Active histone modifications fine-tune DNA N-6 methyladenine deposition and maintain transcriptional stability biorxiv.org 2026-07-21 Epigenetic mechanisms provide sophisticated regulatory layers that modulate gene expression across diverse organisms, yet their organization and cross
De Novo Design of Protein Switches with Diffusion-Based Ensemble Sampling biorxiv.org 2026-07-21 Protein switches are proteins that can respond to biochemical stimuli by rearranging their structural elements, essential for cells to transduce signa
Cryo-EM structures of Alpha-Synuclein(31-100) amyloid fibrils reveal disease-like structural motifs without reproducing the Parkinson's Disease polymorph biorxiv.org 2026-07-21 The structural diversity of alpha-synuclein amyloid fibrils is closely linked to the pathogenesis of Parkinson's disease and related synucleinopathies
Localized Rigidification and Allosteric Modulation Mechanisms of SARS-CoV-2 Spike Neutralization by Class 3 and Class 4 Antibodies at Atomic Resolution: An Integrated Computational Study of Binding, Dynamics, and Allostery biorxiv.org 2026-07-21 The relentless evolution of SARS-CoV-2 and the emergence of highly antibody-evasive variants underscore the need to decipher the molecular principles
Enterococcus faecalis is involved in the progression of the early stages of latent chronic pancreatitis surrounding pancreatic cancer tissue biorxiv.org 2026-07-21 (Objective) In our previous research, we identified latent chronic pancreatitis in the normal tissue surrounding pancreatic cancer.
Caffeinated Coli: Inspiring the Next Generation of Scientists through Synthetic Biology biorxiv.org 2026-07-21 The Caffeinated Coli Educational Module brings inquiry-driven learning to high schools, introducing students to scientific research, synthetic biology
The HIV-1 restriction factor RPRD2 does not inhibit transcription of HIV-1 or endogenous retroelements biorxiv.org 2026-07-21 A vital question in transcription regulation is how and to what extent transcription of different DNA species, including viral DNA, episomal DNA and e
A Novel Plasmid-Encoded Mobile Colistin Resistance Gene mcr-13.1 Detected in Escherichia coli Isolated from Grassland. biorxiv.org 2026-07-21 Plasmid-encoded mobile colistin resistance (mcr) genes have raised concern due to dissemination potential.
Integrative structure determination of a human mitochondrial contact site and cristae organizing system (MICOS) sub-assembly biorxiv.org 2026-07-22 The Mitochondrial contact site and Cristae Organizing System (MICOS) complex is an inner mitochondrial membrane (IMM) assembly present at the cristae
Super-resolution imaging with deep learning-based segmentation for detailed characterization of mitochondrial arrangement in Pompe disease skeletal muscle biorxiv.org 2026-07-22 Pompe disease (glycogen storage disease type II) is an autosomal recessive lysosomal storage disorder characterized by progressive glycogen accumulati
Geometry-based dynamics of the postsynaptic density explain protein capture by an actin-spine-geometry-dependent synaptic tag biorxiv.org 2026-07-21 The synaptic tagging and capture (STC) hypothesis explains how early-phase plasticity is converted into its late phase through the coincidence of syna
Stable Network Homeostasis during Multi-Level Postnatal Maturation of the Mouse Tuberoinfundibular Dopamine-Prolactin Axis biorxiv.org 2026-07-21 The hypothalamus orchestrates endocrine function via specialized neuronal populations that interface with the pituitary gland.
Short-term dietary change rapidly remodels microbial community assemblages and reprogrammed systemic immune phenotypes biorxiv.org 2026-07-21 Diet is a major determinant of the gut microbiome and immune homeostasis, yet the extent to which short-term dietary interventions can remodel establi
Elicitation of stem-directed antibodies in rhesus macaques by a conventional hemagglutinin immunogen biorxiv.org 2026-07-21 Because they can bind many strains of influenza, antibodies targeting the hemagglutinin (HA) stem have been attractive targets for vaccine development
Progressive neuronal network reorganisation in glioblastoma drives pathological activity in vitro biorxiv.org 2026-07-21 Glioblastoma (GBM) is the most aggressive primary brain tumour and is frequently accompanied by severe neurological symptoms, including epilepsy and c
Transglutaminase 2 Deletion Enhances Astrocyte-to-Neuron Metabolic Support and Attenuates Subacute Pathology Following Repetitive Mild Traumatic Brain Injury biorxiv.org 2026-07-21 Mild traumatic brain injury (mTBI) is the most common form of central nervous system (CNS) injury and is often characterized by persistent neuroinflam
Microglia from Friedreich Ataxia patients are intrinsically primed for neuroinflammation biorxiv.org 2026-07-21 Friedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder characterized by progressive loss of cerebellar and proprioceptive neuro
Chemogenetic Inhibition of the Ventrolateral Orbitofrontal Cortex Disrupts Prediction Error and Salience-Guided Memory-Updating at the Hippocampal Engram Level biorxiv.org 2026-07-21 Rationale: Adaptive behavior requires revising existing memories when outcomes deviate from expectations.
