Short chain fatty acids potentiate azoles by reprogramming fungal acetyl-CoA metabolism biorxiv.org 2026-06-30 Pathogens colonise metabolically diverse host environments.
Identification and Inhibition of GLUT like proteins in Trichuris spp as a druggable target biorxiv.org 2026-06-30 Over a quarter of the worlds population is at risk of infection by soil transmitted helminths (STH).
Plasmodium berghei liver stages establish a damage-mimicking vacuole to hijack host ER membrane contact site machinery for lipid uptake biorxiv.org 2026-06-30 Plasmodium liver stage parasites undergo massive intracellular replication and therefore require extensive acquisition of host-derived lipids.
Micafungin exposure drives multidrug resistance in Clavispora lusitaniae biorxiv.org 2026-06-30 Fungal infections are an escalating global health concern, with rare Candida species posing an urgent threat due to emerging multidrug resistance.
Longitudinal analysis of vaccine-associated alterations in the faecal microbiota of layer chickens using a vaccination schedule representative of commercial practice biorxiv.org 2026-06-30 The gut microbiota is crucial for immune development and overall health in chickens.
Statistical learning of bacterial growth in combinatorially constructed environments biorxiv.org 2026-06-30 Optimizing growth conditions and culture media is a major goal in microbiology.
Epistasis between SARS-CoV-2 M and N Proteins Balances Particle Assembly and Immune Evasion biorxiv.org 2026-06-30 Since its emergence in the human population, SARS-CoV-2 has continuously evolved to evade immune responses and robustly establish global circulation.
Near-complete genomes for nine haplochromine cichlid fishes reveal a novel centromeric satellite structure organised around a pair of inverted elements biorxiv.org 2026-06-30 The haplochromine cichlid fishes of Lake Malawi form one of the most dramatic examples of recent rapid radiation in vertebrates.
A refined Saccharomyces cerevisiae reference transcriptome from Direct RNA Sequencing, with a reusable pipeline for UTR annotation updates biorxiv.org 2026-06-30 Untranslated regions (UTRs) flanking the coding sequence govern mRNA translation, localisation, stability, and decay, making accurate UTR boundaries e
The hand microbiome is sensitive to topical antibiotics and has varying sensitivity to liquid soaps biorxiv.org 2026-06-30 Hand eczema has been described as having an increased prevalence in persons with increased frequency of hand washing.
Oligella otitidis sp. nov., isolated from middle ear discharge of children with chronic suppurative otitis media biorxiv.org 2026-06-30 Oligella otitidis MSHR-50489EDL strain (ATCC: TSD462; DSMZ: DSM118617) is a new species of the genus Oligella that was isolated from a middle ear disc
CoalMiner: a coalescent model generator for fastsimcoal2 biorxiv.org 2026-06-30 Demographic inference using the Site Frequency Spectrum (SFS) is often constrained by the number and complexity of models tested.
Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development biorxiv.org 2026-06-30 Rupture of the fibrous cap is the primary cause of clinical complications from atherosclerosis.
Context-Aware Evidence-Gated Plasticity for Multi-Goal Learning in Spiking Neural Networks biorxiv.org 2026-06-30 Background / Introduction: Biologically inspired spiking neural networks can model adaptive behavior, but learning multiple goals is difficult because
Hippocampal microcircuits constrain the generation of epileptiform activity biorxiv.org 2026-06-30 Epilepsy is largely characterized using macroscale measures of neural activity, such as electroencephalography, which are unable to resolve the underl
Spatial Recruitment Model for Motor Potentials Evoked By Transcranial Magnetic Stimulation (TMS) for In-Silico Testing and Tuning of Closed-Loop Procedures biorxiv.org 2026-06-30 The primary motor cortex has a prominent role in transcranial magnetic stimulation (TMS).
β-cell-specific Ahr expression is critical to high-fat diet-induced hyperinsulinemia biorxiv.org 2026-06-30 Objective: The aryl hydrocarbon receptor (AhR) pathway primarily mediates pollutant responses by activating xenobiotic metabolism enzymes like cytochr
Intravital imaging of age-related conjunctival lymphatic changes on the ocular surface biorxiv.org 2026-06-30 Purpose: Lymphatic system plays a critical role in fluid regulation and immune response.
