How specific structural differences of Bcl2 proteins modulate the interaction with BH3 domains and apoptotic function biorxiv.org 2026-07-17 Intrinsic apoptosis is mainly regulated through a network of conserved interactions between Bcl-2 proteins involving hydrophobic binding grooves and B
Multi-modal MRI characterisation of vascular remodelling, muscle fibre integrity, and inflammatory recovery in a hindlimb ischaemia mouse model biorxiv.org 2026-07-17 The hindlimb ischaemia (HLI) mouse model is a widely used preclinical model of chronic limb-threatening ischaemia (CLTI).
E-HAPLOS: Electrical Impedance Human-guided Assesment with Pressure for Lump Observation System biorxiv.org 2026-07-17 Breast cancer is the leading cause of cancer-related deaths among women in the Philippines.
Food Ration Affects mRNA Processing, Translation, Proteostasis, and Cytoskeletal Responses During Heat Shock in Mytilus californianus biorxiv.org 2026-07-17 Despite a likely role in setting stress tolerance limits, food ration has received limited attention as an ecological factor affecting the cellular st
Glial subcellular specialisation resolved with high resolution spatial transcriptomics biorxiv.org 2026-07-17 Cells in the brain have complex structures with extended processes.
Computational Counterfactuals Reveal Non-Additive Audiovisual Semantics in Natural Movie Responses biorxiv.org 2026-07-17 Natural audiovisual perception may not be fully captured by decomposing movies into auditory and visual streams.
Textural features for pathway-level representation of omics data in biological networks biorxiv.org 2026-07-17 More than 50 years ago, Haralick and co-authors proposed a family of gray-level co-occurrence statistics that became known as textural features.
Mapping absolute membrane voltage using dynamic photocycle control biorxiv.org 2026-07-17 Fluorescent voltage indicators are widely used to report relative changes in membrane potential, but mapping absolute voltages remains difficult.
Mechanosensation, habituation, and behavioural plasticity in tintinnid ciliates biorxiv.org 2026-07-17 Unicellular organisms sense, integrate and respond to environmental cues despite lacking neurons or a nervous system.
Excited state Relaxation Activation Energy (ESRAct) of Di-4-ANEPPDHQ Maps Nanoscale Molecular Organization in Biomembranes biorxiv.org 2026-07-17 Live cell plasma membranes show spatially heterogeneous liquid-ordered (Lo)-like and liquid-disordered (Ld)-like regions similar to the co-existing Lo
Coarse-grained simulations of long intrinsically disordered proteins: a benchmark of Martini 3 force-fields biorxiv.org 2026-07-17 Martini 3 is a force field ideally suited to simulating long intrinsically disordered proteins (IDPs) in cell-like surroundings.
Neural correlates of the subjective experience of free-will during value-based risky decisions: a pilot study biorxiv.org 2026-07-17 Underlying the very notion of choice is the fundamental idea of free-will, which is challenged by decision-neuroscience aiming to explain and predict
Multiscale learning and topological analysis across complex postures enable robust nematode size quantification in pharmacological assays biorxiv.org 2026-07-17 Body size is an important trait that reflects animal development and physiology.
Integrating activation-induced costimulation and cytokine signals enhance TCR-based cell therapies biorxiv.org 2026-07-17 TCR based cell therapies offer broad targeting of tumor antigens with high sensitivity but often low durability due to insufficient costimulation (sig
ITPKB is a conserved regulator of natural killer cell desensitization/education that constrains antitumor immunity biorxiv.org 2026-07-17 Natural Killer (NK) cell desensitization induced by persistent stimulation limits durable antitumor immunity, yet the molecular mechanisms governing t
Frequent errors are the worst: robustness to individual failures in collective foraging biorxiv.org 2026-07-17 The collective behavior of complex systems emerges from the actions and interactions of their individual components.
Recent social loss, not chronic isolation, reshapes sleep in Drosophila biorxiv.org 2026-07-17 Drosophila melanogaster is widely used to study social experience, yet it remains unclear whether sleep phenotypes attributed to isolation reflect chr
Turning an object into a scene: buildings activate scene-selective visual cortex independently of visual features biorxiv.org 2026-07-17 Human visual cortex contains regions that selectively respond to both scenes and large objects, particularly buildings.
