Beyond paternal care: career stage and reproductive opportunities shape male services in vervet monkeys biorxiv.org 2026-06-26 Why male primates invest in costly behaviours producing public goods remains debated, with two leading explanations, paternal care and reputation-base
Dynamics of individual visual biases in space and time biorxiv.org 2026-06-26 Recent work has brought to light a number of stimulus families whose perception is shaped by strong idiosyncratic biases.
Electron confurcation drives photosynthetic H2 production in cyanobacteria biorxiv.org 2026-06-26 Cyanobacteria are major contributors to global photosynthesis and are intensively studied for sustainable green H2 production.
Conversion of a Viral Glycan Shield into a Binding Anchor via Causal-Driven Antibody Optimization biorxiv.org 2026-06-26 Therapeutic antibodies are challenged by rapidly evolving pathogens that exploit glycosylation to shield epitopes.
Agentic AI for Structural Elucidation and Discovery of Drug Metabolites from Mass Spectrometry Data biorxiv.org 2026-06-26 The majority of chemical signals detected in public metabolomics repositories remain structurally undefined.
The Gompertz curve for estimating growth rates of Protein Data Bank and protein folds biorxiv.org 2026-06-26 The Protein Data Bank (PDB) is an ever-growing, open-access repository of structural data of biological molecules.
KozakExplorer: an interactive framework for genome-wide Kozak sequence analysis biorxiv.org 2026-06-26 Translation initiation signals shape gene expression across all domains of life.
A Snakemake-based bacterial whole genome comparison pipeline for multi-group clinical isolates biorxiv.org 2026-06-26 Organisms have continuously evolved in response to environmental conditions.
Recurrent Duplication of the REST-NOA1 Locus Reveals a Hotspot of Regulatory Evolution Across Even-Toed Ungulates biorxiv.org 2026-06-26 Gene duplication is a major source of evolutionary novelty, yet recurrent duplication of the same genomic locus across independent lineages remains un
SPEAK: Spatial Prompting with Expert Aligned Knowledge for Tissue Domain Identification in Spatial Transcriptomics biorxiv.org 2026-06-26 Spatially resolved transcriptomic (SRT) data requires spatial domain identification to enable tissue microenvironment-specific downstream analyses.
EpiESM-GA: Resource-Efficient Protein Foundation Model Features for Equitable B-Cell Epitope Prediction biorxiv.org 2026-06-26 Prediction of B-cell epitopes can assist in reducing costly wet-lab screening in vaccine design, diagnostics, and antibody discovery.
Defining Pseudo-Haplotype Analysis Reveals Multi-Gene Genetic Pattern Across BAF Chromatin Remodeling Complexes biorxiv.org 2026-06-26 BRG1-associated factor (BAF) is a crucial chromatin remodeling complex.
Evaluating sequence-to-function deep learning models for ancestry-stratified regulatory variant effect prediction using multi-ancestry blood eQTLs biorxiv.org 2026-06-26 Background: Sequence-to-function (S2F) deep learning models are increasingly used to prioritize non-coding regulatory variants, but their behavior acr
HALPred-B: Host-Aware Linear B-Cell Epitope Prediction: Challenges, Limitations, and Variability Across Species biorxiv.org 2026-06-26 Predicting linear B-cell epitopes is a basic immunoinformatics task that has a direct impact on vaccine design and antibody engineering.
Kente: A Graph-based Pangenomic Approach for Horizontal Gene Transfer Detection in Microbiomes biorxiv.org 2026-06-26 Motivation: Horizontal gene transfer (HGT) shapes bacterial evolution and microbial ecosystems, yet detecting HGT within microbiomes remains a challen
Acquiring Improved Protein Variants With Probabilistic Preferential Learning biorxiv.org 2026-06-26 Variant effect prediction (VEP) models can be used to select promising novel enzymes from a pool of candidates.
