Evolutionary Dynamics of the Complete Chemosensory Repertoire in Kissing Bugs of the Genus Rhodnius: Divergent Odorant Receptors Contrast with Conserved Gene Families biorxiv.org 2026-07-10 Chemosensory systems play a central role in host detection, feeding behavior, and habitat selection in hematophagous insects.
Integrating Bottleneck Size into Selection Tests for Biological Diversity Data biorxiv.org 2026-07-10 Population bottlenecks profoundly shape genetic diversity, but distinguishing stochastic drift from selective pressure requires precise estimation and
AAV VP1 unique region (VP1u) determines GPR108 dependence for AAV transduction of human airway epithelium and its rescue by Doxorubicin biorxiv.org 2026-07-10 rAAV2.5T was identified through directed evolution of an AAV capsid library in polarized human airway epithelium (HAE) cultured at an air-liquid inter
Diverse and novel lanthanide-binding PQQ-dependent enzymes biorxiv.org 2026-07-10 First described pyrroloquinoline quinone-dependent (PQQ) eight-bladed {beta}-propeller proteins are calcium (Ca)-dependent, but many homologous bacter
A nitrite-responsive regulatory RNA locus sustains commensal resilience against nitrosative stress biorxiv.org 2026-07-10 Commensal microbes in the gastrointestinal tract are central to host health, yet they must adapt to frequent perturbations such as intestinal inflamma
Microcystin-Driven Control of the Carbon-Concentrating Mechanism Shapes CO2 Fixation Dynamics in Microcystis aeruginosa PCC 7806 biorxiv.org 2026-07-10 Bloom-forming cyanobacteria thrive in highly dynamic light environments, yet the mechanisms enabling rapid acclimation to fluctuating irradiance remai
Iron Metabolism and Adaptative Traits Associated with Virulence in Enterobacter cloacae Complex biorxiv.org 2026-07-10 Iron is an essential micronutrient that shapes host pathogen interactions during infection.
Chronic Disease Emergence in Coevolving Social Networks via Behavioral Feedback and Demographic Turnover biorxiv.org 2026-07-10 Chronic diseases emerge within social systems where individuals reorganize their ties, adapt their behaviors, and turn over through demographic proces
Transformer models of mutation risk at base-pair resolution identify non-coding hotspot cancer driver mutations biorxiv.org 2026-07-10 Recurrent somatic mutations reveal cancer drivers, but in whole genomes many non-coding hotspots are passengers generated by localized mutational proc
Concerted evolution and unorthodox recombination of human subtelomeres biorxiv.org 2026-07-10 Human subtelomeres contain duplicated sequence that is shared among the ends of non-homologous chromosomes and provides a substrate for ectopic exchan
An endogenous retrovirus insertion disrupting bovine ALKBH8 causes a failure-to-thrive syndrome with immunodeficiency associated with juvenile mortality in Brown Swiss cattle biorxiv.org 2026-07-10 The Brown Swiss (BS) cattle breed is one of the major Swiss dairy breeds.
Evolutionary dynamics of Aegilops revealed through comparative genome assembly of all 25 species biorxiv.org 2026-07-10 Aegilops species are the closest wild relatives of wheat and an important reservoir of genetic diversity for its improvement.
Allosteric Gating Mechanism Regulates Odorant Selectivity and Antagonism in Odorant Receptors biorxiv.org 2026-07-10 Odorant receptors (ORs) belong to class A G protein coupled receptors that detect diverse small molecules, yet the steps that link odorant association
Impact of chemotherapy on leukocyte stiffness -A longitudinal RT-DC study in a breast cancer patient biorxiv.org 2026-07-10 Background: The physical properties of leukocytes, such as cell size and stiffness, are critical for their circulation in microcapillary networks wher
Mechanism of fatty acid uptake and inhibition in human FATP2 biorxiv.org 2026-07-10 Fatty Acid Transport Protein 2 (FATP2) couples fatty acid uptake to intracellular activation and is associated with pathological lipid accumulation in
Discovery of non-nucleoside inhibitors of the enterovirus D68 3D polymerase through crystallographic fragment and high-throughput biochemical screening biorxiv.org 2026-07-10 Enterovirus D68 (EV-D68) is a non-polio picornavirus that has caused increasing rates of severe respiratory illness and acute flaccid myelitis in chil
Selenium-enriched rapeseed extract synergizes with chemotherapy drug cisplatin in inhibiting proliferation and promoting apoptosis of colorectal cancer cells biorxiv.org 2026-07-10 Chemotherapy treatment of colorectal cancers (CRC) using cisplatin (CDDP) encounters problems of drug resistance by the cancer cells and cytotoxicity
PLAGUE: Improved confidence plasmid reconstruction from short read assemblies biorxiv.org 2026-07-10 As the vast majority of archival data is short-read based, reliable strategies for detecting and classifying plasmids out of these data are still need
Laboratory evolution enhances resilience of a symbiont yeast and its honeybee host against agrochemical exposure biorxiv.org 2026-07-10 Yeasts are key microbial members of several ecosystems. Yet, the impact of widespread chemical pollutants on yeasts is only sparsely studied.
Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity biorxiv.org 2026-07-10 Influenza virus poses a potential risk of triggering the next global pandemic.
Age-Related Differences in Bimanual Coordination Are Associated with Increased Cerebellar Activity and Reduced Frontal Recruitment biorxiv.org 2026-07-10 Bimanual coordination declines in late adulthood, but the neural mechanisms underlying these changes remain unclear.
Individual differences in post-encoding sleep continuity predict context memory accuracy and supporting ERPs in younger and older adults biorxiv.org 2026-07-10 Post-encoding sleep plays an essential role in episodic memory consolidation.
Restricted MHC-II trafficking in Mycobacterium tuberculosis-infected M2-like macrophages limits CD4+ T cell activation biorxiv.org 2026-07-10 Recognition of infected macrophages by CD4+ T cells is essential to immune protection against Mycobacterium tuberculosis (Mtb), the causative agent of
AI-Informed neoantigen prioritization enables a multi-epitope mRNA/LNP vaccine with antigen-specific immunogenicity and antitumor activity biorxiv.org 2026-07-10 Personalized neoantigen vaccines are an emerging strategy for cancer immunotherapy, but their effectiveness depends on selecting tumor-specific antige
A rhizobial extracellular vesicle-conveyed auxin transporter mediates phytohormone mobilization and optimizes rhizobium-legume symbiosis biorxiv.org 2026-07-10 Bacterial extracellular vesicles (bEVs) are emerging as key players in interkingdom communication, yet their role in delivering functional proteins to
SigA forms amyloid fibrils and supports the competition of Shigella with the microbiota biorxiv.org 2026-07-10 Shigella sonnei is an enteropathogen that causes bacillary dysentery.
Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV biorxiv.org 2026-07-10 Background: People with HIV (PWH), despite effective antiretroviral therapy (ART), experience disrupted intestinal homeostasis characterized by microb
Regulatory memory and growth-coupled inheritance shape nutrient-dependent flagella number variation in Salmonella biorxiv.org 2026-07-10 Bacteria must balance the advantage of movement against the cost of building flagella, yet how nutrient availability shapes variation in flagellar num
Data-driven oscillatory network modeling with condition-dependent coupling laws: Identifying directed neural interactions in working memory attention dynamics biorxiv.org 2026-07-10 Learning new information in the presence of distracters and changing conditions requires the ability to adapt.
A metacognitive response of the face and the heart in rats biorxiv.org 2026-07-10 Humans make emotional facial expressions and have a cardiac response when they catch themselves in a mistake or receive feedback about task performanc
Prior experience establishes a proactive cortical filter that blocks redundant associations biorxiv.org 2026-07-10 Prior experience allows selective learning by filtering out redundant cues, as exemplified by blocking, in which prior learning about one cue prevents
Dopamine Compensates for Amyloid-Induced Default Mode Network Dysfunction to Support Learning biorxiv.org 2026-07-10 Throughout the preclinical phase of Alzheimer's disease (AD) {beta}-amyloid (A{beta}) accumulates preferentially within the default mode network (DMN)
The interplay between detection and localization in human vision biorxiv.org 2026-07-10 Fixational eye movements (FEMs) comprise the involuntary small scale eye motion conducted during fixation on a stationary stimulus.