Increased expression of Cd74 and MHC II genes by aortic macrophages links atherosclerosis with aging in mice biorxiv.org 2026-07-21 Atherosclerosis is a chronic inflammatory condition of the arteries leading to myocardial infarction, ischemic stroke and peripheral arterial diseases
Timed STING Inhibition Mitigates Gastrointestinal GvHD While Preserving Graft-versus-Leukemia Activity After Allo-HSCT biorxiv.org 2026-07-21 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is curative for hematological malignancies but limited by graft-versus-host disease (Gv
Plate-based ISD-SPE enables dual proteome-secretome concentration-response profiling of TLR signalling in iPSC-derived macrophages biorxiv.org 2026-07-21 Protein secretion represents a key functional output of cellular signalling, capturing dynamic responses to stimulation and pharmacological perturbati
Decadal tracking reveals species-specific limits to coral thermal acclimatization biorxiv.org 2026-07-21 Mass coral bleaching events driven by marine heatwaves are increasing in frequency and severity, yet the long-term recovery trajectories of surviving
Intrinsic ignition-based propagation networks reveal hierarchical propagation pathways of spontaneous activity in the human brain biorxiv.org 2026-07-21 Directed communication across brain regions is fundamental to human brain function, yet how local spontaneous activity links to directed whole-brain p
Temporal structure of postural sway reveals altered cortical postural coupling in aging and stroke: insights from nonlinear dynamics and state-space analysis biorxiv.org 2026-07-21 Background: Balance maintenance in humans is not only a mechanical process, but it also relies on continuous interactions between cortical activity an
Contribution of Wide Dynamic Range neuronal activation to somatosensory evoked potentials supports use as biomarker of spinal nociceptive processing biorxiv.org 2026-07-21 Identifying objective translational biomarkers of spinal nociceptive processing is important to accelerate analgesic development.
From Subconscious to Insight: Decoding the Incubation Process in Creative Problem Solving biorxiv.org 2026-07-21 Creative problem-solving is a fundamental aspect of human cognition, yet its underlying neural mechanisms remain incompletely understood.
Exploring the role of prior exposure and image quality in neural and behavioural prediction effects biorxiv.org 2026-07-21 According to predictive processing theories, the brain achieves efficiency in perception by comparing current sensory inputs with stored representatio
A scalable mesh microelectrode array platform for longitudinal electrophysiology in neural spheroids biorxiv.org 2026-07-21 Electrophysiological interfacing remains difficult in three-dimensional in vitro models, when using planar microelectrode arrays or optical methods.
Social agency buffers pain sensitivity during a critical window following spared nerve injury biorxiv.org 2026-07-21 Social buffering of pain, in which social contact blunts emotional or nociceptive intensity, is well established.
Engineering Oncolytic Measles Virus with MG53 Couples Pyroptotic Tumor Killing with Immune Microenvironment Remodeling to Enhance Checkpoint Immunotherapy in Non-small Cell Lung Cancer biorxiv.org 2026-07-21 Lung cancer is the leading cause of cancer-related mortality worldwide, with only approximately 30% of patients benefiting from current immune checkpo
Tumor-derived stearic acid induces macrophage Egr2 signaling to suppress anti-tumor immunity in breast cancer biorxiv.org 2026-07-21 Macrophages in breast cancer are highly heterogeneous and targeting both tissue-resident and bone marrow-derived macrophages represents a high-potenti
CITE-seq of murine bone marrow plasmacytoid dendritic cells and haematopoietic progenitor cells in sepsis biorxiv.org 2026-07-21 Abstract: This dataset contains single-cell transcriptomic and surface protein profiles of bone marrow cells enriched for plasmacytoid dendritic cells
Germinal center-independent memory B cells provide rapid protection from lethal influenza challenges biorxiv.org 2026-07-21 Memory B cell recall responses are crucial for rapid protection from pathogens expressing previously encountered antigens.
