Microscopy-informed structural connectivity mapping in the in vivohuman brain via domain adaptation biorxiv.org 2026-06-18 Characterising human brain connectivity remains a major challenge in neuroscience.
Age-related loss of brain demyelinating and remyelinating potential is overcome by microglia renewal biorxiv.org 2026-06-18 Multiple sclerosis (MS) is an immune-mediated demyelinating disease, with progressive neurodegeneration that is refractory to current therapies.
HIV-1 Tat protects macrophages from killing by the Exoenzyme U from Pseudomonas aeruginosa biorxiv.org 2026-06-18 People living with HIV (PLWH) have a higher risk of developing other diseases, such as bacterial pneumonia.
Differential efficiency of sampling devices in the measurement of microbial diversity of Yellowstone National Park hot springs biorxiv.org 2026-06-18 Metagenomic characterization of low-biomass Yellowstone National Park (YNP) hot spring waters remains challenging because microbial recovery is influe
Hi-C data from the filamentous fungus Podospora anserina and associated 3D models to visualize the spatial organization of its chromosomes biorxiv.org 2026-06-18 Objectives: Model species are essential for fundamental research in biology.
Predicting optimal growth temperatures of bacteria using learned structural information from a single protein biorxiv.org 2026-06-18 Temperature is a fundamental determinant of bacterial physiology and ecology.
MorphoStat: A Statistics-Aware Pipeline for Morphological Profiling Analysis biorxiv.org 2026-06-18 High-content imaging produces thousands of morphological measurements per cell.
DNA Sequence and Histone Variant H2A.Z Jointly Govern Nucleosome Unwrapping Pathways biorxiv.org 2026-06-18 Nucleosome unwrapping governs chromatin accessibility and gene regulation, yet the molecular determinants of unwrapping directionality remain poorly u
Cardiac Myosin Activation Enhances Contractility While Preserving Myocardial Energetics Compared With β-Adrenergic Stimulation biorxiv.org 2026-06-18 Impaired contractility and reduced myocardial energetic reserve underlie heart failure with reduced ejection fraction.
Pyocyanin disrupts airway regeneration to favor chronic Pseudomonas aeruginosa infection biorxiv.org 2026-06-18 During chronic infections, host tissues undergo repeated cycles of injury and repair while being exposed to bacterial products.
Beyond competence: a mechanistic model of avian demographic drivers in West Nile virus dynamics biorxiv.org 2026-06-18 Background West Nile virus (WNV) is a vector-borne zoonotic pathogen maintained in an enzootic cycle between birds and mosquitoes which is considered
Validation of a multiscale Hill-type actuator against comprehensive benchmarks of motor unit and muscle force measurements biorxiv.org 2026-06-18 Computational Hill-type muscle models are widely used to simulate muscle force production because of their efficiency and physiological interpretabili
Bayesian modeling of longitudinal metatranscriptomes of broiler meat spoilage microbiomes shows shared predictive signature associated with spoilage at refrigerated temperatures biorxiv.org 2026-06-18 Microbial spoilage of packaged meat is driven by complex microbial succession and related metabolic activity, yet conventional shelf-life assessment i
GTRspmix: Capturing Heterogeneity of Exchangeabilities Across Sites to Improve Protein Phylogenetics biorxiv.org 2026-06-18 Site rate and profile mixture models capture the heterogeneity of the amino acid substitution process across sites.
Design, Fabrication, and Ex-vivo Validation of an Active Capsule Endoscope biorxiv.org 2026-06-18 Background and Aims: Active capsule endoscopy could advance gastrointestinal diagnostics by enabling controlled navigation beyond passive peristalsis.
