First characterization of metabolomic and lipidomic exchange over the healthy human brain biorxiv.org 2026-06-21 The energy turnover and metabolic flexibility of the human brain extend beyond a primary reliance on carbohydrates and oxygen.
Integrative Multi-Omics Analysis of Gut Microbiota Dysbiosis and Host-Microbiome Interaction Mechanisms in Hypertension biorxiv.org 2026-06-21 Objective:To characterize gut microbiota dysbiosis in hypertension and investigate its multilevel interactions with the host immune system.
Identification of heterotic group-specific haplotypes and impact of residual inbreeding on grain yield of maize elite hybrids biorxiv.org 2026-06-21 Modern hybrid maize (Zea mays L.) breeding programs are based on the management of distinct complementary heterotic groups to maximize heterosis in hi
Antibody-Antigen Affinity Prediction with Chain-Aware Protein Language Modeling biorxiv.org 2026-06-21 Motivation: Antibody-antigen affinity determines which antibodies advance in therapeutic discovery, repertoire analysis and affinity maturation, but e
A novel preclinical mouse model recapitulates progressive phenotypes of Bryant-Li-Bhoj Syndrome biorxiv.org 2026-06-20 Bryant-Li-Bhoj Syndrome (BLBS; OMIM: 619720, 619721) is a Mendelian neurogenetic condition, first described in 2020, with a mixed neurodevelopmental/n
Long-term population decline and recombination heterogeneity shape genomic diversity in the American alligator biorxiv.org 2026-06-20 The loss of genetic diversity caused by population bottlenecks can significantly impact the ability of a species to adapt to disease, natural disaster
Genetic Modulation of Oxycodone Self-Administration Trajectories: From Initiation to Escalating Burst Patterns biorxiv.org 2026-06-20 Opioid Use Disorder (OUD) remains a prominent threat to global health.
SAbDab2: The structural antibody database in the age of machine learning biorxiv.org 2026-06-20 The Structural Antibody Database (SAbDab) is a publicly available repository of experimentally determined antibody structures, first released in 2013.
MIRATS framework: Normative multiscale characterization of brain regulatory systems across sex and age using multimodal MRI biorxiv.org 2026-06-20 Deep brain systems involved in arousal, autonomic regulation, sensory integration, and homeostatic control remain underrepresented in conventional who
Evaluation of Trypanosoma brucei Phosphofructokinase Allosteric Inhibition: An In-Silico Study biorxiv.org 2026-06-20 Human African trypanosomiasis, caused by a protozoan parasite Trypanosoma brucei, is a neglected tropical disease for which well-tolerated, convenient
RNAStabFormer: Region-Aware Multi-Task Hybrid Learning for RNA Stability Prediction from Pulse-Chase Transcriptomics biorxiv.org 2026-06-20 RNA stability is a central layer of post-transcriptional gene regulation, yet large-scale stability labels derived from pulse-chase transcriptomics de
Non-contact direct sensing of material properties of biomolecular condensate using Scanning Ionic Conductance Microscopy biorxiv.org 2026-06-20 Biomolecular condensates are important regulators of cellular compartmentalization and biochemical processes.
Viral RNAs as Dual Graphs: Extending the Motif Universe of RNAs biorxiv.org 2026-06-20 In the evolving landscape of RNA research, the classification and analysis of RNA motifs is necessary to uncover the intricate mechanisms governing ce
Multiple routes to red-shifted chlorophyll d-based photosynthesis biorxiv.org 2026-06-20 Strains of the cyanobacterium Acaryochloris marina exhibit diverse far-red light-harvesting properties during chlorophyll d-based photosynthesis.
Defining reversible binding rates in 1D systems dependent on diffusion, density, and excluded volume biorxiv.org 2026-06-20 Binding reactions in effectively one-dimensional systems, such as proteins diffusing along DNA or other filaments, pose a fundamental coarse-graining
Dose-Dependent Softening of Bacterial Model Membranes by Structurally Distinct Antimicrobial Peptides: A Coarse-Grained Molecular Dynamics Study biorxiv.org 2026-06-20 Antimicrobial peptides (AMPs) act at the membrane interface, where they remodel lipid packing defects and redistribute lateral stresses, yet a quantit
Reach-and-hold at a musculoskeletal arm posture is an unstable-equilibrium stabilization problem: the limits of fixed equilibrium-point and impedance controllers biorxiv.org 2026-06-20 Holding a redundant limb at a commanded posture against gravity is a basic problem in musculoskeletal motor control.
