Galectin-3 is Necessary for Selective Cathartocytosis, which Expedites the Development of Proliferative Gastric SPEM biorxiv.org 2026-06-11 The expression and secretion of sulfated colonic-type mucins is a feature of high-risk metaplasias of the gastrointestinal foregut (Barrett's esophagu
Preserving Native Cellulose-Xylan Architecture Enables Structure-Property Control in Holocellulose Nanofibrils and High-Performance Sustainable Materials biorxiv.org 2026-06-11 The hierarchical organization of cellulose microfibrils and their intimate interactions with hemicelluloses such as xylan underpin the exceptional mec
Somatic Genome Diversification and Clonal Evolution of Pathogenic B Cells in Systemic Autoimmunity biorxiv.org 2026-06-11 Systemic autoimmune rheumatic diseases are characterized by persistent immune activation and clinical heterogeneity, yet the molecular processes susta
A high-quality chromosome-scale reference genome assembly for Asparagus racemosus var. CIM-Shakti (Shatavari), a medicinal plant of Ayurvedic importance biorxiv.org 2026-06-11 Asparagus racemosus Wild., commonly known as Shatavari, is an important medicinal plant in Ayurveda and is valued for its steroidal saponins, particul
Perinatal Semaglutide Treatment Improves Maternal Health and Mitigates Offspring Metabolic Dysfunction in a Mouse Model of Maternal Obesity biorxiv.org 2026-06-11 Early-life exposures during critical periods of development significantly impact lifelong metabolic risk and likely contribute to the rising rates of
Dietary fructose promotes MASH/HCC progression through enhanced intestinal HIF-2α-dependent iron absorption biorxiv.org 2026-06-11 Dietary fructose is a major risk factor driving the progression of metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinom
Estrogen-related receptor signaling counters sarcopenia and preserves exercise fitness in naturally aged mice biorxiv.org 2026-06-11 Background.
CSF1R-Mediated Microglial Engagement Is Required for Stress-Induced MMP-2/9 Activity biorxiv.org 2026-06-11 Stress is a major risk factor for numerous neuropsychiatric disorders and induces enduring synaptic plasticity within the nucleus accumbens core (NAco
The Limited Range of Motion of the Knee Does Not Fully Explain the Altered Neural Control of Plantar Flexors During Gait in Non-Neurological Knee Flexion Contracture biorxiv.org 2026-06-11 Knee flexion contracture (KFC) may occur in the late stages of arthropathies, including osteoarthritis and haemophilic arthropathy.
A Fully Endovascular Neural Interface biorxiv.org 2026-06-11 Electrical stimulation of neural circuits is expanding therapeutic strategies to modulate brain, autonomic, and immune functions.
Acute running improves mood via changes in interoceptive sensibility biorxiv.org 2026-06-11 Running can improve mood, but the proximal processes linking exercise-induced bodily changes to subjective affective changes remain unclear.
A Computational Framework for Domain Insertion into Type IV Pili for Bacterial Display and Living Material Assembly biorxiv.org 2026-06-10 Bacterial surface structures have enabled display systems with broad impact across biotechnology, but their narrow host range limits their deployment
FEABAS: A Stitching and Alignment Tool for Serial EM Data biorxiv.org 2026-06-10 Volume electron microscopy (vEM) is the most advanced and scalable technique for reconstructing synaptic-level wiring diagrams of the nervous system.
STN-DBS frequency-tuned beta subband dynamics are associated with speech tempo in Parkinson's disease biorxiv.org 2026-06-10 In Parkinson's disease, subthalamic nucleus deep brain stimulation (STN-DBS) frequency modulated narrow beta subbands, with low-frequency stimulation
Identification of the complete pathway for conversion of bilirubin to urobilinogen by human gut bacteria biorxiv.org 2026-06-10 Bilirubin, the predominant product of heme catabolism in mammals, enters the intestine via the hepatobiliary system and subsequently is metabolized by
Skin microbiome mirrors habitat divergence in amphibious combtooth blenny fish (Teleostei, Blenniidae) biorxiv.org 2026-06-10 Host-associated microbiomes play vital roles in organismal health, ecological interactions, and evolution, yet little is known about how microbial com
Non-stationary Markovian dynamics shape swim bias fluctuations in zebrafish larvae biorxiv.org 2026-06-10 Animals are capable of internally modulating behavior as a function of internal state, environmental sensory conditions, and context.