Neuronal Activity-Dependent Electroosmosis and Its Potential Role in Interstitial Fluid Flow in the Glymphatic System biorxiv.org 2026-06-18 The mechanisms driving interstitial fluid flow through brain parenchyma remain unresolved, limiting our understanding of how fluid transport contribut
Benchmarking attention-based methods for vision transformers' interpretability in retinal fundus imaging biorxiv.org 2026-06-18 Deep learning models based on Vision Transformers (ViTs) have shown strong performance in retinal fundus imaging, but their interpretability remains p
ScriptManager: a platform for scalable and reproducible high-resolution analysis of genomics datasets biorxiv.org 2026-06-18 Background: The growing diversity of genomic and epigenomic assays has driven a parallel expansion in data formats, analysis workflows, and figure-gen
Haplotype-resolved genome architecture mapping uncovers pervasive structural heterogeneity between human homologous chromosomes biorxiv.org 2026-06-18 Resolving the three-dimensional structure of chromatin with haplotype specificity remains a fundamental challenge for understanding genetic and epigen
Accounting for allelic diversity and multicopy gene detection improves the accuracy of antibiotic resistance genotypic determination biorxiv.org 2026-06-18 Background Genomic prediction of antimicrobial resistance (AMR) relies on the accurate detection of resistance genes or allelic variants of core genes
A mammalian-specific domain of MSH5 drives the transition from crossover licensing to designation during meiotic prophase I biorxiv.org 2026-06-18 Meiotic recombination initiates with DNA double-strand breaks (DSBs) repaired as either crossovers (COs) or non-crossovers.
CFTR function in nasal airway cells from symptomatic and asymptomatic CF heterozygotes biorxiv.org 2026-06-18 Rationale An estimated 25 million people worldwide have one deleterious variant in the cystic fibrosis transmembrane conductance regulator (CFTR) gene
Clinical and primary cell evidence reveals complex CFTR function-phenotype relationships biorxiv.org 2026-06-18 Rationale: The CFTR function-phenotype relationship remains incompletely understood, with prior work yielding heterogeneous findings suggesting linear
Structural Connectivity Selectively Constrains Intrinsic BOLD Timescales through Graph-Smooth Neural Activity biorxiv.org 2026-06-18 Structural connectivity defines the network architecture supporting large scale brain dynamics, yet how this network constrains the temporal statistic
Quantum machine learning for detection of sleep deprivation from EEG signals biorxiv.org 2026-06-18 Approximately 50% of the population in India is estimated to experience sleep-related disorders.
Hyperalignment Reveals Shared Information in Macaques' Idiosyncratic Fine-Grained Movie fMRI Patterns biorxiv.org 2026-06-18 We modeled shared representational spaces in macaque brains using fMRI data from 12 rhesus monkeys obtained during movie-viewing and response hyperali
Predicting pain location from resting-state brain fMRI biorxiv.org 2026-06-18 Low back pain is a prevalent issue with few reliable treatments.
Type I Natural Killer T Cells Suppress Infection-Induced Hypercytokinemia via an IL-22-Dependent Mechanism biorxiv.org 2026-06-18 Severe infections can trigger systemic inflammatory response syndrome (SIRS), wherein excessive cytokine release generates a cytokine storm causing ti
The optical origin of the human skin color 'banana' in CIELAB space biorxiv.org 2026-06-18 Human skin colors occupy a characteristic banana-shaped region in CIE L*a*b* space, but why skin color coordinates are restricted to this region and h
Parametric Engineering of Atrioventricular Living Valve Transplants biorxiv.org 2026-06-18 Diseases of the (mitral and tricuspid) atrioventricular valves (AVV), which regulate inflow from the atria to the ventricles, can result in severe obs
"Fuzzy specificity" shapes diazotroph diversity and composition in nodulating plants of the Southeastern USA biorxiv.org 2026-06-18 Nitrogen-fixing symbioses, particularly those occurring in root nodules, are among the most consequential mutualisms in natural and agricultural syste
Extreme conservation of cnidarian stinging cell identity despite 600 million years of evolution biorxiv.org 2026-06-18 Understanding how cells specialize is essential for reconstructing the diversification of life on earth.
No support for cell size as a driver of tissue-level metabolic rates at the upper limits of animal cell size biorxiv.org 2026-06-18 Evolutionary diversity in metabolic rate underlies differences in physiology, morphology, and life history across the tree of life.
Systemic degradation of repressive transcription factors gates gene expression and cell fate specification biorxiv.org 2026-06-18 While proteasomes are best known for eliminating defective proteins or turning off signaling pathways, they also enable crucial cellular activities.
