Proteomic profiling of xenobiotic and nutrient transporters in human placenta of different gestational ages biorxiv.org 2026-06-30 Background The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus.
Reduced Somatosensory Oscillatory Dynamics and Inhibition in Moderate-to-Severe Nociceptive Pain biorxiv.org 2026-06-30 Nociceptive pain is the most common pain condition, and moderate-to-severe nociceptive pain substantially impacts daily functioning, constituting a si
Microscopic Motor Alterations in Psychosis and Chronic Cannabis Use biorxiv.org 2026-06-30 Background and Hypothesis. Motor alterations represent an important component of psychotic disorders.
A neurorecording toolkit for longitudinal assessments of transplanted human cortical organoids <i>in vivo</i> doi.org
Unified Transcriptome and Mechanics Map of the Intact Mammalian Preimplantation Embryo In Situ doi.org
DATRASextra: An R package for streamlined workflows with ICES DATRAS bottom-trawl survey data biorxiv.org 2026-06-30 Scientific bottom-trawl surveys provide essential fisheries-independent data for fisheries and ecosystem research.
Form I and II Rubiscos Exhibit Temperature Dependent Carbon Kinetic Isotope Effects biorxiv.org 2026-06-30 Nearly all carbon on Earth today is fixed by the enzyme ribulose-1,5-bisphopshate carboxylase/oxygenase ('rubisco'), which converts carbon dioxide (CO
Ontological Analysis of Brain Proteostasis Highlights the Sex-Dependent Trajectory of ApoE Isoform-Specific Regulation biorxiv.org 2026-06-30 Apolipoprotein E (ApoE) is the strongest genetic predictor of Alzheimers disease (AD) risk, with ApoE4 increasing and ApoE2 decreasing risk relative t
Evaluating Approaches for Inference Testing of Whole-Brain Densely Sampled Single-Subject Task fMRI Data biorxiv.org 2026-06-30 Task-based precision mapping has become a promising technique in functional MRI (fMRI) to robustly characterize and map an individual's unique activit
A Selective Multivalent NET-Associated Chromatin Neutralizer Resolves Infection-Associated Inflammation in Severe Sepsis biorxiv.org 2026-06-30 Targeting the overwhelming inflammation driven by neutrophil extracellular traps (NETs) during infection provides an opportunity to manage severe seps
Computational Fluid Particle Dynamics (CFPD)-Based Virtual Next Generation Impactor (vNGI) to Predict the Aerodynamic Particle Size Distribution (APSD) of Respiratory Drug Delivery Products: Toward New Approach Methodologies (NAMs) in Inhaler Performance biorxiv.org 2026-06-30 The Next Generation Impactor (NGI) is one of the regulatory gold standards for characterizing aerodynamic particle size distributions (APSDs) of orall
From field naturalism to Bayesian models: fog-frost interaction shapes growth form partitioning along Himalayan gradient biorxiv.org 2026-06-30 Mountain gradients facilitate our understanding of species' range limits, competition dynamics, stress-resilience trade-offs, and determinants of vege
Latitude, not geography, globally structures Oscheius tipulae into three deeply divergent lineages biorxiv.org 2026-06-30 Free-living nematodes are among the most abundant animals on Earth and play critical ecological roles in soil ecosystems.
GeneBench-Pro: Evaluating Multistage Statistical Reasoning\\in Genomics, Quantitative Biology, and Translational Biomedicine biorxiv.org 2026-06-30 We introduce GeneBench-Pro, an expanded and improved version of GeneBench that comprises harder problems across a wider breadth of domains.
