Diaphragmatic EMG Uncovers Left-Right Diaphragmatic Imbalance After Ischemic Stroke with Implications for Motor Recovery biorxiv.org 2026-07-16 Background: Stroke-associated respiratory dysfunction has been increasingly recognized, yet whether diaphragmatic impairment after stroke involves lat
Discovering Heterogeneous Neurodegenerative Disease Patterns From MRI Data for Improved Prediction biorxiv.org 2026-07-16 Neurodegenerative diseases exhibit substantial heterogeneity, complicating both diagnosis and prognosis.
Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease biorxiv.org 2026-07-16 Microglia are central regulators of neuroinflammation in Alzheimers disease (AD), yet how metabolic states modulate function remains unclear.
Dissociable Neural Responses to Conditioned Social Threats are Modulated by Spatial Proximity in PTSD and MDD biorxiv.org 2026-07-16 The brain's response to potential threats is shaped by the egocentric spatiotemporal distance to the threat.
A claustro-cortical loop times state transitions for flexible behavior biorxiv.org 2026-07-16 Metastable dynamics, in which neural activity moves between transiently stable patterns, have been proposed to underlie the real-time coordination on
Distinct Computational and Temporal Mechanisms Underlie the Joint Effects of Motivation and Working Memory on Perceptual Sensitivity biorxiv.org 2026-07-16 Human perception is continuously shaped by internal cognitive states, yet how motivation and working memory jointly influence perceptual sensitivity r
Convergent Inhibitory Cortical Circuit Disruption Drives Genetically Distinct Absence Seizures biorxiv.org 2026-07-16 Absence seizures, the most common childhood epilepsy, are characterized by brief involuntary lapses in consciousness and 3-Hz spike-wave EEG discharge
Bacterial histone-like proteins released during antibiotic treatment mediate vascular injury in meningococcal sepsis. biorxiv.org 2026-07-16 Vascular injury and coagulopathy are key drivers of mortality in bacterial sepsis.
Essential Molecular Variables of liverworts in biological soil crusts biorxiv.org 2026-07-16 (1) In plant ecology, functional traits are widely used to predict plant performance in ecosystems.
Combinatorial MAPK states drive opposing gene programmes: a reanalysis of MAP3K-driven transcriptional responses in MCF10A cells biorxiv.org 2026-07-16 Background.
Open Digital Bioassays Enabled by Aqueous Two-Phase Microreactor Arrays biorxiv.org 2026-07-16 Digital bioassays enable precise single-molecule quantification but are difficult to adapt to point-of-care testing (POCT) because conventional protoc
Molecular mechanism of partially open Kv7.2 gate stabilization by gain-of-function variants biorxiv.org 2026-07-16 Gain-of-function (GoF) variants in the Kv7.2 channel are associated with a clinically relevant subset of neurodevelopmental disorders.
A Multi-Institution Biobanking Pipeline for Primary Human Satellite Cells and Fibro-Adipogenic Progenitors biorxiv.org 2026-07-16 Satellite Cells (SCs) and Fibro-Adipogenic Progenitors (FAPs) are muscle-resident cell populations crucial for maintaining skeletal muscle homeostasis
Deformability screening identifies NUDT5 as a mediator of cellular mechanobiology biorxiv.org 2026-07-16 How cells deform, sense, and respond to mechanical cues drives physiological and disease processes ranging from development to cancer metastasis; howe
Habitat Type and Seasonal Variation as Drivers of Mosquito Proliferation in Urban Aquatic Microhabitats biorxiv.org 2026-07-16 Aedes aegypti is the primary vector species for dengue, Zika, and chikungunya viruses, and is adapted to thrive in urban environments.
How reliable is the use of ovarian dilatations for mosquito age-grading? A blinded multi-rater validation of the Polovodova method in Anopheles mosquitoes. biorxiv.org 2026-07-16 Accurate estimation of mosquito age is critical for malaria surveillance, as only older female Anopheles mosquitoes can transmit the parasite.
