Early life adversity disrupts adult social reward motivation biorxiv.org 2026-07-22 Early life adversity can produce persistent changes during development that increase vulnerability to neuropsychiatric disorders.
Cognitive impairments in a mouse model for Huntington's disease correlate with presymptomatic locomotion and number of CAG repeats biorxiv.org 2026-07-22 Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene.
Reprogramming protein interfaces between adenylation and carrier protein domains in nonribosomal peptide synthetases biorxiv.org 2026-07-22 Nonribosomal peptide synthetases (NRPSs) assemble structurally diverse bioactive natural products through selective communication between adenylation
Cyclic-Phe-Pro Binds the ToxRS Interface to Promote Signal Transduction in Vibrio vulnificus biorxiv.org 2026-07-22 In Vibrio vulnificus, the quorum-sensing signal cyclo-(L-phenylalanine-L-proline) (cFP) binds the membrane receptor ToxRS to activate genes linked to
A domain-swapped proPC1/3 structure reveals a conformational checkpoint for ER export biorxiv.org 2026-07-22 Prohormone convertase 1/3 (PC1/3, encoded by PCSK1) is a serine protease expressed in neuroendocrine cells that is required to produce insulin, glucag
Post-loading ribonucleic acid into lipid nanoparticle carriers biorxiv.org 2026-07-22 Lipid nanoparticles (LNPs) are effective carriers for messenger ribonucleic acid (mRNA) delivery in vaccines; however, their reliance on extreme cold
Polyvinylpyrrolidone enhances AAV transduction in vitro and shows preliminary utility for subretinal delivery biorxiv.org 2026-07-22 Adeno-associated virus (AAV) vectors are widely used for gene delivery, but inefficient transduction can require high vector doses.
The Role of Secondary Chordae Tendineae in Mitral Valve Mechanics: A Benchtop Study biorxiv.org 2026-07-22 Purpose: Secondary chordae tendineae (CT) are frequently disregarded during mitral valve (MV) repair.
Tunable Laminar Perfusion Coordinates Endothelial and Perivascular Remodeling in Angiogenic Vasculature-on-Chip biorxiv.org 2026-07-22 Perfusable vascular microphysiological systems are increasingly used to model angiogenesis, tissue crosstalk, and disease.
On-demand, reversible blood-brain barrier opening via electrical activation of piezoelectric nanoparticles for targeted brain drug delivery biorxiv.org 2026-07-22 Delivering therapeutics to the brain remains one of the most persistent challenges in medicine, because the blood-brain barrier (BBB) excludes over 98
Topical Activatable Fluorescence Probes for Rapid Intraoperative Detection of Peritoneal Dissemination in High-Grade Serous Ovarian Carcinoma biorxiv.org 2026-07-22 Background: Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic malignancies, largely because most patients are diagnosed at an adva
Whole transcriptome analysis reveals ELK3 as a key driver of metastasis through regulation of 3D migration and stemness in triple-negative breast cancer cells biorxiv.org 2026-07-22 Metastasis is the leading cause of mortality in breast cancer and remains largely untargeted therapeutically.
A Modular, AI-assisted Digitization Toolkit for Resource-Constrained Herbaria: A Case Study from Zimbabwe biorxiv.org 2026-07-22 Herbaria serve as invaluable spatio-temporal repositories of plant diversity information.
Dynamic holocentric genomes facilitate divergent evolutionary paths through chromosomal rearrangements, hybrid dysfunction, and recombination suppression biorxiv.org 2026-07-22 Theory predicts chromosomal rearrangements (CRs) to promote reproductive isolation and local adaptation by disrupting meiosis and altering recombinati
The systemically induced sugar transporter SWEET11 regulates growth-defense trade-offs during Serendipita indica symbiosis in Arabidopsis biorxiv.org 2026-07-22 Sugar exchange at the root interface is a pivotal process governing the establishment and stability of plant-fungal symbioses.
Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease biorxiv.org 2026-07-22 Cerebral Small vessel disease (cSVD) is a prevalent feature of Alzheimer's disease (AD) pathology.
