Cognitive resilience despite metabolic dysfunction after adolescent-onset high-fat high-sucrose diet exposure in rats biorxiv.org 2026-07-03 Adolescence is a sensitive period during which unhealthy diets may shape metabolic health and cognition.
A bistable UV-sensitive opsin from a reef building coral showing a switchable and tunable regulation of Gs-signaling by different wavelengths of light biorxiv.org 2026-07-03 Cnidarians possess large number of opsins in their genomes for their various photoreceptive functions.
Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes biorxiv.org 2026-07-03 Generating bioengineered cartilage that recapitulates the depth-dependent phenotype, structure, and function of native articular cartilage remains a c
AART enables fast and accurate cross-platform proteomic translation biorxiv.org 2026-07-03 Plasma proteomic profiling has been widely used for biomarker discovery, disease prediction and diagnosis, and patient stratification.
Scalable and rare-variant aware genome inference across the 1kGP cohort biorxiv.org 2026-07-03 Pangenome graphs built from haplotype-resolved de novo assemblies enable accurate analysis of genetic variation.
Disease Stage- and Risk-Associated RNA Editing Signatures in Acute Myeloid Leukemia and Their Utility for Peripheral Blood-Based Assessment biorxiv.org 2026-07-03 RNA editing is a widespread post-transcriptional regulatory mechanism, but its role in acute myeloid leukemia (AML) remains incompletely understood.
Location dependence of protein intrinsic disorder in Drosophila melanogaster biorxiv.org 2026-07-03 The relevance of protein structural flexibility in function remains contested, but experimental and computational evidence continues to accumulate.
Neuraminidase-Mediated Desialylation Modulates Red Blood Cell Aggregation biorxiv.org 2026-07-03 The glycocalyx of red blood cells (RBCs), a negatively charged surface layer rich in sialic acid residues, plays a crucial role in modulating RBC aggr
Using spIsoNet to address the preferred-orientation problem in cryoEM reconstructions biorxiv.org 2026-07-03 Cryogenic electron microscopy (cryoEM) is now routinely used for high-resolution structure determination of biological macromolecules.
Maternal effects shape scale-dependent convergence in gut microbial responses to environmental change biorxiv.org 2026-07-03 Animals can experience environmental variability across multiple temporal scales, from predictable within-year seasonal fluctuations to rarer, irregul
When suitable habitat is not enough: climate change, habitat loss, and dispersal limitation increase the vulnerability of bald-headed uakaris (Cacajao sp.) in the Amazon Rainforest biorxiv.org 2026-07-03 Aims: Species' distributions are determined by the interplay between ecological niche and dispersal ability, constrained by biogeographical barriers.
Resolving symmetry-masked allosteric cooperativity in the M. tuberculosis proteasome core particle biorxiv.org 2026-07-03 The 20S proteasome core particle (CP) is a stacked 7-{beta}7-{beta}7-7 assembly in which the central {beta}-rings host fourteen catalytic active sites
A generalizable interface-seeded framework for de novo design of functional oligomers biorxiv.org 2026-07-03 Protein oligomers are ubiquitous in biological systems and essential for function.
Modeling mosquito control strategies and their effect on pathogen transmission biorxiv.org 2026-07-03 The mosquito Aedes albopictus is a competent vector for the transmission of several arboviruses and is currently spreading across many continents.
Full-length COI barcodes improve eDNA metabarcoding data denoising relative to mini-barcodes biorxiv.org 2026-07-03 Animal COI (mitochondrial cytochrome oxidase I) metabarcoding of environmental DNA (eDNA) is increasingly used to assess biodiversity in complex subst
Microbial, dietary insect, and pathogen communities in fresh and decomposing guano of anthropic little brown bat (Myotis lucifugus) maternity colonies biorxiv.org 2026-07-03 The guano of insectivorous bats holds ecological information that can be assessed non-invasively to characterize the gut microbiome and diet, alongsid
Substrate-dependent epistasis probes active site intramolecular wiring biorxiv.org 2026-07-03 Enzyme adaptation toward novel substrates involves the rewiring of intramolecular residue networks, yet how this rewiring differs across multiple subs
Lung hypoperfusion stimulates liquid absorption in alveoli biorxiv.org 2026-07-03 Tissue hypoperfusion is common in clinical settings, but how tissues respond to hypoperfusion on a microphysiological scale is not clear.
