Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targets biorxiv.org 2026-06-24 SARS-CoV-2 replication depends on a tightly coordinated series of intracellular processes that remain incompletely quantified.
Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy biorxiv.org 2026-06-25 Innate immune agonists are promising therapeutic agents to induce immune responses against cancer.
The "osteostat": a theory of bone mechanosensing and setpoint adaptation based on osteocytes biorxiv.org 2026-06-25 The osteocyte network in bone is believed to play an important role for how bone tissues sense and respond to mechanical stimulation.
Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice biorxiv.org 2026-06-25 Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances.
Assessing the influence of edge effects on macrofaunal contributions to decomposition rates across forest-field ecotones. biorxiv.org 2026-06-25 Understanding the relationships between soil macrofauna and decomposition is crucial for predicting how land-use change impacts ecosystem function in
Individual-level traits outweigh neighborhood and landscape level factors for frugivorous insect parasites in small forest patches biorxiv.org 2026-06-25 Frugivorous insect larvae are dependent on fruiting plants for development, leading to complex host-parasite interactions that may be influenced by ma
Intra-African Geographic Domain Shift in Wildlife Camera Trap Species Classification: A Comparative Study of Supervised and Zero-Shot Foundation Models biorxiv.org 2026-06-25 Camera trap networks such as Snapshot Safari have generated millions of labelled wildlife images across Africa, enabling the training of deep learning
Drought alters volatile profiles in European beech saplings across genetically diverse backgrounds biorxiv.org 2026-06-25 European beech (Fagus sylvatica L.) is a widely distributed, ecologically and economically important deciduous tree species in European forests, but i
Rapid vegetation reorganization in Hengduan Mountains driven by high climatic oscillations biorxiv.org 2026-06-25 The accelerating global climate change has been triggering large-scale vegetation reorganizations, yet our understanding of how mountain ecosystems re
Climate at seed origin drives germination and seedling trait responses to warming in sessile and pubescent oaks biorxiv.org 2026-06-25 Tree early life stages are particularly sensitive to warming, yet their responses remain poorly understood despite their importance for forest regener
The effects of fox movement and landscape heterogeneity on the spread of sarcoptic mange in urban settings biorxiv.org 2026-06-25 Context - The movement of vertebrate hosts across urbanized landscapes can play a key role in the transmission of direct-contact diseases.
Seasonal succession of nano- and picoplankton communities in Lake Constance: conserved dynamics despite compositional shifts under contrasting mixing and oxygen regimes biorxiv.org 2026-06-25 Lake Constance is a pre-Alpine, monomictic, oligotrophic lake situated at the southern end of Germany composed of two main water bodies: deep, oligotr
Using semi-folded arenas to observe spontaneous emergence of collective trails in whole colonies of termites biorxiv.org 2026-06-25 Collective movement in social organisms emerges from local interactions and can generate large-scale spatial patterns of ecological relevance.
Navigating the salinity gradient: Individual variation in habitat use and migration of European eel revealed by otolith microchemistry biorxiv.org 2026-06-25 Knowledge regarding variation in habitat use among individuals is crucial for understanding population dynamics and for management and conservation me
Biodiversity material remains where capacity and governance are strong, but taxonomic resources concentrate with geopolitical power biorxiv.org 2026-06-25 Aim: Biodiversity-rich regions often lack the scientific infrastructure needed to document and curate their own biodiversity, creating inequalities in
Spatiotemporal differences in salmon nutrient inputs restructure functional and taxonomic fungal communities in riparian system biorxiv.org 2026-06-25 Spawning salmon transport marine-derived nutrients (MDN) into riparian forests, influencing soil, plant, and animal communities, yet their effects on
Diverging Hydroclimatic Trends in Global Tropical Dryland Ecosystems Based on ERA-5 and CHIRPS Analysis Data biorxiv.org 2026-06-25 Tropical dryland ecosystems are highly biodiverse and fragmented and are experiencing significant anthropogenic and climatic changes.
