivation: RNA inverse folding, the design of RNA sequences that fold into specified target structures, is a central problem in RNA design, with appl
Does Borrelia afzelii outer surface protein E coevolve with complement factor H of its rodent host? Insights from GxG and spatial associations biorxiv.org 2026-07-11 Background: Lyme borreliosis is a common tick-borne disease in Europe caused by spirochetes of the Borrelia burgdorferi sensu lato complex, including
Comparative 3D analysis reveals species-specific patterns of coral polyp morphology and gastrovascular integration biorxiv.org 2026-07-11 Coral reefs are constructed by colonial cnidarians whose survival depends on the coordinated growth and physiological integration of thousands of inte
Characterizing the Small Non-Coding RNA Pathways in the Invasive Zebra Mussel (Dreissena polymorpha) biorxiv.org 2026-07-11 The zebra mussel (Dreissena polymorpha) is an invasive species that causes extensive economic and ecological damage.
Comparative Analysis of Transposable Elements in Hermetia illucens biorxiv.org 2026-07-11 Background The black soldier fly (Hermetia illucens) is an emerging model for bioconversion and industrial rearing.
Panomap: Unbiased Nanopore Signal Mapping with Pangenome Variation Graphs biorxiv.org 2026-07-11 Motivation: Signal-space nanopore mappers enable real-time mapping and filtering decisions directly from raw nanopore signals.
M6AFormer Prioritizes Unannotated Functional m6A Candidate Sites in the Human m6A Epitranscriptome biorxiv.org 2026-07-11 N6-methyladenosine (m6A) is a pervasive RNA modification with critical roles in post-transcriptional regulation, yet accurate transcriptome-wide ident
onsite: An Integrated Framework for Phosphosite Localization and False Localization Rate Estimation biorxiv.org 2026-07-11 With the rapid development of mass spectrometry-based proteomics, the volume of phosphoproteomic data has increased substantially.
ArthroVerse: mapping protein family diversity across arthropod-associated microbiomes biorxiv.org 2026-07-11 Metagenomic studies of arthropod-associated microbiomes have generated vast amounts of sequence data, yet the functional and structural organization o
High resolution Streptococcus pyogenes core genome MLST and LIN coding scheme for outbreak detection biorxiv.org 2026-07-11 Streptococcus pyogenes is a globally important pathogen responsible for at least 500,000 deaths a year, causing significant burden on healthcare syste
Signaling metabolites spatially organize a multispecies mutualism in the soil microbiome biorxiv.org 2026-07-11 A plant-independent avenue for N2-fixation takes place in desert topsoils through a "C-for-N" mutualism between heterodiazotrophs and the cyanobacteri
Locus-Level Transposable Element Profiling Resolves Division-Coupled Transcriptional Dynamics During Human Endoderm Specification biorxiv.org 2026-07-11 Background: Transposable elements (TEs) constitute nearly half of the human genome and are now recognized as significant contributors to mammalian gen
Multiscale harmonization and semantic integration of biomedical data enable biological insights through immersive exploration biorxiv.org 2026-07-11 The Human Reference Atlas (HRA) enables multiscale data exploration and visualization.
Single-cell RNA-seq reveals conserved and divergent cellular states across wound types and species biorxiv.org 2026-07-11 Chronic wounds, such as diabetic foot ulcers, fail to progress through the normal healing process and impose a significant burden on healthcare system
Benchmarking AI Protein Structure Predictors Reveals a Persistent Bias in Multi-State Proteins biorxiv.org 2026-07-11 Protein structure predictors achieve high single-state accuracy, but it remains unclear whether they can recover functionally relevant conformational
RNA and proteins joined up at the Origins of Life: Persistence is the point biorxiv.org 2026-07-11 What drove nucleic acids (NA) to associate with proteins (PR) at the Origins of Life?
Bioelectrical phase transitions biorxiv.org 2026-07-11 Electrical signaling in biological systems is generally understood through the lens of single-channel biophysics, yet whether ensembles of ion channel
Mycobacterium tuberculosis Δlsr2 Vaccine Enhances Protection Against Tuberculosis biorxiv.org 2026-07-11 Tuberculosis (TB) has been a leading cause of death from a single infectious agent for decades.
Root rot by Phytophthora cinnamomi shifts the composition and structure of avocado rhizosphere fungal communities biorxiv.org 2026-07-11 Rhizosphere microbial communities contribute to the growth and health of their host but may be altered by the incidence of soil-borne pathogens.
Macro evolutionary patterns do not predict micro evolutionary trajectories biorxiv.org 2026-07-11 As the world's oceans change in response to climate change, phytoplankton communities will adapt to warmer, more stratified surface waters via plastic