An Unprecedented Cluster in a Methanotroph Acetol Dehydrogenase biorxiv.org 2026-06-15 Biocatalytic metal-containing clusters are nanometer-sized chemical reactors that enable enzymes to perform chemistry far beyond what would be possibl
Weak evidence for change in wind-induced bending moments on raised and thinned Colorado spruce (Picea pungens) biorxiv.org 2026-06-15 Trees are routinely pruned to mitigate the risk of wind damage, but there are few studies examining changes in wind loads after pruning, especially fo
Efficient Transmission in the Blowfly Early Visual Synapses Through the Regularization of Vesicle Release biorxiv.org 2026-06-15 Early studies of synaptic transmission by Bernard Katz and colleagues suggested that neurotransmitter release at graded-potential synapses occurs thro
Mechanical analysis of spatiotemporal traction stress dynamics in a bleb-driven migrating cell, Amoeba proteus biorxiv.org 2026-06-15 Many adherent eukaryotic cells exhibit amoeboid locomotion, where traction stress exerted on the substrate is essential for movement.
A latent 5-dimensional space for action representation: Geometric validity and dissociation from kinematics biorxiv.org 2026-06-15 A fundamental question in visual perception is how the human visual system transforms the rich kinematic information present in observed actions into
SMS: Symmetric Mediation Statistics for Powerful High-Dimensional Mediation Analysis biorxiv.org 2026-06-15 Background: Mediation analysis of high-dimensional features, particularly molecular-level omics features, provides important opportunities to uncover
Albumin integrates liver functional status to initiate regeneration biorxiv.org 2026-06-15 How an organism detects organ injury to initiate regeneration remains one of the central unresolved questions in regenerative biology.
Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain biorxiv.org 2026-06-15 Polarization-sensitive optical coherence tomography (PS-OCT) is a label-free imaging technique that exploits birefringence to visualize myelinated axo
Scout-based Multi-Echo NAvigator (SMENA) for high temporal resolution motion and B0 estimation and correction: applications to multi-echo GRE and EPTI biorxiv.org 2026-06-15 Purpose: To develop a data-driven technique, Scout-based Multi-Echo NAvigator (SMENA), for joint estimation of motion and B0 inhomogeneity ({delta}B0)
How to Catch a Blank Mind? Brain Similarities and Differences between Self- and Probe-Caught Mind Blanking biorxiv.org 2026-06-15 Mind Blanking (MB) is a mental state characterized by the experience of a seemingly empty mind.
Resolution of MALDI-TOF MS Compared to Whole Genome Sequencing for the Identification of Vibrio parahaemolyticus Strains Isolated from Oysters biorxiv.org 2026-06-15 Climate change and eutrophication are driving the expansion of the range of Vibrio species, including V. parahaemolyticus.
Anthropogenic disturbance inverts microclimate stratification in tropical forests biorxiv.org 2026-06-15 Tropical rainforests generate and maintain their own microclimate regimes and the resultant cooler, more humid and stable environments foster the hype
An ancient receptor family illuminates the evolution of animal sensation biorxiv.org 2026-06-15 Animals use nervous systems to sense and respond to their environment.
Diversity and Spatial Segregation of TRP Channels in Choanoflagellates Provide Insight into the Evolutionary Origin of Animal Sensory Systems biorxiv.org 2026-06-15 Sensory systems, built around specialized cell types, are central to how animals perceive and respond to their environments.
Deep evolutionary origins of the connexin gene family biorxiv.org 2026-06-15 The vertebrate connexin family encodes a diverse repertoire of transmembrane channels that mediate both intercellular communication and cytosol to ext
The old pipe gives the sweetest smoke: A phylogenetic turn for eDNA metabarcoding biorxiv.org 2026-06-15 Environmental DNA (eDNA) metabarcoding has transformed biodiversity monitoring, yet most analyses rely on taxonomic metrics that are sensitive to meth
Trustworthy agentic genomics through versioned skill libraries biorxiv.org 2026-06-15 Genomics is adopting autonomous AI agents that interpret genomes from natural-language instructions faster than it is building the means to trust them
GENE-FAM: An automated pipeline for mining gene families and its application to MADS-box genes in Cannabis sativa biorxiv.org 2026-06-15 Understanding how gene families evolve can offer great insight into adaptation at the phenotypic and ecological levels.
