Alzheimer's Disease Selectively Perturbs Age-Sensitive Brain Radiomic Features Across the Disease Continuum biorxiv.org 2026-06-22 Normal brain aging and Alzheimer's disease both involve progressive structural brain alterations, making it challenging to distinguish pathological ne
Aperiodic exponent ceases to track changes in propofol dose at deep surgery-level hypnotic depths biorxiv.org 2026-06-22 Background: Accurately tracking hypnotic depth during surgery is key to deliver personalized and precise anaesthesia.
Fluorogenic labelling for tracking extracellular vesicle nanocarriers in the brain biorxiv.org 2026-06-22 Background: Reliable tracking of extracellular vesicles (EVs), key biological nanocarriers in nanomedicine, remains a major technical challenge due to
Interaction forces reflect the perception of texture during active exploration biorxiv.org 2026-06-22 We are constantly exploring the world around us through touch.
Ovarian hormonal state at exercise initiation interacts with nigrostriatal circuitry to determine long-term voluntary exercise behavior biorxiv.org 2026-06-22 Despite the well-established health benefits of exercise, adherence to physical activity remains low, highlighting the need to identify biological fac
Optimal Practice Schedules in a Dual-Rate Model of Motor Adaptation, and Their Recovery by Reinforcement Learning biorxiv.org 2026-06-22 A clinician guiding a stroke patient through a 45-minute rehabilitation session, a coach planning a training day, a teacher choosing the order of prac
Distributed representations of chemosensory valence in a naive vertebrate brain biorxiv.org 2026-06-22 Chemical cues guide essential behaviors by signaling food, danger, and social information.
Neural acceleration drives adaptations in working memory encoding speed biorxiv.org 2026-06-22 Humans and non-human animals adaptively boost their encoding speed when they expect limited sensory exposure time, so that they can capture essential
Relationship between cognitive flexibility and disordered eating attitudes across the non-clinical spectrum biorxiv.org 2026-06-22 Disordered eating attitudes exist on a continuum that extends well below clinical diagnostic thresholds, yet the cognitive correlates of this non-clin
nanoASM: Long-Read Allele-Specific DNA Methylation Profiling Enables Functional Annotation of Regulatory Noncoding Variants in Human Prostate Tissues biorxiv.org 2026-06-22 Long-read nanopore sequencing enables simultaneous detection of germline variation and native DNA base modifications on individual DNA molecules, prov
An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body biorxiv.org 2026-06-22 The trabecular meshwork (TM) and ciliary body (CB) regulate aqueous humor dynamics and intraocular pressure (IOP), and TM/Schlemm's canal (SC) dysfunc
The vocal repertoire of white-nosed coatis: structural features, temporal dynamics, and social variations biorxiv.org 2026-06-22 For many group living species, vocal signals are a vital form of communication needed to coordinate social behaviours.
Conspecific Presence Facilitates the Reliable Expression of Nicotine Reward in Juvenile Zebrafish biorxiv.org 2026-06-22 Rationale Adolescence is a period of heightened vulnerability to nicotine reinforcement.
Dynamic balance of sparse flux vectors for efficient simulation of culture dynamics and metabolic network reduction biorxiv.org 2026-06-22 Dynamic Flux Balance Analysis (DFBA) enables simulation of microbial culture dynamics under changing environmental conditions, but remains computation
Multivariate Random Forests for Cross-Modal Multi-Omics Integration biorxiv.org 2026-06-22 Multi-omics studies are widely used across many areas of biomedical research.
HTS-Oracle X: AI-Guided Prospective Discovery of Small Molecule Immune Checkpoint Binders biorxiv.org 2026-06-22 Targeting immune checkpoint protein-protein interactions (PPIs) using small molecules remains limited by the shallow, featureless binding surfaces of
Drug-Prot: A query system for statistical inference of drug effects and interactions in dynamic proteomic networks biorxiv.org 2026-06-22 Understanding drug effects and drug-drug interactions is essential for developing combination therapies.
