Nuclear adenosine metabolism defines a metabolic vulnerability unmasked by TP53 loss biorxiv.org 2026-07-07 Metabolic adaptation is essential for cells experiencing chronic genomic stress, yet how such adaptations are organized at the nuclear level remains p
Distinct colorectal cancer genotypes shape microbial ecosystems and reveal stage-specific microbiota dependencies biorxiv.org 2026-07-07 The gut microbiota has emerged as an important modifier of colorectal cancer (CRC), yet how tumor genotype influences host-microbiota interactions and
Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis biorxiv.org 2026-07-07 Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity; however, metabolic reprogramming within the tumor microenvironment often com
Metallothionein loss in cancer cells contributes to increased mutations through defective DNA repair and metabolic imbalance biorxiv.org 2026-07-07 Understanding which genes are involved in mutagenesis is essential for developing cancer prevention and treatment strategies; establishing protectors
Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability biorxiv.org 2026-07-07 Dissecting how metabolite availability impacts drug sensitivity is critical for understanding therapy resistance.
LsGCRPred: lncRNA-SNP regulated gene expression-based breast and ovarian cancer risk prediction model biorxiv.org 2026-07-07 Long non-coding RNAs (lncRNAs) and single nucleotide polymorphisms (SNPs) within them play crucial role in cancer susceptibility and disease outcomes.
Dosimetric Characterization and Workflow Optimization of the FLASH-SARRP for Reliable Preclinical Radiobiological Studies biorxiv.org 2026-07-07 Objective: Preclinical small-animal irradiators such as the FLASH-SARRP can support the advancement of photon-FLASH toward the clinic.
From Phenomics to Genomics: Macro-GWAS of Almond Morphology and Quality biorxiv.org 2026-07-07 In plant breeding and genetics, recent advances in high-throughput phenotyping are beginning to meet the growing demand for large-scale, high-quality
Mineral geochemistry and mycorrhizal allocation define root architectural strategy during early vascular plant colonization biorxiv.org 2026-07-07 The emergence of vascular plants on land is one of evolution greatest triumphs.
Specialized layer 5 cortical terminals target functional thalamic spines biorxiv.org 2026-07-07 Dendritic spines are ubiquitous morpho-functional elements of excitatory synaptic transmission and plasticity.
Trisomy 21 cerebral organoids exhibit Alzheimer's disease amyloid and apolipoprotein E co-pathologies biorxiv.org 2026-07-07 Adults with Down syndrome (DS) develop Alzheimer's disease (AD) brain pathology by age 40 due to triplication of the Amyloid Precursor Protein (APP) g
Structural connectivity of auditory-linguistic brain networks predicts success in speech categorization and listening in noise biorxiv.org 2026-07-07 Successful speech perception requires listeners to bin continuous acoustic information into discrete phonetic categories.
Selective convergence and graded divergence of hippocampal and amygdala subregions using functional connectivity biorxiv.org 2026-07-07 The hippocampus and amygdala are neighboring medial temporal lobe structures linked to memory and affect, yet how their subregions are jointly embedde
FCRL5 is a fucose-sensitive IgG-Fc receptor with binding properties distinct from classical Fcγ receptors biorxiv.org 2026-07-07 Fc receptor-like protein 5 (FCRL5) is a low-affinity IgG receptor expressed on B cells, with emerging therapeutic relevance due to its expression on m
A Multidimensional Analysis of the Bimodal Piperaquine Response in Plasmodium falciparum biorxiv.org 2026-07-07 Malaria remains a pressing global health challenge, with the continued emergence of resistance threatening the long-term efficacy of artemisinin-based
SLC16A6 is a tyrosine transporter for the melanosome biorxiv.org 2026-07-07 Cells enable specialized metabolism by compartmentalizing metabolic pathways into distinct organelles, which requires the membrane transport of metabo
Unbranched SPIN90-Arp2/3 actin promotes stress fiber speed and focal adhesion maturation biorxiv.org 2026-07-07 The Arp2/3 complex has long been considered to only assemble branched actin structures in the cell (lamellipodia, endocytic patches, comet tails, and
ATG-9-Induced Lysosomal Membrane Permeabilization and Cell Death in a Caenorhabditis elegans model of Mucolipidosis type IV biorxiv.org 2026-07-07 Mucolipidosis type IV is a lysosomal storage disease that is characterized by delayed psychomotor development and retinal degeneration due to cell dea
Structural Mechanism of Filamentation Induced Dampening of GTP Inhibition of Glutamate Dehydrogenase biorxiv.org 2026-07-07 Glutamate dehydrogenase (GDH) is a highly regulated key enzyme that catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate
An allosteric pocket in KV1.3 defines a distinct chemical space for immunomodulator design biorxiv.org 2026-07-07 KV1.3 is a validated autoimmune drug target, yet all disclosed inhibitors converge on a narrow set of conserved binding sites, suffering from poor sel
Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite biorxiv.org 2026-07-07 During an immune response, metabolism changes dramatically.
