iPSC Neurodegenerative Disease Initiative isogenic CAG repeat iPSC line for Huntingtons disease biorxiv.org 2026-07-04 STRUCTURED ABSTRACT Purpose of Research: The generation of iPSC lines expressing 21, 56 and 79 glutamine repeats within the HTT protein and homozygous
ESCRT Machinery Dysfunction in Motor Neurone Disease: TSG101, CHMP2B, and VPS4a Differentially Regulate TDP-43 Pathology, Autophagy, and Exosome Biogenesis biorxiv.org 2026-07-04 Motor Neurone Disease (MND) is characterised by progressive degeneration of upper and lower motor neurons, accompanied by cytoplasmic mislocalisation
Quantitation of Spatial Proteoforms in Alzheimer's Disease biorxiv.org 2026-07-04 Alzheimer's disease (AD) pathogenesis involves complex, multifactorial changes to the brain proteome that conventional unfractionated analyses may obs
Single-cell analysis of an adult IBD INCEPTION cohort reveals Galectin-linked disease mechanisms biorxiv.org 2026-07-03 Background and Aims: The molecular pathogenesis of Inflammatory Bowel Disease (IBD) remains unclear.
Variable latency between the founder genetic event and rhabdoid tumor expansion biorxiv.org 2026-07-03 Rhabdoid tumors are very aggressive rare pediatric cancers with poor survival affecting very young children.
From junk to deleterious: Natural subtelomeric repeat amplifications impact fitness and cellular phenotypes in yeast biorxiv.org 2026-07-03 Eukaryotic genomes exhibit astounding levels of complexity.
Long-range regulatory target prediction reveals shared genetic background across ulcerative colitis, Crohn's disease, primary sclerosing cholangitis and ankylosing spondylitis biorxiv.org 2026-07-03 Common variants detected by the genome-wide association studies (GWAS) create a wealth of knowledge on genetic component of individual traits and dise
Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic disease biorxiv.org 2026-07-03 The human pancreas contains diverse endocrine and exocrine cell populations whose spatial organization is essential for tissue physiology.
Generative cell phenotyping with structured latent populations biorxiv.org 2026-07-03 Flow cytometry produces high-dimensional single-cell protein measurements central to immunophenotyping and clinical monitoring.
Phosphorylation-dependent Remodeling of the CLOCK/BMAL1/nucleosome Complex biorxiv.org 2026-07-03 Phosphorylation of the CLOCK/BMAL1 complex is a reversible post-translational modification that plays a central role in regulating circadian oscillati
Direct visualization of Na,K-ATPase clustering by 3D DNA-PAINT MINFLUX nanoscopy biorxiv.org 2026-07-03 Direct validation of the nanoscale structural organization of membrane proteins requires localization precision that matches their molecular dimension
β-alanine betaine and nAChRs in Ascaris biorxiv.org 2026-07-03 Anthelmintic drugs are used to control soil-transmitted helminths that infect a third of the worlds human population.
Circulating soluble urokinase-type plasminogen activator receptor reflects disease severity in a mouse model of diabetic kidney disease and heart failure with preserved ejection fraction biorxiv.org 2026-07-03 Circulating biomarkers are increasingly used for patient risk stratification in chronic kidney disease (CKD) and heart failure with preserved ejection
GDF5 as a Multimodal Protector of the Motor Unit in Amyotrophic Lateral Sclerosis biorxiv.org 2026-07-03 Amyotrophic lateral sclerosis is characterized by the progressive dismantling of the motor unit.
Human primary auditory cortex and insula encode perceptual decisions, not stimulus features biorxiv.org 2026-07-03 The traditional view of perceptual decision-making assumes a largely feedforward cortical hierarchy, in which sensory regions encode stimulus features
Shared and disease-specific human brain vascular signatures in Alzheimer's disease, frontotemporal dementia, and Huntington's disease biorxiv.org 2026-07-03 The blood-brain barrier (BBB) plays a central role in brain function and is increasingly implicated in neurodegenerative disease.