Conformational Basis of Functionally Selective Allosteric Modulation of the Angiotensin II type 1 Receptor by Small Molecules biorxiv.org 2026-07-16 Blockade of signaling through the angiotensin II type 1 receptor (AT1R), a prototypical G protein-coupled receptor (GPCR), by angiotensin receptor blo
MEMS-Based Ultrasonic Energy Harvesting Platform Enabling Sustained In Vivo Operation of Implantable Microdevices biorxiv.org 2026-07-16 Implantable microdevices capable of autonomous operation over extended lifetimes are promising enablers for minimally invasive diagnostics and therapy
Combinatorial screening of biological degrader modules identifies heterobifunctional molecules that efficiently destroy MYC, leading to rapid tumour cell death in vitro and in vivo biorxiv.org 2026-07-16 Targeted protein degradation is a potent strategy against intracellular proteins impervious to traditional drugs.
Increased Interstitial Flow and Elastic Lamina Degradation Precede Aortic Dissection biorxiv.org 2026-07-16 Aims: To elucidate the relationship between interstitial flow (IF) and structural changes in the aortic media during the development of aortic dissect
Phylogenize2: robust phylogenetic methods link genes to phenotypes across host-associated and environmental microbiomes biorxiv.org 2026-07-16 In microbiome studies, associations between microbial functions and the environment are often confounded by phylogeny.
MSstatsBioNet: Integrating Statistical Analyses with Prior Knowledge Biomolecular Networks for Quantitative Proteomics and Phosphoproteomics biorxiv.org 2026-07-16 A common outcome of quantitative mass spectrometry-based proteomic and phosphoproteomic experiments is a list of proteins that are differentially abun
Unraveling the Comedone Switch through Single-Cell Resolution of Human Acne Lesions biorxiv.org 2026-07-16 Acne vulgaris is one of the most prevalent inflammatory skin diseases worldwide, yet the molecular events initiating comedogenesis remain poorly under
A hierarchy of spatial confinements governs chromatin dynamics and genomic encounters biorxiv.org 2026-07-16 Antibody diversity is generated through stochastic rearrangement of the immunoglobulin heavy chain locus (Igh) involving the recombination of variable
Feedback between filament spacing, crosslinker binding, and self-organization in cytoskeletal bundles biorxiv.org 2026-07-16 The lateral spacing between filaments in crosslinked cytoskeletal bundles is a critical yet poorly understood physical parameter that affects force ge
In vitro effects of tensile strain on cancer-associated and matched normal fibroblasts derived from oral squamous cell carcinoma: an exploratory study biorxiv.org 2026-07-16 Background: Mechanical forces, particularly tensile stress, influence tumor progression by modulating cancer-associated fibroblast (CAF) behavior and
Parallel DNA Holliday Junctions: Myth or Reality? An Atomistic Molecular Dynamics Study biorxiv.org 2026-07-16 Holliday junctions (HJs) are key intermediates of homologous recombination and fundamental building blocks in DNA nanotechnology.
Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma biorxiv.org 2026-07-16 Somatic oncogenic mutations are typically defined by their molecular alterations, yet how they reorganize cellular architecture within intact tissues
Assessing the relative contributions of different Arabidopsis thaliana stigma factors to pollen hydration. biorxiv.org 2026-07-16 Following pollination, Arabidopsis pollen grains rapidly hydrate through the transfer of water from the stigma to the pollen.
Surprisal contributes little beyond contextual embeddings in high-gamma ECoG encoding biorxiv.org 2026-07-16 Surprisal and contextual embeddings are both derived from large language models and are widely used to predict neural responses during language compre
Brain-wide gaze-dependent activity during eyes-closed rest and sleep biorxiv.org 2026-07-16 Gaze behavior and brain activity are tightly coupled during perception and mental imagery.
Diminished Stimulus-Evoked Activity During Sustained Attention Without Behavioural Cost in ADHD biorxiv.org 2026-07-16 Attention-Deficit/Hyperactivity Disorder (ADHD) is often accompanied by attentional challenges, sleep difficulties and increased reports of daytime sl
Uncovering the spatiotemporal structure of neural avalanches through optimal transport and dynamic time warping biorxiv.org 2026-07-16 Neural avalanches - or threshold-defined bursts of coordinated activity - are traditionally characterised by scale-free statistics.
An Approach to Measure Conductivity Gradients of Brain Tissue Transitions using Electrode Arrays biorxiv.org 2026-07-16 Accurate determination of surgical margins is critical in tumor resection to ensure complete removal of tumorinfiltrated tissue while preserving healt
A Whole-Brain Dynamical Framework Linking Resting-State Activity to TMS-Evoked Responses biorxiv.org 2026-07-16 A major challenge in systems neuroscience is understanding how external perturbations interact with ongoing brain activity.