vDeepInsight: an injective three-dimensional voxel carrier for tabular-feature neighborhood learning biorxiv.org 2026-06-26 DeepInsight-style methods make tabular feature relationships accessible to convolutional networks by placing each feature at a fixed position on an im
Structural characterization of human endogenous retrovirus integration and strand transfer inhibition biorxiv.org 2026-06-26 Human endogenous retroviruses (hERVs) are remnants of ancestral retroviral infections that have shaped the human genome through their capacity to mobi
Exploring the large-scale properties of a protein secondary structure genotype-to-phenotype map biorxiv.org 2026-06-26 We perform a large-scale computational characterization of the map of protein primary to secondary structure using an AVR3a class protein effector dom
Interplay of Structural Heterogeneity and Active Remodeling Controls Chromatin Condensate Organization and Dynamics biorxiv.org 2026-06-26 Chromatin is an actively remodeled polymeric system whose organization emerges from the interplay of equilibrium interactions and ATP-dependent proces
Non-invasive in vivo lactate monitoring via NIR spectroscopy biorxiv.org 2026-06-26 We present a non-invasive approach for continuous monitoring of lactate dynamics in-vivo using near-infrared (NIR) spectroscopy.
A Chromatin Biology Assessment of AlphaFold3 biorxiv.org 2026-06-26 Biomolecular structure prediction tools such as AlphaFold have achieved remarkable success in predicting structures of single proteins and multiprotei
Ecological drivers of social complexity: the role of predation risk and nesting resource in group-living cichlid biorxiv.org 2026-06-26 Understanding how social complexity responds to environmental variation remains a longstanding challenge in evolutionary biology.
The Vertebrate Genomes Project Phase I: A global reference genome resource biorxiv.org 2026-06-26 The Vertebrate Genomes Project (VGP) aims to produce complete and near-error-free reference genomes for all [~]70,000 extant vertebrate species.
Aposematic signals are dynamic over time in bioluminescent ostracods biorxiv.org 2026-06-26 Colour and contrast are commonly deployed in anti-predator signals like aposematism or deimatism.
Cardiolipin modulation of MmpL3 in mycobacteria biorxiv.org 2026-06-26 The complex cell envelope of mycobacteria is characterized by the presence of a unique outer membrane (OM) rich in mycolic acids (MAs).
Conjugation dynamics and persistence of a carbapenem resistance gene blaOXA-72 from Acinetobacter pittii to Acinetobacter baumannii biorxiv.org 2026-06-26 Carbapenem-resistant Acinetobacter (CRA) has been associated with increased morbidity and mortality in clinical settings.
MYC and RNA Polymerase II Binding Near Transcriptional End Sites Regulate the Expression of Functionally-Related Genes biorxiv.org 2026-06-26 MYC oncoprotein binding at promoters and enhancers influences RNA polymerase II (RNAPII)-driven gene expression.
TDP-43 subtypes shape transcriptomic signatures in Alzheimer's disease biorxiv.org 2026-06-26 TAR DNA-binding protein 43 (TDP-43) pathology frequently co-occurs with Tau neurofibrillary tangles (NFTs) and amyloid {beta} plaques in Alzheimer's d
Ferroptosis is a Physiologic Vulnerability of Iron-Recycling Macrophages biorxiv.org 2026-06-26 Iron deficiency anemia affects one-third of the global human population.
RNAPII and NER stall loop extrusion at UV lesions, shaping the 3D genome during repair biorxiv.org 2026-06-26 The three-dimensional (3D) genome architecture is highly elastic, adapting to nuclear processes such as transcription and the DNA damage response (Dek
Learning Perturbation Effects Through Contrastive Alignment of Multimodal Biological Embeddings biorxiv.org 2026-06-26 Multimodal single cell perturbation screens offer a scalable approach for characterizing the effects of genetic and chemical interventions on cellular
Microglia-Specific Molecular Magnetic Resonance Imaging Probe Enables Noninvasive Separation of Parkinsonian Mice from Controls biorxiv.org 2026-06-26 Neuroinflammation mediated by reactive microgliosis is a central driver of Parkinsons disease (PD) pathogenesis.
Spatially mediated interactions shape founder-cell fitness and community assembly in multi-species soil bacteria biorxiv.org 2026-06-26 Microbial communities spontaneously colonize pristine environments, yet how species growth kinetics and individual cell variation shape community asse
Predictable induction responses of gut prophages biorxiv.org 2026-06-26 Temperate bacteriophages are dominant members of the human gut microbiome that can infect and lyse their bacterial hosts or integrate as prophages.
