A finite element model of pregnancy derived from maternal sonography: effect of uterine and cervical structural properties on cervical mechanical loading biorxiv.org 2026-06-23 Identification and treatment of pregnancies at risk for preterm birth is a central challenge in obstetric research.
Engineering of CAR-less lentiviral vectors via ER retention-mediated CAR blockade biorxiv.org 2026-06-23 Chimeric antigen receptor (CAR)-T cell therapies have transformed the treatment of various tumor types by redirecting and activating T cells against t
Engineering an in vitro spinal column: Manufacturing designs and emerging solutions for producing an axial mechanobiological system biorxiv.org 2026-06-23 The human spine is a complex, coordinated biomechanical system.
Temporal and Regional Circular RNA profiling in a Tauopathy Mouse Model: Implications for Tau Pathology and Neurodegeneration biorxiv.org 2026-06-23 MicroRNAs (miRNA), are non-coding RNA that act as post-transcriptional regulators of gene expression in various organs including the brain where they
Single-molecule insights into DNA gyrase in live bacteria biorxiv.org 2026-06-22 Molecular motors travelling along DNA introduce positive supercoils that present as barriers to replication leading to genome instability.
Thrombospondin-2 deficiency primes the synovial joint for aberrant tissue remodeling and injury response biorxiv.org 2026-06-22 Objective.
Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipid biorxiv.org 2026-06-22 The mechanism by which T cell receptors (TCR) recognise mycobacterial lipids presented by CD1 family members not well understood.
Chitin oligomers induce atypical NLRP3 inflammasome activation and innate immune training biorxiv.org 2026-06-22 Chitin is a highly abundant poly- N-acetyl-glucosamine (GlcNAc) and linked to immune recognition of fungal infections and asthma in humans.
IL-38 limits alloreactivity through modulating myeloid and T cell activation biorxiv.org 2026-06-22 Interleukin-38 (IL-38) is a cytokine of the IL-1 cytokine family that promotes the resolution of inflammation.
Real-world results from a Machine Learning-guided, phenotypic High-Throughput Screen for novel antibiotics biorxiv.org 2026-06-22 Antimicrobial resistance is an urgent global health threat, with over 2.8 million multidrug-resistant infections killing over 35,000 annually in the U
A representative of a ubiquitous bacterial lineage parasitically feeds on host RNA biorxiv.org 2026-06-22 Cellular metabolism is widely understood as an integrated network of redox reactions, energy conservation, and biosynthetic pathways.
DNA cytosine methylation modulates UV resistance and nucleotide excision repair gene expression in Escherichia coli biorxiv.org 2026-06-22 Bacterial survival after ultraviolet (UV) exposure is shaped not only by the extent of DNA damage but also by the physiological state-dependent capaci
Active non-redundancy and viral orchestration sustain diel microbial successions in the coastal ocean biorxiv.org 2026-06-22 Ecosystem resilience in dynamic coastal oceans is conventionally ascribed to functional redundancy, where taxonomically distinct microbes buffer envir
The primate gut bacterial microbiome: a systematic review of research methodologies, taxonomic coverage, and conservation implications biorxiv.org 2026-06-22 Primates are central to both human evolutionary research and ecosystem functioning, serving as seed dispersers, predators, pollinators, and prey.
Organic availability and microbial competition for acetate suppress methane emissions during the conversion of gypsum in sewage sludge biorxiv.org 2026-06-22 Conventional anaerobic digestion emits methane from organic waste.
Efficient septum formation is essential for chromosome segregation in Bacillus subtilis when SMC function is impaired biorxiv.org 2026-06-22 Structural maintenance of chromosomes (SMC) complexes play conserved roles in chromosome organization, segregation, and repair in all domains of life.
