GDTR: Layer-wise Settling Depth Reveals Biological Grammar in Genomic Foundation Models biorxiv.org 2026-07-20 Genomic foundation models capture sequence regularities, yet existing interpretability tools rarely ask where in the layer stack a biological grammar
EBD-DTI: Episodic Bridge Diffusion for Zero-Shot Cold-Start Drug-Target Interaction Prediction biorxiv.org 2026-07-20 Predicting drug-target interactions (DTI) for entirely unseen drugs or proteins---the cold-start problem---remains a critical challenge in computation
Neocortical astrocyte diversity stems from distinct developmental origins biorxiv.org 2026-07-20 Key regulators of neural network activity in multiple advanced cognitive processes and essential components of the blood-brain barrier, astrocytes con
Diversity and evolution of the transcriptional regulatory networks of Pseudomonas strains revealed using machine learning biorxiv.org 2026-07-20 The genus Pseudomonas consists of diverse and ecologically significant species that form close associations with both plants and animals.
Patient-Derived Inner Ear Organoids as a Disease Modeling and Therapy Validation Platform For Hereditary Inner Ear Disorders biorxiv.org 2026-07-20 Background Hereditary inner ear disorders comprise a highly heterogenous group of disorders and are a major cause of hearing and vestibular dysfunctio
The Human Rectus Femoris Muscle Receives an Independent Common Synaptic Input During Isometric Leg Extensions biorxiv.org 2026-07-20 The distribution of common synaptic inputs across spinal motor neuron pools within and across synergist muscles reveals direct insight in the neural c
Rhythmic expression of a cAMP phosphodiesterase switches neuronal excitability states in the mammalian suprachiasmatic nucleus biorxiv.org 2026-07-20 How the transcriptome of a neuron determines its electrophysiological properties and how this change in different contexts are major questions in neur
Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology biorxiv.org 2026-07-20 Immunoproteasome induction is prominent in Alzheimers disease (AD), but whether it protects proteostasis or amplifies neuroinflammation remains unreso
Ferulic acid eicosyl ester enhances cognitive flexibility and modulates arousal-related neural circuits in mice biorxiv.org 2026-07-20 Cognitive deficits are a major contributor to disability in numerous neuropsychiatric and neurodegenerative disorders, yet effective pharmacological t
Ensembles of in silico structures enable T cell peptide-MHC binding prediction biorxiv.org 2026-07-20 Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC).
Development and behavior of Steinernema hermaphroditum nematodes are impacted by a bacterial flavin monooxygenase biorxiv.org 2026-07-20 Beneficial animal-microbe symbioses occur across the tree of life, with observable impacts on animal development and behavior.
Mutualisms as engines for rapid adaptation: Rhizobium evolution facilitates plant drought resistance biorxiv.org 2026-07-20 Mutualisms play critical roles in organismal stress tolerance; yet environmental stressors may simultaneously alter the evolution of the mutualism its
Large-scale single-cell mapping of concealed mitochondrial ageing biorxiv.org 2026-07-20 Mitochondrial DNA (mtDNA) mutations have been linked to ageing.
Learnable Graph Network Model (LGNM): A Physics Constrained Graph Neural Network with Quantum Hamiltonian Learning biorxiv.org 2026-07-20 Elastic Network Models (ENMs), particularly the Gaussian Network Model (GNM) and its distance-weighted variant (mENM), predict per-residue protein fle
DPCGS: a computational framework for linking GWAS to single-cell transcriptomics in complex traits and diseases biorxiv.org 2026-07-20 Complex traits and diseases arise from the interplay between genetic variation and cellular heterogeneity, making it essential to understand how genet
Advancing Plant Health in Sub-Saharan Africa: Understanding National Agricultural Research Institutions capacities for Strategic Investment Priorities to Boost Genetic Gains Against Crop Biotic Stress biorxiv.org 2026-07-20 Plant health research within National Agricultural Research and Extension Systems (NARES) represents a critical yet neglected pillar of agricultural r
Spatial MALDI-MSI Reveals a Coordinated Vicious Cycle of Oxidative Membrane Damage and Ceramide-Driven Sphingolipid Dysregulation in the Chronically Neuroinflamed Brain biorxiv.org 2026-07-20 Background: Chronic neuroinflammation is a major driver of cognitive decline, vascular cognitive impairment, and Alzheimer disease.