Segregation and integration between visuo-spatial attention and semantic memory across large-scale brain networks biorxiv.org 2026-07-22 Visuo-spatial attention and semantic memory are supported by distinct, largely competing brain networks, yet they are frequently engaged together in d
Neural-vocal phase coupling reveals structured timing in birdsong production biorxiv.org 2026-07-22 Understanding how neural population activity is temporally coordinated with behavior remains a central challenge in neuroscience.
Mechanisms regulating combination effect of antibody-drug conjugates and cancer immunotherapy biorxiv.org 2026-07-22 Background.
Flux-species sampling enables holistic exploration of biocircuit behavior biorxiv.org 2026-07-22 Biocircuit behavior is usually discovered by drawing uncertain kinetic parameters and simulating, but the scored phenotypes are functions of steady-st
Early life adversity shapes adult behavior in a free-ranging primate biorxiv.org 2026-07-22 Early life adversity (ELA) causes lasting psychological and behavioral consequences in humans, with parallel stress and fear responses observed in cap
AI-guided Protein Inhibitor Design for Modulating FAD-dependent Glucose Dehydrogenase Redox Output biorxiv.org 2026-07-22 Flavin adenine dinucleotide-dependent glucose dehydrogenase (FAD-GDH) is a redox enzyme widely used in glucose monitoring, bioelectronic devices, and
Rational Redesign of an Fc-Binding Peptide for Multivalent Antibody Assembly biorxiv.org 2026-07-22 Multivalent antibody assemblies offer opportunities to enhance avidity, organize immune complexes, and modulate higher-order protein interactions, but
Acute Increase of Excitatory Activity in Pyramidal Neurons of Rat Motor Cortex under Static Magnetic Field biorxiv.org 2026-07-22 Objectives: Transcranial application of a static magnetic field (SMF) was reported to result in subsequent modulation of neural excitability in the hu
Multilevel engineering of cyanobacterial energy metabolism advances photosynthetic hydrogen production while revealing its constraints biorxiv.org 2026-07-22 Hydrogen (H2) is a promising sustainable energy carrier, and its direct production from photosynthetic water splitting is appealing.
Surprise gates two distinct mechanisms to support memorability in music biorxiv.org 2026-07-22 Music is a uniquely memorable human creation that, when skillfully composed, can persist in individual memory (as in e.g., earworms) and cultural tran
A lethal human H5N5 influenza virus isolate exhibits low pandemic risk traits biorxiv.org 2026-07-22 In fall of 2025, a fatal infection of highly pathogenic avian influenza (HPAI) virus H5N5 occurred.
AI4Life Open Calls and Public Challenges: why, how, and what we have learned. biorxiv.org 2026-07-22 Within AI4Life, we ran three Open Calls and three Public Challenges (2023-2025), supporting 22 bioimage analysis projects from 151 applications and en
Direct measurement of in vitro response to Praziquantel in Schistosoma mansoni populations from Western Kenya biorxiv.org 2026-07-22 Large-scale treatment with praziquantel (PZQ) monotherapy is used to control schistosomiasis, leading to concerns about the emergence of PZQ-resistanc
Colonization of 3D-organotypic human skin by the Lyme Disease pathogen, Borrelia burgdorferi biorxiv.org 2026-07-22 Borrelia burgdorferi is a bacterial pathogen transmitted by ticks that is the causative agent of Lyme Disease. When studying interactions between B.
The sympathetic nervous system initiates liver regeneration biorxiv.org 2026-07-21 Within hours of injury to the liver, signals from damaged hepatocytes activate Kupffer cells, inducing the production of inflammatory cytokines and pr
Disentangling the temporal signatures of conditioned pupil dilation: Distinct valence- and prediction-error-related components revealed by mega-analysis biorxiv.org 2026-07-21 Pupil dilation offers a sensitive, non-invasive window into the neurocognitive processes supporting human associative learning.
Rat mediodorsal thalamic subdivisions differentially modulate the sensory and affective components of pain through distinct prefrontal pathways. biorxiv.org 2026-07-21 The mediodorsal thalamus (MD) modulates pain through thalamocortical regulation of the mPFC.