A Master-Key DNA System Enabling Programmable Cross-Talks in Biomimetic Networks via An Artificial Chaperone biorxiv.org 2026-06-18 Biological systems operate through complex molecular networks programmed by genetic information; however, constructing artificial systems with multila
Adaptive Charge Modulation Enables Focal, Selective Spinal Cord Stimulation biorxiv.org 2026-06-18 Clinical neuromodulation primarily employs near-field low frequency electrical stimulation to activate neurons in the immediate vicinity of the electr
PTEN Subcellular Localization Dictates Function biorxiv.org 2026-06-18 Mutations in phosphatase and tensin homolog (PTEN) drive unregulated activation of the phosphatidylinositol-3-kinase (PI3K) pathway, resulting in neur
Striatal activity maintains a short-term action-outcome memory to guide future choice biorxiv.org 2026-06-18 Adaptive behavior requires animals to use the outcomes of recent actions (action-outcomes) to guide future decisions.
OPULATION CHARACTERISATION AND PROPAGATION STRATEGYFOR WILD Coffea eugenioides IN NYUNGWE AND CYAMUDONGO FORESTS, RWANDA: A field assessment of mother trees and an evidence-based seed-source pathway. biorxiv.org 2026-06-18 This report presents a field assessment of wild Coffea eugenioides, the diploid maternal progenitor of cultivated Arabica coffee, in Nyungwe Forest Na
Muscle Loss as a Foundational Step in the Development and Evolution of the Turtle Shell biorxiv.org 2026-06-18 Modern biodiversity is built on a series of disparate body plans whose origins are obscured by deep time.
Ancient admixture catalyzes homoploid hybrid speciation and intense genomic erosion in Asian langurs biorxiv.org 2026-06-18 Ancient admixture is a powerful catalyst for evolutionary innovation, yet its long-term genomic consequences for newly formed lineages remain poorly u
Hepatocyte-, but not myeloid cell-Rictor/mTORC2 deficiency moderately attenuates steatotic liver disease induced by intake of a choline-deficient, amino acid-defined high-fat diet biorxiv.org 2026-06-18 Previous studies have demonstrated that mechanistic target of rapamycin complex 2 (mTORC2) deficiency provides complete protection against steatotic l
Palaeoproteomic deconvolution of physical and genetic collagen mixtures biorxiv.org 2026-06-18 Species identification in palaeoproteomics relies on genome-derived protein sequences which are often poor-quality, and lacks tools to cope with multi
Beyond mean trabecular separation: decomposing metaphyseal marrow space into local trabecular spacing and marrow cavity expansion biorxiv.org 2026-06-18 Micro-computed tomography (CT) is widely used to assess trabecular bone microarchitecture, with trabecular separation (Tb.Sp) among the core parameter
Bayesian-enhanced closed-loop optimization of ultrasound protocols for targeted and precise neuromodulation biorxiv.org 2026-06-18 Low-intensity focused ultrasound (LIFU) is a promising neuromodulation modality, but challenges related to high response variability and the poorly un
Deciphering shared and divergent tissue architectures from cross-species spatial transcriptomics biorxiv.org 2026-06-18 The integration of spatial transcriptomics (ST) data across species is essential for cross-species and translational studies, but remains challenging
Benchmarking gene expression reconstruction from single-cell latent representations biorxiv.org 2026-06-18 Single-cell transcriptomics is typically modeled in low-dimensional latent representations that improve the signal-to-noise ratio of the data.
Acute hypercapnic stress modulates innate and learned defensive behavior biorxiv.org 2026-06-18 Survival depends on avoiding threats, a process shaped by experience and internal states.
Parallel basal ganglia and frontal cortical outputs differentially encode context-dependent evaluation and categorical commitment during choice biorxiv.org 2026-06-18 Adaptive choice requires transforming the evaluation of available options into commitment to a specific action but understanding how this transformati
A hippocampal neuroimaging signature of neurovascular insulin signalling links metabolism to mood biorxiv.org 2026-06-18 Depression is a leading cause of global disability and is increasingly linked to systemic metabolic dysfunctions, including insulin resistance.