Mechanoresponsive modulation of nuclear pore complex structure and function by O-GlcNAc biorxiv.org 2026-07-08 Nuclear pore complexes (NPCs) control molecular exchange across the nuclear envelope, but how they tailor their selective permeability to meet the nee
CCN3-derived peptide BLR-200 impairs YAP activation and attenuates bleomycin-induced skin fibrosis through blocking the generation of Sfrp2-positive fibroblasts biorxiv.org 2026-07-08 An autocrine pro-adhesive/pro-contractile signaling loop, through the mechanosensitive transcriptional cofactor YAP, promotes fibrosis.
Regulated apoptosis is a conserved mechanism pausing female reproduction and establishes the sterile worker caste in the eusocial wasp, Polistes biorxiv.org 2026-07-08 Female reproduction is an energetically expensive process, so species evolve to balance survival with reproductive output.
Cetacean Mammals of the Black and Azov Seas as Indicators of Habitat Quality via Stacked Species Distribution Models biorxiv.org 2026-07-08 Habitat degradation and biodiversity loss in the Black and Azov Seas necessitate improved tools for spatially explicit conservation planning.
Anthropogenic-driven loss of an adaptive radiation reduces thermal response diversity biorxiv.org 2026-07-08 Biodiversity is predicted to stabilize ecosystems if species have different environmental responses.
Evolutionary diversification of lipid logistics shapes synaptic maturation in primates biorxiv.org 2026-07-08 The prolonged developmental trajectory of the human brain is a hallmark of our evolution; however, the cellular mechanisms underlying this delay remai
Current challenges in GWAS integration and fine-mapping for variant interpretation biorxiv.org 2026-07-08 Over the past two decades, genome-wide association studies (GWAS) have identified thousands of trait- and disease-associated loci.
EpiBinder: a multimodal framework for cell-type-specific prediction and interpretation of transcription factor binding biorxiv.org 2026-07-08 Transcription factor (TF) occupancy in vivo depends not only on the underlying DNA sequence but also on the local epigenetic environment, which varies
Interface swapping orchestrates carbon transfer in the archaeal acetyl-CoA decarbonylase/synthase biorxiv.org 2026-07-08 The Wood-Ljungdahl pathway is one of biology's most ancient routes for carbon fixation and energy metabolism, used by organisms such as methanogenic a
Sonification of Elephant Infrasound biorxiv.org 2026-07-08 Elephants and other large mammals produce low-frequency vocalizations extending well below the 20 Hz lower limit of human hearing, a regime known as i
Beyond infinite sites: Generalized ABBA-BABA statistic for deeper phylogenies biorxiv.org 2026-07-08 The Patterson's D statistic detects gene flow from ABBA-BABA site patterns, but its biallelic site patterns fail under deeper divergences where multip
Origin of Fe ions in ROS production induced in magnetic hyperthermia anti-cancer nanotherapy: release from iron oxide nanoparticles or not? biorxiv.org 2026-07-08 The first and critical reaction in magnetic hyperthermia to induce the death of cancer cells is the production of ROS (reactive oxygen species).
Toward pharmacologic therapy for glioblastoma: Characterization of the very long-chain acyl-CoA synthetase 3 (ACSVL3) inhibitor Grassofermata biorxiv.org 2026-07-08 Malignant brain tumors are among the most aggressive and difficult to treat human cancers.
