Insulin synthesis is sustained by Tent5 poly(A) polymerases biorxiv.org 2026-07-10 Insulin is an essential regulator of glucose homeostasis in vertebrates, and impairment of its synthesis or action leads to diabetes with severe healt
Cardiomyocytes possess an intrinsic catecholaminergic machinery that regulates cellular homeostasis and electrophysiological stability biorxiv.org 2026-07-10 BackgroundCatecholamines play a central role in cardiac performance, coordinating myocardial contractility, conduction, metabolism, and electrophysiol
Semi-automated reconstruction of glomerular architecture from 3D confocal microscopy data biorxiv.org 2026-07-10 Nephrons are the functional units of the kidney; within each nephron, the glomerulus is the initial site of selective filtration that allows removal o
Neuropeptide Y4 receptor activation delays autoimmune diabetes by reprogramming β-cell stress and immune tolerance biorxiv.org 2026-07-10 Type 1 diabetes (T1D) involves immune-mediated destruction of pancreatic {beta}-cells, yet current disease-modifying therapies mainly target immunity
TLR7 Signaling Regulates Embryonic Hematopoietic Stem Cell Development by Sensing microRNA-146a in Vertebrates biorxiv.org 2026-07-10 The specification of hematopoietic stem cells (HSCs) is tightly regulated by multiple transcription factors and signaling pathways.
Sulfoquinovosylacylpropanediol monotherapy suppresses canine hemangiosarcoma patient-derived xenograft models with vascular remodeling biorxiv.org 2026-07-10 Canine hemangiosarcoma (HSA) is an aggressive endothelial malignancy with limited therapeutic options, and its progression is closely associated with
Physioxia Reprograms Glioblastoma Cells Enhancing Migration and Altering Therapeutic Sensitivity biorxiv.org 2026-07-10 Background/ObjectivesGlioblastoma is an aggressive primary brain tumor that develops within a chronically low-oxygen microenvironment, yet most precli
Peer-Led Leadership, Mentoring and Promotion: Conversations Among Female Academics from South Africa, Ghana and the United Kingdom biorxiv.org 2026-07-10 The focus was on leadership, mentoring and promotion.
The Drosophila FET orthologue Cabeza is an essential cofactor for ETV4-mediated activation of GGAA microsatellite neoenhancers biorxiv.org 2026-07-10 The conversion of transcriptionally silent GGAA microsatellites (GGAASats) into functional enhancers by FET::ETS oncogenic fusions is a hallmark of Ew
Deconvolving the spatiotemporal chromatin landscape through the cell cycle biorxiv.org 2026-07-10 Profiling genomic processes during the cell cycle is challenging because synchronized populations gradually lose synchrony as individual cells progres
The atypical RHO-GTPase RND3/RHOE interacts with FLRT3 to regulate cortical migration and folding biorxiv.org 2026-07-10 Cortical gyrification, characterized by the formation of sulcal fissures and gyral peaks, is a distinctive feature of large mammalian brains and is as
Integrative multiomics profiling of cortical brain organoids reveals a druggable alternative splicing program in schizophrenia biorxiv.org 2026-07-10 Clozapine (CLZ) is the only available pharmacological option for treatment resistant schizophrenia (TRS), but its use is limited due to adverse drug r
Parvalbumin and somatostatin interneurons support distinct computations during auditory scene analysis biorxiv.org 2026-07-10 Auditory scene analysis requires cortical circuits to preserve target-sound representations while suppressing interference from competing sound source
Neurophysiological Evidence for Reduced Use of Prior Sound Patterns to Shape Speech Processing in Autism biorxiv.org 2026-07-10 Reported perceptual differences in autism may arise from reduced use of prior context to shape incoming sensory input.
Learning the wiring rules of a mammalian cortical column biorxiv.org 2026-07-10 Characterization of neural circuits' architecture typically relies on measurable neuronal features such as morphology, molecular identity, and spatial
Human medial temporal lobe neurons link future reward coding with intertemporal choice and impulsivity biorxiv.org 2026-07-10 The ability to delay gratification emerges early in life and is linked to long-term health and economic success.
Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study biorxiv.org 2026-07-10 Inhibitory control matures progressively from childhood to early adulthood, yet the neural mechanisms driving this development and their relevance to
Correlation analysis of changes in the expression of C1qtnf superfamily genes in the hypothalamus, thymus, and lungs against the background of chronic social stress during the development of Lewis lung adenocarcinoma in mice biorxiv.org 2026-07-09 It has been previously shown that chronic social defeat stress caused by paired agonistic interactions between male mice is accompanied by the develop
Abbapolin inhibitors of the PLK1 PBD as Prostate Cancer Therapeutics, in vivo activity and synergy with androgen therapy biorxiv.org 2026-07-09 Polo-like kinase 1 (PLK1), a key regulatory protein controlling entry into and passage through mitosis, has been targeted through its kinase domain (K
Radioligand therapy in combination with CAR T cells overcomes the heterogeneous immunosuppressive prostate tumor microenvironment biorxiv.org 2026-07-09 177Lu-PSMA-617 (PluvictoTM, Lu-177 RLT) is an FDA-approved targeted radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCR
Rhpn2 promotes zebrafish melanoma development and aggressiveness in vivo biorxiv.org 2026-07-09 Melanoma, one of the most metastatic and multidrug resistant cancer, is the first leading cause of death from skin cancer.
Multi-omics, organoid-based modeling reveals an SRC/mTOR-dependent fetal-like stem cell trajectory in colorectal cancer biorxiv.org 2026-07-09 BackgroundSingle-cell atlases have described diverse stem cell states in colorectal cancer (CRC), however, the overarching trajectories of those state
A plasmodesmata-specific exocyst complex regulates symplastic connectivity by affecting callose turnover biorxiv.org 2026-07-09 Plasmodesmata are intercellular channels that mediate symplastic communication between plant cells.
Editing Efficiency Across Crop Families: A Systematic Review and Meta-Analysis of CRISPR/SpCas9 Knockout Outcomes in Cucurbitaceae, Brassicaceae, Solanaceae and Poaceae biorxiv.org 2026-07-09 Reported CRISPR/SpCas9 editing efficiencies in crops span 0-100%, but no quantitative synthesis has separated taxonomic family from delivery method, p
Scalable biophysical constraints for physiologically consistent metabolic states biorxiv.org 2026-07-09 Systems biology aims to develop predictive models that connect molecular mechanisms to cellular behavior.
HnRNPAB-targeted antisense oligonucleotides ameliorate tau pathology and cognitive deficits by modulating Alzheimers disease-associated alternative splicing biorxiv.org 2026-07-09 Aberrant alternative splicing alters multiple disease-associated splicing events, including MAPT exon 10 inclusion linked to tau pathology, and thereb
Fibronectin Coating of Tissue Culture Polystyrene to Improve Superficial Zone Chondrocyte Expansion biorxiv.org 2026-07-09 The surface layer of articular cartilage provides for low-friction joint movement and protects the tissue from mechanical wear.
Bone Marrow Mesenchymal Stem Cells Therapy for Premature Ovarian Insufficiency: A Systematic Review and Meta-analysis of Preclinical Studies biorxiv.org 2026-07-09 BackgroundPremature ovarian insufficiency (POI) affects approximately 1% of women under 40 and is characterized by elevated levels of gonadotropins, r
Atonosomes, compartments involved in membrane tension decrease biorxiv.org 2026-07-09 To ensure survival, cells need to buffer the effects of environmental stress on their plasma membrane, yet the structural mechanisms by which this is
Optic cup folding is driven by the geometry and tension of the Retinal Pigmented Epithelium (RPE) cells biorxiv.org 2026-07-09 While optic cup folding is known to involve specific geometrical changes of RPE cells, the precise gene regulatory mechanisms orchestrating the adopti
Rapamycin Mitigates a Sex-biased Convergent Aging Trajectory biorxiv.org 2026-07-09 Rapamycin extends lifespan across species, yet its cell-type-specific benefits and vulnerabilities remain unclear at whole-organism scale.
Apoptosis-induced self-renewal of neurogenic progenitors safeguards retinal development against extensive cell loss biorxiv.org 2026-07-09 Developing embryos have a striking ability to buffer external and internal perturbations.
