Simultaneous Functional Ultrasound, Intrinsic Optical Signal and Widefield Calcium Neuroimaging biorxiv.org 2026-07-02 Functional ultrasound (fUS) maps cerebral blood volume (CBV) but lacks molecular and neuronal specificity.
Electroencephalogram recordings in Jhana states: An open dataset biorxiv.org 2026-07-02 The use of meditation as a tool to improve human wellbeing is receiving considerable scientific interest.
Shared Pain, Shared Decisions: How Empathy Shapes Social Conformity Through Physiology and Visual Attention biorxiv.org 2026-07-02 Empathy enables individuals to attune to others' experiences through shared affective, sensorimotor, and neural representations, but its influence on
A Simple Subject Independent Channel Selection in EEG for Motor Imagery Task biorxiv.org 2026-07-01 Classification of motor imagery (MI) tasks through EEG is valuable in brain-computer interfacing and rehabilitation engineering.
Phenotypic inference from sparse tumor genomes informs an explainable deep-learning model for cancer prognosis biorxiv.org 2026-07-01 Somatic genomic alterations are widely profiled in cancer and remain the primary source for personalized therapy, yet their clinical utility is limite
A modular generalist-specialist AI framework for ROI selection across spatial profiling workflow biorxiv.org 2026-07-01 Selection of regions of interest (ROIs) is often a crucial step in spatial molecular profiling and many pathology tasks, with substantial implications
Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress in female Wistar Kyoto rats biorxiv.org 2026-07-01 Treatment-resistant depression and anxiety remain major challenges in psychiatry, particularly in female patients, who are disproportionately affected
Age-Dependent Spatiotemporal Remodeling of Brain Sphingolipids During LPS-Induced Neuroinflammation: MALDI-MSI Reveals Accelerated Sphingomyelin Depletion and Sulfatide Accumulation Linked to Mitochondrial Oxidative Stress biorxiv.org 2026-07-01 Aging is a major risk factor for exacerbated neuroinflammation and neurodegenerative diseases, yet the underlying lipid metabolic mechanisms remain in
HARMONY: A large-scale harmonized neuroimaging dataset for research on anxious misery disorders biorxiv.org 2026-07-01 Patterns of brain circuit dysfunction underlying depression and anxiety have been increasingly characterized, including dimensional and subtype variat
Cryo-EM reveals alternative modes of dimerization driving activation of IKK biorxiv.org 2026-07-01 The inhibitor of {kappa}B kinase (IKK) complex integrates diverse cellular inflammatory responses, and induces transcription factor NF-{kappa}B.
Unveiling the Hidden Rules: Enhancing NMD Prediction for Protein-Truncating Variants biorxiv.org 2026-07-01 Nonsense-mediated decay (NMD) is a conserved RNA quality-control pathway that degrades transcripts containing premature termination codons.
Tabular Foundation Models Are Competitive Cellular Perturbation Predictors Across Biological Scales biorxiv.org 2026-07-01 Predicting how cells respond to genetic and chemical perturbations is a central challenge in drug discovery and functional genomics.
Collective fluctuations underlying nanobody inhibitory activity targeting B. anthracis S-layers revealed by multiscale simulations biorxiv.org 2026-07-01 Nanobodies (Nbs) that depolymerize bacterial surface-layers (S-layers) offer a route to antivirulence therapeutics, but their mechanisms have been dif
A cell line model for the study of CD4-negative HIV-1 infection and latent virus reservoirs biorxiv.org 2026-07-01 Although controversial, limited publications support the notion that HIV-1 can infect CD4-negative cells.
Endothelial Baf60c in BPD-Associated Pulmonary Hypertension biorxiv.org 2026-07-01 BACKGROUND Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) complicates prematurity and carries substantial morbidity in extremel
Unilateral resistance training induces greater rate coding adaptations in high-threshold motor units during maximal voluntary contractions biorxiv.org 2026-07-01 Resistance training lasting a few weeks increases maximal force mainly through neural adaptations that enhance the drive from the nervous system to mu
The Ca2+-Sensitivity of Contraction is Increased in the Left Atrium and Left Ventricle of Patients with Ischemic Heart Failure biorxiv.org 2026-07-01 Background Ischemic heart failure (IHF) has been shown to impair contractility and disrupt sarcomere function in the left ventricle.