Model-Dependent Renal Phenotypes in Diabetic Kidney Disease: Comparative Histopathological Characterization of Commonly Used Animal Models biorxiv.org 2026-07-08 Background: Diabetic kidney disease (DKD) remains a leading cause of end-stage renal disease worldwide, characterized by progressive structural and me
Involvement of Mitophagy in Endothelin-1 Mediated Neurodegeneration in Rodent Models of Glaucoma biorxiv.org 2026-07-08 The ultimate cause of blindness in glaucoma is the death of retinal ganglion cells, and understanding the mechanism behind retinal ganglion cell loss
An Integrated Knowledge Graph and Network Medicine Pipeline for Drug Repurposing: Benchmarking Across Human Diseases and Application to Amyotrophic Lateral Sclerosis biorxiv.org 2026-07-08 Drug repurposing offers a practical strategy to identify new therapeutic uses for approved drugs, potentially reducing the time and cost associated wi
DNA-FISH Metaphase Spreads to Distinguish Extrachromosomal DNA from Homogeneously Staining Regions in Human Cancer Cell Lines biorxiv.org 2026-07-08 Whole-genome sequencing identifies focal DNA amplifications with base-pair resolution but cannot determine whether amplified sequences reside on extra
Perspectives in conducting task-based research in pediatric surgical epilepsy patients biorxiv.org 2026-07-08 Objective: Pediatric epilepsy patients undergoing stereo-electroencephalography (sEEG) for ictal onset evaluation provide a rare window to study the d
Dose and sex-specificity in Canagliflozin-mediated neuroprotection in aging mice biorxiv.org 2026-07-08 Canagliflozin (Cana), an SGLT2 inhibitor prescribed for type 2 diabetes, extends median lifespan by 14% in male but not female UM-HET3 mice at 180 ppm
Cold Shock Domain Protein LIN-66 cooperates with microRNA-pathway buffering to safeguard developmental timing biorxiv.org 2026-07-08 Robust execution of developmental cell fates requires precise spatiotemporal control of the fate-defining regulators.
Should I stay or should I go? Modelling the decision-making process behind ungulate partial migration biorxiv.org 2026-07-08 Despite the ecological importance of ungulate migrations, we lack a complete understanding of why some ungulates migrate and others do not.
Temperature and ecomorphology linked to blood pathogen incidence in neotropical amphibians biorxiv.org 2026-07-08 While emerging diseases pose a global threat to amphibians, the dynamics of understudied vector-borne blood pathogens remain poorly understood.
Hepatic stearoyl-CoA desaturase deficiency ameliorates hyperglycemia through bile acid signaling in an insulin-independent manner biorxiv.org 2026-07-08 Hyperglycemia in Type 1 Diabetes (T1D) is managed almost exclusively via exogenous insulin therapy, an approach restricted by significant glycemic flu
Consistency Analyses of Open-source Software for Motor Unit Decomposition Using High-density Electromyography Signal biorxiv.org 2026-07-08 Motor unit (MU) decomposition using high-density surface electromyography (HD-sEMG) has been widely used to characterize MU behavior in neurophysiolog
When Color Adds Nothing: A Causal Audit of Channel Triplication in Alzheimer's MRI Classification biorxiv.org 2026-07-08 Medical imaging pipelines routinely copy single-channel grayscale data into three identical RGB channels before classification, usually without justif
CD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates β-thalassemia model biorxiv.org 2026-07-08 Clinical evidence demonstrates that ex vivo gene therapy and genome engineering of hematopoietic stem and progenitor cells (HSPCs) could represent one
Differences between suspended and sinking particles regulate carbon flux in the upper mesopelagic during a Phaeocystis Bloom biorxiv.org 2026-07-08 Despite decades of research, the factors determining the sinking velocity of marine biogenic particles remain poorly constrained, and growing evidence
Night-to-night sleep EEG variability over one year biorxiv.org 2026-07-08 This study aimed to explore night-to-night variability of multiscale sleep patterns by analyzing subcutaneous electroencephalography (sqEEG) from 20 h
A Comprehensive Analysis Comparing Isotropic ADC to BOLD-fMRI: Sensitivity to Resting State Networks and Grey to White Matter Functional Connectivity biorxiv.org 2026-07-07 While Blood Oxygenation Level-Dependent (BOLD) fMRI remains the gold standard for mapping functional brain networks with MRI, its vascular origins inh
De novo missense variants in TRIM28 identified in individuals with neurodevelopmental delay show features of transposable element activation biorxiv.org 2026-07-07 TRIM28 is an epigenetic co-repressor protein that silences transposable elements (TEs).
Phasic arousal sharpens, rather than amplifies, goal-dependent feedback control biorxiv.org 2026-07-07 Voluntary movements tolerate variability that does not threaten the goal: when reaching toward a wide target the hand can drift sideways, whereas a na
Rheumatoid Arthritis-associated IgG N-glycan agalactosylation diminishes neutrophilic inflammation by reducing FcgammaR binding and downstream signaling biorxiv.org 2026-07-07 The IgG Fc chain carries a single N-linked glycan which may undergo changes.
