Data requirements for accurate extinction-risk prediction in bistable populations biorxiv.org 2026-06-22 Understanding and predicting extinction risk is a central challenge in population biology.
A global analysis of climate-driven reversal risks in forests biorxiv.org 2026-06-22 The integrity of forest-based climate solutions and carbon credits requires persistent carbon storage, but climate change is increasing the risk of na
kontakteUR: transforming coordinates to chemical intuition to focus on essential interactions in biomolecular systems biorxiv.org 2026-06-22 Molecular interactions govern cellular function, making them essential to discover biomolecular mechanisms by unravelling structure-function relations
Structural and functional insights into yeast Rqc1p, a protein required for thermotolerance with potential nuclear localization biorxiv.org 2026-06-22 Protein homeostasis (i.e., proteostasis) is the biological process by which the qualitative and quantitative balance of the proteome is conducted, eit
Near-Infrared Turn-On Fluorogenic Probe for Versatile Detection of Inorganic Polyphosphates biorxiv.org 2026-06-22 Inorganic polyphosphate (polyP) is a ubiquitous phosphate biopolymer involved in diverse cellular processes.
Systematic Quantitative Proteomics Defines Age, Sex, and Region-Dependent Remodeling of Lung Extracellular Matrix biorxiv.org 2026-06-22 The lung extracellular matrix (ECM) governs tissue architecture, mechanics, and function, yet how it remodels with age across sex and anatomical regio
Structural basis of microtubule destabilization by GTP hydrolysis biorxiv.org 2026-06-22 Microtubules are cytoskeletal filaments that dynamically grow and shrink to support vital biological functions.
Stress Granule Coarsening Is a Pathological Inflection Point for Cardiac Electrophysiological Dysfunction biorxiv.org 2026-06-22 Arrhythmia risk rises early in many forms of cardiac stress, often before contractile failure is evident.
Snake Venom Fluidic Properties and Design of Venom Mimics as Rheological Surrogates biorxiv.org 2026-06-22 Snake venom composition and its contribution to toxic effects has been heavily researched, but there is a comparative lack of information on venom flu
Soft silicone surface stiffening by oxidation upon deep UV treatment as characterized using nanoindentation biorxiv.org 2026-06-22 Silicones are elastomers that have a wide variety of uses, including biomedical applications such as the coating of biomedical devices and as implants
Intraspecific morphological variability of the invasive mosquito Aedes koreicus in Europe: genetic characterisation and population-level insights biorxiv.org 2026-06-22 Background: The invasive mosquito Aedes koreicus has established populations in several European countries during the past decade, raising increasing
DNA barcoding and olfactory identification of attractive nectar sources for Aedes aegypti mosquitoes biorxiv.org 2026-06-22 Adult mosquitoes rely on plant-derived sugars for survival, reproduction, and flight, yet the plant taxa that mosquitoes encounter in nature and the o
Maternal ranging strategies facilitate offspring social play at energetic cost in the most solitary ape biorxiv.org 2026-06-22 In most vertebrates, social play among peers is considered essential for behavioral development.
Discovery of CDK4-selective molecular glue degraders by high-throughput proteomics biorxiv.org 2026-06-22 Molecular glue degraders (MGDs) are proximity-inducing molecules that promote the destruction of disease-causing proteins by stabilizing novel interfa
A complete RXFP1-relaxin interaction model unlocks the design of potent mini-protein modulators biorxiv.org 2026-06-22 Relaxin family peptide receptor 1 (RXFP1) is a multi-domain GPCR with compelling therapeutic potential, yet uncertainty surrounding the mechanism of i
Targeted Photodegradation of Misfolded Proteins via Self-photosensitizing with Molecularly Produced Light biorxiv.org 2026-06-22 Misfolded proteins are tightly associated with various neurodegenerative diseases, and removing these misfolded proteins is one of the actively pursue
How stimulation waveform shape affects collective oscillations in the brain networks biorxiv.org 2026-06-22 Brain oscillations emerge from nonlinear interactions across anatomically connected neural populations, alternating between transiently coordinated an
GENATATORs: ab initio Gene Annotation With DNA Language Models biorxiv.org 2026-06-21 Inference of gene structure and location from genome sequences - known as de novo gene annotation - is a fundamental task in biological research.
