Distributions of host heterogeneity in susceptibility show signatures of pathogen geographic structure in an insect baculovirus biorxiv.org 2026-06-19 Segregated variation between populations is a fundamental evolutionary process leading to parasite specialization, yet the resulting impacts on infect
Ubiquitin selective ribosome profiling reveals systematic principles of co-translational quality control biorxiv.org 2026-06-19 Protein biogenesis is a stress- and error-sensitive process that can lead to nascent protein misfolding and aggregation, challenging cellular proteost
Simulation-based Bayesian deep learning enables uncertainty-aware tumor fraction estimation in cell-free DNA biorxiv.org 2026-06-19 Background: Estimating tumor fraction from whole-genome cell-free DNA sequencing is critical for liquid biopsy, but is hampered by weak signals and ba
Intersegmental transfers drive target search in an RNA-targeting CRISPR system biorxiv.org 2026-06-18 Sequence-specific RNA-binding proteins (RBPs) must efficiently locate their targets among a multitude of cellular RNAs.
Buffered sweat microfluidics with AI-enabled translation for clinically actionable blood urea estimation and renal risk stratification biorxiv.org 2026-06-18 Kidney-function assessment relies on blood urea as a clinically informative metabolic marker; however, its dependence on venipuncture and centralised
Exploring the Structural and Functional role of α,β-unsaturated Ketoesters as Anti-Staphylococcal Agents Targeting Glutathione Peroxidase biorxiv.org 2026-06-18 Multiple-drug resistant (MDR) Staphylococcus aureus strains (like methicillin-resistant S.
Stochasticity and Bet Hedging Drive Cryptococcal Capsule Dynamics biorxiv.org 2026-06-18 Cryptococcus neoformans and related species are major human pathogens that cause cryptococcosis, a disease with high mortality and morbidity despite a
MALDI-ToF detection of Leishmania infantum infection in Lutzomyia longipalpis and Nyssomyia neivai biorxiv.org 2026-06-18 Background Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF MS) is widely used for sand fly identification, but
Oxidative stress reshapes diatom-microbiome interactions by shifting benefits from mutualistic to opportunistic bacteria biorxiv.org 2026-06-18 The roles of reactive oxygen species (ROS) as signaling molecules and inhibitors of phytoplankton growth are well documented.
Multidimensional Characterization of Novel Phage UCB24 Targeting Erwinia amylovora biorxiv.org 2026-06-18 This study evaluates the novel bacteriophage UCB24 as an eco-friendly biocontrol agent against Erwinia amylovora, the bacterial pathogen responsible f
Low Shear Modeled Microgravity Induces Unexpected Motility Phenotypes in Salmonella Typhimurium biorxiv.org 2026-06-18 Bacteria routinely exhibit unexpected phenotypic and molecular changes in response to spaceflight and spaceflight-analogue conditions, yet the mechani
Intracellular barriers and receptor masking limit success of a Pseudomonas aeruginosa clinical phage family biorxiv.org 2026-06-18 Bacteriophage therapy is needed to treat antibiotic resistant infections; however, when a clinical isolate resists a given phage, it is often unclear
Enzyme-Linked Cycloaddition Assay (ELCA) for rapid, ultra-sensitive monitoring of secreted sialoglycoproteins biorxiv.org 2026-06-18 Glycosylation of proteins is central to cell signaling, immune function, and pathogen interactions, yet existing methods for monitoring glycan changes
Structure-Based Immunoinformatics Design of a CTB-Adjuvanted Multi-Epitope Mucosal Vaccine Against Helicobacter pylori biorxiv.org 2026-06-18 Background: Helicobacter pylori coloniz the gastric mucosa of nearly half of the global population and is classified as a Group I carcinogen by the Wo
Structure Bioinformatics of Eight Human ATP Synthase Fo Subunits and Their AlphaFold3-Predicted Water-Soluble QTY Analogs biorxiv.org 2026-06-18 Human mitochondrial ATP synthase is an essential rotary motor enzyme that produces most of the cellular ATP through oxidative phosphorylation.
Target DNA-Mediated Plasmonic Coupling and Assembly Kinetics of Gold Nanorods for Label-Free Nucleic Acid Detection biorxiv.org 2026-06-18 DNA-programmed assembly of plasmonic nanostructures provides a powerful route to couple molecular recognition with optical signal generation.