Statin-Induced Mitochondrial Coenzyme Q Deficiency Alters Mitochondrial Redox Homeostasis and Bioenergetic Function in Astrocytes biorxiv.org 2026-06-10 Statins, widely used cholesterol-lowering drugs, inhibit the mevalonate pathway and reduce coenzyme Q (CoQ) biosynthesis, potentially impairing mitoch
HOMED enables hierarchical and multimodal optimization of DNA methylation deconvolution across tissues biorxiv.org 2026-06-10 Cellular heterogeneity is a major confounder in bulk DNA methylation data for epigenome-wide association studies.
Sennoside A and Ceftazidime Inhibit Nucleocapsid RNA BindingAcross SARS-CoV-2, SARS-CoV, and MERS-CoV biorxiv.org 2026-06-10 SARS-CoV, MERS-CoV, and SARS-CoV-2 exemplify the persistent threat posed by coronaviruses, with their capacity for zoonotic spill over, rapid transmis
Phylogenetic coherence in microbiome composition across environmental gradients biorxiv.org 2026-06-11 Global surveys of microbial communities across biomes have shown that environmental variables such as depth and pH are strong determinants of communit
Thriving to surviving: light wavelength modulates photoacclimation response in the siphonous green alga Derbesia biorxiv.org 2026-06-11 Algae require specific acclimation strategies to cope with spectral variability in shallow marine habitats.
Parental care is a genetic capacitor biorxiv.org 2026-06-11 Parental care is widespread across the animal kingdom and plays a critical role in offspring development.
Distinct effects of different metabolic stress models on human-derived neuronal networks biorxiv.org 2026-06-11 Different in vitro models are widely used as experimental platforms to assess neuronal responses to metabolic stress and test potential treatments for
High-throughput discovery of arginine-depleted peptides enables effective antisense delivery for Duchenne muscular dystrophy biorxiv.org 2026-06-11 Phosphorodiamidate morpholino oligomers (PMOs) are approved exon-skipping antisense therapeutics for Duchenne muscular dystrophy (DMD), but their clin
Robust semi-supervised scRNA-seq integration from virtual adversarial learning biorxiv.org 2026-06-11 Single-cell RNA sequencing integration methods that rely solely on transcriptomic data often struggle to preserve fine-grained distinctions between cl
Sequence-Based Therapeutic Peptide Classification with Augmented Negative Sampling biorxiv.org 2026-06-11 Therapeutic peptides offer high target specificity, low toxicity, and the ability to modulate protein-protein interactions, yet experimental functiona
FluoVolt Staining Induces Photodamage During Live-Cell Voltage Imaging biorxiv.org 2026-06-11 Fluorescent voltage-sensitive dyes (VSDs) enable non-invasive, high-throughput optical measurement of membrane potential in living cells, but the anal
Drift drives phenotypic evolution in a rapid island radiation biorxiv.org 2026-06-11 Understanding the processes that generate phenotypic diversity is central to explaining how new species form.
β-Hydroxybutyrate maintains energetically demanding neural functions during glucose deprivation biorxiv.org 2026-06-11 Ketone bodies are a major source of cerebral energy during fasting and the ketogenic diet, but whether they can independently sustain brain tissue met
Posterior Periodic Alpha Power as a Neural Marker of Early Biliteracy Skills: The Mediating Role of Rapid Automatized Naming in Chinese-English Bilingual Children biorxiv.org 2026-06-11 In school-aged children, resting-state posterior alpha activity has been linked to thalamocortical signal coordination and literacy-related cognition.
Hypothalamic Representation of Aggressiveness across Mouse Strains biorxiv.org 2026-06-11 Aggression is an innate behavior conserved across species, serving as a critical means to compete for food, mating opportunities, and other essential
Functional brain organization is stable within individuals across years biorxiv.org 2026-06-11 Brain regions exhibit dynamic yet highly coordinated activity patterns that form large-scale functional networks measurable through resting-state corr
Suboptimal human inference reflects an efficient and flexible information bottleneck biorxiv.org 2026-06-11 Human decision-making behavior varies widely across individuals and task conditions.