Characterisation of Peripheral Blood B Cell Receptor Repertoire in Severe Eosinophilic Asthma and EGPA biorxiv.org 2026-06-20 Background: Severe eosinophilic asthma (SEA), eosinophilic granulomatosis with polyangiitis (EGPA) and nasal polyposis (NP) are immune-mediated diseas
TCR signal strength during positive selection shapes CD25 expression patterns on thymically derived regulatory T cells biorxiv.org 2026-06-20 Regulatory T cells (Tregs) are a suppressive subset of CD4 T cells that maintain immune homeostasis.
Whats SUPP, developing an in vitro model for healthy oral biofilms biorxiv.org 2026-06-20 Human supragingival plaque (SUPP) is a polymicrobial biofilm whose contents undergo dysbiotic transitions during multiple oral diseases.
ARID1B damaging variants from more than one million genomes, cause human diseases by impairing protein-protein interactions, stability, and regulation biorxiv.org 2026-06-20 ARID1B is the most frequently de novo altered gene across a spectrum of human neurodevelopmental disorders and cancers.
A chromosome-scale super-pangenome of the lichen genus Peltigera reveals genome architecture and expanded interaction repertoires shared across pathogenic and mutualistic fungi biorxiv.org 2026-06-20 Fungi engage in associations with other organisms across a continuum from pathogenic to mutualistic lifestyles.
Systematic Evaluation of Feature Representations for Cancer-Associated sORF Prediction in Non-coding RNA biorxiv.org 2026-06-20 Short open reading frames (sORFs) within non-coding RNAs (ncRNAs) have arisen as a hidden layer of gene regulation, encoding small peptides that repre
Seed variation impacts clustering stability in Single-Cell RNA-Seq and can be mitigated by StAbility-BasEd-Reassignment (SABER) biorxiv.org 2026-06-20 Single-cell RNA-seq clustering is commonly treated as reproducible once a random seed is fixed, yet the choice of seed itself may alter cell assignmen
Vesicle Internalization Proceeds via a Morphological Phase Transition biorxiv.org 2026-06-20 Vesicle internalization proceeds through a series of multivesicular topologies essential for endocytic transport and cellular compartmentalization.
CD8-mediated organization of the TCR-pMHC interface shapes its force response and dissociation pathways biorxiv.org 2026-06-20 The mechanical response of the interaction between the T cell receptor (TCR) and the peptide major histocompatibility complex (pMHC) is fundamental to
Generating antimicrobial peptides via genomic transfer learning biorxiv.org 2026-06-20 We present a generative machine learning pipeline for the design of linear antimicrobial peptides (AMPs).
Chemical augmentation of the validated HepaRGTM CYP enzyme induction test method Part 1: The Goliath two laboratory study biorxiv.org 2026-06-20 Cytochrome P450 (CYP) enzymes play a key role in the metabolism of both xenobiotics and endogenous compounds, and the activity of some CYP isoforms ar
Chemical augmentation of the validated HepaRGTM CYP induction test method Part 2: Additional laboratory study supported by mRNA analysis biorxiv.org 2026-06-20 Cytochrome P450 (CYP)-mediated biotransformation of endogenous and xenobiotic substances can lead to altered exposure, toxicological impact, or advers
Capillary bundling of microtubules by condensates biorxiv.org 2026-06-20 The cytoskeleton organizes the cellular interior using cytoskeletal filaments that rely on bundling, usually executed by stable and ordered crosslinki
Assessing the efficacy of human mesenchymal stromal cells of different tissue origins in a mouse model of kidney ischaemia reperfusion injury biorxiv.org 2026-06-20 Rodent models of kidney disease have been widely used to assess the efficacy, safety and mode of action of mesenchymal stromal cells (MSCs) as therapi
NEK1 autophosphorylation is disrupted by amyotrophic lateral sclerosis-associated missense variants: activity biomarkers and structural insights biorxiv.org 2026-06-20 Rare variants in NEK1, encoding a serine/threonine kinase, are amongst the most consistently implicated genetic contributors to amyotrophic lateral sc
Distinct melanoma EV subpopulations reflect immune- and stress-induced tumor states biorxiv.org 2026-06-20 Melanoma is the deadliest form of skin cancer, and improved non-invasive approaches to monitor tumor burden and immune dynamics are needed.