Pharmaceutical TAS2R14 Agonists Display Diverse Potency, Efficacy, and Binding-Site Sensitivity biorxiv.org 2026-06-22 Bitter taste receptors (TAS2Rs) are G- protein coupled receptors that detect chemically diverse compounds, including many clinically used drugs.
Individual differences in ethanol drinking meal structure are shaped by social environments biorxiv.org 2026-06-22 Alcohol use disorder (AUD) is marked by substantial heterogeneity in drinking behaviors and health outcomes, underscoring the need for preclinical mod
Targeting Synaptic Vesicle Endocytosis in Nociceptors Provides Sustained Pain Relief biorxiv.org 2026-06-22 Endocytosis replenishes synaptic vesicle (SV) pools that are required for persistent transmission of chronic pain signals within nociceptive spinal ci
Reduced dopaminergic reinforcement, not learning capacity, limits operant learning in aging Drosophila biorxiv.org 2026-06-22 Aging is associated with a progressive decline in cognitive function, including the ability to adapt behavior based on its consequences.
A novel texture backward masking method to locate critical recurrent processes in human vision biorxiv.org 2026-06-22 Mounting evidence suggests that recurrent neural processes taking place within the visual system are recruited when we recognize challenging images---
Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models biorxiv.org 2026-06-22 Parkinson's disease (PD) is known to alter the intrinsic properties of striatal cholinergic interneurons (ChIs).
Reference-guided immune recovery matching prioritizes traditional Chinese medicine ingredients biorxiv.org 2026-06-22 Therapeutic prioritization from single-cell transcriptomes requires a target that is closer to treatment response than disease-signature reversal.
From hotspot dependence to distributed robustness in resistance-aware lead optimization biorxiv.org 2026-06-22 Drug resistance remains a recurrent failure mode in targeted anticancer and antiviral therapy, and resistance evidence often enters only after compoun
Revisiting post-stimulus theta activity: evidence for an aperiodic rather than oscillatory origin biorxiv.org 2026-06-22 The aperiodic, 1/f-like component of electrophysiological activity is increasingly recognized as a meaningful feature of neural function, rather than
Environmental color statistics shape the anisotropic geometry of human color discrimination biorxiv.org 2026-06-22 Hue is a powerful cue for object discrimination, but human color discrimination is anisotropic: hue thresholds are lower than chroma thresholds for or
Searchlight Optimization Using Representational Similarity Analysis for Subject-Level Voxel Selection in Emotional State Decoding biorxiv.org 2026-06-22 Identifying informative voxels is a critical, yet challenging step in functional magnetic resonance imaging (fMRI), particularly for multivariate anal
An aorta to insulin producing cell sensor for internal state in Drosophila biorxiv.org 2026-06-22 The cellular circuits through which the internal state of an organism is sensed and relayed to the brain, and through which they bring about appropria
Parental transport induces a dormant state while maintaining oxytocin recruitment in poison frog tadpoles biorxiv.org 2026-06-22 Parental care can have pervasive effects on offspring neurodevelopment.
Human dental pulp stem cells grafted into C57BL/6J hippocampus differentiate towards immature neuronal like cells displaying action potential firing activity biorxiv.org 2026-06-22 Stem cell therapy represents a promising strategy for the replacement and functional restoration of damaged neural tissue in neurodegenerative conditi
Decoding Chronic Pain States from Distributed Intracranial Recordings biorxiv.org 2026-06-22 Chronic pain engages distributed cortical and subcortical circuits, and large-scale intracranial recordings in humans offer a valuable opportunity to
Visual uncertainty and task demands shape active sensing strategies in mice biorxiv.org 2026-06-22 In natural environments, animals actively sample visual information to guide behavior.
Seeing the world in a grain of sand: Fine global and local representations in foveal and parafoveal vision biorxiv.org 2026-06-22 Foveal vision enables primates to perceive small objects with remarkable precision by resolving both global form and fine local detail.
