Remodeling of mRNA by eIF4F in human translation initiation biorxiv.org 2026-06-19 For the ribosome to load onto an mRNA during the early steps of translation initiation, the mRNA must be activated by the eIF4F complex.
BiDBiC: A novel ultra-high-throughput pipeline for Bead-in-Droplet Biofilm Cultivation and Characterization biorxiv.org 2026-06-19 Biofilms are a form of microbial growth consisting of cells, often attached to a surface, embedded in a structured 3D extracellular matrix that confer
A beneficial megaplasmid transforms an opportunistic bacterial pathogen to benefit coral by extending their thermal range biorxiv.org 2026-06-19 Resilient turbid coral reefs, found 1{degrees} north of the equator, experience fewer and less intense bleaching events despite being situated within
Multisensory integration of a host metabolite coordinates bacterial predation of macrophages biorxiv.org 2026-06-19 Chemical communication across kingdoms underpins infection, yet how pathogens actively decode host signals to launch coordinated attacks remains a fun
Antiviral activity of anisomycin against chikungunya virus biorxiv.org 2026-06-19 Chikungunya virus (CHIKV) is a globally prevalent arbovirus transmitted by Aedes mosquitoes, which causes acute fever accompanied by debilitating join
Rapid spread of nutritional Wolbachia symbionts across and within solitary bee species biorxiv.org 2026-06-19 Maternally inherited, intracellular Bacteria of the genus Wolbachia are extremely widespread among arthropods.
A missense mutation in FBXL3 links circadian regulation to out-of-season estrus in sheep biorxiv.org 2026-06-19 Seasonal breeding is a remarkable adaptive trait, but it constrains efficient production in the sheep industry.
The gut bacterial community of black soldier fly larvae is a reservoir of antibiotic resistance and virulence genes biorxiv.org 2026-06-19 Antimicrobial resistance (AMR) is a serious threat to global health.
Morpho-FM: spatial molecular reconstruction from routine H&E histology using transcriptomic foundation-model priors biorxiv.org 2026-06-19 Routine haematoxylin and eosin (H&E) histology captures tissue architecture at clinical scale, but lacks a direct molecular readout of the transcr
Spatiotemporal proteomics elucidates trafficking and localization of Neuroligins to the axon initial segment plasma membrane biorxiv.org 2026-06-19 Neuronal development and function rely on precise sorting of membrane proteins to distinct neuronal domains, yet the underlying mechanisms remain inco
Cell-specific transcription dysregulation in human Huntington's disease-positive developing striatum biorxiv.org 2026-06-19 Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG-repeat expansion in the HTT gene.
Patterns of molecular conservation along tooth development are only partly shaped by evolutionary pressures on tooth biorxiv.org 2026-06-19 Although it is well established that certain stages of development are molecularly more conserved than others, the reasons for this phenomenon remain
Altricial, but not unusual: Comparative analysis of human dependency period within mammalian life history patterns biorxiv.org 2026-06-19 Humans are widely regarded as unusually slow to develop, exhibiting prolonged childhood and extended dependence on caregivers.
Brain structural and genetic correlates of motor coordination and learning behaviours: modelling developmental coordination disorder biorxiv.org 2026-06-19 Developmental coordination disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination and learning, yet its
Examining Action Potential Waveform Diversity in Neuronal Populations of Midbrain Organoid Models biorxiv.org 2026-06-19 Over the last decade, pre-clinical research has witnessed the advancement of human induced pluripotent stem-cell derived 3D brain organoid models and
Infantile engram modulates memory formation during adulthood biorxiv.org 2026-06-19 Infantile amnesia refers to the inability to recall early-life experiences, despite their lasting influence on adult behavior.
Regional connectivity and partial residency of capelin (Mallotus villosus) in the Gulf of St. Lawrence inferred from otolith chemistry biorxiv.org 2026-06-19 Capelin (Mallotus villosus), a key forage fish in the Northwest Atlantic, links zooplankton to predators including commercial fishes, seabirds, and ma
Condition manipulation reveals an increase in sex-specific additive genetic variance, and reduced intersex genetic covariances in Drosophila prolongata, a species with sexual trait exaggeration biorxiv.org 2026-06-20 The between sex genetic correlation for traits has long been hypothesized as a constraint to the evolution of sexual dimorphism.