PACAPergic BAC engages basolateral amygdalar and anterodorsal thalamic networks during looming-threat learning and memory in a labyrinth biorxiv.org 2026-07-03 The bed nucleus of the anterior commissure (BAC) is a small pituitary adenylate cyclase-activating polypeptide (PACAP)-rich glutamatergic cell populat
Dense CRISPR Mapping of the WAVE Complex Identifies Pharmacological Modulators of AD-Linked Myeloid Migration biorxiv.org 2026-07-03 Although genetic risk for Alzheimer's disease (AD) strongly converges on microglial pathways, the druggable functional protein regions that control di
Trans-presentation of IL-15 by IL15Rα attenuates tumor immune surveillance and is dispensable for IL-15-dependent tumor growth control biorxiv.org 2026-07-03 Abstract Introduction: IL-15 is one of the most promising candidate cytokines in cancer immunotherapy due to its ability to promote the activity of di
Long-read sequencing maps transposable element variation and its regulatory and epigenetic effects in the human brain biorxiv.org 2026-07-03 Transposable elements (TEs) are mobile DNA sequences that shape genome architecture and gene regulation, yet their roles in the human brain remain lar
Social isolation biases female rats toward safety-oriented, efficient foraging biorxiv.org 2026-07-03 Social isolation has profound effects on behavior and cognition, but these effects can differ across sex and behavioral domains.
AptBacterialDB: A Comprehensive, Manually Curated Database of Antibacterial Aptamers biorxiv.org 2026-07-03 In recent years, aptamers have transitioned from mere laboratory tools to highly potent molecular recognition agents capable of overcoming the strict
Older adults show overexaggerated and larger noise-related degradation in their neural tracking of speech biorxiv.org 2026-07-03 Background: Speech-in-noise (SIN) perception is a difficult everyday listening task that becomes more difficult with age.
Intratelencephalic neurons in the medial prefrontal cortex mediate the acquisition of goal-directed actions. biorxiv.org 2026-07-03 The medial prefrontal cortex (mPFC) and its connections with the posterior dorsomedial striatum are implicated in goal-directed learning, but the spec
The pERKs of Temporal Order Memory in mice biorxiv.org 2026-07-03 Temporal Order Memory (TOM), the ability to discriminate between events according to when they occurred, is a key component of episodic-like memory.
Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes biorxiv.org 2026-07-03 Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their roles in astrocyte biology and neurodegener
Caloric restriction and intermittent fasting during lactation are linked to impaired maternal care, increased impulsivity and amygdala redox imbalance in dams biorxiv.org 2026-07-03 The lactational period requires substantial metabolic and behavioral adaptations, and more than 70% of mothers report weight concerns and attempt weig
Anticipatory organization of neural population dynamics speeds behavioral decisions biorxiv.org 2026-07-03 Expectations guide behavior and shape sensory responses in single neurons, but their influence on population-level neural dynamics is unknown.
A body-brain-behavioral cross-frequency architecture links biological and behavioral periodicities biorxiv.org 2026-07-03 Spontaneous behaviors, e.g., walking and speaking, are thought to rely on an internal sense of time that provides a scaffold for precise temporal coor
Complementary frontoparietal and corticothalamic contributions to relational reasoning biorxiv.org 2026-07-03 Complex reasoning depends on flexible coordination among frontal, parietal, and thalamic systems, but the circuit mechanisms that support increasing r
Impacts and interactions of stress, noradrenaline and serotonin signalling on probabilistic reversal learning biorxiv.org 2026-07-03 Rationale: Early life stress (ELS) is acknowledged to underlie cognitive and emotional abnormalities linked to stress-related mood disorders.
Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation biorxiv.org 2026-07-03 The human thalamus is composed of multiple nuclei that differ in structure and function.