Cell-sized droplet interfaces reorganize protein secondary structures through confinement-enhanced membrane interactions biorxiv.org 2026-06-21 Cell membranes are recognized as regulators of protein organization, yet it remains unclear whether membrane-associated structural transitions arise f
BioBrain: A Multi-Agent Framework for Natural Language Driven Quantitative Microscopy Data Analysis biorxiv.org 2026-06-21 Advances in fluorescence microscopy have dramatically expanded the range of biological questions that can be addressed, enabling quantitative observat
Revealing interactions between glutathione peroxidase 4 and phosphoinositides biorxiv.org 2026-06-21 Glutathione peroxidase 4 (GPx4) is the primary enzyme reducing lipid hydroperoxides, preventing membrane oxidative damage and protecting against ferro
Sequence-dependent modulation of hepatorenal biochemical markers following Artemether-Lumefantrine and Sulfadoxine-Pyrimethamine exposure in Wistar rats biorxiv.org 2026-06-21 Malaria remains one of the most pressing health problems, especially in Sub-Saharan Africa.
Analysis of the off-target interaction of amyloid PET tracers with human brain sulfotransferases biorxiv.org 2026-06-21 Positron emission tomography (PET) tracers targeting amyloid-{beta} (A{beta}) are central to the diagnosis and staging of Alzheimer's disease (AD).
Olfactory Loss Enhances Visual Learning in Drosophila through Structural and Functional Reorganisation biorxiv.org 2026-06-21 Loss of a sensory modality can enhance performance in the remaining senses.
VFB-MCP: Natural-Language Access to Drosophila Neuroscience Grounded by an Expert-Curated Ontology-Led Knowledgebase biorxiv.org 2026-06-21 Biological databases store curated knowledge that researchers traditionally access through web interfaces or APIs.
Molecular mechanisms underlying amyloid lowering by aducanumab: differential and comparative effects of sex and IgG reveal the post-treatment disease brain biorxiv.org 2026-06-21 INTRODUCTION: Improving the predictive validity of preclinical studies for Alzheimer's disease (AD) requires rigorous evaluation of therapeutic effica
Raman spectral signatures reflect altered metabolic state of exhausted T cells biorxiv.org 2026-06-21 T cell exhaustion within the tumor microenvironment drives CD8 T cells into a dysfunctional state characterized by progressive loss of proliferative c
Changes in the translational landscape during red clover necrotic mosaic virus infection biorxiv.org 2026-06-21 Viruses alter host gene expression to create a proviral environment while the host simultaneously regulates gene expression to restrict the virus spre
A Diploid Panax Genome Reveals Ginsenoside Diversity Driven by UGT Diversification and Network Rewiring, Rather Than Gene Family Expansion biorxiv.org 2026-06-21 The medicinal herb Panax notoginseng produces a structurally diverse array of triterpene saponins (ginsenosides), yet the genetic basis of this chemic
OracleScreen-LILRB4: Machine Learning-Guided Discovery of Myeloid Immune Checkpoint Binders Validated in Patient-Derived Cells biorxiv.org 2026-06-21 The identification of small molecule modulators of immune checkpoint proteins remains a significant challenge in drug discovery due to the flat, featu
SPA-C: an hybrid tool to accurately scaffold genomes using Hi-C and Deep-Learning biorxiv.org 2026-06-21 Genome assembly is a computational pipeline designed to reconstruct chromosomes from small sequencing reads.
DeepCDS: Ab initio coding sequence prediction in prokaryotic short reads biorxiv.org 2026-06-21 Accurate coding sequence prediction in short prokaryotic metagenomic reads remains challenging due to sequence fragmentation, unknown sequence origins
Expanding the GUSome: Structure-guided identification and characterization of gut microbial β-glucuronidases biorxiv.org 2026-06-21 The gut microbiome-encoded {beta}-glucuronidase (GUS) enzymes have a significant effect on human physiology through their deglucuronidation activity o
Machine learning evaluation of gene expression-based ALS subtypes across brain and blood tissues biorxiv.org 2026-06-21 The clinical and molecular heterogeneity observed in amyotrophic lateral sclerosis (ALS) presents a challenge for diagnosis, prognosis, and treatment.