Population-specific selective sweeps contribute to the maintenance of genetic structure in Chlamydomonas reinhardtii biorxiv.org 2026-06-20 Microbial eukaryotes often exhibit large effective population sizes and broad dispersal, yet the extent of population structure and the forces shaping
Traits and hidden states: is self-fertilization associated with rates of diversification across mating and sexual systems? biorxiv.org 2026-06-20 Reproductive biology is a key determinant of fitness.
Hybridisation and herbivory fuel Amazonian tree radiations biorxiv.org 2026-06-20 Tropical rainforests, and Amazonia in particular, contain more tree species than anywhere else, most of which arose through rapid evolutionary radiati
Probability of Antibiotic Resistance During Treatment in Stochastic PK/PD-Based Bacterial Model with Distinct Drug and Mutation Modes biorxiv.org 2026-06-20 Mathematical models, e.g.
The shape of evolution: persistent homology of genetic-distancedata as an observable of reticulate processes in pathogen andplant genomes biorxiv.org 2026-06-20 Evolutionary biology has long theorized processes recombination, lineage divergence, drug-resistance sweeps, introgression, refugial persistence whose
Museum specimens reveal evolutionary drivers and functions of oral microbiome in mammals biorxiv.org 2026-06-20 The microbiomes of wild animals, despite being integral to host survival, remain largely unexplored, particularly beyond the gut.
Reconstructability of evolutionary intermediates in generative epistatic landscapes biorxiv.org 2026-06-19 Evolutionary intermediates connect observed proteins, but the sequence of steps that produced them is rarely recoverable from extant data alone.
Genomics Analysis Illuminates Morphology, Ecology, Phenology and Distribution of Two Cryptic Atrytonopsis Skippers (Hesperiidae: Hesperiinae) biorxiv.org 2026-06-19 The Hesperiine genus Atrytonopsis Godman, 1900, occurs broadly across the American Southwest.
Parallel connectivity and genomic divergence but heterogeneous demographic history in sympatric Mediterranean clingfishes biorxiv.org 2026-06-19 Understanding the extent to which marine connectivity can be predicted from shared oceanographic and biogeographic conditions remains a central challe
Caste-specific ageing emerges from the evolution of resource allocation in eusocial insects biorxiv.org 2026-06-19 Eusocial insects have extreme intraspecific lifespan variation, where queens are long-lived (up to 30 years) whereas workers only live for a few month
The recount3 Python package for programmatic access to uniformly processed RNA-seq data biorxiv.org 2026-06-20 The recount3 online resource provides tens of thousands of uniformly processed RNA-seq samples across human and mouse from major sequencing repositori
Vessel Spatial Analysis (VeSpA): a tool for whole slide image segmentation, morphometry, and QuPath extension. biorxiv.org 2026-06-20 Quantifying vascular architecture in histological whole slide images is needed to study tissue organisation, tumour microenvironment biology, and dise
From Nuisance to Signal: Leveraging Close Relatives in Biobank-Scale Demographic Inference biorxiv.org 2026-06-19 Biobank-scale datasets now routinely include hundreds of thousands to millions of individuals, and as sample sizes grow, close relatives become increa
DNA methylation regulates a key sex differentiation gene in Pogona vitticeps, a dragon lizard with sex reversal biorxiv.org 2026-06-19 During embryonic development bipotential gonads differentiate into either testes or ovaries under the direction of mutually exclusive gene networks.
Whole genome sequencing of endometrial cancer identifies novel subgroups, drivers, and actionable alterations biorxiv.org 2026-06-19 Endometrial cancer (EC) is the most common gynaecological malignancy in high income countries, and is increasing in incidence.
