Activity-Dependent Postsynaptic Mitochondrial ROS Signaling Drives Avoidance Plasticity in C. elegans biorxiv.org 2026-06-09 Reactive oxygen species (ROS) are signaling molecules involved in neuronal excitatory function, with mitochondrial ROS (mitoROS) playing key roles in
Human ASPDH is a 2-aminomuconate reductase that produces L-2-aminohex-3-enedioic acid in tryptophan catabolism biorxiv.org 2026-06-09 Most tryptophan catabolism in animals occurs through the kynurenine pathway, which generates the essential NAD cofactor and multiple bioactive metabol
D-Retro-Inverso Peptide Candidates for Inhibiting SAA Cardiac Amyloidosis biorxiv.org 2026-06-09 n a recent study of a mice model it was suggested that after myocardial infarction Serum Amyloid A (SAA) aggregates are formed that contribute to the
ECMME: an atlas of selection pressures on the mammalian extracellular matrix reveals contrasting evolutionary dynamics biorxiv.org 2026-06-10 The extracellular matrix (ECM) is a fundamental metazoan innovation that provides structural support and regulatory cues essential for multicellular l
Functional Continuum of GABAergic Synaptic Dynamics Reflects Genetic Identities biorxiv.org 2026-06-10 The language of the brain is articulated by temporal patterns of neuronal activity, which individual synapses interpret through distinct forms of syna
Crossmodal plasticity effects of hearing loss and ageing in the human auditory cortex biorxiv.org 2026-06-10 Crossmodal plasticity refers to the phenomenon by which typical sensory areas respond to stimulation in other sensory modalities when their main input
Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects. biorxiv.org 2026-06-10 Mitochondria support the bioenergetic processes that enable brain function and cognition, but we have lacked a label-free, non-invasive approach to ex
Pathological variants in HPDL cause collapse of the neuro-glial unit during human cortical maturation biorxiv.org 2026-06-10 Biallelic variants in HPDL cause a severe neurological disorder in childhood, but the mechanisms linking early developmental abnormalities to later co
Longitudinal consensus clustering reveals the functional architecture of the developing rat brain biorxiv.org 2026-06-10 Resting-state fMRI-based mapping of functional networks in developing human populations holds promise for enhancing the diagnosis and treatment of psy
Structured and flexible representations in medial-frontal cortex support goal-directed navigation biorxiv.org 2026-06-10 Humans and animals plan actions to achieve goals in worlds that are complex and continually changing.
A non-canonical pallidothalamic pathway for motor control biorxiv.org 2026-06-10 Coordinated movement relies on interactions between the basal ganglia and the thalamus, yet the circuits linking these structures are not fully unders
An Effective Metal Nanoparticle-Based Drug Delivery System for an In Vitro Model of Non Small Cell Lung Cancer biorxiv.org 2026-06-09 This study presents the development and spectroscopic characterization of an erlotinib functionalized gold nanoparticle (erlotinib:AuNP) nanosystem de
Spatially-resolved integration of microglia morphological diversity and gene expression using Visium with protein co-detection biorxiv.org 2026-06-09 Microglia exhibit a dynamic range of morphologies that actively shift in response to local environmental cues.
HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neuro-cognitive Modeling biorxiv.org 2026-06-09 Computational models are central to cognitive neuroscience, but their rigorous application to experimental datasets is often constrained to a narrow s
Learning induces activation-mechanism--dependent neural plasticity in an intracortical microstimulation task biorxiv.org 2026-06-09 Electrical microstimulation provides high-resolution control of neural circuits for causal studies and restoration of impaired functions, yet how resp
Interplay of pupil-linked arousal and cortical decision computations in mice biorxiv.org 2026-06-09 Influential frameworks hold that brainstem neuromodulatory systems are rapidly recruited in a top-down manner during decision-making, adapting brain-w
Theta phase-locked memory reactivation during REM sleep reduces memories emotional tone biorxiv.org 2026-06-09 REM sleep appears to be involved in emotional memory processing, yet the nature and neural underpinnings of this involvement remain largely unclear.