An optimized "hypoxia in a pill" regimen reverses neurodegenerative disease phenotypes in multiple preclinical models biorxiv.org 2026-07-03 A growing body of pre-clinical research has demonstrated the therapeutic potential of chronic, continuous hypoxia (11% FIO2) for treating both rare an
Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotection biorxiv.org 2026-07-03 Human genetics implicates innate immunity as a key modifier of tau toxicity, yet human-specific neuroimmune mechanisms remain difficult to test in viv
The NORAD-pumilio regulatory axis links lncRNA dysregulation to tau propagation-associated phenotypes biorxiv.org 2026-07-03 Long non-coding RNAs (lncRNAs) are increasingly implicated in neurodegenerative disease, yet their roles in tauopathy remain poorly understood.
Competing Inter-Domain Quorum-Sensing Systems Control Prophage Lysis-Lysogeny Decisions biorxiv.org 2026-07-03 Phaeobacter inhibens T5T harbors three LuxI/LuxR quorum-sensing systems: one encoded by the host and one in each of two prophages.
Inhibition of Stemness Pathways during Acute SIV Limits Infection of Central Memory CD4+ T Cells and Alters Viral Reservoir Activity in Macaques biorxiv.org 2026-07-03 The establishment of a reservoir of latently infected CD4+ T cells that persist on antiretroviral therapy (ART) through proliferation represents the m
Initiation codon context governs translation-coupled mRNA decay and coordinated expression in the human parasite Leishmania biorxiv.org 2026-07-02 In the absence of canonical, promoter-based transcriptional regulation, Leishmania has evolved alternative regulatory mechanisms for adaptive gene exp
ProteoDUDes: Taxonomic profiling for metaproteomics with false positive reduction biorxiv.org 2026-07-02 Metaproteomics is the investigation of the protein composition of multi-organism samples.
Zero-Shot Metabolite Prediction from Gene Expression via Physics-Informed Graph Neural Networks biorxiv.org 2026-07-02 Predicting metabolite concentrations from gene expression is instrumental for linking regulatory programs to metabolic phenotypes.
WattmaMod enables high-resolution and extensible RNA modification profiling for nanopore direct RNA sequencing biorxiv.org 2026-07-02 Nanopore direct RNA sequencing enables direct profiling of RNA modifications on native transcripts, but accurate multi-modification detection remains
Near-Infrared II Scintillator for High-Resolution X-ray Imaging biorxiv.org 2026-07-02 Light scattering in scintillators is a pervasive problem and a key factor limiting X-ray imaging resolution.
Heterogeneous flux capacity and oxygen sensitivity lead to subcellular ETC flux gradients in mouse oocytes biorxiv.org 2026-07-02 Mitochondria are metabolic hubs of the cell that provide energy and metabolites to meet the energetic, biosynthetic and signaling demands of the cell.
Evaluation of Retinal Safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors biorxiv.org 2026-07-02 Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors are widely used for the treatment of renal anemia; however, their effects on intraocul
Perceptual, metacognitive, and computational signatures of temporal landmark uncertainty in tactile motion perception biorxiv.org 2026-07-03 Motion perception depends on estimating the relative timing of sensory events under internal uncertainty.
