Generalisable signatures of anaesthesia in the large-scale functional organisation of the marmoset brain biorxiv.org 2026-06-10 How the activity and connectivity of the brain support consciousness remains a central question in neuroscience.
Disentangling mechanisms of single-cell growth rate fluctuations biorxiv.org 2026-06-10 Single-cell growth rates fluctuate across time and generations, but identifying the biological origin of this variability is difficult because growth
Tagging C. elegans septins disrupts cytoskeletal scaffolding but not post-embryonic roles biorxiv.org 2026-06-10 Septins are conserved polymer-forming proteins that scaffold the actomyosin cytoskeleton, its regulators, and other factors to cellular membranes.
In situ molecular architecture of PML bodies reveals open-state columnar trinucleosome assemblies within a porous, chromatin-permissive interior biorxiv.org 2026-06-10 Genome function in the nucleus is organised through membrane-less compartments enriched with specific proteins and nucleic acids.
Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 biorxiv.org 2026-06-10 Lysosomal membrane damage triggers a multi-stage repair response essential for cellular homeostasis.
Dynamics of phosphofructokinase condensation are regulated by metabolic and redox cues biorxiv.org 2026-06-10 Condensation of phosphofructokinase, the rate-limiting enzyme of glycolysis, into granules has been observed across species and in various stress cond
Senescent and reactive astrocytes display distinct expression profiles and divergent functional capacities. biorxiv.org 2026-06-10 Astrocytes assume multiple phenotypes in the brain in response to stress, injury, inflammation, and aging.
Structural Mechanism and Cellular Restriction of Tau Seeding from Endolysosomes biorxiv.org 2026-06-10 The prion-like spread of tau from cell to cell in the central nervous system involves escape from the endolysosomal network, which is counteracted by
Mitochondrial-derived compartments buffer outer membrane protein load during acute mitochondrial adaptation biorxiv.org 2026-06-10 Cells undergoing metabolic transitions rapidly remodel mitochondria through coordinated expansion and reorganization of the mitochondrial proteome.
Mitochondrial degradation of metallothionein enables local zinc mobilization during zinc limitation biorxiv.org 2026-06-10 Zinc is an essential structural and enzymatic cofactor for roughly 10% of proteins, including transcription factors, metabolic enzymes, and cytoskelet
Stretched Exponential Modeling Reveals Drug-Specific Kinetics in Human Engineered Skeletal Muscle biorxiv.org 2026-06-10 Understanding muscle tissue is key not only for advancing our knowledge in biophysical function of the human body, but can also open new paths to bett
Multi-timescale learning signals in Drosophila dopaminergic neurons biorxiv.org 2026-06-10 Learning often requires inference over hidden task structure, including features that predict outcomes.
4 Phenylbutyrate Plus Gene augmentation: A dual therapy To Rescue of SLC6A1 Variant Associated Developmental And Epileptic Encephalopathy biorxiv.org 2026-06-10 Background: Pathogenic variants in SLC6A1, which encodes the {gamma}-aminobutyric acid (GABA) transporter GAT-1, cause developmental and epileptic enc
In-vitro evaluation of Ozenoxacin and other Antibiotics against Staphylococcus aureus and Streptococcus pyogenes isolated from Skin and Soft Tissue Infections biorxiv.org 2026-06-10 Staphylococcus aureus and Streptococcus pyogenes are major causative bacteria responsible for skin and soft-tissue infections (SSTIs) such as impetigo
Subtype-specific differences in susceptibility to monoclonal antibodies and vaccines among contemporary RSV-A and RSV-B isolates biorxiv.org 2026-06-10 Respiratory syncytial virus (RSV) continues to circulate at high levels despite the introduction of new monoclonal antibodies (mAbs) and vaccines targ
M6A-modified circEZH2 Protects Endothelial Cells from Senescence and Suppresses Atherosclerosis by Stabilizing ZNF326 biorxiv.org 2026-06-10 Objective: Endothelial cell senescence induces endothelial dysfunction, thereby contributing to atherosclerosis progression.