Genetic context alters central nervous system compartment dependent responses to lipopolysaccharide biorxiv.org 2026-07-10 Systemic inflammation drives neurodegeneration, yet its differential effects across neural tissues and genetic backgrounds remain poorly understood.
Akkermansia muciniphila-derived LPS links gut dysbiosis to pathogenic miR-21 signaling in experimental autoimmune encephalomyelitis. biorxiv.org 2026-07-10 Multiple sclerosis (MS) is a chronic T cell-mediated autoimmune disease characterized by blood-brain barrier (BBB) disruption, neuroinflammation, and
Single-cell analysis of pre-rRNA in Escherichia coli indicates distinct pathways of action for YbeX and YbeY proteins in ribosome biogenesis biorxiv.org 2026-07-10 The Escherichia coli protein YbeX/CorC is encoded in the same operon as the ribosome biogenesis factor YbeY, and its deletion leads to accumulation of
Non-coding DNA dictates cell size and impairs fitness by sequestering RNA polymerase biorxiv.org 2026-07-10 Genome size varies greatly between organisms, largely because of varying amounts of non-coding DNA.
Chemogenetic timestamping for the precise tracing of cell history into protein assemblies biorxiv.org 2026-07-10 Self-assembling protein fibers enable to record events in single cells, bypassing the need for long-term time-lapse imaging.
Pollination responses to artificial light at night may vary with lighting arrangement biorxiv.org 2026-07-10 Artificial light at night (ALAN) can alter the movement of nocturnal pollinators such as moths, with potential consequences for pollination services.
Kernelized approach enables explainable gene prioritizations for complex traits biorxiv.org 2026-07-10 Genome-wide association studies (GWAS) have identified numerous variant-trait associations; yet, assigning effector genes to GWAS loci remains challen
Enhanced proteome relative quantification using refined quantotypic spectral libraries biorxiv.org 2026-07-10 Plasma proteomics is used for a variety of applications including biomarker discovery, disease monitoring, and drug development.
Simulations show increased lipid interdigitation in transmembrane coupling of protein condensates biorxiv.org 2026-07-10 Liquid-liquid phase separation of proteins has been observed to occur on biological membranes, where it is thought to play a role in diverse cellular
A single chromosome 3p break initiates clear cell renal cell carcinoma evolution biorxiv.org 2026-07-10 Clear cell renal cell carcinoma (ccRCC) is initiated by chromosome 3p loss, yet chromosome losses impose a profound fitness burden on normal cells.
Hormone-dependent receptor docking controls calcium channel activity in plants biorxiv.org 2026-07-10 The phytohormone auxin is a central coordinator of plant growth and development.
Interspecific transfer of specialized metabolites in root exudates coincides with root chromatin regulation and systemic chemical defenses in rice biorxiv.org 2026-07-10 Benzoxazinoids are a paradigmatic class of indole-derived specialized metabolites released into the soil through root exudates and originally studied
Quantification of cardiac-locked brainstem velocity at high resolution based on retrospectively-gated DENSE MRI at 7T biorxiv.org 2026-07-10 Purpose: The motion of the brain tissue within the skull is thought to be induced by cardiac pulsations and other hemodynamic processes and may influe
Voluntary oral fentanyl intake produces dose- and sex-dependent physical dependence in mice without overt affective disturbances biorxiv.org 2026-07-10 The ongoing opioid epidemic underscores the need for scalable and translational preclinical models of voluntary opioid intake and dependence.
N-Methyl-D-Aspartate receptors control in vivo striatal calcium and the updating of action policy biorxiv.org 2026-07-10 Animals must execute learned behaviors and update them when outcomes change, yet the neural substrates controlling this phenomenon are not fully under
The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infection biorxiv.org 2026-07-10 Tonate virus (TONV) is a neglected mosquito-borne alphavirus of the Venezuelan equine encephalitis complex associated with febrile illness, encephalit
Molecular-level analysis of serum IgG repertoires in COVID-19-vaccinated people with cystic fibrosis identifies abundant convergent antibodies biorxiv.org 2026-07-10 Background: People with cystic fibrosis (pwCF) are at increased risk of severe disease following respiratory viral infections including influenza and