Identification and quantification of neurological responses in patients with dentine hypersensitivity biorxiv.org 2026-07-02 Evaluation of the effectiveness of therapeutic interventions for dentine hypersensitivity is limited by a lack of standardisation and objectivity in m
Blinks are strategically coupled with head movements in unconstrained natural gaze behavior biorxiv.org 2026-07-02 Blinks are a ubiquitous yet largely unnoticed aspect of human vision, despite causing frequent interruptions of visual input that can amount to up to
1 Hz rTMS Is Not Inherently Inhibitory: Current Direction Determines Aftereffects and Reliability biorxiv.org 2026-07-02 Objective: Aftereffects of 1 Hz repetitive transcranial magnetic stimulation (rTMS) often differ within and between subjects and thus show low reliabi
Astrocytic morphology in the Medial Habenula: sex differences and modulatory factors biorxiv.org 2026-07-02 The medial habenula (MHb) is an epithalamic structure involved in aversive processing and emotional regulation, notable for its marked cellular hetero
Near-critical slow dynamics enable flexible temporal computations and generalization biorxiv.org 2026-07-02 Although neural activity often evolves along low-dimensional manifolds, such descriptions do not explain the dynamical mechanisms that generate, const
Spinal circuit regionalization diversifies motor output along the vertebrate body axis biorxiv.org 2026-07-02 The evolution of the vertebrate limb-torso-limb body plan drove a diversification of motor behavior.
Temporal fingerprints of TMS-evoked potentials across thalamocortical circuits biorxiv.org 2026-07-02 Background: Electroencephalographic (EEG) potentials evoked by transcranial magnetic stimulation (TMS) offer a direct window into cortical dynamics.
Mapping the immune landscape in small cell lung cancer unveils a distinct tumor-reactive CD8+ T cell molecular signature biorxiv.org 2026-07-03 Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited therapeutic advances.
A Sensory Pathway Controls Motile Microcolony Formation and Spatial Organization in Gliding Bacteria biorxiv.org 2026-07-02 How motile bacteria navigating external surfaces convert environmental cues into transitions from dispersed states to cohesive, multicellular assembli
A Male Expressed Copulatory Plug Increases Female Fertility in Caenorhabditis Nematodes biorxiv.org 2026-07-03 The genomes of self-fertilizing hermaphrodites offer a unique opportunity to probe why some genes with sex-specific functions are lost while others ar
An open-access CT-based 3D anatomical dataset of extant sharks across all major lineages biorxiv.org 2026-07-02 Sharks exhibit extraordinary morphological diversity across a wide range of ecological niches, yet large-scale, high-resolution digital datasets of th
Conserved Genic Composition Unravels Rapid Karyotype Evolution and Polyploidization across Plants biorxiv.org 2026-07-02 Chromosomal variation underlies species evolution, but reconstructing its large-scale dynamics remains challenging, obscuring its adaptive significanc
Preclinical translation of Neurofibromatosis type 1 (NF1) exon 17 skipping using targeted U7-SnRNA packaged into engineered AAV serotypes. biorxiv.org 2026-07-02 To facilitate the translation of NF1 exon 17 skipping as a mutation-specific therapy for Neurofibromatosis type 1 into in vivo testing, we have contin
Scalable multi-group nonnegative spatial factorization for spatial genomics data with cell-type heterogeneity biorxiv.org 2026-07-03 Spatial transcriptomics (ST) technologies enable the study of gene expression within the spatial context of tissues, providing insights into tissue st
HiFi-ST: High-Fidelity Reconstruction of Continuous Spatial Transcriptomic Expression Fields via Conditional Neural Fields biorxiv.org 2026-07-02 Spatial transcriptomics characterizes tissue-scale gene expression patterns, yet its observations are sparse discrete samples of an underlying continu
A chromosome-level genome assembly of the Eurasian great grey owl, Strix nebulosa lapponica (Thunberg 1798) biorxiv.org 2026-07-02 We present a chromosome-level genome assembly of a female great grey owl (Strix nebulosa lapponica).
A Hall-Effect Sensor-Based Queen Bee Detection System -- a Proof of Concept biorxiv.org 2026-07-03 The queen bee is the central individual responsible for colony establishment, growth, and survival.
Simulating population pangenomes under coalescent demographic models with MSpangenome biorxiv.org 2026-07-03 Motivation: Pangenome variation graphs (PVGs) are increasingly used to represent genomic diversity, yet there is currently no general framework for ge
Inferring differentiation trajectories from T cell clonotype distributions biorxiv.org 2026-07-02 Single-cell RNA sequencing (scRNA-seq) enables reconstruction of cellular differentiation trajectories, but most trajectory inference methods rely lar