Reducing background ion burden in tributylamine ion-pairing LC-MS improves signal intensity and feature coverage in metabolomics biorxiv.org 2026-06-25 Background chemical ions are a pervasive but often underappreciated limitation in LC-MS metabolomics, where they can suppress analyte signal, obscure
Regulating Light-Harvesting Protein Assembly through Engineered Trimers of Phycocyanin and Allophycocyanin biorxiv.org 2026-06-25 Phycobiliproteins form oligomeric assemblies essential for photosynthetic light harvesting.
Postprocessing of P300 Speller Output with a Large Language Model biorxiv.org 2026-06-25 P300 spellers convert electroencephalographic (EEG) activity into text by presenting users with a matrix of flickering characters.
Insect COI barcoding data as an untapped resource for surveying Wolbachia symbioses biorxiv.org 2026-06-25 1.
Evaluating the potential role and contribution of transposable elements to the evolution of microbial multicellularity across the tree of eukaryotes biorxiv.org 2026-06-25 Multicellularity has evolved multiple times across the eukaryotic tree of life, including among protist lineages.
Structural and Biochemical Analysis of the CABIT1 Domain of THEMIS biorxiv.org 2026-06-25 T cells are important components of the adaptive immune system and develop through a selection process regulated by signaling through the T-cell recep
Endophilin B1 primes mitochondria for execution biorxiv.org 2026-06-25 Intrinsic apoptosis, or programmed cell death, is a vital response to stress and DNA damage in cells, and dysregulation of the intrinsic apoptotic pat
Environmental filtering across seasons and host-associated selection shape the gut microbiome of sympatric European Sepsis dung flies biorxiv.org 2026-06-25 Animal microbiomes are shaped by both environmental exposure and host-associated filtering, but the relative importance of these processes remains poo
High-speed volumetric single-molecule imaging using dual-wavelength light sheets and PSF-engineered enhanced biplane detection biorxiv.org 2026-06-25 Single-molecule localization microscopy (SMLM) enables nanoscale imaging but remains limited in three-dimensional (3D), high-speed, and high-density a
Optimization of Gadolinium-Based Contrast Agent Protocols for Reliable Ex Vivo Diffusion-Weighted Imaging in the Avian Brain biorxiv.org 2026-06-24 Ex vivo diffusion weighted imaging (DWI) enables high-resolution characterization of brain connectivity and is increasingly applied in comparative and
CD73-derived adenosine at the blood-brain barrier confers protection in a mouse model of ischemic stroke biorxiv.org 2026-06-24 Ischemic stroke remains a leading cause of death and disability, and current reperfusion therapies do not address the secondary neuroinflammatory resp
Performance-impacting brain state maladaptation driving disease progression in early mouse and human neuroinflammation biorxiv.org 2026-06-24 The neuronal mechanisms driving progression in neuroinflammatory disorders from early relapse-remitting phases to later neurodegenerative phases remai
Bathymetric Resolution-Dependent Biases in Antarctic Benthic Biodiversity Models: Hotspots Hold, Counts Shift biorxiv.org 2026-06-24 Antarctic benthic organisms are highly diverse and play a critical role in the Southern Ocean ecosystem.
Integrating Machine-learning and Ultra-high-throughput Screening for Enzyme spaces exploration biorxiv.org 2026-06-24 The systematic navigation of biocatalyst space is constrained by elusive structure-activity rules and a lack of evolutionary history.
MICAL-Inspired Chiral Vanadate Nanoclusters Decelerate Actin Dynamics in Live Cells biorxiv.org 2026-06-24 Actin turnover is a fundamental cellular process essential for cell dynamics, whose control is critical for both medicine and biotechnology.
Overexpression of flavodiiron protein Flv3 in engineered Synechocystis stimulates sucrose production and growth by altering cellular redox balance through enhanced sulfur metabolism biorxiv.org 2026-06-24 Biotechnological applications of oxygenic photosynthetic organisms depend on conversion of light energy into chemical energy through photosystems (PS)
Force sharing between plantarflexor muscles in sheep during treadmill gait biorxiv.org 2026-06-24 Muscle force sharing during locomotion is influenced by the mechanical demands of movement and the contractile properties of synergistic muscles.