Rapid value learning reveals generalized and context-dependent codes in frontal cortex biorxiv.org 2026-07-03 Studying how the brain represents value spans distinct methods and training histories, from neuroimaging in task-naive humans to single-neuron recordi
Multi-Site Reproducibility Study of 3D High-Content Analysis with Dual-View Oblique Plane Microscopy biorxiv.org 2026-07-03 High content imaging is being applied to achieve quantitative fluorescence readouts in increasingly complex 3-dimensional (3D) cell culture models suc
Segmentation and classification of retinal pigment granules in fluorescence lifetime imaging microscopy (FLIM) data biorxiv.org 2026-07-03 Alterations of fluorescence properties in retinal pigment epithelium (RPE) cells caused by diseases such as age-related macular degeneration (AMD) hig
Quantifying Asymmetric Coevolutionary Dynamics using Normalized Phylogenetic Costs biorxiv.org 2026-07-03 Coevolutionary studies aim to characterize associations, such as virus-host relationships, by using phylogenetic distances to quantify the topological
Females Adapt to Dietary Protein Restriction on Enhanced Gut-Brain Axis during Aging biorxiv.org 2026-07-03 Growing evidence supports a critical role for the gut-brain axis in regulating metabolic health, inflammation,and cognitive function during aging.
P-DOpE probes reveal local amplification of phasic noradrenergic release in the hippocampus biorxiv.org 2026-07-03 Fiber photometry (FP) has become a tool of choice for in vivo monitoring of genetically encoded biosensors.
Modelling sterilisation strategies to maximise population impact and cost-efficiency in free-roaming dog populations biorxiv.org 2026-07-03 Free-roaming dog populations pose challenges to public health and animal welfare, and their management and protection is legally mandated in many coun
Interspecies Differential Gene Expression Analysis with Regularized Phylogenetic Linear Models biorxiv.org 2026-07-03 Comparative transcriptomic datasets are increasingly used to investigate the molecular basis of phenotypic diversification across species.
Model-free inference of evolution from allele frequency timeseries using permutation tests biorxiv.org 2026-07-03 Allele frequency (AF) timeseries allow us to directly observe the dynamics of evolution at a genetic level.
Rare sex punctuates strict asexual reproduction in the clonal raider ant, Ooceraea biroi biorxiv.org 2026-07-03 While asexual species can often outcompete their sexual counterparts over ecological timescales, their long-term evolutionary success is hindered by a
Negative Autoregulation Promotes the Evolution of Strong Environmental Switching biorxiv.org 2026-07-03 Living systems rely on gene regulatory circuits to respond to environmental change.
Ancestral gene flow shaped the singular origin of the Amazon molly biorxiv.org 2026-07-03 The evolutionary origins of asexuality remain poorly understood, despite extensive research on its ecological and evolutionary consequences.
Across Species Identification of Genes Bridging Cognition and Reproduction biorxiv.org 2026-07-03 Evolutionary success in mammals requires coordinated regulation of cognitive functions and reproductive capacity.
Anthropogenic effects, not climatic, shaped Holocene population expansion of an insular bee fauna biorxiv.org 2026-07-03 Remote island systems with small landmasses and reliable estimates of human occupancy are ideal model systems to disentangle the roles of global clima
Emergence of histone-based chromatin complexity in Asgard archaea biorxiv.org 2026-07-03 The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that cons
Evidence for the 1/e-law predicting optimal timing of reproduction across taxa biorxiv.org 2026-07-03 Reproductive success requires allocating effort across lifespan in a manner that balances the risk of early mortality against the benefit of higher fe
Drug Functional Site-Unknown Molecular Targets Exemplified by SARS-CoV-2 pseudoknot and ribosomal frameshifting-modulators biorxiv.org 2026-07-03 The -1 Programmed Ribosomal Frameshifting (-1 PRF) signal of SARS-CoV-2, driven by a conserved three-stemmed RNA pseudoknot (PK), is indispensable for
ViralEpiBase: a manually curated repository of epitranscriptomic modification sites across viral RNA genomes and virus-encoded transcripts biorxiv.org 2026-07-03 Post-transcriptional chemical modifications of RNA, collectively termed the epitranscriptome, have emerged as critical regulatory layers governing vir