Cell Cycle Sensing Shapes Human T Cell Fate and Exhaustion Programs biorxiv.org 2026-06-12 Cell cycle (CC) dynamics are reflected in diverse T cell processes such as TCR activation, expansion, contraction, differentiation, senescence, anergy
Trypanosoma brucei infection remodels the uterine immune environment and drives neuroendocrine dysfunction biorxiv.org 2026-06-12 Human African Trypanosomiasis (HAT) or sleeping sickness is a systemic parasitic infection caused by the protozoan parasite Trypanosoma brucei.
MAHLER: Integrating Metadynamics and Inverse Folding to Predict Antibody-Antigen Kinetics biorxiv.org 2026-06-12 Binding kinetics are crucial for antibody function, shaping pharmacokinetics and in vivo efficacy beyond what equilibrium affinity captures.
Sweet interference: oral fermentation volatile confounders in exhaled breath revealed by minimal glucose exposure. biorxiv.org 2026-06-12 Volatile organic compounds (VOCs) in human breath have been explored as non-invasive biomarkers for disease, including respiratory infections and canc
High school science fair: Characterizing student communication and presentation practices and their association with SEF outcomes biorxiv.org 2026-06-12 Obtaining, Evaluating, and Communicating Information is one of the eight Science and Engineering Practices in the National Research Council framework
WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate biorxiv.org 2026-06-12 Seizures upregulate Na+-K+-2Cl- (NKCC1)-mediated Cl- influx and downregulate K+-Cl- (KCC2)-mediated Cl- efflux via the WNK-SPAK/OSR1 kinases, leading
The Influence of Prior Precision on the Inference of Hidden Causes biorxiv.org 2026-06-12 Perception is widely understood as Bayesian inference, integrating prior expectations with sensory evidence to infer the most probable latent cause of
Spatial collinearity constrains multivariate molecular-enriched network estimation biorxiv.org 2026-06-12 Analyses of neuroimaging data increasingly leverage the distribution of neurotransmitter receptors derived from Positron Emission Tomography (PET) to
Interferon-γ promotes SMAP production by cytotoxic T lymphocytes in a thrombospondin 4 dependent manner biorxiv.org 2026-06-12 Cytotoxic T lymphocytes (CTLs) eliminate infected and cancerous cells by exocytosing cytotoxic granules, either as single-core granules (SCGs) releasi
Antigen Stimulation Reactivates HIV-1 Proviruses Despite Integration in Repressive Chromatin biorxiv.org 2026-06-12 Intact HIV-1 proviruses become progressively enriched in transcriptionally repressive genomic regions during long-term antiretroviral therapy (ART) an
Distinct Programs of Tissue Adaptation Shape Vitreous CD4+ and CD8+ T-cell States in Chronic Uveitis biorxiv.org 2026-06-12 Tissue-resident memory (TRM) T-cells are increasingly recognized as key mediators of chronic autoimmune inflammation, yet their organization and funct
Host and environmental factors differentially affect patterns of diversity in specialist and generalist parasites biorxiv.org 2026-06-12 Aim: Elucidating the mechanisms shaping parasite diversity patterns is critical because parasites encompass about 40% of known species, and are crucia
Genetic Modeling of Dyadic Behavioral Traits: Implications for Estimation and Interpretation of Variance Components biorxiv.org 2026-06-12 Studying the genomic control of dyadic social interactions is gaining traction in animal genetics.
Scaling Across Environments: Temperature and nutrition independently shape the genetics of size plasticity and morphological scaling biorxiv.org 2026-06-12 Across animals, variation in adult body size is accompanied by coordinated variation in the size of individual morphological traits.
Mimosa pudica-derived zinc oxide nanoparticles preserve mesenchymal stromal cell viability, morphology, and osteogenic competence biorxiv.org 2026-06-12 Abstract Introduction: Musculoskeletal disorders remain a major cause of disability worldwide and require non invasive regenerative strategies that su
Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia biorxiv.org 2026-06-12 Understanding how receptor-level pharmacological modulation reorganizes large-scale brain circuits remains a central challenge in neuropharmacology.