Aquaporin-4-Specific T Cell Responses in NMOSD Revealed by mRNA-Engineered Dendritic Cells biorxiv.org 2026-06-09 Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system characterized by loss of immune tolerance to the
Varying parameter ranges alters both Partial Rank Correlation Coefficient results and phenomenological behavior when modeling the epithelial mesenchymal transition biorxiv.org 2026-06-09 Partial Rank Correlation Coefficient (PRCC), usually performed following Latin Hypercube Sampling (LHS), is a global sensitivity analysis that quantif
Rapid and Cost-Effective Preparation of a RuBisCO-Rich Protein Fraction from Dried Leafy Biomass biorxiv.org 2026-06-09 Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), the most abundant protein on Earth, is an attractive and sustainable food ingredient owing
Thiosemicarbazone T2 suppresses WNT/β-catenin signaling and limits progression to invasive disease in a mouse intraductal model of triple-negative breast cancer biorxiv.org 2026-06-09 We have previously shown that T2, an N4-aryl-substituted thiosemicarbazone, exerts cytotoxic and anti-invasive effects in triple-negative breast cance
AI-guided analysis of human pancreatic islet sociology reveals distinct cell compositional changes in type 1 diabetes biorxiv.org 2026-06-09 Human pancreatic islets exhibit greater anatomic and cellular heterogeneity than previously appreciated, raising fundamental questions about how their
The pseudoproteinase iRhom2 critically promotes acute lung inflammation biorxiv.org 2026-06-09 ADAM17 sheds cell surface molecules such as TNF-, IL-6R and L-selectin. This activity requires either iRhom1 or iRhom2 as adapter molecules.
One operator to rule them all: Unifying connectome harmonics, turbulence and complex harmonics in brain dynamics biorxiv.org 2026-06-09 Brain dynamics can be described in three different convenient mathematical languages, namely connectome harmonics, turbulence and complex harmonics (C
Decoding molecular programs that define macrophage responses to tumor-derived cues biorxiv.org 2026-06-09 Tumor-associated macrophages (TAMs) comprise functionally diverse states that can suppress anti-tumor immunity and promote tumor progression, yet the
Insulin preservatives trigger neutrophil extracellular trap formation through SYNE1-mediated nuclear disassembly biorxiv.org 2026-06-09 Neutrophil extracellular traps (NETs) are critical effector molecules in sterile inflammation, yet the molecular mechanisms by which xenobiotic chemic
An integrated human immunoglobulin germline resource linking allele diversity to expressed repertoire structure biorxiv.org 2026-06-09 Human immunoglobulin (IG) loci are highly polymorphic, yet existing germline resources remain noisy and incomplete, limiting our ability to link inher
Loss of perinuclear theca protein ACTRT2 causes subfertility and acrosome destabilization in mice biorxiv.org 2026-06-09 Actin-related protein T2 (ACTRT2) localizes to the perinuclear theca (PT) of male germ cells, yet its functional significance remains unclear.
Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex biorxiv.org 2026-06-09 Deubiquitylases modulate cellular processes by cleaving monoubiquitin or polyubiquitin chains.
Methylmalonic acid: a new target for Hadamard-edited MRS biorxiv.org 2026-06-09 Background: Methylmalonic acidemia (MMAemia) is a genetic metabolic disorder characterized by an accumulation of methylmalonic acid (MMA) and impaired
Kinetics of Hypoglycemia in Diabetes Patients Informs Development of New Modes of Glucagon Therapy biorxiv.org 2026-06-09 Insulin therapy revolutionized the care of patients with diabetes starting ~100 years ago, yet insulin-induced hypoglycemia remains a serious life-thr
SHIP2-SRC-β-catenin signaling axis sustains thymidylate synthase expression and promotes fluoropyrimidine resistance. biorxiv.org 2026-06-09 Fluoropyrimidine-based chemotherapies, including 5-fluorouracil (5-FU) and floxuridine (FuDR), are widely used in cancer treatment, but their efficacy
Single-cell transcriptomics of heterogeneous patient-derived organoids reveals novel therapeutic targets in high-grade serous ovarian cancer biorxiv.org 2026-06-09 High-grade serous ovarian carcinoma (HGSOC) is characterized by widespread peritoneal dissemination and poor long-term survival, largely driven by met
Development of a Multidose Irradiation Protocol for Clonogenic Assays in Cell Culture Plates biorxiv.org 2026-06-09 Purpose In vitro experimental radiobiology is a fundamental tool for understanding the cellular and molecular mechanisms involved in the response to i
Individual traits shape hemispheric vlPFC sensitization to Cyberball exclusion: Evidence from single-trial fNIRS analyses biorxiv.org 2026-06-09 Ostracism (i.e., social exclusion) threatens social security and individuals who are hypersensitive to it may face long-term negative mental health co
Age-Related Alterations in Multispectral Somatosensory Gating: Evidence for Partial Compensation in Attentional Performance biorxiv.org 2026-06-09 Healthy cognitive aging involves selective changes, with relative preservation of some domains and decline in others, particularly attention, inhibito
Temporal transcriptomic and microbial changes in American bison during experimental SARS-CoV-2 challenge biorxiv.org 2026-06-09 SARS-CoV-2 continues to pose a threat to humans as well as domestic and wild animals.