CcpNmr AnalysisDynamics: a unified framework for NMR dynamics data analysis biorxiv.org 2026-06-20 Nuclear Magnetic Resonance (NMR) relaxation experiments provide a powerful residue-resolved access to biomolecular dynamics across a wide range of tim
The dynamic inositol phosphate network during development in Drosophila melanogaster biorxiv.org 2026-06-20 Inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs) are key regulators of cellular signaling and metabolism, yet developmental changes
Identifying cytokine-release signatures of flow-driven endothelial remodelling in an intracranial aneurysm cell culture model biorxiv.org 2026-06-20 Intracranial aneurysm (IA) rupture is catastrophic, yet current models of rupture-risk inadequately capture underlying IA remodelling mechanisms.
Intracortical BCI Performance is Robust to Changes in Attentional Load During Dual-Tasking biorxiv.org 2026-06-20 High performance intracortical brain-computer interface (iBCI) control has been demonstrated in research settings, but performance can still vary with
A general model for the evolution of thermal performance curves with application to real time-series data biorxiv.org 2026-06-20 Thermal performance curves (TPCs) are widely used to investigate the effect of changes in body temperature on an organism's performance.
Ecological axes of skull diversification in a massive 1 vertebrate radiation biorxiv.org 2026-06-20 Eupercarian spiny-rayed fishes are one of the largest vertebrate radiations, rivaling mammals and occupying nearly every aquatic habitat.
Multiple evidence supporting a novel species amid complex phylogenomic discordance: a case of Indian Ledebouria based on Angiosperms353 target capture sequencing biorxiv.org 2026-06-20 Ledebouria, a geophytic herb native genus to Africa and represented by a few species in the Arabian Peninsula, Madagascar, India and Sri Lanka.
Quantifying the evolutionary potential for Delta Smelt persistence in a warming habitat biorxiv.org 2026-06-20 Long-term persistence of managed species will depend, in part, on whether the species harbors the physiological or genetic potential to adjust to warm
Population structure of the rice blast fungus Pyricularia oryzae in the context of elevated host heterogeneity biorxiv.org 2026-06-20 In a context where pathogen emergence threatens global food security, crop resistance to pathogens is crucial for preventing and controlling epidemics
Evolution of Menopause and the Mamas Boy Hypothesis biorxiv.org 2026-06-20 Post-reproductive lifespan is an evolutionary puzzle.
Reticulate evolution and climate driven diversification shaped the origin and geographic structure of Linum bienne biorxiv.org 2026-06-20 Hybridization, incomplete lineage sorting and climatic oscillations can interact across evolutionary timescales, but their combined effects on plant d
Lineage-specific evolution of LTR retrotransposons under natural selection drives genomic divergence in diploid Oryza species biorxiv.org 2026-06-20 LTR retrotransposons (LTR-RTs) are major drivers of plant genome evolution.
Ribosomes are covered by a coat of flexible protein fragments biorxiv.org 2026-06-20 Ribosomal proteins contain flexible terminal regions that are averaged out during electron density reconstructions, rendering them absent from experim
A network approach to DNA methylation clocks biorxiv.org 2026-06-20 Biological age predicts health and lifespan better than chronological age, but remains difficult to measure.
Dawn of segmented bilaterians unveiled by soft-bodied fossils in microbial pseudomorphs from the Basal Cambrian biorxiv.org 2026-06-20 It is estimated that the evolution of segmented bilaterians occurred during the Ediacaran, whereas most of their unambiguous body fossils did not appe
Systemic viral vector vaccination induces brain resident memory T cells to drive anti-glioblastoma immunity biorxiv.org 2026-06-20 Glioblastoma is a lethal brain tumor that is unresponsive to current cancer immunotherapeutic approaches, including immune checkpoint blockade (ICB).
Incremental AMR acquisition driving successive genotype replacements and the rise of extensively drug resistant (XDR) Shigella sonnei in Australia over 20 years. biorxiv.org 2026-06-20 Background In Australia, the burden of shigellosis is predominantly in returning travellers or in men who have sex with men (MSM).