SYNGAP1 haploinsufficiency disrupts early neurodevelopment and accelerates intrinsic neuronal maturation in human patient-derived models biorxiv.org 2026-07-16 SYNGAP1 developmental and epileptic encephalopathy (DEE) is a severe neurodevelopmental disorder characterised by intellectual disability, development
Unifying transcranial focused ultrasound and transcranial magnetic stimulation effects with calcium-dependent synaptic plasticity theory biorxiv.org 2026-07-16 Low-intensity transcranial focused ultrasound stimulation (TFUS) is an emerging technology that shares features of both established invasive (e.g.
Scaling of anesthesia-dependent cerebrospinal fluid dynamics across rat and pig brains biorxiv.org 2026-07-16 This study presents a novel in vivo neuroimaging approach using dynamic single photon emission computed tomography (SPECT/CT) to investigate cerebrosp
Bifurcation Structure and Cross Nuclei Universality Govern Frequency-Selective Deep Brain Stimulation biorxiv.org 2026-07-16 High-frequency deep brain stimulation (DBS, >90 Hz) reliably suppresses Parkinsonian motor symptoms, whereas sub-therapeutic frequencies (<60 Hz
Predicting the protein interaction landscape of a mycobacterial pathogen biorxiv.org 2026-07-16 High-dimensional phenotypic screens of bacterial loss-of-function mutant libraries have determined gene-gene connections and specific phenotypes for t
Plant Functional Type Composition, Rather Than Species Diversity, Shapes Soil Microbial Functional Diversity and Redundancy biorxiv.org 2026-07-16 Cover crops (CCs) are widely used to improve soil health, but their species-specific effects on microbial functional diversity and redundancy remain p
Systematic Development of a Compact Genome-Editing Tool Leveraging the TAM-Independent DNA Nuclease TasR in Bacillus subtilis biorxiv.org 2026-07-16 Bacillus subtilis is a core microbial chassis in biomanufacturing, and establishing efficient gene editing technologies is key to engineering this str
Spatial Topology Reveals Biologically Distinct Recurrent Motifs in Colorectal Cancer biorxiv.org 2026-07-15 Most spatial transcriptomic analyses of solid tumors focus on individual cell states or single-sample spatial domains rather than on recurrent multice
α5β1 and αvβ3 integrins employ two distinct adhesion strengthening modes to respond to fibronectin stiffness within seconds of initiating adhesion biorxiv.org 2026-07-15 The complex interplay between extracellular matrix stiffness and actomyosin contractility regulates long-term integrin-based adhesion and signaling in
From exact gradients to exact standard errors: third-order sensitivity equations for the FOCE and FOCEI population likelihood biorxiv.org 2026-07-15 Asymptotic standard errors for the parameter estimates of a nonlinear mixed-effects model fitted by first-order conditional estimation (FOCE) or FOCE
Spaceflight-relevant microgravity triggers a sublethal Parkinson's-like dopaminergic decline in human neurons and organoids. biorxiv.org 2026-07-15 Spaceflight stressors may increase Parkinson's disease (PD) risk, but microgravity-specific contribution to human dopaminergic (DA) vulnerability rema
Allele-specific correction of dominant Best vitelliform macular dystrophy in patient-derived retinal pigment epithelium biorxiv.org 2026-07-15 Autosomal dominant Best vitelliform macular dystrophy (BVMD) caused by variants in BEST1 is characterized by dysfunction of the macular retinal pigmen
The Role of Training Paradigms in Shaping Connectivity and Dynamics: A Comparison of Gradient-Based and Evolutionary Methods in Recurrent Neural Network Models biorxiv.org 2026-07-15 Recurrent neural networks (RNNs) trained with backpropagation through time (BPTT) use gradients and global error signals to solve tasks, while evoluti
The plant specific VPS2.2/HYADE of the ESCRT-III protein sorting machinery localizes to a secretory compartment and is required for cell division plane determination in Arabidopsis biorxiv.org 2026-07-16 Positioning of the division plane is a critical step during cellular development.
Neuroanatomical Subtypes of Callous-Unemotional Traits in a Community Sample of Youth biorxiv.org 2026-07-16 Importance.