Sequencing, Chromosome-scale Assembly, and Annotation of the Genome of the Halophilic Nanoflagellate Halocafeteria seosinensis biorxiv.org 2026-06-30 Compared with bacterial and archaeal extremophiles, single-celled eukaryotes living in extreme habitats are understudied and underrepresented in genom
Computational Design of Two Novel BRAF V600E Inhibitors: Exploiting Sulfoximine Bioisosterism and Chiral Constraints to Evade Paradoxical Activation biorxiv.org 2026-06-30 Metastatic melanoma is an aggressive cutaneous malignancy frequently driven by the oncogenic V600E mutation within the BRAF kinase.
Diel metabolic variation and the energetic demands of courtship in bioluminescent Photeros ostracods biorxiv.org 2026-06-30 The energetic demands of courtship are central to sexual selection, but their magnitude and temporal variation remain poorly quantified in many signal
STING restrains calcium-dependent microglial phagocytosis and protects against neuronal loss and cognitive impairment during epileptogenesis biorxiv.org 2026-06-30 Epileptogenesis is accompanied by robust neuroinflammation, yet the molecular pathways linking innate immune activation to neuronal dysfunction remain
A Two-Fluid Model of Brain Dynamics biorxiv.org 2026-06-30 We develop a theoretical proposal linking vacuum stability and brain dynamics through superconductivity-inspired coherence, symmetry reduction, and th
Immune responses to infection modulate peripheral sympathetic neuron functions biorxiv.org 2026-06-30 The central nervous system interprets inflammatory signals in the body and directs the modulation of inflammatory responses by reflexively engaging pe
Smooth move: Behavioural changes in captive western lowland gorillas (Gorilla gorilla gorilla) after group split and relocation biorxiv.org 2026-06-30 Zoological gardens strive to prioritize excellent animal care and adhere to the highest standards of animal welfare, ensuring that the conditions of a
From innovation to integration: Personality, sex, and learning drive recombination of innovative behaviours in lovebirds biorxiv.org 2026-06-30 Behaviour innovation plays a pivotal role in a species' adaptability to dynamic environments.
Effects of aging on multiple object tracking under normal and altered viewing conditions biorxiv.org 2026-06-30 Multiple object tracking (MOT) is a core function of dynamic visual attention that relies on the ability to simultaneously monitor several moving obje
DNA: A Nanoscale Archimedes Screw biorxiv.org 2026-06-30 Rotating helices have been utilized for many purposes, including the transport of solid material and fluids within man-made machines, for a little ove
Homologous recombination deficiency prediction from whole slide images using label refinement and foundation-model benchmarking in ovarian cancer biorxiv.org 2026-06-30 Background: Homologous recombination deficiency (HRD) is clinically imperative in high-grade serous ovarian carcinoma (HGSOC), particularly because of
Basal Internalization and Subcellular Localization of XCR1 biorxiv.org 2026-06-30 Chemokines orchestrate immune cell trafficking through receptor-mediated signaling and are implicated in inflammatory, autoimmune, and neuropathic dis
Dietary protein source dictates the impact of obesogenic diets on hepatic steatosis and insulin resistance via carnitine-dependent regulation of acetyl-CoA carboxylase biorxiv.org 2026-06-30 Nutritional strategies to mitigate obesity and type 2 diabetes (T2D) have largely focused on dietary fat and carbohydrate composition, with less atten
MicroRNA regulation of stress-survival signalling and protein quality control in human heatstroke biorxiv.org 2026-06-30 Heatstroke is a life-threatening condition in which heat-shock and unfolded-protein responses are strongly activated but fail to prevent proteostasis
Retinal resuscitation in post-mortem eyes biorxiv.org 2026-06-30 Vision loss compromises the quality of life of millions of people worldwide. Currently, vision-restoring therapies are lacking.
Mitochondrial Hsp60/10 Client Protein Decline Reveals Braak/Tau- and Cognition-Linked Proteostasis Vulnerabilities in Alzheimer's Disease biorxiv.org 2026-06-30 Alzheimer's disease (AD) is classically defined by amyloid and tau pathology and is accompanied by broad disruptions in proteostasis.