Habitat specialization structures population divergence and demographic variation in Amazonian floodplain birds biorxiv.org 2026-07-17 Understanding how species respond to environmental change requires linking ecological traits to gene flow and demographic history across dynamic lands
Rapid expansion overcomes inbreeding in cross-hemisphere colonization of Barn Swallows biorxiv.org 2026-07-17 Switching migratory behavior appears to promote speciation in birds through colonization of their wintering grounds for breeding.
A hybrid approach combining a phylogenetic method and Approximate Bayesian Computation Random Forest for phylogenetic network inference: application to the rice domestication process in Asia biorxiv.org 2026-07-17 Asian rice is one of the best documented crops in terms of genetic diversity.
MetaboXcan: A multiomic framework linking genetically predicted metabolites, gene expression, and complex traits biorxiv.org 2026-07-17 Genetically regulated molecular phenotypes, such as gene expression and metabolites, are widely thought to mediate the effect of disease-relevant gene
Assembling and annotating the Tainung 67 rice genome to trace its japonica and indica ancestries biorxiv.org 2026-07-17 Here we reported the 409.0 Mb assembly of the Tainung 67 (TNG67) genome, an early hybrid of japonica and indica cultivars.
VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation biorxiv.org 2026-07-17 BAX is a major effector of mitochondrial apoptosis and is activated through a series of conformational transitions that lead to mitochondrial outer me
Glycosylation of anandamide and other bioactive N-acylethanolamines in mammalian cells and tissues biorxiv.org 2026-07-17 N-acylethanolamines (NAEs), including the endocannabinoid anandamide, are bioactive fatty acid amides that are normally hydrolyzed by fatty acid amide
Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models biorxiv.org 2026-07-17 The development of cancer immunotherapies requires preclinical models that capture intravenous delivery, immune cell recruitment and intratumoral T ce
Modelling phenotypic plasticity in cancer invasion and metastasis: from microscopic interactions to macroscopic dynamics biorxiv.org 2026-07-17 Cancer progression is driven by the interplay between cancer cell phenotypic variability regulated by EMT/MET, and cell-cell and cell-matrix interacti
It takes two to tango: evolutionary divergence and functional interplay of AZG1 and AZG2 cytokinin transporters biorxiv.org 2026-07-17 The evolution of complex plant body architectures required the refinement of hormone transport networks, yet the evolutionary origins and functional d
FIRST EVIDENCE OF PRESENCE OF RALSTONIA SOLANACEARUM IN THRIPS HAWAIIENSIS (THYSANOPTERA: THRIPIDAE) IN INDANG, CAVITE biorxiv.org 2026-07-17 Bugtok disease remains a major bacterial constraint of cooking banana production in the Philippines and is characterized by vascular discoloration, fr
Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint Restraining Streptococcus pneumoniae Invasion of Respiratory Epithelial Barriers biorxiv.org 2026-07-17 Streptococcus pneumoniae rapidly translocates across polarized human bronchial epithelial barriers, with viable bacteria recovered from the basolatera
Zinc Starvation Drives Respiratory Remodeling and Metabolic Adaptations Associated with Cystic Fibrosis in Pseudomonas aeruginosa biorxiv.org 2026-07-17 Host nutritional immunity restricts microbial growth by altering metal availability.
Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in Plasmodium falciparum biorxiv.org 2026-07-17 A complex transcriptional cascade drives the two-day intraerythrocytic developmental cycle of the most virulent human malaria parasite, Plasmodium fal
Exosome-mediated LNA anti-miR delivery achieves potent miR-21 inhibition and PTEN restoration in podocytes. biorxiv.org 2026-07-17 Background Podocyte injury and loss are central drivers of chronic kidney disease (CKD) progression and are involved in the majority of glomerular dis
Genetically interacting mutations and mechanical stress affect the stochasticity of developmental eye defects in yap1 mutants biorxiv.org 2026-07-17 Congenital abnormalities of eye formation show remarkably variable penetrance with phenotypes even varying between left and right eyes.