Cell-type-specific architecture of the hypothalamus in a socially plastic vertebrate biorxiv.org 2026-06-30 The hypothalamus orchestrates social behaviors by integrating physiological state with environmental information, but the cellular substrates of this
A thalamic inhibitory circuit aligns sensory coding with learned value biorxiv.org 2026-06-30 Adaptive behavior requires sensory systems to prioritize cues that predict meaningful outcomes while suppressing irrelevant stimuli, but how relevance
Non-uniform structural development across human thalamus aligns with risk zones for schizophrenia in adulthood biorxiv.org 2026-06-30 With dense axonal connectivity to every region of cortex, the thalamus plays a central role in the nervous system from sensory processing to cognitive
Long-range inhibitory control of cholinergic network dynamics in the striatum. biorxiv.org 2026-06-30 Striatal cholinergic interneurons (CINs) exhibit a transient pause in tonic firing in response to salient stimuli, a hallmark of reinforcement learnin
MAP1A cleavage regulates TRIM46 transport to the axon in mature neurons biorxiv.org 2026-06-30 Polarised cargo transport is fundamental to neuronal function, ensuring the proper distribution of proteins and organelles between the cell body and a
Spatial synaptic regularization stabilizes learning across biological and artificial neural networks biorxiv.org 2026-06-30 How the spatial organization of synapses contributes to stable learning remains a fundamental question in neuroscience.
Cerebellar microRNA-206 tunes Purkinje neuron firing dynamics to control sensorimotor gating biorxiv.org 2026-06-30 MicroRNAs are potent regulators of gene expression in the brain, yet the cellular mechanisms through which they shape neuronal activity and behavior r
Flexible belief updating drives the childhood advantage in statistical learning biorxiv.org 2026-06-30 Children often outperform adults in probabilistic statistical learning tasks, yet the mechanisms underlying this developmental advantage remain poorly
The kinetochore proteins Ndc80 and Dsn1 are required for survival of postmitotic neurons biorxiv.org 2026-06-30 Dsn1 and Ndc80 are essential proteins of the kinetochore complex and required for chromosome segregation in dividing cells and for regulating developm
Speech and music exploit distinct intrinsic timescales of the sensorimotor system biorxiv.org 2026-06-30 Speech and music consistently differ in their acoustic rhythms, despite the cross-cultural diversity in their surface forms.
Implicit visuomotor adaptation to clamped feedback is reduced in adults who stutter biorxiv.org 2026-06-29 It has been demonstrated that people who stutter exhibit atypical motor control not only in speech tasks but also movements in the non-speech effector
A Meta-Analysis of the Converging Effects of Different Classes of Antipsychotics on the Frontal Cortex Transcriptome in Laboratory Rodents and Non-Human Primates biorxiv.org 2026-06-29 Background: Psychotic illnesses are among the most debilitating classes of psychiatric disorders, requiring targeted and effective treatment strategie
SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function biorxiv.org 2026-06-29 NAD supplementation blunts Th1 and Th17 inflammation, in part, through arginine metabolism-dependent regulation of mitochondrial energetics, redox bal
Antibiotics promote susceptibility to C. difficile infection through a CCR5-dependent immune response biorxiv.org 2026-06-29 Antibiotics (ABXs) represent the current standard of care for treating Clostridioides difficile infection (CDI).
Circulating T-follicular helper and type I regulatory T cells have overlapping phenotypes in P. falciparum malaria and are maintained by parasite exposure. biorxiv.org 2026-06-29 Immunity to P.
Evaluation of selectively-activatable, caged fluorescent probes as species selective markers for beta-alanine aminopeptidase positive bacterial species biorxiv.org 2026-06-29 Aminopeptidases are widely distributed in bacteria, but outside of a few model strains, their function is largely unexplored.
PML nuclear bodies orchestrate the storage and degradation of aggregated HBc in the nucleus and reduce CAM-A-induced apoptosis. biorxiv.org 2026-06-29 The lack of effective anti-hepatitis B virus (HBV) therapies highlights the need for a new type of treatment that targets different stages of the vira
Optical flow reveals motility signatures for inferring pathogenic bacterial mixture compositions via temporal convolutional networks biorxiv.org 2026-06-29 With the rapid expansion of global food demand, aquaculture has become a critical pillar for future food security.