Nutrient-dependent hippocampus dopamine signaling enhances meal-related episodic memory and reduces food intake biorxiv.org 2026-07-01 Background: Dopamine (DA) is a neurotransmitter critically involved in food-related reinforcement learning.
Toward Optimizing Thalamic Deep Brain Stimulation for Cortical Modulation: A Surrogate Brain Approach biorxiv.org 2026-07-01 The thalamus is a central hub that interfaces with widespread cortical and subcortical nodes.
Antibody Correlates of Resilience to Staphylococcus aureus Disease and Recurrence in Children biorxiv.org 2026-07-01 Staphylococcus aureus remains a major global pathogen with no licensed vaccine and high recurrent infection burden, yet correlates of protection remai
The E2F1 regulon orchestrates a proliferative emergency and vascular programming in fetal endothelial progenitors exposed to GDM: a sex-stratified systems medicine approach biorxiv.org 2026-07-01 Maternal Gestational Diabetes Mellitus (GDM) and obesity are major drivers of the Developmental Origins of Health and Disease (DOHaD), predisposing of
B cell-intrinsic IRF8 transcriptionally reprograms antigen presentation to sustain CD8⁺ T cell antitumor immunity biorxiv.org 2026-07-01 Interferon regulatory factor 8 (IRF8) is a master transcription factor of myeloid differentiation, but whether IRF8 intrinsically controls B cell func
Thymic Treg-derived T follicular regulatory cells prevent catastrophic humoral autoimmunity in response to TLR7-driven inflammation biorxiv.org 2026-07-01 T follicular regulatory cells (Tfr) are a follicle-resident subset of regulatory T cells (Treg) that limit germinal center (GC) responses and enforce
Schistosoma mansoni Granulin binds the human neutrophil receptor CD177 and modulates neutrophil activation biorxiv.org 2026-07-01 To establish chronic infection in the vasculature of their infected host, schistosomes have developed multifaceted strategies of immune subversion.
Uncertainty-aware quantitative analysis of the structure and dynamics of T cell receptor repertoires biorxiv.org 2026-07-01 Diversity and dynamics of immune cell receptor repertoires (IRRs) are two factors at the functional heart of adaptive immunity that together make IRRs
Neutrophil Extracellular Trap Formation and Complement Activation Pathways Dominate Microbiota-dependent disease bias in lupus-prone female NZM2328 mice biorxiv.org 2026-07-01 Women are predisposed to systemic lupus erythematosus (SLE) with a prevalence ratio of up to 9:1 over men.
Female genetic variation controlling timing of mating plug ejection in Drosophila melanogaster biorxiv.org 2026-07-01 In multiply-mating species, male-female postcopulatory, prezygotic interactions can influence reproductive outcomes.
The impact of P-Element-induced hybrid dysgenesis on the male germline in Drosophila simulans biorxiv.org 2026-07-01 The P-element, a DNA transposon, has independently invaded two Drosophila species, accompanied by rapid evolution of suppression.
Quantitative Motion-Corrected PALM Links Endosome Structure and Dynamics in Live Cells biorxiv.org 2026-07-01 Quantitative structural analysis by Photoactivated Localization Microscopy (PALM) on the nanoscale is often restricted to fixed cells because motion d
Control theory analysis of dynamic metabolic response elucidates mitochondrial-cytoplasmic coupling and nutrient partitioning biorxiv.org 2026-07-01 Cells adjust their internal circuits in response to changes in their environment.
Structural Topology-based Electrostatic Model (STEM) Reveals Ion-Coordination Exchange as a Driver of RNA Folding Dynamics biorxiv.org 2026-07-01 RNA is a highly charged polyelectrolyte whose folding into functional architectures depends on an ionic atmosphere that screens strong electrostatic r
Monitoring microscope performance in an imaging facility using OMERO-metrics. biorxiv.org 2026-07-01 Microscopes are essential tools for discoveries on a scale invisible to the unaided human eye.
Targeted depletion of CD38+ autoreactive T cells prevents type 1 diabetes biorxiv.org 2026-07-01 Type 1 diabetes (T1D) is caused by T cell-mediated autoimmune destruction of insulin-producing islet beta-cells.