Spatial Organization of Lipids Drives GPCR Conformational Equilibria biorxiv.org 2026-06-12 Despite the widespread use of lipid nanodiscs for structure-function studies of membrane proteins, little is known about how lipids are spatially orga
Interactions between single actin and vimentin filaments biorxiv.org 2026-06-12 The cytoskeleton determines cell shape, mechanical properties, and motility by interconnected networks of protein filaments - actin filaments, microtu
{triangleup}9-Tetrahydrocannabinol exposure shifts eosinophil and macrophage transcriptional programs towards an anti-inflammatory phenotype in helminth infection biorxiv.org 2026-06-12 Cannabis use is increasing globally, yet the immunological effects of {Delta}9-tetrahydrocannabinol (THC), the main intoxicating component of cannabis
Cryoelectron tomography of HIV-1 cell-cell transmission conjugates reveals a secluded environment for viral assembly and transfer biorxiv.org 2026-06-12 Cell-cell transmission of HIV-1 (CCT) is a highly efficient mode of intrahost transmission that provides viral particles broad protection from antiret
A genomic tool to tackle cryptic diversity demonstrates the potential for off-target use of GT-seq panels biorxiv.org 2026-06-12 A comprehensive understanding of life history is vital to successful species conservation and management.
Systematic functional annotation of thousands of BAHD acyltransferases in plant genomes using Protein Language Model and phylogenomic tools biorxiv.org 2026-06-12 The functional annotation of plant genes lags significantly behind their genomic annotation.
Disturbance regime changes leave long-lasting legacies on a microbial community's composition and function biorxiv.org 2026-06-12 Mortality-inducing disturbances are important, ubiquitous drivers of community composition and function.
From Proteome Mining to Structural Validation: Phosphopyruvate Hydratase as a Structurally Tractable Drug Target in Kinetoplastid Parasites biorxiv.org 2026-06-12 Chagas disease, caused by Trypanosoma cruzi, demands novel therapeutic strategies that overcome the toxicity and limited efficacy of current treatment
Differences between males and females in psychostimulant/sucrose self-administration (when observed) may not necessarily be driven by biological sex. biorxiv.org 2026-06-12 Background: Sex differences in psychostimulant-related behaviors are often attributed to biological sex; however, individual variability may also stro
Using HD-DOT in precision accuracy microgenetic research designs to measure change over time in speech, language, and hearing clinical populations biorxiv.org 2026-06-12 Documenting change is fundamental to understanding the process of intervention among individuals with communication disorders.
Timecourse of corticospinal excitability for observed action: evidence of early suppression followed by return to baseline without facilitation biorxiv.org 2026-06-12 Introduction: Action observation modulates corticospinal excitability, with most previous studies indicating an increase in excitability in the muscle
Passive Physiological Responses Fail to Predict Context-Dependent Action Selection in Bats biorxiv.org 2026-06-12 How social animals encode vocalizations, assign them value, and formulate behavioral responses remains largely unknown.
Neuraminidase-Based Cross-Protective Immunity against H5N1 Influenza Viruses in Humans biorxiv.org 2026-06-12 Highly pathogenic avian influenza A(H5N1) virus continues to expand globally across wild birds, poultry, and multiple mammalian hosts, and the detecti
Ecosystem disservices are underrepresented in literature on annual crop agroecosystems biorxiv.org 2026-06-12 Maximising ecosystem service (ES) benefits while minimising ecosystem disservices (EDS) is essential for ecological intensification in annual crop sys
Structural and Mechanistic Basis of F227C-Mediated Hypersusceptibility to Islatravir in HIV-1 Reverse Transcriptase biorxiv.org 2026-06-12 Islatravir (ISL; 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA)), a first-in-class nucleoside reverse transcriptase (RT) translocation inhibitor (NRTTI)
Pulsed electrical stimulation enhances intestinal permeability biorxiv.org 2026-06-12 Oral ingestion of drugs remains the most convenient method for pharmacotherapy.
EEG microstate dynamics during psilocybin intoxication relate to acute experience and persisting psychological changes biorxiv.org 2026-06-12 Psilocybin and other serotonergic psychedelics show therapeutic promise for psychiatric disorders, yet objective neural correlates linking the acute p
Mechanics and fate stochasticity shape stem cell distribution in tissues biorxiv.org 2026-06-12 Balancing cellular loss in tissues requires fine balance of cell proliferation and differentiation.