Organisational principles of long non-coding RNAs revealed by exon deletion biorxiv.org 2026-06-19 Long non-coding RNAs (lncRNAs) regulate cell phenotypes in health and disease, yet how function is encoded in their sequence remains poorly understood
Nonlinear influence of reward volatility on arbitration between multiple learning strategies reflects cost-benefit optimization biorxiv.org 2026-06-19 Action selection involves two systems: a model-free reinforcement learning strategy, which relies on experience with action-outcome pairs, and a model
High side chain promiscuity of the terminal enzyme in the homologation pathway for L-phenylalanine and L-tyrosine biorxiv.org 2026-06-19 Natural product (NPs) and their derivatives are a major source of small-molecule drugs, and the building blocks of these NPs are often amino acids.
A Reusable Non-Adhesive Chest-Wall Acoustic Wearable Estimates Respiratory Rate During Rest and Exercise biorxiv.org 2026-06-19 Respiratory rate is a clinically and behaviourally informative signal, yet continuous monitoring outside quiet rest remains difficult.
Nickel-Driven Dynamics of Urease in Sporosarcina pasteurii: Integrated Computational and Experimental Insights biorxiv.org 2026-06-19 Urease is a nickel-dependent enzyme that plays an important role in urea hydrolysis and in a process named as microbial-induced calcium carbonate prec
ContinuumCellAgent: A Framework-Guided Agent for Long-Horizon Scientific Research biorxiv.org 2026-06-19 AI-scientist systems are beginning to automate parts of scientific research.
Perturbation Curve models continuous transcriptional response trajectories and improves prediction of genetic modulations biorxiv.org 2026-06-19 Single-cell CRISPR screens, Perturb-seq, have revolutionized functional genomics by revealing biological causality.
FeatureMSEA: Metabolic Feature-based Metabolite Set Enrichment Analysis biorxiv.org 2026-06-19 Liquid chromatography-mass spectrometry (LC-MS) untargeted metabolomics detects thousands of metabolic features, but converting these chemical signals
Geroprotective interventions preserve trabecular bone during ageing in female mice biorxiv.org 2026-06-19 Geroprotectors extend lifespan and improve several aspects of healthspan, yet their effects on skeletal ageing remain poorly understood.
Identification of srh-30 as a 2-nonanone receptor in C. elegans biorxiv.org 2026-06-19 C. elegans detects food, mates, and danger through a large repertoire of chemosensory receptors.
Inhibitory Gain and Hub Architecture Confer Dynamic Resilience to Microcircuit Degeneration biorxiv.org 2026-06-19 Neurodegeneration progressively removes synapses and neurons, yet neural circuits can retain stable collective dynamics despite substantial structural
Killer-cell dominance dichotomy governs tumor immune networks and stratifies inflamed cancers biorxiv.org 2026-06-19 Cancer immunotherapy benefits remain limited, even among hot tumors with high killer lymphocyte infiltration.
A gavage-fomite based method to generate mouse models with natural microbiota biorxiv.org 2026-06-19 Laboratory-raised specific pathogen-free (SPF) mice have been indispensable for fundamental immunology research, yet their reliability in predicting h
Polymorphonuclear neutrophils modulate the responses of human immune cells to vaccines in an in vitro blood cell culture system biorxiv.org 2026-06-19 Vaccine-induced immune responses are the result of an intricate interplay between different cell populations of the innate and adaptive immune system,
Cross-species chromatin accessibility pinpoints HIVEP3 as a driver of thymic epithelial maturation and self-antigen expression, preventing chronic inflammation biorxiv.org 2026-06-19 Promiscuous expression of tissue-specific antigens (TSAs) by medullary thymic epithelial cells (mTECs) underpins central T-cell tolerance, relying on
RNAquarium: an archive-scale atlas of zebrafish gene expression coupled with pan-taxonomic profiling reveals diverse viral drivers of transcriptomic states biorxiv.org 2026-06-19 Zebrafish RNA-seq studies span diverse developmental, physiological, and disease contexts, yet most analyses remain confined to individual experiments
The road to nowhere: geolocation-by-genotype traces large-scale yellow-browed warbler vagrancy to central Siberia biorxiv.org 2026-06-19 Vagrant animals - individuals found far outside their normal range - offer powerful natural experiments for understanding migratory mechanisms.