Early Vision Shapes Recurrent Processing in the Human Visual Cortex biorxiv.org 2026-06-22 Recurrent processing involves feedforward, feedback and lateral connections and is thought to allow efficient visual processing.
Ballistic food approaches in Parhyale hawaiensis require the antennae biorxiv.org 2026-06-22 Many arthropods (insects and crustaceans) rely on their antennular chemosensory system to detect key environmental resources like food.
Rapid and divergent changes in the continental-scale organisation of a short-lived songbird's migratory strategy biorxiv.org 2026-06-22 It is hard to predict how rapidly songbird migration will change in the Anthropocene.
Healing cascades and infections in wounds monitored using a wearable sensor of gaseous flux biorxiv.org 2026-06-22 Capabilities for quantitative monitoring of chronic wounds remain an unmet clinical need, as existing diagnostic approaches rely on semiquantitative e
The Burger Battle: The Future is Blended biorxiv.org 2026-06-22 Texture is one of the major barriers to acceptance of sustainable protein products, yet the relationship between instrumental texture and consumer per
EventHorizon: A Foundation Model for Clinical Flow Cytometry biorxiv.org 2026-06-22 Flow cytometry is an essential tool for diagnosis of hematologic malignancies, but existing clinical workflows are highly dependent on expert manual i
Upregulation of ATP-purinergic P2x2 receptors in the cochlea over-amplifies hearing sensitivity leading to hyperacusis and attenuation by antagonists biorxiv.org 2026-06-22 Hearing hypersensitivity (hyperacusis) is a common hearing stress and can cause many psychological diseases, e.g., anxiety, learning disabilities, and
Metabolomic Network Analysis Reveals Reorganization of Lipid and Steroid Programs Linked to Right Ventricular-Pulmonary Vascular Function in Pulmonary Hypertension biorxiv.org 2026-06-22 Background: Pulmonary arterial hypertension (PAH) is characterized by circulating metabolic alterations, but whether these reflect disease-specific me
Nucleotide-driven KaiC dynamics coordinate the core properties of the cyanobacterial circadian clock biorxiv.org 2026-06-22 Circadian clocks generate stable ~24-h rhythms with a defined period, temperature compensation, and entrainment to external cues that set phase.
Response diversity inconsistently predicts functional robustness to simulated zooplankton extinctions biorxiv.org 2026-06-22 Ecosystem functioning can be maintained in species-rich communities even under fairly severe perturbations.
NicheDiv: A DAPC framework to quantify niche divergence across highly multivariate environmental space biorxiv.org 2026-06-22 Quantifying niche divergence is crucial to understanding the ecological and evolutionary processes underlying range limits, coexistence, speciation, b
Capturing early events in aryl hydrocarbon receptor activation using two complementary protein-protein interaction assays biorxiv.org 2026-06-22 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that enables cellular adaptation to environmental, nutritional and meta
Mechanical tension expands the microtubule lattice stepwise and modulates kinesin-1 binding in an isoform-dependent manner biorxiv.org 2026-06-22 Recent work has shown that the microtubule lattice possesses remarkable structural plasticity, with its conformation modulated by microtubule-associat
Cell division dynamics generate heterogeneous contact-mediated signaling outputs biorxiv.org 2026-06-22 Contact mediated cell-cell communication where direct physical contact between adjacent ligand cells and receptor cells trigger signal output is impor
Urbanization effects are trait-specific and city-dependent across a widespread spider's global range biorxiv.org 2026-06-22 Urban environments impose strong selective pressures through biotic and abiotic factors, driving changes in behavior, physiology, and morphology.
Microbial succession in West African secondary forests: rapid internal stabilisation without convergence toward old-growth reference states biorxiv.org 2026-06-22 Secondary forest succession following agricultural abandonment is a dominant land-use transition across the tropics, yet whether soil microbial commun