A Highly Contiguous Reference Genome for Scalesia gordilloi (Asteraceae), a Critically Endangered Plant Endemic to the Galapagos Islands biorxiv.org 2026-06-29 Scalesia gordilloi is a critically endangered species endemic to San Cristobal Island in the Galapagos archipelago and represents one of the most uniq
OpenGerminal: an open-source implementation of the Germinal antibody design pipeline biorxiv.org 2026-06-29 Germinal is a recently described computational pipeline for de novo antibody design that combines AlphaFold-Multimer hallucination with antibody langu
Learning sculpts microstructure in real time: evidence from dense temporal sampling of diffusion MRI biorxiv.org 2026-06-29 Learning induces rapid microstructural plasticity in the human brain, yet the precise temporal dynamics of these changes remain unclear.
Pep2Mol: 3D Molecule Generation Targeting Protein-Protein Interfaces with Diffusion Models biorxiv.org 2026-06-29 Protein-protein interactions (PPIs) are central to biological processes.
AnimalTA: A simple yet flexible tool for video tracking and manual corrections. biorxiv.org 2026-06-30 1. Video-tracking programs have now become an essential tool for researchers measuring animal behavior across biological fields.
Additive Effects of Sleep Loss, Psychological Distress and Physical Inactivity on Cognitive Failures in Young Adults biorxiv.org 2026-06-30 Young adults frequently report cognitive complaints often attributed to sleep loss alone.
High-throughput whole-brain scattering imaging resolves Amyloid plaques through clearing-assisted contrast modulation biorxiv.org 2026-06-29 Label-free scattering imaging is widely used in pathology because it enables sensitive tissue assessment without exogenous contrast agents.
Retention, not flux: endpoint confounding caps computational prediction of peptide skin penetration, with a delivery-aware reframing biorxiv.org 2026-06-29 Bioactive peptides are now central to cosmetic and dermatological actives, yet predicting whether a given sequence will reach its site of action in sk
Causally measuring aging and rejuvenation through transcriptomic damage biorxiv.org 2026-06-29 Aging is caused, fully in large part, by the progressive accumulation of damage, yet quantifying age-related damage across tissues and conditions rema
Cortico-muscular control of postural balance in older adults - effects of training on functional connectivity biorxiv.org 2026-06-29 Background.
Latitudinal effects on weight and age-dependent survival of red fox Vulpes vulpes biorxiv.org 2026-06-29 Age-dependent survival is central to understanding population dynamics and life-history evolution.
Integrated RNA sequencing reanalysis reveals reproducible matrix-immune signatures in idiopathic pulmonary fibrosis biorxiv.org 2026-06-29 In idiopathic pulmonary fibrosis (IPF), the lung is remodeled through coordinated epithelial, stromal, and immune-associated programs, but individual
Critical Scaling Laws and Universality Classes in Biomolecular Condensates biorxiv.org 2026-06-29 Biomolecular condensates are widespread cellular self-assembled structures with essential functions.
Revisiting Cucuruchu, a Late Pleistocene site on the Venezuelan Caribbean coast with megafauna and lithic association biorxiv.org 2026-06-29 The study of historical documents from the original excavation led by J. M.
A transcription factor-pair work in concert to regulate gene expression across the life cycle of the pinewood nematode, Bursaphelenchus xylophilus biorxiv.org 2026-06-29 The migratory endoparasitic pinewood nematode (PWN), Bursaphelenchus xylophilus, is the causal agent of pine wilt disease, causing significant economi
Within-electrode temporal envelope processing predicts multi-channel speech outcomes across cochlear implant pulse rates biorxiv.org 2026-06-29 Cochlear implants (CIs) restore hearing by stimulating auditory neurons to encode amplitude envelopes across frequency bands, providing essential cues
Functional neural signatures of navigation impairment in early Alzheimer's Disease biorxiv.org 2026-06-29 Spatial navigation is impaired early in Alzheimer's disease (AD), but the neural computations affected by AD pathology remain unclear.