Expansion of Olfactory Receptor Family 14 Across Fossorial and Insectivorous Mammals biorxiv.org 2026-07-21 Mammals have incredibly diverse olfactory repertoires, reflected in significant copy number variation of olfactory receptor genes across species.
A hierarchical clock-mixture model for Bayesian phylogenetic dating biorxiv.org 2026-07-21 Conditioning the inference of a Bayesian phylogenetic time tree on a single molecular clock model treats clock choice as fixed, even when support amon
Molecular Basis of High-light Adaptation in Cyanobacteria and Cyanophages through the D1/D2 subunits of Photosystem II biorxiv.org 2026-07-21 High-light (HL) stress imposes substantial pressure on oxygenic photosynthesis by promoting the formation of reactive oxygen species (ROS) and photoda
Complex patterns of biological connectivity highlight risks of local depletion in an Australian fishery biorxiv.org 2026-07-21 Sustainable management of commercial and recreational fisheries depends on accurately resolving population connectivity, across both ecological and ev
Scalable single-cell isoform profiling with sequencing-by-expansion biorxiv.org 2026-07-21 Single-cell RNA sequencing has transformed our understanding of cellular systems, yet the reliance on short-read sequencing restricts analysis to gene
Extracellular vesicle associated nucleic acids and proteins as a complementary fraction for fish biodiversity monitoring and physiological signal recovery biorxiv.org 2026-07-21 Monitoring the biodiversity and physiological condition of aquatic organisms under environmental stress is central to aquatic ecosystem management.
Oleuropein stimulates peripheral serotonin secretion via voltage-dependent Ca2+ channels and acutely regulates central function biorxiv.org 2026-07-21 Serotonin (5-HT) is a monoamine which regulates not only central functions but also various peripheral functions.
An automated platform for spatial functional modeling and fingerprint analysis of tissue molecular landscapes biorxiv.org 2026-07-21 Spatial transcriptomics (ST) enables high resolution molecular profiling while preserving tissue architecture, creating new opportunities to investiga
Stratified Immune Profiling Uncovers Prognostic Heterogeneity Beyond MYCN Amplification and Age in Neuroblastoma biorxiv.org 2026-07-21 Neuroblastoma is the most common extracranial solid tumor in children, presenting remarkable clinical heterogeneity with survival outcomes ranging fro
Thymus Involution across the Human Menstrual Cycle biorxiv.org 2026-07-21 Importance: Thymic involution in humans has traditionally been conceptualized as a linear, age-associated process.
Slow stress-load accumulation dominates BDNF-dependent gain in a ten-state computational model of stress biochemistry biorxiv.org 2026-07-21 Background.
Co-option of CENP-A for activity-induced neuronal plasticity biorxiv.org 2026-07-21 Neuronal activation drives activity-dependent gene expression that underlies experience-associated synaptic modifications, learning and memory.
Estimating trial-wise modulation of functional connectivity using event-related fMRI biorxiv.org 2026-07-21 Understanding the neural basis of human cognition requires measuring not only localized brain activity but also how functional interactions between br
GeneAutomate: A Browser-Based, Integer-Indexed Platform for Dual-Gene-List Functional Annotation and Interactive Network Visualization biorxiv.org 2026-07-21 Comparative interpretation of two gene lists, for example, two treatment arms, two tissues, or a discovery and a validation cohort, is a routine task
COSMOS: A FAIR-aligned infrastructure for clinical trial data validation, warehousing, and interactive discovery biorxiv.org 2026-07-21 The Clinical Omics System for Metadata and Outcome Storage (COSMOS) is an open-source, FAIR- and GCP aligned clinical trial unit (CTU) infrastructure
Extracellular Matrix Proteomic Signatures Associate with Disease-Free Survival in Later Events of Ductal Carcinoma In Situ or Invasive Breast Cancer biorxiv.org 2026-07-21 Background: Ductal carcinoma in situ (DCIS) is a noninvasive breast lesion with variable risk of progression to invasive breast cancer (IBC).
HDAC3 inhibitor RGFP966 acts on the NF-kB pathway and enhances memory persistence in a biphasic manner biorxiv.org 2026-07-21 Nearly five decades ago, it was first observed that long-term memory consolidation requires waves of transcriptional activity and protein synthesis, w