Injectable Electrospun Hydrogel with Antimicrobial, pH Sensing Nanoparticles for Local Infection Control and Monitoring biorxiv.org 2026-07-07 Most antimicrobial drug candidates currently in development are derivatives of established antibiotic classes.
Molecular Clock Dating of Ancient Environmental DNA Reveals Damage Beyond Deamination biorxiv.org 2026-07-07 Ancient environmental DNA (aeDNA) from permafrost, lake, cave, and marine sediments provides a rich source of genetic data that captures broad perspec
Data-informed modelling captures metabolic reprogramming and reveals branch points mediating cold stress response and growth trade-offs in rice biorxiv.org 2026-07-07 Understanding stress-induced metabolic reprogramming in crop plants can inform breeding strategies and support the development of stress-resilient var
Pyramidal neuron synapses in M2 exhibit properties intermediate between prefrontal cortex and M1 synapses biorxiv.org 2026-07-07 Motor planning and control is executed by different motor areas within the neocortex.
Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer's disease using NULISA technology biorxiv.org 2026-07-07 Background: Alzheimer's disease (AD) is clinicopathologically heterogeneous.
High Dimensional Immune Profiling Reveals CD39 as a Correlate of Tuberculosis Disease Severity biorxiv.org 2026-07-07 Immune biomarkers of tuberculosis (TB) disease severity present a challenging area of research that remains poorly understood.
The glucocorticoid dexamethasone influences motility of the sulfate-reducing bacterium Desulfovibrio desulfuricans by targeting the filament cap protein FliD biorxiv.org 2026-07-07 Glucocorticoids such as dexamethasone (DXE) are first-line treatments for inflammatory bowel disease (IBD).
Zn2+ as a secondary messenger for exogenous redox potential sensed through Chemosensory Zinc-Binding (CZB) protein domains biorxiv.org 2026-07-07 Redox environments in nature are shaped by reactive oxygen species (ROS), oxygen availability, and metal ion chemistry, and exert profound effects on
Cas12a-Targeted Multiplexed Nanopore Sequencing biorxiv.org 2026-07-07 Targeted long read sequencing (LRS) of native genomic DNA (gDNA) using Oxford Nanopore Technologies (ONT) is an economically and computationally acces
Culture-Free Rapid Phenotypic Antimicrobial Susceptibility Testing for Helicobacter pylori Based on Fluorescence Rapid On-Site Evaluation Technology: A Preliminary Study biorxiv.org 2026-07-06 Background: Phenotypic antibiotic susceptibility testing (AST) for Helicobacter pylori (H.
Cross-Resistance Limits the Ability of Antimicrobial Peptide Combinations to Delay Resistance Evolution biorxiv.org 2026-07-06 Aims: Antimicrobial peptide (AMP) combinations have been proposed to delay resistance evolution, but it remains unclear what properties of a peptide p
First community challenge for automated virus taxonomy biorxiv.org 2026-07-06 The rapid rate of virus discovery renders manual curation by taxonomy experts increasingly impractical, creating a need for reliable software that can
There is no convincing evidence that Methylobacterium extorquens AM1 can produce N-deoxyschizokinen A biorxiv.org 2026-07-06 It was recently reported that Methylobacterium extorquens AM1 produces the citrate-hydroxamate siderophore N-deoxyschizokinen A, identified by LC-HRMS
Adaptation of Pseudomonas aeruginosa to the lung allograft environment in cystic fibrosis lung transplant recipients biorxiv.org 2026-07-06 Lung transplantation (LT) is the ultimate treatment option for patients suffering from end stage cystic fibrosis (CF).