Host adaptation drives genome evolution and virulence diversification in a bacterial zoonotic pathogen biorxiv.org 2026-06-29 Understanding how zoonotic pathogens diversify across reservoir hosts remains a central question in evolutionary biology and infectious disease resear
Industrialization restructures the domestic dog gut microbiome while preserving host specificity biorxiv.org 2026-06-29 Industrialization has reshaped human gut microbiomes, but its effects on other human-associated mammals remain poorly understood.
Fluorescence in situ hybridization reveals endophytic and epiphytic root colonization of the novel plant growth-promoting bacterium Citrobacter sedlakii CESi7 biorxiv.org 2026-06-29 Plant growth-promoting bacteria are gaining significant attention as promising biofertilizers.
Soil-derived Bacillus pumilus strains demonstrate antagonistic activity against Magnaporthe oryzae and multiple plant growth-promoting traits biorxiv.org 2026-06-29 Biological control strategies are increasingly being explored as sustainable alternatives for managing rice blast disease caused by Magnaporthe oryzae
The Two-Component System CrdRS Mediates Sub-inhibitory Antibiotic-Induced Biofilm Formation in Helicobacter pylori via Bidirectional Regulation of Transporters PlpA and GlnP biorxiv.org 2026-06-29 Biofilm formation by Helicobacter pylori is a major driver of antibiotic tolerance and treatment failure, yet the signaling pathways that trigger biof
Intestinal lipid metabolism controls immune response through NHR-68 and gut-brain signaling in C. elegans biorxiv.org 2026-06-29 Animals must allocate limited energetic resources across competing defense programs in response to infection.
Gut-derived serine protease reduces sleep but extends lifespan biorxiv.org 2026-06-29 Sleep has historically been viewed through a brain centric lens with little known about the contribution of the periphery.
GCBM-DCT-HV-Bio-NL-Grow-CHG-CSM-RHEC: A Unified Geometric, Biological, Causal, and Regenerative Framework for Mechanism-Aware Tissue and Connectome Modeling biorxiv.org 2026-06-29 Modern biological prediction problems increasingly require models that go beyond Euclidean feature regression and local graph smoothing.
Homology-aware cross-validation strategies for generalization assessment in RNA structure prediction biorxiv.org 2026-06-29 RNA secondary structure prediction is a fundamental challenge in bioinformatics, essential for understanding the functional roles of non-coding RNAs.
Function-guided design of active enzymes biorxiv.org 2026-06-29 Designing enzymes from functional descriptions remains challenging because catalytic activity is governed by sequence-structure-function relationships
PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity. biorxiv.org 2026-06-29 Human variants in renal polycystins (PKD1, PKD2) are responsible for most forms of autosomal dominant polycystic kidney disease (ADPKD), a common gene
Social Isolation Alters Hippocampal miR-30e-5p Expression and Impairs Pattern Separation-Related Behaviour in Adult Mice biorxiv.org 2026-06-29 Social isolation is commonly used to model social stress and is a known risk factor for depression, with impacts on hippocampal function and postnatal
Fragmented sleep during pregnancy induces inflammation and tryptophan-kynurenine pathway metabolism: Importance of elevated fetal brain kynurenic acid biorxiv.org 2026-06-29 Maternal sleep disturbance is an underrecognized risk factor for adverse offspring outcomes.
Transition of a Yeast Endosymbiont from a Free-living to Host-reliant Lifestyle Through Gene Loss and Horizontal Gene Transfer biorxiv.org 2026-06-29 Endosymbiosis is widespread throughout the tree of life.
Independent origins of fish endothermy converge on a developmental regulatory signature biorxiv.org 2026-06-29 Why independent origins of the same complex physiological trait repeatedly produce similar body forms and physiological changes remains central in evo
Comparative genomics of the unusual arachnid order Solifugae spotlight the molecular and genetic basis for adaptations to arid habitats biorxiv.org 2026-06-29 The evolutionary transition to terrestrial life required overcoming several physiological hurdles; however, such challenges were amplified in desert e