Absolute quantitative proteomics guides patient-stratified drug repurposing in clear cell and papillary renal cell carcinoma. biorxiv.org 2026-07-17 Background Renal cell carcinoma (RCC) is a highly heterogeneous disease in which distinct molecular subtypes exhibit characteristic genomic, metabolic
Cisplatin-Induced Plasticity Drives Cross-Resistance to CDK4/6 Inhibitors and Reveals Targetable Vulnerabilities Through HDAC Inhibition in Esophageal Squamous Cell Carcinoma. biorxiv.org 2026-07-17 Esophageal squamous cell carcinoma (ESCC) accounts for 90% of esophageal cancer cases worldwide and carries a poor prognosis, with overall survival be
Molecular organization of the Chlorella sorokiniana pyrenoid biorxiv.org 2026-07-17 To overcome the enzymatic limitations of Rubisco, algae operate CO2-concentrating mechanisms (CCMs) that deliver concentrated CO2 to Rubisco tightly p
Differential Metabolite Production Underlies Disruption of the Cystic Fibrosis Airway Microbiota by Pathogens biorxiv.org 2026-07-17 Cystic fibrosis (CF) is a multisystem disease characterized by the accumulation of mucus in the airways that promotes pathogen colonization, leading t
Age-Related Increases in 40Hz Neural Synchrony Are Specific to Typical Development: A Cross-Sectional Study of Autism Spectrum Disorder biorxiv.org 2026-07-17 Background: The 40Hz auditory steady-state response (ASSR) is a measure of gamma-band neural synchrony sensitive to excitation-inhibition (E/I) balanc
Deciphering the Streptococcus mutans essentialome: multi-omic resolution of hypothetical genes and identification of a functional RocS equivalent biorxiv.org 2026-07-17 Genome-wide viability catalogs produced by transposon sequencing (Tn-seq) and CRISPR interference (CRISPRi) have successfully mapped the essential gen
Stabilising effect of modularity in antagonistic networks depends on intraguild interactions biorxiv.org 2026-07-17 Existing literature on ecological networks provides valuable insights into the structure-stability relation of antagonistic, mutualistic or competitiv
Ultrafast light sensing mediated by dermal iridophores in the silverside fish Hypoatherina tsurugae biorxiv.org 2026-07-17 Light-induced body color changes and direct optical sensing in the skin of amphibians and fishes have been debated for more than half a century.
Decoding the oxytocinergic and behavioral signatures of milk ejection biorxiv.org 2026-07-17 Oxytocin-mediated milk ejection (ME) is pivotal to effective breastfeeding and productive health, yet behaviorally decoding and revealing neural mecha
Task-Based Value Generalization Correlates With Positive Overgeneralization and Bipolar Symptoms biorxiv.org 2026-07-17 Positive overgeneralization -- the tendency to generalize from specific successes to broad expectations of future reward -- has been linked to vulnera
Can the heartbeat-evoked potential (HEP) be separated from Cardiac Artefact (CA) using beamforming? biorxiv.org 2026-07-17 The heartbeat-evoked potential (HEP), a cortical response to heartbeats and a neural marker of interoception, is increasingly considered clinically re
Amplitude-Modulated Kilohertz Stimulation Targeting Beta-Band Activity Disrupts Motor Learning biorxiv.org 2026-07-17 Sensorimotor learning is associated with the modulation of neural rhythms in the primary motor cortex (M1).
Edge controllability is associated with treatment response to repetitive transcranial magnetic stimulation in depression. biorxiv.org 2026-07-17 Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), yet variability in treatment resp
Quorum sensing underlies the establishment and maintenance of marginal zone B cells biorxiv.org 2026-07-17 The marginal zone (MZ) of the spleen harbors B cells that play an indispensable role in immune defense, orchestrating rapid responses to blood-borne p
A machine learning model predicts protein stability of annotated and alternate protein isoforms biorxiv.org 2026-07-17 The regulation of protein stability is essential for cellular homeostasis and is determined by a combination of intrinsic sequence motifs and extrinsi
Targeting cellular senescence alleviates bone marrow aging biorxiv.org 2026-07-17 Aging of the hematopoietic system impairs hematopoietic stem cell (HSC) function and alters bone marrow niche behavior, increasing susceptibility to a