Computational simulations reproduce in vivo population receptive field mapping fMRI results biorxiv.org 2026-07-20 Population receptive field (pRF) mapping is widely used to characterize retinotopic organization based on functional magnetic resonance imaging (fMRI)
Sensory origin of oculomotor variability revealed by MT population activity biorxiv.org 2026-07-20 Motor outputs vary even in response to identical sensory inputs, yet the origin of this variability within the sensorimotor pathway remains unresolved
Factorization and spatial encodings: a hypothesis about the foundations of the genomic code biorxiv.org 2026-07-20 The genomic mechanisms that efficiently encode the initial architecture and synaptic connectivity of neural circuits remain poorly understood.
Pseudotyped virus-based platform and structural analysis reveal potential cross-reactivity sites between influenza C and D viruses biorxiv.org 2026-07-20 Influenza C (ICV) and influenza D (IDV) viruses belong to the Orthomyxoviridae family and are classified in the genera Gammainfluenzavirus and Deltain
A Lipocalin and a Hedgehog-related protein are partners in the C. elegans pre-cuticle apical extracellular matrix biorxiv.org 2026-07-20 Apical extracellular matrices (aECMs) line exposed body surfaces to shape tissues and protect them from the environment.
Clonal reproduction as a double-edged sword: antagonistic and synergistic effects on the warmed population maintenance of alpine species across successional stages of plateau zokor disturbance biorxiv.org 2026-07-20 A central question in biodiversity conservation under global change is whether species maintain viable populations under both mammal disturbance and c
High Connectivity, Local Signatures: Genomic and Otolith Evidence from Reef-Associated Snappers. biorxiv.org 2026-07-20 Connectivity in reef-associated fishes emerges from processes operating across multiple spatial and temporal scales, yet these processes are rarely ev
Divergent demographic strategies drive population dynamics of temperate plants across varying deposition biorxiv.org 2026-07-20 A central question in biodiversity conservation is whether species can sustain viable population under current and future atmospheric N deposition.
Semi-automated identification of southern right whales from drone imagery by classical image matching methods biorxiv.org 2026-07-20 Individual southern right whales (Eubalaena australis) can be identified from the callosity pattern on the head, a stable pattern of roughened keratin
Threatened species bycatch hotspots in the tropical Atlantic Ocean biorxiv.org 2026-07-20 Predicting bycatch patterns in tropical tuna purse seine fisheries remain challenging due to low variance explained by existing models, limiting their
Climate warming undermines the benefits of grazing removal for alpine plant population maintenance on the Tibetan Plateau biorxiv.org 2026-07-20 A central question in restoring degraded grasslands is whether grazing removal can sustain viable plant populations under both current and future warm
Decision analysis in support of proactive planning for chronic wasting disease in Vermont, USA biorxiv.org 2026-07-20 Chronic wasting disease (CWD), a fatal, transmissible disease in white-tailed deer (Odocoileus virginianus) and related species, is spreading across N
Evolutionary regimes determine the accuracy of epistasis inference from temporal genetic data biorxiv.org 2026-07-20 Epistasis, the non-additive effects of mutations, shapes fitness landscapes and evolutionary trajectories.
Damaging RBM20 E-rich domain variants are not rescued by gene replacement biorxiv.org 2026-07-20 The promise of precision therapeutics in genetic cardiomyopathies relies on linking specific therapies to variant mechanisms.
Monotremes provide novel insights into evolution of the DMRT gene family in vertebrates biorxiv.org 2026-07-20 Doublesex and mab-3 related (DMRT) genes encode a family of transcription factors central to sexual development across metazoa.
Drosophila Nepl15 controls glycogen and lipid storage by modulating insulin signaling biorxiv.org 2026-07-20 Deletion of the Drosophila-specific gene Neprilysin-like 15 (Nepl15) results in significant reductions in glycogen and glycerolipid storage in mutant
PanvaR: An R package for fine-mapping and visualizing results from genome-wide association studies biorxiv.org 2026-07-20 Genome-wide association studies (GWAS) use statistical models to correlate single nucleotide polymorphisms (SNPs) to a phenotype of interest.