Tyrosine kinases sample unique activation ensembles biorxiv.org 2026-07-01 Protein kinase activation is driven by conformational changes across multiple structural components, including the conserved Asp--Phe--Gly (DFG) motif
FPGA-based scanner and SerialEM server for 4D-STEM Electron Tomography biorxiv.org 2026-07-01 Four-dimensional scanning transmission electron microscopy (4D-STEM) enables the acquisition of diffraction patterns at every probe position in a dens
Development of a multiplex immunofluorescence panel to study heterogenous cancer-associated fibroblast subtypes with spatial resolution biorxiv.org 2026-07-01 Background: Single cell RNA sequencing provides a wealth of information to explore the complexities of the tumour microenvironment, but crucially the
Conserved and diverged patterns of senescence in Pristionchus nematodes biorxiv.org 2026-07-01 Healthspan, the period of life where organisms are without frailty and/or disease, is a major focus of biogerontological research.
Early retinal microglial activation and ganglion cell dysfunction following severe traumatic brain injury in mice biorxiv.org 2026-07-01 Traumatic brain injury (TBI) induces rapid neuroinflammatory responses not only in the brain but also in anatomically and immunologically connected ce
Novel human monoclonal antibodies with enhanced sensitivity for lipoarabinomannan antigens present in urines of TB patients biorxiv.org 2026-07-01 Lipoarabinomannan (LAM) is a useful biomarker for detection of M. tuberculosis infection and disease.
From migrants to residents: Genomic insights into adaptive strategies in European robins (Erithacus rubecula) biorxiv.org 2026-07-01 Bird migration evolved as an adaptation to seasonally changing habitats.
Comparison of directional random walk and weighted least squares modeling of sparse fossil data biorxiv.org 2026-07-01 The general random walk model (GRW) of Hunt (2006) is used to infer directional evolution in mean trait values from sparse fossil data by modeling phe
Pericystic brain transcriptomics reveals molecular signatures of immune activation and neurovascular remodelling in viable and post-treatment porcine neurocysticercosis biorxiv.org 2026-07-01 Neurocysticercosis (NCC), the infection of the central nervous system by Taenia solium larvae, is a leading cause of acquired epilepsy in endemic regi
Direct probabilistic quantification of mosaic loss of chromosome Y from sequencing data biorxiv.org 2026-07-01 Loss of chromosome Y (LOY) is the most common aneuploidy in aging men and is increasingly recognized as a marker of aging and genomic instability.
MCD Stitcher: An open-source tool for whole-slide stitching and conversion of Imaging Mass Cytometry data biorxiv.org 2026-07-01 Imaging Mass Cytometry (IMC) combines metal-tagged antibody labelling with laser ablation mass spectrometry to generate highly multiplexed spatial ima
CryoGO enables high-resolution structural profiling of endogenous cellular macromolecules biorxiv.org 2026-07-01 Resolving macromolecular structures within their native cellular environment is essential for connecting molecular architecture to physiological funct
Molecular Basis of Core Fucosylation-Dependent Modulation of IgG1-FcCD16a Binding biorxiv.org 2026-07-01 Core fucosylation of the IgG1 Fc N297 glycan is known to reduce binding affinity to the FcYRIIIa (CD16a) receptor and attenuate antibody-dependent cel
A CSF Proteomic Clock Reveals Opposing Brain-Aging Programs and Predicts Neurological Disease Progression biorxiv.org 2026-07-01 Aging is a major risk factor for neurological disease, yet the molecular architecture of human brain aging remains poorly defined.
Machine learning on magnetoencephalography data yields generalizable low-dimensional neural fingerprints that distinguish individuals across task conditions biorxiv.org 2026-07-01 Individual brains are unique in structure and function.
Enhanced environmental complexity worsens experimental colitis and dysregulates microbiota-gut-brain axis signalling in female mice biorxiv.org 2026-07-01 Ulcerative colitis (UC) is a chronic inflammatory disease characterized by colonic inflammation and bloody diarrhoea.
Structural determinants of dynamical state transitions in disorders of consciousness: a whole-brain modeling approach biorxiv.org 2026-07-01 Disorders of consciousness (DoC) are associated with large scale alterations in brain dynamics, yet the structural factors that constrain these change