Metabolic Gating and the Evolution of Human Cognitive Plasticity: A Comparative Genomic Analysis biorxiv.org 2026-06-16 The genetic basis of extreme cognitive plasticity in human innovators remains poorly characterized.
Single cell in vivo analysis of type I IFN and NK cell-mediated control of B cell infection densities during acute gammaherpesvirus infection biorxiv.org 2026-06-16 Immunodeficient patients are at risk of severe complications following infection with the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi
Structural Basis of Nidovirus Replication Organelle Evolution Revealed by the Arterivirus DMV Pore Complex biorxiv.org 2026-06-16 Positive-strand RNA viruses of the order Nidovirales - which include coronaviruses and arteriviruses - remodel host membranes into double-membrane ves
Aedes vittatus in Haiti: continued expansion across the Caribbean and implications for the Americas biorxiv.org 2026-06-16 Aedes vittatus, an emerging invasive species and arboviral vector with high ecological plasticity and dispersal capacity, is expanding in the Caribbea
Record-breaking wildfire intensity and nocturnal spread during the extreme 2025 wildfire season in Southwestern Europe: causes and impacts biorxiv.org 2026-06-16 Southwestern Europe faced an extreme wildfire season in 2025, with nearly 700,000 hectares burned in the Iberian Peninsula (IP) alone.
Temporal genomics reveals rapid parallel adaptation in experimental populations of Trinidadian guppies (Poecilia reticulata) biorxiv.org 2026-06-16 Understanding the genomic basis of early adaptation is a central question in evolutionary biology.
CMAPLE 2: Fast and Accurate Phylogenetic Inference for Millions of Pathogen Genomes biorxiv.org 2026-06-16 Phylogenetic analysis is essential to genomic epidemiology, for example in tracing the origin and evolution of SARS-CoV-2 variants during the COVID-19
Summarizing Evolutionary Trajectories from Phylogenetic Character Maps of Discrete Traits biorxiv.org 2026-06-16 When reconstructing phylogenetic character histories, biologists aim to identify distinct evolutionary trajectories, or paths of character state evolu
Population bottlenecks shape laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii and reveal a shared within-patient evolutionary trajectory biorxiv.org 2026-06-16 Laboratory-based experimental evolution is widely used to investigate how antimicrobial resistance (AMR) emerges and to identify resistance-associated
Long-read genome sequencing reveals complex variability in lentiviral provirus insertions in deeply characterized Clonal CD19 CAR-T vector copy number reference cell lines biorxiv.org 2026-06-16 Chimeric antigen receptor (CAR)-T cell therapy is an important therapy involving provirus insertions in the genome.
Vascular and synaptic proteomes reveal blood-brain barrier disruption and postsynaptic remodeling in human temporal lobe epilepsy biorxiv.org 2026-06-16 Blood-brain barrier (BBB) dysfunction and mesial temporal lobe epilepsy (MTLE) are considered to be engaged in a pathological feedback loop, with the
Genetic dependency of atrial fibrillation-associated risk genes across tissue types: Discovering novel therapeutic targets biorxiv.org 2026-06-16 Background: Addressing the underlying causes of atrial fibrillation (AFib) is critically important.
Design of a Low-Latency sEMG Real-Time Correction System Based on High CMRR and EMRMS Mathematical Modeling biorxiv.org 2026-06-16 Wildlife poaching threatens biodiversity across sub-Saharan Africa, and is especially acute for critically endangered species such as the black rhinoc
A Transformer-derived transcriptomic score associates with ex-vivo drug response in AML biorxiv.org 2026-06-16 Background Drug-tolerant persister (DTP) cell states have been implicated in relapse across multiple cancers, including acute myeloid leukaemia (AML)
scIsoAgent enables autonomous isoform-resolved characterization and sequence-informed interpretation of long-read single-cell transcriptomes biorxiv.org 2026-06-16 Alternative isoform usage can alter gene function independently of total gene expression, creating a need to resolve transcript isoforms at single-cel
A minimal thermodynamic theory for re-entrant liquid-liquid phase separation regulated by small molecules biorxiv.org 2026-06-16 Small molecules regulate biomolecular condensates in a biphasic manner, promoting liquid--liquid phase separation (LLPS) at low concentrations while s
First Plant sedaDNA assemblage from California reveals ecological stability throughout 10,000 years of human presence at Lake Elsinore biorxiv.org 2026-06-16 As we face the sixth mass extinction, understanding how ecosystems have persisted -- or collapsed -- through millennia of changing climates and human
Developmental Continuity of Brain Network Core Organization in C. elegans biorxiv.org 2026-06-16 The brain is the most captivating chef d'oeuvre of nature. Naturally then, the mind wonders about the process that births such a fascinating organ.