Catalytic rewiring of RuvC-II catalytic site activates trans-cleavage in Fanzor2 biorxiv.org 2026-06-24 Fanzors are eukaryotic RNA-guided endonucleases that mediate programmable cis-cleavage in eukaryotic cells, but their potential target-induced collate
Small stream restoration increases habitat and plant diversity across scales biorxiv.org 2026-06-24 A majority of stream restoration efforts in central Europe focus on streams that are less than five meters wide.
A Thin Film Transistor Backplane for Scalable Chronic Neural Interfaces biorxiv.org 2026-06-24 Scaling neural interfaces to ever-higher channel counts has accelerated rapidly with advances in thin-film fabrication, lithography, and connectorizat
Organizational principles governing synapse types in a whole-brain connectome biorxiv.org 2026-06-24 Neurons are classically viewed as polarized elements in which dendrites receive synaptic input and axons provide output.
Near-atomic structures of human astrovirus capsids reveal a subunit-specific maturation mechanism biorxiv.org 2026-06-23 Human astrovirus (HAstV) is a major cause of acute gastroenteritis, yet the structural basis of capsid maturation and infectivity remains poorly under
Spicing up urinary tract infections: synergistic action of fosfomycin with trans-cinnamaldehyde - insight to the mode of action biorxiv.org 2026-06-23 Objectives: Fosfomycin (FOS) remains an important therapeutic option for urinary tract infections caused by uropathogenic Escherichia coli (UPEC), but
Reversal effects of Isochlorogenic acid A on HBV-induced transcriptional dysregulation and apoptotic signaling biorxiv.org 2026-06-23 Chronic hepatitis B virus (HBV) infection contributes to hepatocellular carcinoma by disrupting host transcription, cell-cycle control, and apoptotic
Repair outcomes after germline homing endonuclease cleavage in Anopheles gambiae inform the design of synthetic gene drives biorxiv.org 2026-06-23 Homing endonuclease genes spread by cleaving homologous chromosomes that lack the endonuclease cassette, after which repair from the endonuclease-cont
A Scalable Framework for Species-Resolved Human Gut Microbiome Profiling Using Full-Length 16S rRNA Sequencing biorxiv.org 2026-06-23 The gut microbiota plays a fundamental role in human health, nutrition, immune development, and disease, driving widespread adoption of 16S rRNA gene
Surface-specific film assembly of a Vibrio cholerae adhesin peptide modulated by environmental salts biorxiv.org 2026-06-23 Underwater adhesion research increasingly draws on bioinspired systems to uncover the molecular mechanisms that enable strong interfacial binding in a
Directional information flow as a tool for analyzing protein allostery biorxiv.org 2026-06-23 The ability to tune protein function through the binding of modulatory ligands enables the development of therapeutics that steer a biological system
DNA-barcode labelled MHCII multimers for detection of antigen-specific CD4 T cells across large libraries of epitopes biorxiv.org 2026-06-23 The role of antigen-specific T cells responding to antigen is a topic of intense studies, and critical for mechanistic insight of diseases and develop
EndD mediates butyrate-dependent toxin release in Clostridioides difficile biorxiv.org 2026-06-23 Clostridioides difficile is an urgent threat to human health. Current treatments for C.
Malaria parasites coordinate host cell remodeling through the AP2-HCR DNA-binding protein biorxiv.org 2026-06-23 Parasite-induced host cell remodeling is essential for Plasmodium falciparum survival during the intraerythrocytic developmental cycle (IDC), yet the
Unraveling Xanthomonas acetyltransferase GumG: decoding catalytic promiscuity, understanding the mechanism, and enhancing enzymatic versatility biorxiv.org 2026-06-23 Xanthan is a structurally complex exopolysaccharide produced by Xanthomonas campestris and one of the most extensively studied microbial biopolymers.
Distinct taxonomic groups of sponge symbionts have the biosynthetic capacity for the production of ether lipids biorxiv.org 2026-06-23 The marine sponge holobiont, composed of the sponge host and its microbial symbionts, is a known source of abundant and diverse ether lipids (ELs).