Full Scan enhanced Dynamic Range MS improves metabolite coverage and cancer cell-line discrimination in untargeted metabolomics biorxiv.org 2026-06-15 Metabolite detection with mass spectrometry (MS) in untargeted metabolomics is limited by the wide concentration range of metabolites, where high-abun
Infrared light stimulates the mitochondrial large-conductance calcium-activated potassium channel in guinea pig cardiomyocytes. biorxiv.org 2026-06-15 Mitochondrial potassium channels play an important role in regulating cellular metabolism, redox balance, and survival, particularly in excitable tiss
In vivo brain temperature measurement using quantum dot imaging temperature sensors biorxiv.org 2026-06-15 Abstract Temperature regulation in the brain is essential for maintaining neuronal function and preventing thermally induced damage.
Entanglement-governed protein networks enable mechanically adaptive artificial skin for transplantation-scale skin replacement biorxiv.org 2026-06-15 Artificial skin substitutes that simultaneously achieve mechanical robustness, regenerative bioactivity, and transplantation-scale tissue integration
Validation of Dynamic Bayesian Optimization for Human-in-the-Loop Optimization of Exoskeleton Control at User-Driven Walking Speed biorxiv.org 2026-06-15 Human-in-the-loop optimization (HILO) is an established method for identifying subject-specific optimal controllers for performance augmentation.
oxo-flow: compiled, memory-safe bioinformatics workflow orchestration biorxiv.org 2026-06-15 Bioinformatics analyses depend on workflow engines to coordinate dozens of computational tools across complex dependency chains.
AliceDB database and pipeline for identification of natural protein variants based on mass spectrometry measurement data biorxiv.org 2026-06-15 The natural variation that distinguishes living organisms within a single species is currently being studied intensively, primarily at the genetic lev
RepGene: Toward a Unified Gene Representation Space Robust to Missing Biological Views biorxiv.org 2026-06-15 Genes can be described through multiple heterogeneous biological views, including genomic sequence, transcript sequence, protein sequence, textual kno
VrySure: A Multi-Task AI Scientific Fraud Detection Platform for Identifying Manipulated and AI-Generated Biomedical Research Images biorxiv.org 2026-06-15 Integrity of scientific data is critical in biomedical research, where images often serve as primary evidence for experimental observations and conclu
Maternal BMI and Placental Transcriptomic Changes: A Meta-Analysis of Gene Expression at the Maternal-Fetal Interface biorxiv.org 2026-06-15 Objective: Maternal body mass index (BMI) is often used as a measure of metabolic status and increased or decreased maternal BMI is associated with a
Protein-Solvent Shape Complementarity as a Unifying Principle in Excipient-Mediated Protein Thermal Stability biorxiv.org 2026-06-15 Excipient effects on protein stability are critical for biological formulations, yet their selection remains largely empirical.
OrganScaleR: An Open Shiny Tool for Principled Organ-Weight Inference in Mouse Physiology biorxiv.org 2026-06-15 Background: Organ weights are often divided by body weight to report "relative" organ size.
Evolutionary biomechanics of maximum running speed in spiders (Araneae) biorxiv.org 2026-06-15 Background: Maximum running speed is a central performance trait, linking morphology, physiology and behaviour to fitness.
Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice biorxiv.org 2026-06-15 Although prenatal alcohol exposure (PAE) has been proposed as an early-life risk factor for Alzheimers disease and related dementias (AD/ADRD), the me
Climbing-fiber-like online readout adaptation in frozen continuous-time networks reproduces force-field adaptation and after-effects biorxiv.org 2026-06-15 Robotic motor control built on liquid neural networks and related continuous-time models, such as LTC and CfC, is typically trained offline via backpr
Parvalbumin-expressing interneurons improve sensory discrimination by shaping noise geometry in primate V1 biorxiv.org 2026-06-15 The ability to discriminate sensory stimuli is fundamental to sensory-guided behavior.