Methyltransferases in Candidate Phyla Radiation: A Weapon or a Simple Shield? biorxiv.org 2026-07-20 The Candidate Phyla Radiation (CPR) consists of microorganisms with highly reduced genomes and limited metabolic capabilities, including the inability
Constructing a full-length single-nucleus transcriptomic atlas of the obese mouse by UURNA-seq biorxiv.org 2026-07-20 Single-nucleus RNA-seq (snRNA-seq) offers advantages in sample preparation for atlas construction and data mining of gene regulation.
Molecular basis of ubiquitin-independent recognition and degradation of ODC/Antizyme by the 26S proteasome biorxiv.org 2026-07-20 The ubiquitin-proteasome system represents the main pathway for targeted protein degradation in eukaryotic cells.
Identifying endogenous substrates of the 26S proteasome through site-specific photocrosslinking biorxiv.org 2026-07-20 The 26S proteasome is the hub for regulated protein turnover in eukaryotic cells.
ProteinDock: A physics-informed layer to improve protein-protein docking reliability biorxiv.org 2026-07-20 Computational modeling provides geometric insight into protein-protein interactions without requiring the resources of experimentation.
Metagenomic profiling of bacterial endosymbionts in wild mutant and permethrin-susceptible head lice shows an expanded microbiota in the resistant strain biorxiv.org 2026-07-20 Background Human head lice (Pediculus humanus capitis de Geer) are known to harbor diverse maternally inherited bacterial symbionts.
Inactivation of HIF-P4H-1 Stabilizes IKKα, Modulates Non-Canonical NF-κB Signaling, and Sensitizes Cancer Cells to Cell Death biorxiv.org 2026-07-20 Hypoxia and NF-kB signaling are well-established drivers of cancer progression and treatment failure, yet the oxygen-dependent regulation of non-canon
Antibody-drug conjugate combination therapy targeting LGR5 and MET with different payloads enhances efficacy in preclinical colorectal cancer models biorxiv.org 2026-07-20 Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a marker of cancer stem-like cells frequently upregulated in colorectal cancer (
FLD Is Required for N-Hydroxypipecolic Acid Accumulation and Associated Growth Defects in Arabidopsis pmr4 Mutant biorxiv.org 2026-07-20 The Arabidopsis mutants lacking the pathogen-inducible callose synthase POWDERY MILDEW RESISTANCE 4 (PMR4)/GLUCAN SYNTHASE-LIKE 5 (GSL5) exhibit enhan
TurboID-based proximity-dependent labeling using SOBIR1 as a bait in potato leads to the identification of novel defense-related signaling partners biorxiv.org 2026-07-20 The plant immune system comprises a complex signaling network that is activated upon perceiving molecules derived from invading pathogens.
Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors biorxiv.org 2026-07-20 How psychedelics act on cortical dendrites to produce long-lasting structural plasticity remains poorly understood.
The Physics Network is Distinct from the Multiple Demand System in the Human Brain biorxiv.org 2026-07-20 Recent studies implicate regions of the human bilateral fronto-parietal cortices in intuitive physical reasoning -- our ability to perceive, predict,
Enkephalin constrains fear learning via volume transmission to the lateral amygdala biorxiv.org 2026-07-20 Fear learning involves the formation of associations between cues and aversive outcomes, a process that must be tightly regulated to prevent excessive
Spectral organization of individualized connectome harmonics across brain structure, function and cognition biorxiv.org 2026-07-20 Connectome harmonics provide a spectral representation of structural brain connectivity that has emerged as a powerful framework for studying structur
Molecular and cell type-specific determinants of inferior colliculus development and auditory function biorxiv.org 2026-07-20 Sound perception requires sensory information processing through brain regions where alterations to cellular composition or function may impact audito
Deep learning representations of human Immune Health for precision immunology biorxiv.org 2026-07-20 The human immune system is composed of [~]30-50 distinct cell types, each of which can exist in different states of activation or differentiation.