Comparison of Four Density Gradient Centrifugation Protocols for Purification of Toxoplasma gondii PRU Brain Cysts biorxiv.org 2026-06-22 Toxoplasma gondii is an obligate intracellular zoonotic protozoan that establishes persistent brain cysts in infected hosts, causing chronic infection
Generalized Chargaff symmetry in codon usage across the tree of life biorxiv.org 2026-06-22 Codon usage bias is a central record of mutation, selection, drift, and translational constraints, but it is usually treated separately from generaliz
A recombinant dilp2GS-rpr donor line for adult-inducible IPC ablation across Drosophila genetic backgrounds biorxiv.org 2026-06-22 Genetic-background studies require defined perturbations that can be crossed reproducibly into many recipient backgrounds.
Neuroendocrine arylhydrocarbon receptor regulates gut microbiome of C. elegans via redox tone biorxiv.org 2026-06-22 The gut microbiome profoundly influences host health, with disrupted microbial communities implicated in inflammatory, metabolic, and neurological dis
Sex differences in PRDM9-independent fine-scale recombination patterns biorxiv.org 2026-06-22 Meiotic recombination rates exhibit strong, fine-scale variation along the genome of many eukaryotes.
Genetic introgression and transcriptomic plasticity are associated with enhanced Leishmania infantum pathogenicity causing human cutaneous leishmaniasis in Tunisia biorxiv.org 2026-06-22 The protozoan parasite Leishmania infantum exhibits significant genetic variability among isolates, influencing disease manifestation and treatment re
First outbreak of Lumpy Skin disease in Catalonia, Spain, 2025-2026 biorxiv.org 2026-06-22 Lumpy skin disease (LSD) is an emerging cattle disease caused by lumpy skin disease virus (LSDV), with major impacts on the industry, being classified
PanRes: A database of latent and acquired antimicrobial resistance allowing 3D-based protein homology search biorxiv.org 2026-06-22 Antimicrobial resistance databases are central to genomic surveillance, but resistance determinants remain distributed across resources with different
EMAlign: accurate alignment of cryo-EM maps through main-chain probability using deep learning biorxiv.org 2026-06-22 Accurate alignment of cryo-EM density maps is essential for comparing conformational states, searching map libraries, and guiding atomic model buildin
The Dilated Cardiomyopathy E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Crossbridge Cycling biorxiv.org 2026-06-22 The {beta}-cardiac myosin (MYH7) mutation E525K was first identified in 2012 in a patient with dilated cardiomyopathy (DCM).
Simulation of cell-size systems at long timescales with flexible protein structures biorxiv.org 2026-06-22 Protein behavior inside cells is dominated by the crowded nature of the intracellular environment.
Spatial Orchestration of Skin Fibrosis by a CD8+ T cell-Myofibroblast Axis biorxiv.org 2026-06-22 Fibrosing skin diseases are highly morbid conditions with diverse clinical and histopathologic features.
Label-free Pathogen Identification with Microscopy Imaging and Deep Learning biorxiv.org 2026-06-22 Rapid and accurate pathogen identification is crucial for the clinical management of infectious diseases, particularly sepsis and severe respiratory i
MALDI Tandem Mass Spectrometry for Colony-Based Dereplication of Natural Products biorxiv.org 2026-06-22 Microbial libraries remain an important resource for natural product discovery; however, constructing taxonomically and chemically diverse collections
Few-Shot Classification of C. elegans Developmental Stages via Explainable Hierarchical Hyperbolic Graph Embeddings biorxiv.org 2026-06-22 Automated, accurate, and fast developmental-stage classification of C.
Buzzing Frequency Influences Pollen Release in Buzz-Pollinated Poricidal Anthers biorxiv.org 2026-06-22 Buzz pollination is an important behavior in which bees use vibrations to extract pollen from poricidal anthers.
LTP-patterned electromagnetic stimulation induces NMDA receptor-dependent synaptic plasticity in cortical networks biorxiv.org 2026-06-22 Bioinspired electromagnetic stimulation, in which fields are patterned after endogenous neural activity, have emerged as a potential non-invasive appr
Targeting pathogenic VWF/ADAMTS13 dysregulation attenuates CTEPH progression biorxiv.org 2026-06-22 Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening pulmonary vascular disease, characterized by persistent thrombotic obstruc
A human intracranial map of consciousness returning from anesthesia biorxiv.org 2026-06-22 How consciousness arises from the brain remains a central yet unsolved question.