A Two-Dimensional Grid-Cell Code for Three-Dimensional Navigation in Freely Flying Bats biorxiv.org 2026-06-11 Animals have evolved to navigate environments with diverse geometries and dimensionalities, yet how neural circuits for spatial navigation support beh
Cortical Excitation-Inhibition Balance in Autism Varies by Brain Region and Age biorxiv.org 2026-06-11 Autism spectrum disorder (ASD) is characterized by differences in social communication and interaction, alongside restricted and repetitive behaviors.
Cortical cooling reveals a role for visual cortex in generating visual responses in auditory cortex biorxiv.org 2026-06-11 Multisensory integration is a fundamental feature of cortical processing, yet the functional pathways that deliver visual signals to the auditory cort
Top-down attention modulates auditory sustained responses but not the neural processing advantage for vowels biorxiv.org 2026-06-11 Temporal and spectral regularities characteristic of vowels are preferentially encoded by the auditory system, giving rise to a prolonged enhancement
Tuft dendrite spikes are accompanied by selective input from distinct functional networks biorxiv.org 2026-06-11 The tuft dendrites of layer 5 neurons can support regenerative events - dendritic spikes - that have been proposed to coordinate context-specific enga
Learning using switching synaptic plasticity rules biorxiv.org 2026-06-11 Hebbian-like learning has been repeatedly confirmed experimentally, yet computational models usually require non-local signals, such as backpropagatin
An allelic series reveals the genetic requirement for Adnp in cortical neurogenesis and learning behavior biorxiv.org 2026-06-11 Transcriptional regulators and chromatin remodellers are among the most important risk gene categories across the genetic landscape of neurodevelopmen
Inference of elevated mutation rates and variant effects using 700k exomes biorxiv.org 2026-06-10 Genomic sequencing is now widely accessible for genetic diagnostics and is emerging as a component of newborn screening.
Two SID-1-dependent genes sensitive to heritable epigenetic changes can also impact reproduction biorxiv.org 2026-06-10 Import of double-stranded RNA (dsRNA) into the germ line can have consequences that last for many generations.
TOMM40 '523' genotype induces sex- and tissue- specific differences in cholesterol and triglyceride levels in an APOE-TOMM40 humanized mouse model biorxiv.org 2026-06-10 Introduction: Genetic variants within the APOE-TOMM40 locus are associated with Alzheimer's disease (AD).
Uncovering Pseudotime-Varying Genetic Causal Effects Along Single-Cell Trajectories for Pulmonary Disease Trait biorxiv.org 2026-06-10 With the increasing accessibility of single-cell RNA sequencing (scRNA-seq) data, cell-type-specific gene expression can be linked to complex traits t
From FODMAPs to prebiotic candidates: enzymatic transglycosylation of raffinose oligosaccharides towards new mixed-linkage oligosaccharides biorxiv.org 2026-06-10 Raffinose family oligosaccharides (RFOs) are abundant in side streams from food and feed production from legumes, and the transition to plant-based di
Na+-translocating oxaloacetate decarboxylase from Vibrio cholerae: the functional tautomeric form of the substrate and the proton pathways in catalysis biorxiv.org 2026-06-10 Membrane-bound decarboxylases couple carboxylic acid decarboxylation to the transport of Na+ ions out of prokaryotic cells.
Symmetry and force response of cohesin loop extrusion are determined by diffusion of its motor and anchor domains biorxiv.org 2026-06-10 Cohesin, a Structural Maintenance of Chromosomes (SMC) complex is thought to organize genomes by generating DNA loops, yet the molecular basis of loop
MOFF2: A Transferable Coarse-Grained Protein Force Field for Predictive Condensate Simulations biorxiv.org 2026-06-10 Coarse-grained protein force fields enable simulations of biomolecular systems at length and time scales that are difficult to access with atomistic m
Low-Energy Polishing Facilitates Breaking the Resolution Barrier of In Situ Cryo-EM biorxiv.org 2026-06-10 In situ structural analysis allows direct visualization of protein structures in their native cellular environments, but near-atomic resolution in cel