Polytraumatic SCI worsens maladaptive plasticity in spinal motor systems biorxiv.org 2026-06-30 Spinal cord injury (SCI) results in dysfunction of both motor and sensory systems, which can be characterized by neuropathic pain, hypersensitivity, m
Berberine improves motor deficits in the spastic paraplegia SPG7 mutant mice biorxiv.org 2026-06-30 Hereditary spastic paraplegia type 7 (SPG7) is a neurodegenerative disorder characterized by progressive motor impairment and cerebellar dysfunction.
Aberrant neuronal differentiation and splicing defects in Congenital Myotonic Dystrophy (DM1) iPSC models biorxiv.org 2026-06-30 Myotonic Dystrophy type 1 (DM1) is an autosomal multisystem disorder manifested due to unstable CTG nucleotide repeat expansion within the 3'-untransl
APP-CTFβ/C99 oligomers drive synaptic vesicle tethering through C-terminal interactions biorxiv.org 2026-06-30 Proteolytic processing of the amyloid precursor protein (APP) generates a 99-amino acid precursor, {beta}-carboxyl-terminal fragments (APP-CTF{beta} o
Perceptual training selectively strengthens top-down signaling to sensory cortex biorxiv.org 2026-06-30 Sensory cortical neurons adjust their responses to enhance the detection and discrimination of behaviorally relevant stimuli.
Spinal injury induces a stem cell-like progenitor state that promotes regenerative neurogenesis via clcf1 in zebrafish. biorxiv.org 2026-06-30 After spinal injury, zebrafish, in contrast to mammals, show regenerative neurogenesis, characterized by enhanced injury-induced proliferation of epen
Recent history attracts and repels perceptual decisions depending on surprise biorxiv.org 2026-06-30 Past sensory experience shapes our perceptual decision-making in the now.
Diverse origins and transcriptional profiles of macrophages in a spinal lesion in zebrafish biorxiv.org 2026-06-30 The injury responses of tissue-resident macrophages in the CNS (microglia) and blood-derived macrophages (BDMs) play key roles in successful regenerat
Unintentional finger force drifts are minimally influenced by temporal evolution of surface friction biorxiv.org 2026-06-30 Humans consistently decrease the amount of force they produce during isometric finger pressing in the absence of visual feedback, a phenomenon often c
Single-Cell Transcriptomic Analysis of the Immune Response to CHIKVInfection biorxiv.org 2026-06-30 Abstract Background: The Chikungunya virus (CHIKV), a re-emerging mosquito-borne alphavirus, is responsible for acute febrile illness and severe polya
IgG4⁺ plasma cell enrichment and {lambda}-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary disease biorxiv.org 2026-06-30 Background: This study aimed to elucidate B cell subset pathology in COPD, a poorly characterized area, with a focus on its similarities to and differ
Abundance, diversity and activity of endogenous retroviruses in the slow loris. biorxiv.org 2026-06-30 Endogenous retroviruses (ERVs) constitute a significant fraction of vertebrate genomes and serve as genomic records of past retroviral infections, whi
A High-Quality Acetylation Dataset Reveals Modest Data Requirements for Transfer Learning to Identify Little Studied Post-Translational Modifications biorxiv.org 2026-06-30 Dysregulation of post-translational modifications (PTMs) is associated with severe pathologies, including cancers and Alzheimer's disease.
Real-World Progression-Free Survival with Erlotinib versus Osimertinib in EGFR L858R+T790M Compound Mutation Non-Small Cell Lung Cancer: An Exploratory Analysis of the MSK-CHORD Dataset biorxiv.org 2026-06-30 Background: Osimertinib is the standard first-line treatment for EGFR- mutant non-small cell lung cancer (NSCLC) harboring common activating mutations
A robot model of compass cue calibration in the insect brain biorxiv.org 2026-06-30 Dung beetles can use a variety of orientation cues to maintain a consistent bearing during ball-rolling.
Who's driving? Common evolutionary mechanism of activation of class A GPCRs biorxiv.org 2026-06-30 Cells communicate with their environment by integrating signals, often chemical in nature, triggered by specific molecules bind to specific membrane-b