Siphoviridae phage tails co-enrich with ex vivo amyloids biorxiv.org 2026-06-18 Bacteriophages are ubiquitous in the environment and are part of the natural human microbiome.
Solvent accessibility of chlorine-reactive amino acid residues in icosahedral virus structures: A meta-analysis biorxiv.org 2026-06-18 Free chlorine reacts with viral proteins, but the protein structural determinants of viral resistance to chlorine treatment remain poorly understood.
Enterococcus faecalis biofilm rewires neutrophil metabolism to suppress antimicrobial functions biorxiv.org 2026-06-18 Enterococcus faecalis is an opportunistic pathogen that persists in biofilm-associated infections despite robust neutrophil recruitment. How E.
Common ISAV haemagglutinin esterase variants at residues 229 and 230 influence the efficiency of receptor destruction and erythrocyte release in Atlantic salmon biorxiv.org 2026-06-18 Sialic acid-binding viruses often encode receptor-destroying enzymes that modulate infection through host glycan alteration.
Advances in the Design and Functionality of a Compact Multi-Reflecting Time-of-Flight Mass Spectrometer biorxiv.org 2026-06-18 High-resolution mass spectrometry is routinely used for the analysis of complex samples in pharmaceutical, environmental, and omics related studies.
Population-associated molecular variation in histologically normal breast tissue is context-dependent and associated with distinct transcriptional states biorxiv.org 2026-06-18 Population-associated molecular variation in breast tissue may contribute to differences in tissue biology and disease susceptibility, yet the extent
Hard-to-beat animacy perception: EEG evidence of accurate animate-inanimate distinction for ambiguous objects biorxiv.org 2026-06-18 Human recognition of objects as animate or inanimate is fast and accurate.
Conserved herbivore-induced volatile signalling despite divergent VOC-life-history associations in two locally adapted Arabidopsis thaliana populations biorxiv.org 2026-06-19 Volatile organic compounds (VOCs) mediate plant-plant signalling and may contribute to phenotypic differentiation among populations.
Immediate methane and carbon dioxide release from exposed permafrost at an active retrogressive thaw slump in the Canadian Arctic biorxiv.org 2026-06-19 The Arctic is warming rapidly, causing permafrost thaw and accelerating the release of greenhouse gases.
Germline hypomethylation shapes dynamic CpG reservoirs in ape genomes biorxiv.org 2026-06-19 Telomere-to-telomere (T2T) genome assemblies resolve DNA methylation of complete ape genomes, including repetitive and satellite-rich compartments tha
A shared functional architecture for error-based and reinforcement-based motor learning in the human brain biorxiv.org 2026-06-19 The motor system can flexibly learn from fundamentally different teaching signals, from directional errors to rewards.
Flexible decisions arise from resource-rational memory sampling biorxiv.org 2026-06-19 Flexible decision making depends on retrieving and recombining memories.
Selective vulnerability of excitatory cortical neurons to ZMYND11 loss reveals cell-type-specific mechanisms of neurodevelopmental disorder risk biorxiv.org 2026-06-19 Excitation/inhibition (E:I) imbalance is a convergent mechanism in neurodevelopmental disorders (NDDs), yet whether NDD risk genes disrupt excitatory
A Tripartite Map of the Ventromedial Prefrontal Cortex biorxiv.org 2026-06-19 The ventromedial prefrontal cortex (VMPFC) has been repeatedly implicated in affect, valuation, and social cognition, yet how these diverse functions
Replicative senescence of neural progenitors induces astrocyte senescence in 2D cultures and human midbrain organoids biorxiv.org 2026-06-19 Astrocyte senescence (astrosenescence) has emerged as a potential mechanism through which ageing may progressively impair glial homeostatic neuronal s
Frequency magnification in human primary auditory cortex nearly predicts behavioural frequency hyperacuity biorxiv.org 2026-06-19 The auditory system decomposes sounds into different frequencies, but does not represent them equally: in the human cochlea, lower frequencies occupy
The parafascicular thalamus steers attention to facilitate learning biorxiv.org 2026-06-19 Cues that predict reward can acquire strong power to bias orientation and approach, directing seeking behaviors into close proximity with reward.