The engulfment receptor CED-1/MEGF10 activates the GPCR LAT-1/ADGRL3 for apoptotic cell degradation biorxiv.org 2026-06-10 Efferocytosis, the clearance of apoptotic cells, is crucial for tissue homeostasis, inflammation suppression, and repair.
Ca2+-activated CKL3 phosphorylates nucleoporin 58 to reprogram nuclear transport and execute effector-triggered immunity biorxiv.org 2026-06-10 Recognition of pathogen effectors by nucleotide-binding leucine-rich repeat receptors (NLRs) activates effector-triggered immunity (ETI) in plants thr
VIRP1 bromodomain shapes nuclear condensate formation and has a positive effect on PSTVd accumulation biorxiv.org 2026-06-10 -Viroids are small, non-coding RNAs that rely on host proteins for replication, intracellular trafficking and systemic movement.
Clade III HIPP genes encode plasmodesmata-targeted proteins with pleiotropic functions in regulating plant development. biorxiv.org 2026-06-10 Heavy metal-associated isoprenylated plant proteins (HIPPs) are encoded by large gene families, which have diversified specifically in vascular plants
Immunoengineered Chitosanase-Produced Chitosan Oligomers for Elevating Plant Resistance to Viral Infection biorxiv.org 2026-06-10 Chitooligomers can act as plant biostimulants or biopesticides, but current chitosan-based agro-biologics often lack sufficient efficacy.
Evaluating crop models for future climate scenarios: wheat yield predictions using APSIM and STICS under combined CO2, warming, and water deficit conditions biorxiv.org 2026-06-10 Crop models are essential for predicting climate change impacts on agriculture, yet their validation under multi-stress conditions remains limited.
The coordination between xylem and bark hydraulics in temperate Rosaceae species biorxiv.org 2026-06-10 Xylem and bark properties influence tree growth and drought resistance, yet their functional coordination and their environmental drivers remain uncle
Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana biorxiv.org 2026-06-10 Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA
Dual Knockout of StAMY23 and StVINV Improves Postharvest Storage Traits in Potato biorxiv.org 2026-06-10 Starch is the primary carbohydrate reserve in potato (Solanum tuberosum L.) tubers and a critical determinant of their industrial value.
The plant immune receptor LORE binds agonistic and antagonistic 3-hydroxy fatty acid ligands via a dynamic loop in its G-type lectin domain biorxiv.org 2026-06-10 The Arabidopsis thaliana S-domain receptor kinase LORE senses bacterial medium-chain 3-hydroxy fatty acids (mc-3-OH-FAs) as microbe-associated molecul
A Neuronal Gene Expression Program Underlying Sustained Network Activity biorxiv.org 2026-06-10 Neurons function within interconnected networks and must continuously adjust their firing properties to maintain stable network activity.
The Critical Period Microbiota Shape Brain Plasticity biorxiv.org 2026-06-10 The gut microbiota is increasingly recognized as a regulator of brain function, yet its role in experience-dependent plasticity during postnatal devel
Deafness and sign language experience shift visual category representations biorxiv.org 2026-06-10 Childhood visual experiences shape our ability to rapidly recognize faces and objects.
Hearing Lips and Seeing Voices After Fifty Years: A Large-Scale McGurk Illusion Dataset for Audiovisual Speech Research biorxiv.org 2026-06-10 Efficient face-to-face communication relies on the integration of auditory speech and visual articulatory signals.
APOE4 genotype, blood-brain barrier leakage and ischaemic stroke subtype and location biorxiv.org 2026-06-10 Background: Apolipoprotein E (APOE) has been implicated in blood-brain barrier (BBB) dysfunction and may influence ischaemic cerebrovascular disease a
Myofibroblast- specific autophagy drives cyst growth in autosomal dominant polycystic kidney disease biorxiv.org 2026-06-09 Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst expansion, fibrosis and inflammation, leading to
Perturbing glycosylphosphatidylinositol (GPI)-anchor biosynthesis alters cell wall architecture and modulates fungal morphology biorxiv.org 2026-06-09 Filamentous fungi are widely used as expression hosts for industrial protein production.