Human interferon stimulated genes target ancient features of animal and bacterial viral replication biorxiv.org 2026-06-12 Animal and bacterial cells defend against viral infection by rapidly activating antiviral restriction factors.
Long-term Humoral Immune Dynamics After SARS-CoV-2 Vaccination and Infection in Healthcare Workers: The VaCoMRI Study biorxiv.org 2026-06-12 Objectives: The VaCoMRI study tracked a healthcare worker cohort from 2020 through June 2024 to characterize the long-term sustainability of vaccine-
Sociality Drives Sex Differences in Auditory Brainstem Processing Across Rodent Species biorxiv.org 2026-06-12 Although social behavior has been predicted to correlate with increased complexity in vocal signals, its relationship with auditory sensitivity betwee
Colourful predictive templates in early visual cortex biorxiv.org 2026-06-12 Predictive processing theories suggest that our brain constantly predicts incoming sensory information, though the level of granularity and concrete s
Sensory stimulation triggers different spike responses in serotonin and dopamine neurons in the dorsal midbrain tegmentum. biorxiv.org 2026-06-12 The dorsal midbrain tegmentum, including the dorsal raphe nucleus (DRN) and the ventrolateral periaqueductal gray (vlPAG), contains diverse neuronal p
Early resource scarcity drives persistent transcriptional changes and vascular remodeling in the female prefrontal cortex biorxiv.org 2026-06-12 Early childhood poverty is an environmental risk factor for psychiatric and neurodegenerative disorders, yet the cellular mechanisms by which resource
Isolation of postnatal human neural stem cells biorxiv.org 2026-06-12 While it was once thought that neurogenesis is complete by birth, it is now apparent that the human brain continues to generate new neurons postnatall
Anatomical organization and origins of VGLUT3-positive axon terminals in the lateral septum. biorxiv.org 2026-06-12 The lateral septum (LS) integrates afferents from multiple brain regions, including the raphe nuclei.
Synergistic effects of presynaptic and postsynaptic neurons give rise to three-stage short-term plasticity in vivo biorxiv.org 2026-06-12 Short-term plasticity (STP) is the transient fluctuation of connection strength between two neurons depending on the recent history of neuronal activi
RAI1 safeguards fidelity and tempo of human neurodevelopmental gene expression biorxiv.org 2026-06-12 Human brain development proceeds on an unusually long timeline relative to other species, a feature that is thought to foster advanced cognitive abili
Altered Striatal Acetylcholine Dynamics across Dopamine Loss and L-DOPA Treatment biorxiv.org 2026-06-12 LDOPA remains the most effective therapy for Parkinson's disease (PD), yet its chronic use often induces involuntary movements known as L-DOPA-induced
Representations of spatial saliency in auditory cortex are selectively organized through temporal coordination biorxiv.org 2026-06-12 Selective processing of behaviorally relevant sounds in complex environments requires dynamic modulation of auditory representations.
Cannabidiol attenuates chemotherapy-induced peripheral neuropathic pain through a mechanism that requires the enzyme N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD) biorxiv.org 2026-06-12 Cannabidiol (CBD) is a non-psychoactive component of cannabis that has been studied as a potential therapy for chronic pain.
Kombucha-Derived Cellulose Non-wovens: Growth Optimization, Mechanics, and Recycling biorxiv.org 2026-06-12 The environmental impact of synthetic non-woven materials has prompted the search for sustainable and biodegradable alternatives.
A Dual-Locus-Targeting Strategy to Enhance CRISPR/Cas9-mediated CFTR Replacement via Helper-Dependent Adenoviral vector in porcine genome biorxiv.org 2026-06-11 Gene therapy has been the subject of extensive research following the advent of gene-editing technologies.
Divergent activation of the RXFP1 relaxin receptor by protein and small molecule agonists biorxiv.org 2026-06-11 RXFP1 is an unusual G protein-coupled receptor (GPCR) that mediates physiological adaptations to pregnancy and is a therapeutic target due to its bene