PSGL-1 blockade delays relapse to BRAF/MEK inhibition in cutaneous melanoma biorxiv.org 2026-07-07 Advanced BRAF-mutant cutaneous melanoma can be treated with targeted therapy when immune checkpoint inhibitors (ICIs) fail or are not a feasible optio
NK-like and networked CD8+ T cell immunity mediates exceptional HIV control biorxiv.org 2026-07-07 Durable treatment-free remission remains a defining goal for people living with HIV (PLWH).
Ancient and current association of the Trichinella complex with negative-sense and double-stranded RNA viruses biorxiv.org 2026-07-07 The earliest records of Trichinellosis might be found in bibles that recommend against pork consumption due to the spread of a disease that resembles
Reverse genetics and comparative pathogenesis of Lone star virus. biorxiv.org 2026-07-07 Lone star virus (LSV) is a bandavirus first isolated from Amblyomma americanum ticks in the United States (U.S.) and is phylogenetically related to se
Progressive Lineage Restriction of Bergmann Glia-like Progenitors during Postnatal Cerebellar Development biorxiv.org 2026-07-07 Bergmann glia-like progenitors (BGLPs) are transient astroglial progenitors in the postnatal cerebellum, but how their lineage potential changes durin
Humans use optimal eye movements to facilitate mental rotation of objects biorxiv.org 2026-07-07 The ability to mentally rotate objects is a fundamental feature of human cognition, and humans can use this ability to make choices about objects base
Masitinib is an oral, brain penetrant inhibitor of microglial and mast cell activity with neuroprotective potential in progressive forms of multiple sclerosis biorxiv.org 2026-07-07 Introduction: Progressive multiple sclerosis (MS), including primary progressive MS (PPMS) and non-active secondary progressive MS (nSPMS), remains an
Optical pooled screening of a bacterial transposon mutagenesis library biorxiv.org 2026-07-07 Transposon mutagenesis is a powerful method to create deep libraries of genetically diverse cells.
A foundation model enables prediction of natural product molecular properties, bioactivity, and structural similarity from biosynthetic gene cluster sequence biorxiv.org 2026-07-07 Genome mining is a powerful technique in natural product discovery, where biosynthetic gene clusters that are likely to produce novel or desirable nat
The molecular triggers of human labour: a longitudinal plasma proteomics study biorxiv.org 2026-07-07 Spontaneous labour onset is a precisely timed physiological transition that determines outcomes for millions of pregnancies annually, yet its upstream
Plasmid-encoded host reprogramming promotes plasmid dissemination biorxiv.org 2026-07-07 Conjugative plasmids are major drivers of antibiotic resistance dissemination, yet how newly transferred plasmids establish in recipient cells remains
Detrimental effects of advanced glycation end-products (AGEs) on a human neuromuscular junction co-culture model biorxiv.org 2026-07-08 The neuromuscular junction (NMJ) is a specialised synapse between motor neurons and skeletal muscle, and its progressive deterioration contributes to
Nuclear-BRITE: an enhanced MS2 system for live-cell imaging of nuclear RNAs biorxiv.org 2026-07-08 The MS2 system has been widely adopted for live-cell single molecule imaging of mRNA, but is of limited applicability for RNAs present in the cell nuc
The immediate cellular response to whole-genome doubling is conserved across polyploid contexts biorxiv.org 2026-07-08 Polyploid cells, which contain more than two copies of the genome, are widely present across plants and animals, where they are often found in tissues
Regulation of de- and reciliation by KRAS during muscle cell differentiation biorxiv.org 2026-07-07 The primary cilium has been implicated in multiple developmental processes, such as cell migration and asymmetric cell division of stem- and progenito
Population dynamics of Arctic phytoplankton and mycoplankton reveal chytrid-mediated diatom bloom termination biorxiv.org 2026-07-08 Chytrids are unicellular fungi that infect and degrade phytoplankton as parasites or saprotrophs.
Herbivores and pathogens can modulate plant population responses to future climate conditions biorxiv.org 2026-07-08 Climate change is expected to alter plant populations not only through direct environmental shifts but also via changes in biotic interactions, such a
Short-term forecasts of Aedes aegypti relative abundance to enhance mosquito control situational awareness biorxiv.org 2026-07-07 Conventional mosquito surveillance typically relies on contemporaneous data, making it challenging to anticipate future vector surges.