Whole-Brain, Region-Specific Astrocyte Reactivity and Morphological Remodeling After Diffuse Traumatic Brain Injury in A Gyrencephalic Ferret Model biorxiv.org 2026-07-21 Traumatic brain injury (TBI) triggers pathological cascades that evolve across acute, subacute, and chronic phases.
Posterior insula oscillations are not modulated by changes in perceived intensity: Evidence from human intracerebral EEG biorxiv.org 2026-07-21 The human insular cortex is involved in a multitude of processes essential for survival, but its precise role in pain perception remains debated.
Experimental validation of graded arithmetic and linguistic working-memory tasks using behavioral and cerebral hemodynamic measures biorxiv.org 2026-07-21 Graded cognitive tasks are relevant only when increasing nominal difficulty produces measurable changes in performance and a convergent physiological
3D genome remodelling underlies PU.1-dependent granulocyte maturation biorxiv.org 2026-07-21 PU.1 is an ETS-domain transcription factor that has critical roles in many aspects of hematopoiesis and immune cell fate and function.
A novel IL-1β reporter assay identifies tolcapone as a caspase-1 suppressor targeting pyroptosis in endotoxemia biorxiv.org 2026-07-21 Unconventional protein secretion mediated by gasdermin D (GSDMD) pores is essential for the release of pro-inflammatory cytokines such as interleukin-
Bioactive produced by Enterococcus Faecalis targets IL-23 signalling and protects against colitis and joint disease biorxiv.org 2026-07-21 The IL-23/Th17 axis is a central driver of intestinal and spondyloarthritic inflammation, yet upstream regulatory mechanisms linking microbial signals
A preclinical resistance framework discovers the virulence risks of antibiotics in development biorxiv.org 2026-07-21 Several new antibiotics target multidrug-resistant pathogens, yet resistance is still evaluated mainly by drug-susceptibility, leaving consequences fo
Species-dependent antifungal profiles reveal stronger yeast inhibition by chitosan than by a sulfate-containing polysaccharide-rich extract from Jania adhaerens biorxiv.org 2026-07-21 Yeast infections are becoming an increasing public health concern, mainly due to the spread of opportunistic species and the emergence of strains resi
Rod pathway blockade improves visual function in a mouse model of photoreceptor degeneration biorxiv.org 2026-07-21 Retinitis pigmentosa (RP) refers to a group of inherited photoreceptor degenerations characterized by the initial death of rods and secondary loss of
Environmental history shapes host-associated dynamics of sporulating and non-sporulating bacterial subpopulations during infection biorxiv.org 2026-07-21 Host-associated environments represent ecological contexts that can structure microbial population dynamics, yet their effects on sporulating pathogen
Conserved lifestyle-associated chromosome architectures across mammalian symbionts biorxiv.org 2026-07-21 Bacterial chromosome biology has largely focused on bacteria that are either free-living or facultatively associated with eukaryotes.
Cryptosporidium sequentially remodels its single rhoptry into the host interface biorxiv.org 2026-07-21 The apicomplexan parasite Cryptosporidium is a leading cause of diarrheal disease in young children.
Conserved folds enable immune antagonism across the tree of life biorxiv.org 2026-07-21 Many components of human innate immunity are conserved in prokaryotes.
Salmonella SiiE-mediated apical invasion into colonocytes depends on MUC1 α2,3-linked sialic acids biorxiv.org 2026-07-21 MUC1 is a highly O-glycosylated cell-bound mucin that plays key roles in intestinal mucosal maintenance and microbe-host interactions.
RNA degradation by ribonuclease T2 is required for phosphate homeostasis in S. cerevisiae biorxiv.org 2026-07-21 Inorganic phosphate (Pi) is a critical building block for key biomolecules including ATP, DNA, RNA, and phospholipids.
Evolution of informed dispersal strategies in trophic meta-communities biorxiv.org 2026-07-21 Living organisms move and their movement is both a response to local conditions and, often, the cause of change in those conditions.
The genetic architecture of maize yellow mosaic virus resistance in corn biorxiv.org 2026-07-21 Maize yellow mosaic virus (MaYMV) is an emerging polerovirus of corn and other grass species.