Extending the osmophobic effect to protein side chains with a unified transfer model across osmolyte classes biorxiv.org 2026-06-21 Understanding the role of the protein backbone and side chains on cosolvent-induced stabilization is essential for a molecular picture of osmolyte act
Artificial Intelligence Models for Classifying Wrist Ligament Injuries Using Synthetically-Generated Joint Proximity Maps from Finite Element Models biorxiv.org 2026-06-21 Background/Purpose: Diagnosing wrist ligament injuries is challenging; early detection and treatment are important to prevent osteoarthritis progressi
Population genetics meets precision-cut kidney slices: Nephrotoxicity modelled ex vivo in the founder strains of the BXD mouse consortium biorxiv.org 2026-06-21 Acute kidney injury (AKI) affects millions of patients annually and is associated with high morbidity and mortality, to date no curative treatment exi
Development of a Complement Hemolysis Assay Using Aldehyde-Modified Human Erythrocytes biorxiv.org 2026-06-21 Background: Complement-mediated hemolysis assays are essential for assessing immune function and diagnosing complement-related disorders.
Caenorhabditis becei recombinant inbred lines (beRILs) reveal the scope of heritable variation within a gonochoristic nematode population. biorxiv.org 2026-06-21 Caenorhabditis nematodes are a powerful model clade for evolutionary genetics.
Using somatic data to aid germline clinical variant interpretation in developmental disorders biorxiv.org 2026-06-21 Accurate interpretation of rare germline variants remains a major challenge in developmental disorders (DD).
Consistent MYORG and STRADB Downregulation in DMD and LGMD: Rationale for Deoxygalactonojirimycing Repurposing in Dystrophic and Aging Muscle biorxiv.org 2026-06-21 Background: MYORG (myogenesis-regulating glycosidase) and STRADB (STE20-related kinase adapter protein beta) were previously identified as activity-me
Killiverse: an interactive multi-omics web resource for killifish biorxiv.org 2026-06-21 Background: Killifish have emerged as valuable vertebrate model systems for investigating several disciplines including aging, regeneration, and devel
ReSeT: a taxonomy-aware reference genome selection tool biorxiv.org 2026-06-21 Motivation: Reference genome composition determines which taxa a profiling pipeline can detect and distinguish, and becomes of critical importance for
Mechanical Checkpoint for Cell Division in Three-Dimensional Microenvironments biorxiv.org 2026-06-21 Cell division within mechanically confining extracellular matrices (ECMs) is a key regulator of tissue morphogenesis and cancer progression.
Changes in cuticle composition co-regulate drought and herbicide resistance in horseweed (Erigeron canadensis) biorxiv.org 2026-06-21 Horseweed (Erigeron canadensis) is a widely distributed annual weed that can cause significant yield losses if not properly controlled.
Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation biorxiv.org 2026-06-21 Enhancers are key regulators of mammalian gene expression, yet how they interact with promoters in space (contact vs.
Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas biorxiv.org 2026-06-21 Immunotherapy approaches have shown limited efficacy in pediatric sarcomas, partly because these tumors have low mutation burden and few neoantigens.
Cytokines driven by caspase-1 and RIPK3 are antagonistic biorxiv.org 2026-06-21 Pyroptosis, apoptosis, and necroptosis are thought to provide redundant protection against intracellular pathogens.
Targeting the Mannitol Biosynthesis Pathway in Aspergillus fumigatus: Characterisation and Inhibition of Mannitol-2-Dehydrogenase biorxiv.org 2026-06-21 Infections caused by the opportunistic fungal pathogen Aspergillus fumigatus pose a serious public health system burden.
Evidence of maternal resilience in two mouse strains in the context of permanent mouse breeding strategies biorxiv.org 2026-06-21 Breeding female mice represent an essential but often overlooked workforce sustaining biomedical research.