Combinatorial community coalescence in early tomato assembly reveals a rhizosphere attractor in composition and abundance architecture biorxiv.org 2026-07-06 The rhizosphere microbiome plays fundamental roles in plant health and productivity, yet the ecological rules governing microbiome assembly remain poo
Virus-driven tRNA competition universally represses host genes with similar codon usage biorxiv.org 2026-07-06 Viral infection induces tRNA competition between viral and host genes, often repressing host translation.
Fitness flux in SARS-CoV-2 and influenza H3N2 biorxiv.org 2026-07-06 The tempo of viral adaptation is usually read indirectly from the composition of mutations, through measures such as dN/dS.
Multimodal temporal mapping of macrophage transcriptome remodeling during Salmonella infection biorxiv.org 2026-07-06 Macrophages are equipped to eliminate invading pathogens, yet several intracellular bacteria exploit them as replicative niches.
Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis biorxiv.org 2026-07-06 Cryptococcus neoformans is the predominant causative agent of cryptococcal meningitis in immunocompromised individuals.
EDTA v2: enabling scalable TE annotation in animal genomes biorxiv.org 2026-07-06 The Extensive de-novo TE Annotator (EDTA) automates transposable element annotation in plant genomes but lacks direct LINE/SINE detection, limiting it
Benchmarking AlphaFold and related deep learning approaches for modeling antibody and TCR antigen recognition biorxiv.org 2026-07-06 Determining the structural basis of antigen recognition by antibodies and T cell receptors (TCRs) provides critical insights into effective immune tar
Scop3P in 2026: an expanded proteomics-informed resource contextualizing phosphorylation sites through sequence, structure, mutation, and experimental provenance biorxiv.org 2026-07-06 Protein phosphorylation is a central regulatory mechanism controlling protein activity, interactions, and cellular signalling, and its dysregulation i
FORGE reveals an information spectrum encoded in RNA tertiary-structure geometry biorxiv.org 2026-07-06 Coarse RNA coordinate representations are increasingly used for inverse folding and structural annotation, but the biological information encoded in s
Accurate ΔTm Prediction Without Protein Structure Inputs for Biomolecular Stability biorxiv.org 2026-07-06 Predicting protein stability, like changes in melting temperature ({Delta}Tm) caused by mutations, is a critical task in therapeutic protein engineeri
Integrated analysis of ribosomal DNA copy number and methylation using nanopore long-read sequencing biorxiv.org 2026-07-06 Ribosomal RNA (rRNA) provides the structural and catalytic core of ribosomes and is encoded by ribosomal RNA genes (rDNA) arranged in tandem repeat ar
SpliSync: Genomic language model-driven splice site correction of long RNA sequencing reads biorxiv.org 2026-07-06 Long RNA sequencing reads are rapidly replacing short reads in transcriptomic analyses, enabling full-length transcript sequencing and better identifi
Solvent-buffer effects in molecular dynamics simulations of nucleic acids biorxiv.org 2026-07-06 Molecular dynamics simulations of nucleic acids are performed using a solvent-buffer distance of 10 [A] between the solute surface and the simulation
Solvation Shapes the Conformational Landscape of a Therapeutically Relevant SMN2 Splice-Site Defect biorxiv.org 2026-07-06 The SMN2 exon 7 5' splice-site/U1 snRNA duplex contains an A$_{-1}$ bulge that weakens splice-site recognition and represents a therapeutically releva
Unearthing a fungal giant: Dianjunaceae fam. nov., a novel Paleocene lineage of Xylariales harbouring Dianjunus rex gen. et sp. nov. biorxiv.org 2026-07-06 During mycological surveys in Yunnan Province, China, specimens of a fungus producing massive, upright stromata up to 50 cm high and individually 2.2