Temporal phosphoproteomics reveals rapid restoration of kinase signaling by Glycyrrhiza glabra in a rotenone-induced Parkinson disease model biorxiv.org 2026-06-18 Parkinsons disease is a progressive neurodegenerative disorder associated with mitochondrial dysfunction, oxidative stress, impaired autophagy, and dy
Chronic Intermittent Ethanol Exposure Produces Sex- and Tissue-Specific Metabolomic Signatures Across the Gut-Liver Axis in Adult Mice biorxiv.org 2026-06-18 Alcohol misuse leads to a range of health complications and induces various metabolic perturbations that impacts multiple physiological systems, inclu
Dopaminergic neuronal dysfunction induced by newer generation systemic insecticides in Caenorhabditis elegans biorxiv.org 2026-06-18 While a growing number of studies have linked environmental exposures and Parkinson's disease (PD), the impact of many pesticides remains understudied
Multitrophic interaction networks mediate biodiversity effects on ecosystem multifunctionality biorxiv.org 2026-06-18 Biodiversity loss threatens the multifunctionality of ecosystems on which human well-being ultimately depends.
Characterising differential gene expression and alternative splicing in a sex reversing skink, Bassiana duperreyi biorxiv.org 2026-06-18 In some reptiles, genetic and environmental sex determination interact whereby extreme incubation temperatures override genetic sex determination (GSD
3dcon: tomogram denoising by deconvolution biorxiv.org 2026-06-18 Cryo-electron tomography is an expanding technology for the study of macromolecules, viruses, and cells.
Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation biorxiv.org 2026-06-18 Removal of the 5' mG cap by the Dcp1/Dcp2 complex commits mRNAs to degradation, yet the mechanisms regulating decapping remain incompletely understood
A hybrid framework integrating structural machine learning and 3D liver-on-chip assay for drug-induced liver injury prediction biorxiv.org 2026-06-18 Drug-induced liver injury (DILI) remains one of the most pressing challenges in drug development, contributing to 25-30% of late-stage clinical attrit
Looking beyond stereotyped neuron structures reveals links between beading and morphological rearrangements in aging phenotypes. biorxiv.org 2026-06-18 Understanding how neuronal morphology changes during aging and acute stress is essential for elucidating mechanisms of neurodegeneration.
Calculation of sequence space coverage in a mutagenesis library biorxiv.org 2026-06-18 Directed evolution requires screening of large mutagenesis libraries, but accurate calculation of library sizes needed to discover functional variants
Bioinf-Farma: supervised integration of epitope prediction and recombinant protein developability for automated vaccine candidate prioritization biorxiv.org 2026-06-18 Vaccine antigen discovery requires prioritizing protein candidates according to both immunogenic potential and recombinant expression feasibility.
novelBGC: An interactive dual-score framework for biosynthetic gene cluster novelty assessment and candidate prioritisation biorxiv.org 2026-06-18 Genome mining now yields tens of thousands of putative biosynthetic gene clusters (BGCs) per project, yet, separating genuinely novel candidates from
A unified smoothing framework for protein domain bigram model biorxiv.org 2026-06-18 Biomolecular sequences can be represented as strings over an alphabet, an analogy that has motivated many applications of computational linguistic tec
Elucidating the Design Space of Generative Models for Single-Cell Perturbation Prediction biorxiv.org 2026-06-18 Next-token prediction has produced predictable scaling in language, but the recipe presumes a sequence of tokens with a meaningful order.
Trajectory inference of epithelial-centered neighborhood profiles reconstructs a pseudo-temporal continuum in idiopathic pulmonary fibrosis biorxiv.org 2026-06-18 Idiopathic pulmonary fibrosis (IPF) is characterized by complex lung architecture and spatially heterogeneous remodeling, which have hindered integrat
Variation in infant subcortical brain development from 6 to 12 months in Down syndrome biorxiv.org 2026-06-18 Introduction: Down syndrome (DS), arising from Trisomy 21, is the most common genetic condition associated with intellectual disability.
Adaptive Neural Reorganization Enables Real-Time Finger-Level Robotic Control in BCI-Naïve Stroke Survivors biorxiv.org 2026-06-18 Restoring hand function remains a major challenge for individuals with motor impairments following stroke.