Structural basis for GluA1 AMPA receptor regulation by PRRT1/SynDIG4 in LTP biorxiv.org 2026-06-29 AMPA receptor (AMPAR) signalling underlies long-term potentiation (LTP), a cellular mechanism for learning that selectively involves GluA1-type AMPARs
Effects of bromodomain and extraterminal domain protein inhibition in a mouse model of Niemann-Pick type C disease biorxiv.org 2026-06-29 Defects in lysosomal lipid handling provoke fatal disorders presenting neurovisceral symptoms with variable onset and life spans.
Maintenance DNA methylation is necessary for age-related alterations in regulatory T cell transcriptional and DNA methylation signatures biorxiv.org 2026-06-29 CD4+FOXP3+ regulatory T (Treg) cells maintain self-tolerance, restrain immune responses during inflammatory stimuli, and promote tissue function and r
Strategic coexistence theory for evolutionary games biorxiv.org 2026-06-29 Evolutionary game theory and ecological coexistence theory both seek to predict the outcome of competition between biological entities, be they strate
Haplotype-specific chromosome painting unveils recombination patterns in the holocentric species Rhynchospora breviuscula H.Pfeiff. biorxiv.org 2026-06-29 The genus Rhynchospora Vahl (beak-sedges) comprises approximately 381 accepted species with a worldwide distribution, all of which possess holocentric
Constrained body mass evolution and decoupled morphological rates in plesiosaurs biorxiv.org 2026-06-29 Body size, through its links to various physiological traits, has often been hypothesized to influence evolutionary rates.
Opposing immunomodulatory effects of the Alternaria mycotoxin tenuazonic acid in immune and intestinal epithelial cells biorxiv.org 2026-06-29 Tenuazonic acid (TeA) is one of the most frequently detected Alternaria mycotoxins in contaminated food.
Legacy Effects of Early β-Adrenergic Stimulation Program Adipose Plasticity and Confer Metabolic Resilience in Obesity biorxiv.org 2026-06-29 Pathologic white adipose tissue (WAT) remodeling, characterized by fibrosis, inflammation, and adipocyte dysfunction, is a hallmark and driver of meta
Resident myeloid-derived immune cells contribute to early lipopolysaccharide-induced cytokine secretion in mouse soleus muscle biorxiv.org 2026-06-29 Skeletal muscles secrete a variety of cytokines in response to inflammatory stimuli such as lipopolysaccharide (LPS); however, the contributions of re
IP3R-TRPM4 Coupling Determines the Spatial Reach of Pericyte-Mediated Capillary Constriction biorxiv.org 2026-06-29 Ensheathing pericytes extend multiple projections that wrap around capillary vessels to regulate diameter and direct blood flow distribution across th
Inherent Biomechanical Properties of the Lung: In vivo-Ex vivo Comparisons in Mice biorxiv.org 2026-06-29 Mammalian lungs operate within a thoracic cage composed of parietal pleura, rib cage, skeletal muscle, and diaphragm, yet clinical ventilator metrics
Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys biorxiv.org 2026-06-29 Slowly varying internal states govern our ability to sustain goal-directed behavior over minutes to hours, imposing fundamental constraints on cogniti
Viral infection drives cell-intrinsic re-localization of the C. elegans immune-repressive STAT transcription factor STA-1 biorxiv.org 2026-06-29 Detection of viral infection leads to both cell-intrinsic and cell-extrinsic responses.
B-cell SIGLEC-5 engages T-cell components of the elastin receptor complex (ERC) to suppress inflammatory T-cell cytokines biorxiv.org 2026-06-29 SIGLECs remain poorly defined in human B-cell biology beyond SIGLEC-2/CD22 and SIGLEC-10.
Host transcriptional programs underlying lesion development in contagious bovine pleuropneumonia biorxiv.org 2026-06-29 Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp.
The contribution of recent and historical demographic histories to genomic diversity and conservation status in plant species biorxiv.org 2026-06-29 Demographic factors are intrinsically crucial to evaluate species' extinction risk.