Vitamin D3 Deficiency Exacerbates Abdominal Aortic Aneurysm Progression Via Complement C3a Activation biorxiv.org 2026-06-09 Abdominal aortic aneurysm (AAA) is a chronic inflammatory vascular disease characterized by progressive extracellular matrix degradation, vascular smo
Paclitaxel Dosing Regimens Drive Differential CD4⁺ T Cell Responses in the Dorsal Root Ganglia and Modulate Neuropathic Pain Severity biorxiv.org 2026-06-09 While chemotherapy is effective in killing cancer cells, its non-specific cytotoxicity harms peripheral neurons, leading to chemotherapy-induced perip
Human tissue-resident CD8 T cells contribute to trophoblast homeostasis in health and during acute inflammation biorxiv.org 2026-06-09 Previous studies have highlighted that some T cell subsets in tissues can provide signals to support tissue cell homeostasis and differentiation.
A novel coronavirus associated with enteritis in broiler chickens, France, 2025 biorxiv.org 2026-06-09 Coronaviruses of the genus Gammacoronavirus cause major poultry diseases, including infectious bronchitis in chickens and enteritis in turkeys and gui
Comparative Evaluation of DDA and DIA Based Proteomic Workflows in Beryllium Related Lung Disease biorxiv.org 2026-06-09 We compared traditional data dependent acquisition mass spectrometry (DDA MS) with the increasingly adopted data independent acquisition (DIA MS) to e
Phosphoinositide turnover through PLCγ regulates Draper-dependent engulfment in glia biorxiv.org 2026-06-09 Glial engulfment of degenerating neuronal material is essential for nervous system development, maintenance and repair.
Deconstructing a behavioral state: parallel neural integrators control distinct features of an aversive behavioral state in C. elegans biorxiv.org 2026-06-09 Transient sensory stimuli can trigger long-lasting changes in behavior and cognition.
Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function biorxiv.org 2026-06-09 Older adults experience disproportionate morbidity and mortality from Clostridioides difficile infection (CDI); however, existing toxoid- and receptor
Scalable generation of pure CD103⁺ cDC1 from iDC1 cultures biorxiv.org 2026-06-09 Conventional type 1 dendritic cells (cDC1) specialize in cross-presentation and interleukin-12 production and are critical for immunity against intrac
Quantifying annotation-stratified pleiotropy and co-polygenicity between complex traits biorxiv.org 2026-06-09 Understanding shared genetic architecture is essential to interpreting disease comorbidities and trait correlations.
A Facile and Versatile Technique for Creating Antifibrotic Coatings on Biomedical Implants biorxiv.org 2026-06-09 Foreign body response is a common yet serious challenge for biomedical implants.
Fluctuating DNA methylation sites encode colorectal tumour growth history biorxiv.org 2026-06-09 Determining the nature of human tumour growth is challenging given the impracticality of obtaining detailed data across time.
Individual, behavioural, and environmental determinants of personal light exposure in daily life: A multi-country wearable and experience-sampling study biorxiv.org 2026-06-09 Personal light exposure is a modifiable determinant of circadian and neurobehavioural health, yet its everyday structure across populations remains po