Prediction of fMRI activity using vector autoregressive models: a comparison of sparse and low-rank approaches biorxiv.org 2026-06-15 Vector autoregressive (VAR) models have a history of being used to examine functional connectivity in the brain, as captured by functional MRI studies
Erythrocyte Count and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study biorxiv.org 2026-06-15 Erythropoiesis is the most replication-intensive process in the body.
Hemispheric Dissociation in the Cognitive Control of Word Production biorxiv.org 2026-06-15 This study investigated the hemispheric contributions of the inferior frontal gyrus (IFG) to word production across constrained and unconstrained task
Multi-platform reassessment of human mitochondrial DNA methylation reveals signals consistent with technical artifacts biorxiv.org 2026-06-15 The existence and functional relevance of mitochondrial DNA methylation remain controversial.
Circadian clock gates retinal regeneration by orchestrating Cxcl12-dependent immune coordination biorxiv.org 2026-06-14 The circadian clock orchestrates tissue homeostasis and repair, yet its role in central nervous system (CNS) regeneration remains largely unexplored.
Species responses to nutrient loading promote resistance but not temporal stability in floating macrophyte communities biorxiv.org 2026-06-14 Determining the drivers of ecological stability amid accelerating global environmental change is a critical goal of contemporary ecology.
Internal decay in living trees: a quantitative tomography framework and its application in a temperate forest biorxiv.org 2026-06-14 Internal decay in living trees is an important component of carbon and nutrient cycling as well as species and structural diversity maintenance in for
Digging deeper into the immunopeptidome with TripleToolWF biorxiv.org 2026-06-14 While the field of immunopeptidomics has matured substantially over the last years, high input amounts of cellular or tissue material are still requir
Molecular Insights into Solvent-Mediated Stabilization and Aggregate Suppression during Refolding of Recombinant Leucyl Aminopeptidase biorxiv.org 2026-06-14 Production of recombinant proteins frequently yields inclusion bodies that must undergo refolding to yield active protein.
Biochemical Characterization of Fatty Acid Thioesterase Target Site Mutants and their Implication on Herbicide Resistance biorxiv.org 2026-06-14 Herbicide resistance threatens effective weed control in modern agriculture, particularly in grass weeds such as Alopecurus myosuroides and Lolium mul
Virtual phenotypic screening discovers novel scaffolds inhibiting the PI3K/mTOR pathway biorxiv.org 2026-06-14 Phenotypic drug discovery has yielded many first-in-class small-molecule drugs by discovering modulators of disease phenotypes in physiologically rele
FENNEC: Fine-Tuned Ensemble Neural Networks Accelerate Chemically Modified siRNA Design and Screening biorxiv.org 2026-06-14 Small interfering RNAs (siRNAs) are a clinically validated therapeutic modality, yet designing potent chemically modified siRNAs remains a costly and
Generative design of antigen-specific T-cell receptor sequences with a conditional diffusion model biorxiv.org 2026-06-14 T cell receptor (TCR)-based immunotherapy holds immense potential for treating cancers and infectious diseases, where highly antigen-specific TCR reco
Ingestion of the potent neurotoxin epibatidine does not compromise locomotion or behavior in the poison frog Epipedobates tricolor biorxiv.org 2026-06-14 Most organisms have evolved mechanisms to reduce the negative effects of toxins in their diet.
Experimental breeding reveals mating patterns and F1 phenotypic diversification in the cosmopolitan diatom Cylindrotheca biorxiv.org 2026-06-14 Diatom mating activity contributes to their enormous phenotypic and genetic diversity, yet little is known about patterns in diatom reproductive compa
Freshwater input and tidal position regulate species turnover and interaction rewiring in intertidal ecological networks biorxiv.org 2026-06-14 The effect that environmental conditions have on community and network assembly processes remains unclear, in part because these processes operate at