Hydrophobic mismatch induces lipid sorting based on tail unsaturation biorxiv.org 2026-06-29 Biological membranes contain a diverse set of membrane proteins surrounded by many different lipids, and the lateral organization and function of thes
RNA-Encoded PGT121-LS Anti-HIV Antibody: Comprehensive Preclinical Characterization and Translational Pharmacokinetics biorxiv.org 2026-06-29 Human Immunodeficiency Virus (HIV)-1 broadly neutralizing antibodies (bNAbs) have demonstrated clinical efficacy, but face manufacturing challenges as
Droplet single-cell CRISPR screens identify regulators of T cell-mediated target-cell killing biorxiv.org 2026-06-29 Cytotoxic CD8 T cells kill target cells through brief cell-cell encounters, but pooled genetic screens cannot readily link perturbations in individual
A substrate recursion principle for biological information, with empirical anchoring through a templating-mode taxonomy biorxiv.org 2026-06-29 Biological inheritance can be treated as a class of catalytic templating reactions in which a daughter molecule, generated by a kinetic kernel acting
Fructooligosaccharide Supplementation Improves Glucose Homeostasis in Human-Relevant hyperglycemic Diet-Induced Obese Mice biorxiv.org 2026-06-29 Fructooligosaccharides (FOS) are prebiotic fibers that influence gut microbiota and host metabolic function.
Neprilysin mediated cleavage of phospholamban dysregulates SERCA in heart failure biorxiv.org 2026-06-29 Background Neprilysin (NEP) is a zinc-dependent metalloprotease targeted in heart failure therapy to prevent it degrading circulating cardioprotective
Leptin alleviates obesity hypoventilation via serotonergic pathways biorxiv.org 2026-06-29 Rationale. There is no effective pharmacotherapy for obesity hypoventilation syndrome (OHS).
Apparent Anatomical Variability Through Rigid Augmentation Enables Reliable Corpus Callosum Segmentation biorxiv.org 2026-06-29 The corpus callosum is a major white matter bundle responsible for connecting both hemispheres.
Compensation of the effects of temperature on a motor system in the crab, Cancer borealis biorxiv.org 2026-06-29 Rising ocean temperatures challenge ectothermic animals to maintain essential behaviors such as movement and feeding.
Much stronger coarse-to-fine visual processing in primate superior colliculus than primary visual cortex neurons biorxiv.org 2026-06-29 The visual system optimizes its signal processing properties to efficiently encode natural scenes.
MECP2-mutant marmosets exhibit primate-specific phenotypes of Rett syndrome biorxiv.org 2026-06-29 We used genome editing to generate MECP2-knockout marmosets and establish a new primate model for Rett syndrome (RTT), a neurodevelopmental disorder.
Paralogous lncRNAs CYTOR and MORRBID share a conserved trans acting function in MEK ERK signaling biorxiv.org 2026-06-29 Background: Long non-coding RNAs (lncRNAs) exhibit rapid evolutionary turnover, often driven by genomic duplication.
Conserved transcriptomic heat stress response signatures in coral recruits selectively bred from thermally distinct broodstock in a low-differentiation system biorxiv.org 2026-06-29 Thermal history provenancing can guide the choice of parental broodstock for selective breeding of corals from distinct reefs and has been proposed as
Assembly of a high-quality reference genome for the rat tapeworm Hymenolepis diminuta biorxiv.org 2026-06-29 The rat tapeworm, Hymenolepis diminuta, is an important laboratory model for uncovering molecular processes that underly the success of tapeworms as p
Healthy-to-Stroke Translation of EEG-Based BMIs: EEG Characterization and Reinforcement Learning-Based Decoder Evaluation biorxiv.org 2026-06-29 Purpose: EEG-based brain-machine interfaces (BMIs) may support assistive technologies for individuals with stroke-related motor impairment by translat
Metrics for Distinguishing Biological and Interventional Change in AI Models biorxiv.org 2026-06-29 Statistical and machine-learning models of longitudinal biological data evaluate change by comparing each new observation against the trajectory impli
Crossmodal Expectations in Material Perception biorxiv.org 2026-06-29 Humans rely on multiple sensory modalities, such as vision, audition, and touch, to perceive materials in everyday life.