Structural Composition Enables Very Fast Learning biorxiv.org 2026-07-15 There is a gap between neuroscientific theories of learning and the speed of learning observed in many experiments.
Insights into mechanisms of ATM activation via constitutively active mutants biorxiv.org 2026-07-15 The Ser/Thr kinase ATM orchestrates cellular responses to DNA double-strand breaks (DSBs) and promotes DSB repair by homologous recombination.
Homeostatic control of stem cell activity during intestinal regeneration. biorxiv.org 2026-07-15 Stem cells proliferate rapidly to maintain fast tissue turnover during regeneration.
Transcription controls chromatin-nuclear lamina contacts through distinct Lamin A and LBR tethering mechanisms biorxiv.org 2026-07-15 Lamina-associated domains (LADs) are large genomic regions that interact with the nuclear lamina (NL).
An IL-34-IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression biorxiv.org 2026-07-15 Macrophages are innate immune cells of embryonic or adult origin with tissue specific roles in homeostasis, disease surveillance, and wound repair tha
Characterisation of gene expression markers and glucosinolates during discrete infection stages of Pyrenopeziza brassicae in Brassica napus biorxiv.org 2026-07-15 Light leaf spot (LLS), caused by subcuticular hemibiotrophic ascomycete fungus Pyrenopeziza brassicae, is a major constraint on oilseed rape (Brassica
Articulatory timing and form support distinct neural benefits during audiovisual speech biorxiv.org 2026-07-15 In noisy environments, visible speech articulations improve listening comprehension.
Teneurins Are SPARCL1 Receptors biorxiv.org 2026-07-15 Extensive experiments document that SPARCL1, a secreted protein that is produced primarily by astrocytes in brain and endothelia throughout the body a
Frozen Protein Foundation-Model Embeddings Improve Antibody-Antigen ΔΔG Ranking biorxiv.org 2026-07-14 We investigate whether representations from AINN-P1--a protein foundation model trained autoregressively on tens of millions of natural protein sequen
Evidence for lanthanide and PQQ dependent dehydrogenases in Eukarya biorxiv.org 2026-07-14 Lanthanides function as enzyme cofactors in bacteria, where they are widely distributed in pyrroloquinoline quinone-dependent 8-bladed beta-propeller
De novo design of ligand binding and sensing with a physics based generative approach biorxiv.org 2026-07-14 The de novo design of ligand-binding proteins has tremendous potential to revolutionize biosensor technology, yet converting these designs into functi
elDORS: An elevated Database Of RNA Sequences biorxiv.org 2026-07-14 Massive and integrated sequence databases have revolutionized computational protein structure prediction.
Fast prediction of acidic amino acid sidechain conformations for cryo-EM modeling biorxiv.org 2026-07-14 Cryogenic-electron microscopy (cryo-EM) has revolutionized the field of protein structural biology.
Combining phase analysis and causal stimulation enables longitudinal mesoscale connectivity mapping biorxiv.org 2026-07-14 Uncovering the circuit mechanisms of flexible behavior requires characterizing how neural signals propagate across large-scale networks and tracking h
Natural variation in NifU and NifS enhances chloroplasts compatibility for nitrogenase engineering biorxiv.org 2026-07-14 Reconstitution of functional nitrogenase in plants requires the coordinated expression of the [Fe-S] cluster assembly proteins NifU and NifS.
VC1 and the production of vicine and convicine in the genus Vicia biorxiv.org 2026-07-14 Many Vicia species contain vicine and convicine (VC), which limit the use of faba bean and some vetches in food and feed.
An experimental model system to investigate microscale mechanisms behind the soil priming effect biorxiv.org 2026-07-14 The soil priming effect plays an important role in the global carbon cycle. Although well-studied, the mechanisms behind it remain elusive.
Linking geography and mutation profiles across goat species biorxiv.org 2026-07-14 Recent studies have characterised the mutational profile across multiple mammalian species, highlighting substantial differences across lineages.
Gene model for the ortholog of raptor in Drosophila erecta biorxiv.org 2026-07-14 Gene model for the ortholog of raptor in the May 2011 (Agencourt Dere_CAF1/DereCAF1) Genome Assembly (GenBank Accession: GCA_000005135.1) of Drosophil
A Multi-Omics Framework Reveals Phosphorylation-Dependent Control of Protein Interactions biorxiv.org 2026-07-14 Protein phosphorylation regulates nearly every cellular process, yet most of the hundreds of thousands of human phosphosites remain functionally uncha
Live-cell co-translational folding tracking reveals bidirectional coupling between translation and folding biorxiv.org 2026-07-14 Translation elongation and protein folding have long been proposed to coordinate during co-translational folding, yet the lack of technologies capable
Potent substoichiometric inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins biorxiv.org 2026-07-14 The non-amyloid {beta} component (NAC) domain of alpha synuclein (Syn) drives Syn aggregation in Parkinson disease, yet as an intrinsically disordered
Kelch13 stochastics determine drug survival in resistant malaria parasites biorxiv.org 2026-07-14 As resistance to the frontline antimalarial artemisinin (ART) in the deadliest malaria species Plasmodium falciparum spreads, it threatens the gains m
Rusty Blackbirds (Euphagus carolinus) appear to exhibit predator satiation with a resident raptor species biorxiv.org 2026-07-14 Predator satiation is an understudied topic among vertebrate organisms, especially avian species.
Population Genetics of Native Red Mulberry at Its Northwestern Boundary Suggests Postglacial Founder Effects biorxiv.org 2026-07-14 Morus rubra is native to the eastern United States, with its range extending into the Upper Midwest and southern Ontario, Canada.