Encoding-related fMRI BOLD activity predicts subsequent memory for studied scenes, but not subsequent identification of perceptually similar lures. biorxiv.org 2026-06-22 Pattern separation is widely regarded as a hippocampally mediated process that reduces interference between memories of similar experiences.
Data aggregation strategies for a P300 speller: decoding models, epoch averaging, cross-subject ensembles, and multi-channel models biorxiv.org 2026-06-22 Accurate detection of P300 event-related potentials from electroencephalography (EEG) remains challenging for small numbers of trials due to low signa
Multi-Parametric Phase-Cycled Balanced Steady-State Free Precession Brain Tissue Characterization in Relapsing-Remitting Multiple Sclerosis biorxiv.org 2026-06-22 Quantitative MRI enables the detection of subtle microstructural alterations in normal-appearing white matter (NAWM) associated with pathological cond
Alzheimer's Disease Selectively Perturbs Age-Sensitive Brain Radiomic Features Across the Disease Continuum biorxiv.org 2026-06-22 Normal brain aging and Alzheimer's disease both involve progressive structural brain alterations, making it challenging to distinguish pathological ne
Aperiodic exponent ceases to track changes in propofol dose at deep surgery-level hypnotic depths biorxiv.org 2026-06-22 Background: Accurately tracking hypnotic depth during surgery is key to deliver personalized and precise anaesthesia.
Fluorogenic labelling for tracking extracellular vesicle nanocarriers in the brain biorxiv.org 2026-06-22 Background: Reliable tracking of extracellular vesicles (EVs), key biological nanocarriers in nanomedicine, remains a major technical challenge due to
Interaction forces reflect the perception of texture during active exploration biorxiv.org 2026-06-22 We are constantly exploring the world around us through touch.
Ovarian hormonal state at exercise initiation interacts with nigrostriatal circuitry to determine long-term voluntary exercise behavior biorxiv.org 2026-06-22 Despite the well-established health benefits of exercise, adherence to physical activity remains low, highlighting the need to identify biological fac
Optimal Practice Schedules in a Dual-Rate Model of Motor Adaptation, and Their Recovery by Reinforcement Learning biorxiv.org 2026-06-22 A clinician guiding a stroke patient through a 45-minute rehabilitation session, a coach planning a training day, a teacher choosing the order of prac
Distributed representations of chemosensory valence in a naive vertebrate brain biorxiv.org 2026-06-22 Chemical cues guide essential behaviors by signaling food, danger, and social information.
Neural acceleration drives adaptations in working memory encoding speed biorxiv.org 2026-06-22 Humans and non-human animals adaptively boost their encoding speed when they expect limited sensory exposure time, so that they can capture essential
Relationship between cognitive flexibility and disordered eating attitudes across the non-clinical spectrum biorxiv.org 2026-06-22 Disordered eating attitudes exist on a continuum that extends well below clinical diagnostic thresholds, yet the cognitive correlates of this non-clin
nanoASM: Long-Read Allele-Specific DNA Methylation Profiling Enables Functional Annotation of Regulatory Noncoding Variants in Human Prostate Tissues biorxiv.org 2026-06-22 Long-read nanopore sequencing enables simultaneous detection of germline variation and native DNA base modifications on individual DNA molecules, prov
An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body biorxiv.org 2026-06-22 The trabecular meshwork (TM) and ciliary body (CB) regulate aqueous humor dynamics and intraocular pressure (IOP), and TM/Schlemm's canal (SC) dysfunc
The vocal repertoire of white-nosed coatis: structural features, temporal dynamics, and social variations biorxiv.org 2026-06-22 For many group living species, vocal signals are a vital form of communication needed to coordinate social behaviours.