Autophagy suppresses microglial activation and enhances M2 polarization via the mTOR/ULK1 pathway after optic nerve crush biorxiv.org 2026-06-16 This study is designed to investigate whether rapamycin can regulate microglial activation and polarization via mTOR and its downstream signals via au
GPCR-mediated regulation of glial TNF production biorxiv.org 2026-06-16 Neuromodulators generally act through G-protein-coupled receptors, but their effects on glia are not well defined.
Visual consequences of saccades explain early cortical response dynamics during natural vision biorxiv.org 2026-06-16 During natural vision, each saccadic eye movement evokes a large cortical potential known as the lambda response.
Cognitive Control Adjusts to Behavioral Constraints at Short Timescales biorxiv.org 2026-06-16 Cognitive functions encompass a large set of abstract constructs used for adapting our behavior to environmental constraints, each of them acting at s
Aligned multicompartment collagen scaffolds support stratified myoblast and fibroblast behavior for musculotendinous tissue engineering biorxiv.org 2026-06-16 Injuries to musculoskeletal tissue junctions are exceedingly common and notoriously difficult to repair due to the inability to restore overlapping gr
Machine learning surrogate forward models for biomechanical laryngeal control biorxiv.org 2026-06-16 Accurate modeling of laryngeal motor control is key to understanding typical and disordered voice production.
Super-Resolved Single Small Extracellular Vesicle Assay enabled by a Plasmonic Nanohole Array biorxiv.org 2026-06-16 The accurate quantification of biological nanoparticles, such as small extracellular vesicles (sEVs), is fundamentally hindered by a resolution-coinci
Filling the Void: Rapid Revascularization via Vasculogenic Assembly in Semi-synthetic Granular Hydrogel Grafts biorxiv.org 2026-06-16 Rapid revascularization is critical to tissue graft survival, as delayed reperfusion drives tissue ischemia and compromises cell viability and graft f
MetaPilot: genome-aware adaptive search-space refinement for unified DDA and DIA metaproteomics biorxiv.org 2026-06-16 Metaproteomic peptide identification is constrained by the structure and size of the protein search space.
OmicOS: A Comprehensive Omics Ecosystem Infrastructure and Agent System for the AI Era biorxiv.org 2026-06-16 Biology has accumulated a vast ecosystem of omics methods, but much of this ecosystem remains built for expert humans rather than scientific agents.
THEOBROMA: an aggregated open database of 1.13 million natural products with per-compound license auditing, three-tier classification, and stereochemistry-aware deduplication biorxiv.org 2026-06-16 Natural products remain one of the most productive sources of pharmacologically active compounds for drug discovery, yet the current open aggregator l
Buprenorphine Restricts the Conformational Landscape of the μ-Opioid Receptor biorxiv.org 2026-06-16 Biased signaling and partial agonism in GPCRs are considered promising strategies to develop safer and more effective drugs.
Dissecting and directing pathology foundation models biorxiv.org 2026-06-16 Foundation models (FMs) are central to digital pathology, encoding histology images into dense embeddings for facilitating diagnostic classification,
The fungicide mancozeb induces astrocyte atrophy and disrupts Calcium signaling via inhibition of Orai1/STIM1-mediated SOCE biorxiv.org 2026-06-16 Mancozeb, a widely used fungicide composed of manganese ethylene-bis-dithiocarbamate with zinc salts, has raised concerns due to its potential neuroto
Induced alanine auxotrophy as a therapeutic strategy against Mycobacterium tuberculosis biorxiv.org 2026-06-16 New antitubercular agents that act through previously unexploited mechanisms are urgently needed.
AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid Pathology biorxiv.org 2026-06-16 The inhibitory microglial receptor LILRB4 (ILT3) suppresses amyloid-beta clearance in Alzheimers disease (AD) through ApoE-dependent signaling but rem
The Two Tube Volatile Assay: a non-contact benchtop bioassay for monitoring susceptibility to transfluthrin biorxiv.org 2026-06-16 Introduction: Progress against malaria has stalled since 2015, with insecticide resistance a key driver.
Chronic alpha-Synuclein Over-Expression and Ceruloplasmin Challenge Promote Distinct Iron and Redox Responses in M17 Cells biorxiv.org 2026-06-16 Abstract Background: While alpha-synuclein (alpha-syn) accumulation and iron dysregulation are hallmarks of Parkinson's Disease, the adaptations that
Context-dependent effects of microglial MyD88 removal on voluntary ethanol consumption in mice biorxiv.org 2026-06-16 Neuroimmune signaling is increasingly implicated in alcohol use disorder (AUD).
Ratiometric iGluSnFr imaging to assess tonic glutamate in the cerebral cortex biorxiv.org 2026-06-16 Tonic glutamate signaling by ambient levels of extracellular glutamate has been implicated in development, brain injury, pathologies, and physiologica
DeltaQ: Value-Guided Hebbian Learning in Spiking Neuronal Networks for Multi-Goal Navigation biorxiv.org 2026-06-16 Animals must often navigate environments where feedback about progress toward a goal is sparse or delayed, requiring internal representations of space
Stimulus identity rather than emotion drives EEG classification on the FACED dataset biorxiv.org 2026-06-16 Reliable benchmark datasets are critical for advancing EEG-based emotion recognition.
Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem biorxiv.org 2026-06-16 In recent decades, the psychedelic psilocybin has been studied as a potential treatment for major depressive disorder (MDD), offering an alternative t
The ENIGMA-PD-WML Pipeline: A Containerized, User-Friendly Approach for Accurate, Standardized Segmentation of White Matter Lesions in Multi-Site MRI Data biorxiv.org 2026-06-16 Understanding vascular contributions to disease is a major unmet need.
Modeling quantifies in vivo neutralization, Fc-mediated killing, and resistance in human clinical trials of five anti-HIV broadly neutralizing antibodies biorxiv.org 2026-06-16 Broadly neutralizing antibodies (bnAbs) are a promising intervention for HIV prevention, therapy, and cure.
Identifying Ecological Restoration Priority Areas through a Function-Structure-Dynamic Framework: Integrating Ecological Security Patterns and Future Land-Use Simulation in the Anhui Section of the Yangtze River Basin biorxiv.org 2026-06-16 Rapid urbanization has intensified ecological degradation and threatened ecosystem sustainability in the Yangtze River Basin.
Blockages to biodiversity data access for conservation and sustainability management biorxiv.org 2026-06-16 Governments, civil society organizations and businesses often lack the biodiversity data they need for decision-making and adaptive management, impact
Are bio-sourced nanoplastics inert for aquatic species? A toxicity study on three micro-algae species and a freshwater bivalve biorxiv.org 2026-06-16 Concerns raised by ubiquitate plastic contamination are urging to develop alternative materials.
Physics-Driven Zero-Shot Reconstruction of Isotropic 3D Fluorescence Microscopy under Undersampled Acquisition biorxiv.org 2026-06-16 Three-dimensional (3D) imaging represents the development of next generation of fluorescence microscopy.
DynamicDemiLog: A Single Sketch for Ultrafast Similarity, Frequency, and Cardinality Estimation biorxiv.org 2026-06-16 Probabilistic cardinality estimators (HyperLogLog), similarity sketches (MinHash), and frequency estimators (Count-Min Sketch) are fundamental approxi
α-synuclein pathology drives multi-scale reorganization of fronto-limbic networks and cognitive flexibility in the common marmoset biorxiv.org 2026-06-16 Understanding how -synuclein misfolding and spreading affect brain systems is central to synucleinopathy research, yet evidence from primate models re
Microplastics disrupt adaptive predator-induced behavioural plasticity in Rana dalmatina tadpoles biorxiv.org 2026-06-16 The accumulation of microplastics (MP; plastic particles 1 {micro}m - 1 mm in diameter) in the environment is an increasing global concern.