AptCancerDB: A Curated Knowledgebase and Translational Discovery Platform for Anticancer Aptamers biorxiv.org 2026-07-09 Aptamers are emerging as important molecular recognition ligands in oncology, playing significant roles in cancer diagnostics, targeted therapies, dru
Functional Data Analysis of Spatial Clustering Identifies Prognostic T Cell Patterns in Ovarian Cancer biorxiv.org 2026-07-09 Spatial proteomic imaging technologies enable the simultaneous assessment of immune cell abundance and spatial organization within the tumor microenvi
Single-cell multi-omics analysis reveals heterogeneity and plasticity of neutrophil states in response to immunotherapies biorxiv.org 2026-07-09 BackgroundTumor-associated neutrophils (TANs) are emerging as functionally heterogeneous and plastic cells in the tumor microenvironment.
Machine Learning Gap-Fills Missing Transporter Kinetics in Biosystems Across Scales biorxiv.org 2026-07-09 Understanding transporter kinetics is essential for deciphering metabolite exchanges in biosystems, particularly for cells subject to substrate gradie
Multi-layered regulatory networks driving human dopaminergic neuron differentiation biorxiv.org 2026-07-09 Neuronal differentiation requires coordinated regulation across chromatin organization, gene expression, protein abundance, and post-translational mod
Differentiable Design for Morphogenesis I: Simulation and Simulacra biorxiv.org 2026-07-09 Cells build tissues through local exchanges of force and information, yet the rules governing these interactions are difficult to infer from sparse ob
A pipeline for identifying small noncoding RNA (sRNA) candidates in bacteria biorxiv.org 2026-07-10 Bacterial small non-coding RNAs (sRNAs) are central post-transcriptional regulators, yet their computational identification suffers from high false-po
Regulation of Human Erythroferrone Expression biorxiv.org 2026-07-09 Erythroferrone (ERFE) is an erythroblast-secreted hormone that suppresses hepatic hepcidin expression to increase iron availability for erythropoiesis
The nucleolus is a mechanosensitive condensate that adapts ribosome biogenesis to mechanical forces biorxiv.org 2026-07-10 Intracellular compartmentalization is fundamental to cellular organization, yet mechanobiology has been largely understood through membrane-delimited
Dynein-microtubule forces drive nucleokinesis and transmigration in T cells biorxiv.org 2026-07-09 Beyond the mechanical capacity of canonical actomyosin-driven amoeboid motility in permissive extracellular environments, the nucleus becomes the prin
Organ-resolved endothelial regulatory programs link aging and metabolic overload to vascular immune remodeling biorxiv.org 2026-07-09 Systemic aging and metabolic overload remodel the vasculature; however, how endothelial cells integrate these stresses across organs remains unclear.
Transmembrane aminopeptidase Q (Taqpep) is a common mechanism in the establishment of periodic patterning in skin and intestine biorxiv.org 2026-07-09 Periodic patterns are a frequent motif in biology that occurs across diverse tissues and species.
Domain Insertion Improves the Precision of a CRISPR Adenine Base Editor biorxiv.org 2026-07-10 Adenine base editors (ABEs) enable efficient A*T to G*C conversion, but their broad activity windows frequently cause unintended bystander edits.
Gene Supplementation of MYO7A or activation of Myo7b for treatment of Usher syndrome 1B biorxiv.org 2026-07-10 Mutations in MYO7A result in the most severe subtype of Usher syndrome, the leading genetic cause of deafblindness.
Volatile diacetyl triggers rapid fmo-2 expression through DHAP-glycerol shunt induction biorxiv.org 2026-07-10 C. elegans can locate ephemeral food sources by sensing bacterially-derived volatiles.
Extracellular Vesicles Derived from Activated Dendritic Cells Loaded with Curcumin Promote Early Activation-associated Functional and Molecular Reprogramming of Primary CD8+ T Cells biorxiv.org 2026-07-09 Extracellular vesicles (EVs) derived from activated dendritic cells (DCs) are promising cell-free mediators capable of shaping CD8+ T-cell responses.
A druggable ATP13A3-antizyme switch controls adaptive polyamine uptake in cancer biorxiv.org 2026-07-09 Cellular polyamine depletion is a promising anticancer strategy, but compensatory polyamine uptake limits efficacy when synthesis is blocked by DFMO (
K63-linked ubiquitin chains mark inactive Smoothened for packaging into ciliary extracellular vesicles biorxiv.org 2026-07-09 Signaling receptors can exit cilia either by retrieval back into the cell or by secretion in extracellular vesicles (EVs), a process known as ectocyto