Plasmid-encoded anatoxin biosynthesis in benthic cyanobacteria biorxiv.org 2026-06-26 Anatoxin-producing cyanobacteria pose growing ecological and public health risks, yet the genomic organization of anatoxin biosynthesis remains poorly
Early rhizosphere assembly during the onset of photosynthesis reveals inoculum-constrained succession with increased phylogenetic clustering, filtering and diversity biorxiv.org 2026-06-26 The rhizosphere microbiome, one of the most diverse and metabolically active microbial ecosystems known, plays fundamental roles in plant health and p
Anaerobic conditions increase plasmid transfer rates across Escherichia coli strains biorxiv.org 2026-06-26 Bacterial conjugation is the primary mechanism by which antibiotic resistance genes spread in microbial populations, yet our understanding of this pro
OmrA sRNA Inhibits Translation of Phosphoenolpyruvate Carboxylase to Impair TCA-Cycle Flux biorxiv.org 2026-06-26 Small RNAs (sRNAs) rarely cause strong growth phenotypes upon overexpression, complicating efforts to link regulatory interactions to physiological ou
Bacterial Mercury Resistance Reveals a Robust Species-Structured Human Antimicrobial Mobilome biorxiv.org 2026-06-26 Antimicrobial resistance (AMR) is increasingly recognized as an ecological and evolutionary phenomenon that extends beyond clinical environments.
LRP1 is an entry receptor for the botulinum toxin complex in the gut biorxiv.org 2026-06-26 Botulinum neurotoxin (BoNT) is an etiologic agent of food poisoning caused by Clostridium botulinum.
PlantGeneAnn: a strand-specific genome foundation model for ab initio gene structure annotation of plant genomes biorxiv.org 2026-06-26 High-quality plant genome assemblies are rapidly increasing, but accurate structural annotation remains reliant on transcript and homology evidence, l
Coherent scene context accelerates and reshapes neural object representations biorxiv.org 2026-06-26 Coherent scenes facilitate object recognition, but the representational basis of this facilitation and its temporal evolution in the brain remain uncl
Scaling of Neuronal Growth and Excitability Through Separable mTORC1 and mTORC2 Pathways biorxiv.org 2026-06-26 As neurons grow, they must regulate intrinsic excitability to maintain an appropriate level of spiking based on synaptic inputs.
Mass-transfer-constrained thermodynamics links fluid motion to the preferential use of hydrogen and formate in syntrophic propionate oxidation biorxiv.org 2026-06-26 Syntrophic propionate oxidation in methanogenic environments depends on interspecies electron transfer through hydrogen and formate, yet the physical
Rapid assessment of nitrification inhibitor efficacy, competitiveness, and specificity using microrespirometry biorxiv.org 2026-06-26 Nitrification inhibitors are applied to reduce nitrogen losses and greenhouse gas emissions from fertilized agricultural ecosystems.
Structural basis of multimodal adsorption and infection initiation by Vibrio phage Peru-2 biorxiv.org 2026-06-26 Phage Peru-2, isolated during the 1993 cholera outbreaks in Peru, is distinct from the three ICP phage lineages typically associated with epidemic Vib
Consistent gut bacterial microbiota in European sea bass fed aquafeeds containing sustainable plant and invasive fish-based ingredients biorxiv.org 2026-06-26 The aim of this study was to evaluate the impact of two sustainable dietary protein sources on the structure and composition of the gut microbiota in
PhenoXtract: combining Large Language Model and Knowledge Graph embedding to extract phenotypes from clinical descriptions biorxiv.org 2026-06-26 Motivation: Standardized phenotypic descriptions are essential for accurate diagnosis, yet clinicians and researchers face challenges in manually extr
Coalescing nephron and ureteric bud progenitors potentiates nephrogenesis in recellularized kidney scaffolds biorxiv.org 2026-06-26 Bioengineered, transplantable kidney tissue using decellularized scaffolds offers a promising strategy to overcome the shortage of donor kidneys that