Conserved core RNAi machinery in trematode-vectoring snails indicates gene silencing potential in the absence of classical systemic and amplification effectors biorxiv.org 2026-07-14 RNA interference (RNAi) is a widely exploited reverse-genetics tool with potential uses for disease control.
A gapless telomere-to-telomere reference genome of Ostreococcus tauri RCC4221 with expanded annotation of medium-sized ncRNAs biorxiv.org 2026-07-14 Marine photosynthetic microbes contribute substantially to global primary production, yet many algal lineages still lack reference genomes with the co
Sex-specific functions of duetting in the Galapagos Yellow Warbler (Setophaga petechia aureola) biorxiv.org 2026-07-14 In over a thousand avian species, pairs coordinate vocalizations to form duets.
Responses to novel food resources in the extinct-in-the-wild 'alala biorxiv.org 2026-07-14 One challenge of reintroduction programs is ensuring that captive individuals are prepared for life in the wild, including having the ability to forag
Social hierarchy assays measure independent features of competitive ability biorxiv.org 2026-07-14 Social hierarchies are a nearly universal feature of animal groups, but whether dominance reflects a single generalized trait or a collection of conte
The gene yellow influences aversive mate preference learning in a butterfly biorxiv.org 2026-07-14 Reproductive isolation is a central driver of speciation and can be reinforced by both innate mate preferences and mate preference learning.
Speed Synchrony Promotes Collective Motion in Mixed-Species Fish Schools biorxiv.org 2026-07-14 Principles of collective motion are now well established, though research has largely focused on homogeneous groups.
miR319-targeted LsTCP4 and non-target LsTCP17 act in parallel to promote leaf senescence in lettuce biorxiv.org 2026-07-14 Leaf senescence directly affects lettuce quality and postharvest shelf life, but the regulatory roles of miR319-targeted and non-target CIN-TCP transc
Laterality of subcortical structures predicts spontaneous brain dynamics biorxiv.org 2026-07-15 Subcortical structures play a key role in shaping cortical computation through distributed cortico-subcortical networks, yet it remains unclear whethe
Decoding and Characterizing the Intracranial Representation of Semantic Information biorxiv.org 2026-07-15 Brain-computer interfaces (BCIs) have achieved impressive performance by decoding motor and articulatory signals associated with speech production.
Molecular dynamics simulations demonstrate reduced antibiotic affinity to mirror bacterial targets biorxiv.org 2026-07-15 Mirror life, self-replicating organisms composed of non-natural-chirality biomacromolecules, presents a future threat with potentially global conseque
SF3B3 / SF3B5 form a metazoan specific transcription module of the U2 snRNP that coordinates Pol II elongation in a splicing independent manner biorxiv.org 2026-07-15 Co-transcriptional splicing is a conserved feature of eukaryotic gene expression.
Beyond climatic drought indices : an hydraulic approach to quantifying forest water stress biorxiv.org 2026-07-15 The article introduces a new Forest Stress Index (ISF) based on a plant hydraulic modelling approach rather than classical climatic drought indices.
The UPRMT is a critical mediator of nutrient immunity biorxiv.org 2026-07-14 Mitochondria serve as critical signaling hubs that monitor the intracellular environment to orchestrate cellular stress responses during pathogen infe
The paraspeckle protein NONO potentiates the antiviral innate immune response through chromatin regulation biorxiv.org 2026-07-14 Type-I interferons (IFN-I) and IFN-stimulated genes (ISGs) are central to antiviral defense, while dysregulation can drive autoimmunity.
Intermolecular disulfide bond formation promotes Hsp42 higher-order assembly and shapes client selection in yeast biorxiv.org 2026-07-14 Cellular redox homeostasis plays a critical role in regulating protein function, including chaperone activity, through reversible oxidation of cystein
Forest degradation reshapes trophic functioning in vertebrate food webs across Amazonian forests biorxiv.org 2026-07-14 The Amazon is a mosaic of ecosystems, accounting for 13% of all known species globally, and responsible for providing a variety of ecosystem services,
Synonymous codon usage is biased for and against m⁶A RRACH motifs in mammals biorxiv.org 2026-07-14 RNA methylation at N-adenosine (mA) predominantly occurs within RRACH motifs, yet the forces shaping these motifs in coding regions remain unclear.
BBB-Nuke: Transport-Aware Prediction of Blood-Brain Barrier Penetration in Small Molecules biorxiv.org 2026-07-14 Predicting blood-brain barrier (BBB) penetration remains a central challenge in CNS drug discovery.
Characterization of Fetal Cortical Development Using Spectral Analysis of Gyrification (SPANGY) biorxiv.org 2026-07-14 The prenatal period of human brain development is critical for mental health and cognition across the entire lifespan.
Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD biorxiv.org 2026-07-14 Frontotemporal dementia (FTD) is characterized by selective neuronal vulnerability, yet the features that predispose specific neuron types to degenera
PV interneuron-targeted CRISPRa rescue of SCN1A haploinsufficiency in Dravet syndrome biorxiv.org 2026-07-14 Dravet syndrome is a severe epileptic encephalopathy caused by SCN1A haploinsufficiency, which leads to reduced NaV1.1 expression in parvalbumin (PV)-
A canine brain bank for comparative neuroscience and brain aging research biorxiv.org 2026-07-14 Companion animal brain banking has been recognized as a valuable approach for translational aging and dementia research.
Frontolimbic Functional Connectivity Development from Birth to Emerging Adulthood biorxiv.org 2026-07-14 Frontolimbic circuits connecting the frontal cortex with the amygdala and the hippocampus are critical for emotion and learning.
Processing at Phrase Boundaries During Self-Paced Reading biorxiv.org 2026-07-14 Sentence comprehension requires the incremental construction of syntactic structure and semantic interpretation.