Accurate de novo design of peptides from programming biophysical landscape biorxiv.org 2026-06-09 Peptides regulate virtually every cellular process and emerge as transformative modalities in bioengineering and therapeutics.
Deciphering the limitations of immortalized hepatocyte cell lines for the study of liver cis-regulatory elements biorxiv.org 2026-06-09 Immortalized cell lines are widely used in biological research despite their known differences from their tissues and cell types of origin.
Whole genome sequencing and variant discovery in 344 global grasspea (Lathyrus sativus L.) lines biorxiv.org 2026-06-09 The rapid expansion of genomic data resources for major crops is opening new options for crop improvement, while resources for most underutilised crop
Discovery of a novel dehalogenase from Achromobacter mucicolens for PFAS defluorination biorxiv.org 2026-06-09 Here, we report the purification and characterization of a haloacid dehalogenase type II (HAD-II) enzyme capable of direct and cell-free enzymatic def
Early detection of pancreatic ductal adenocarcinoma by single-molecule profiling of pancreatic enzyme activities biorxiv.org 2026-06-09 Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer-related mortality, largely due to diagnosis at advanced stages.
Revealing the spatiotemporal dynamics of methionine metabolism with a genetically encoded single-fluorophore biosensor biorxiv.org 2026-06-09 Methionine is an essential amino acid, used for protein synthesis, redox homeostasis, and methylation reactions throughout the cell.
The KN domain of KANK proteins contains separable talin-binding and intramolecular interaction modules biorxiv.org 2026-06-09 KANK proteins link integrin adhesions to the cortical microtubule stabilising complex (CMSC) through interactions with the adhesion adaptor talin.
Differentiating 5-thiooxazoles from oxazolone-coupled thioamides in RiPP natural products biorxiv.org 2026-06-09 Conversion of cysteine residues to 5-thiooxazole moieties by multinuclear nonheme iron-dependent oxidative enzymes (MNIOs) is a prevalent modification
Porphyrin driven redox tuning in structurally defined de novo heme proteins biorxiv.org 2026-06-09 Designing redox proteins with predictable and tuneable electron transfer properties is a major goal in de novo bioenergetics.
Mapping metabolic phases through online pressure and backscatter rates biorxiv.org 2026-06-09 Microbial metabolism can be represented as an energy-conserving process (catabolism) and a biomass-forming reaction (anabolism).
Redox-regulated cysteine acylation governs β-lactam sensing by the Vibrio histidine kinase VbrK biorxiv.org 2026-06-09 The ability of pathogens to develop resistance mechanisms makes the continuous search for novel therapeutic targets indispensable.
Yersinia pestis lipoprotein SlyB promotes plague pathogenesis via envelope stress tolerance biorxiv.org 2026-06-09 Yersinia pestis, the etiological agent of plague, persists in an enzootic cycle involving mammals and fleas, requiring constant outer membrane (OM) ad
Functional divergence of the NSs protein defines interferon antagonism and viral fitness across Bhanja virus lineages. biorxiv.org 2026-06-09 Bhanja virus (BHAV) is a tick-borne bandavirus (Family Phenuiviridae) with a broad geographic distribution and documented neuroinvasive capacity, yet
TileBac: A Benchmark CryoEM Dataset of Bacteria in Ultralow-Dose Montage Tiles biorxiv.org 2026-06-09 Current segmentation models are capable of routine identification of biological features in noisy cryogenic electron microscopy (cryoEM) images.
Measure Catabolism: Real-time shifts in microbial metabolism through online pressure measurements biorxiv.org 2026-06-09 Microbial activity is often inferred from cell density measurements; however, biomass formation is merely an indirect, cumulative result of metabolism
TDP-43 self-assembly is regulated by its disordered NLS-region biorxiv.org 2026-06-09 Cytosolic inclusions of the RNA-binding protein TDP-43 are a pathological hallmark of several neurodegenerative diseases, such as amyotrophic lateral
Intensity-dependent topographical expansion of sensory representations biorxiv.org 2026-06-09 Neuroimaging studies typically assume that sensory properties are encoded in response magnitude within fixed neural populations.